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동의보감(東醫寶鑑) 외형편(外形篇) 권(卷)1 [두(頭)]부분 관련처방의 재해석
박선동,Park, Sun-Dong 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1
許浚(Heo Jun), the best physician on his day, wrote 東醫寶鑑(DongEuiBoGam, 1613) based on his clinical experience as a court doctor and life-long study of over 500 medical books. Now most clinicians consult 東醫寶鑑(DongEuiBoGam) for its practicality. And it is also considered as one of the most valuable medical books for basic medical studies. As 許浚(Heo Jun) mentioned on the 東醫寶鑑(DongEuiBoGam) preface. we should practice flexibility on the interpretation of the medical classics instead of binding ourselves to the precedents. But worship of 東醫寶鑑(DongEuiBoGam) may hinder the studying of new pathways. The treatment and its understandings of a disease should be based on objectivity of observation. Finding the common traits of the recipes in 東醫寶鑑(DongEuiBoGam) is important for the study of 東醫寶鑑(DongEuiBoGam). Accordingly, group synthesis of symptoms and resultant classification of recipes are vital. In this research, symptoms listed in the head part(頭門) of External Shape vol. I(外形篇 卷1) of 東醫寶鑑(DongEuiBoGam) are synthesized into 3 different parts: head-wind syndrome(頭風證), dizziness(眩暈), headache(頭痛). Classification of prescriptions according to these 3 parts is also suggested.
박선동,문진영 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
Sihosamultang has been used in treatment for puerperal fever, liver disease in traditional medicine. The present study was carried out to evaluate the antioxidant effects of Sihosamultang methnol extract(SME) in vitro. The inhibitory effect of SME on lipid peroxidation was examined in the linoleic acid autoxidation system. In this test, SME significantly inhibited the time course of the lipid peroxidation. And SME showed about 77% scavenging effect on DPPH radical, also exhibited about 89% inhibitory effect on lipid peroxide formation induced by hydroxyl radical derived from H₂O₂-Fe^2+ in the rat liver homogenate. And SME dose-dependently inhibited superoxide generation from xanthine-xanthine oxidase system. In addition, SME protected the hepatic cell death induced by tert-butyl hydroperoxide. These data indicated that SME might play a protective role against oxidative injury by free radicals.
朴宣東,朴賢俊,朱旺錫 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
This study was performed to research the antioxidant activities of Guibitang and its component groups. The experimental group was divided into six group: Guibitang (GB), Gamiguibitang (GA), Hyul-yak group (GB1), Gi-yak group (GB2), Ansinhaenggi-yak group (GB3) and Gami-yak group (GA1). The results were obtained as follows: In vitro All experimental groups had antioxidant activity in linoleic acid system on concentration in comparison with control group. And in DPPH radical scavenging experiment, all experimental groups had scavenging activity on concentration, especially GA1 group was higher than any others. The inhibitory effect experimental groups had inhibitory effects of superoxide generation on concentration, and the effect of Guibitang was better than Gamiguibitang. In component groups GA1 was highest and GB1 was lowest respectively. The inhibitory effect experiment on lipid peroxidation reaction in H₂O₂-Fe^2+ system showed that each experimental groups had inhibitory effects on lipid peroxidation reaction compared with control group. And GA1 group exhibit the best inhibition effect on lipid peroxidation reaction. In vivo the amounts of lipid peroxide rat on the level of serum was reduced in comparison with control group, especially gamiguibitang. The amounts of LPO on the level of liver was also reduced compared with control group. espeially gamiguibitang, guibitang, GB1 group. In hepatic catalase activity test, all experimental groups increased catalase activity, and that of guibitang, gamiguibitang, GB1 group were evident. The amounts of hepatic glutathione of experimental group increased in comparison with control group. And that of gamiguibitang, guibitang was more significant than component group.
血府逐瘀湯과 그 構成藥物群이 Alloxan 糖尿 白鼠의 血淸 組成 및 抗酸化 效果에 미치는 影響
朴宣東,朱旺錫,高元道 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
This study was reseached to investigate the effect of Hyulbuchukeotant(?????) and its component groups on diabetes, free radical and antioxidative defense system in alloxan-induced diabetic rats, The experimental group was divided into three groups: Hyulbuchukeotang (HCT), and its components groups, Sayeoksan(H-sa) and Dohong- samultant(H-do). The results were obtained as follows: In the study of effect on diabetes, the level of glucose was considerablely reduced by HCT, H-sa and H-do with high significancy. In the change of fat metabolism, all experimental groups significantly changed the level of triglyceride, total cholesterol and HDL cholesterol expecially HCT and H-do group, but H-sa group has less significancy. In the change of protein metabolism, all experimental groups changed the level of total protein and albumin with high significancy. In the change of kidney function, HCT decreased the level of creatinine and BUN with high significancy, H-sa and H-do did with some significancy too. In the study on free radical scavenging effect in vitro, it has shown that all experimental groups have significant suppressing effect on peroxidation of linoleic acid on concentration, and in the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and inhibitory effect on lipid peroxidation reaction by hydroxy radical in H₂O₂-Fe^2+ system, all experimental groups have some activity. In the study on antioxidative defense system in vivo, HCT reduced the amount of lipid peroxide in serum and liver with high significantcy, and H-sa, H-do group did too with some significancy. In hepatic catalase activity, all experimental groups had showed activity on catalase, but H-sa no significancy. In the level of hepatic hlutathione, HCT increased the amount of glutathione significantly, but other groups with no significancy. In the activity of glutathione-s-transferase, all experimental groups has decreasing effect with significancy. These results suggest that Hyulbuchukeotant(?????) has strong effect on diabetes and peroxidative damage by free radical, so it is useful to prevent diabetes.