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돼지 난자-난구 복합체의 분산에 따른 미세구조의 변화에 관한 연구
문연자,김정중,최민규,문철성,정연태 圓光大學校 醫科學硏究所 1990 圓光醫科學 Vol.6 No.1-2
Light and electron microscopic studies were undertaken to elucidate the structural changes of cumulus cells from the dispersed cumulus-oocyte complexes. Cumulus dispersion were induced by culturing porcine cumulus-oocyte complexes in the medium supplemented with FSH for 48hrs. The results were summarized as follows ; 1. In intact porcine cumulus-oocyte complexes, shape of cumulus cells were round or ellipsoid but in the complexes treated with FSH, shape of cumulus cells were irregular and have well-developed cytoplasm processes. 2. In FSH-stimulated complexes, light and electron microscopic findings revealed that the cumulus cells were dettached from the zona pellucida surrounding the oocyte, intercellular space between cumulus cells became wide and junctions between them were disappeared. 3. Dispersed cumulus cells showed a remarkable increase of the smooth endoplasmic reticulum, a reduced number of rough endoplasmic reticulum, well-developed Golgi apparatus around the nucleus, and numerous lipid droplets which are variable in size and shape.
문연자,김진,임난영,이승연,곽섭,황충연,우원홍 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.6
This study was conducted to evaluate the effects of Glycyrrhizae Radix water extract, known as depigmenting agent, on melanin biosynthesis in cellular level. The inhibitory effect of Glycyrrhizae Radix water extract on melanogenesis was identified by mushroom tyrosinase assay. To determine whether Glycyrrhizae Radix water extract suppress melanin synthesis in cellular level, B16 mouse melanoma cells were cultured in the presence of different concentrations of Glycyrrhizae Radix water extract. The maximum concentration of Glycyrrhizae Radix water extract that was not inhibitory to growth of the cells was 2 mg/ml. At that concentration, melanin synthesis was significantly inhibited without cytotoxicity after 5 days, compared with untreated cells. The treatment with Glycyrrhizae Radix water extract reduced tyrosinase and DOPAchrome tautomerase activity in a dose-dependent manner. These results suggest that the inhibitory effect of Glycyrrhizae Radix water extract on melanogenesis is due to the suppression of tyrosinase and DOPAchrome tautonerase activity.
중추신경의 방사선 조사와 회복효과: 항산화제와 NMDA-receptor 길항제의 작용
문연자,박승택,최민규,정동혁,문성록,정연태,Mun, Yeun-Ja,Park, Seung-Taeck,Choi, Min-Kyu,Jeong, Dong-Hyeok,Moon, Sun-Rock,Chung, Yeun-Tai 한국현미경학회 1998 Applied microscopy Vol.28 No.4
The neurotoxic effects of radiation have been studied in NSC-34 hybrid cells derived from embryonic mouse spinal cord cells. NSC-34 cells irradiated at 25Gy were decreased the cell viability in a time and dose dependent manner. The decrease in cell viability induced by the irradiation was blocked by catalase. Antagonists of the N-methyl-D-aspartate (NMDA) receptor, including D-2-amino-5-phosphonovaleric acid (APV) and chlorokynurenic acid (CKA), similarly blocked radiational induced in cell viability. We performed morphological analysis of light and electron microscope. NSC-34 cells irradiated at 25Gy were decreased the cell density and increased lysosomes and vacuoles in the cytoplasm. Especially chromatin modification was observed. These results indicated that radiation was involved in the oxidant-initiated neurotoxicity and the compounds catalase, APV and CKA were shown to be neuroprotective against radiation.
홍삼과 어유(魚油) 복합식이에 의한 UV-유도 광노화 억제효과
문연자,전병국,김태현,이진호,최형욱,임규상,우원홍,Mun, Yeun-Ja,Jeon, Byoung-Kook,Kim, Tae-Hyun,Lee, Jin-Ho,Choi, Hyung-Wook,Lim, Kyu-Sang,Woo, Won-Hong 대한한방안이비인후피부과학회 2014 한방안이비인후피부과학회지 Vol.27 No.3
Objective : UV irradiatiion causes skin-aging involving coarse wrinkles, thickning, dyspigmentation, and rough skin surface. This study was aimed to elucidate the anti-winkle activity of complex diet of Korean red ginseng (RG) and fish oil (FO) on UV-induced Photoaging. Methods : To investigated photo-protective effects of Korean red ginseng and fish oil on UV-induced damaged skins, SKH hairless female mice were randomly divided into six groups [control, UV, UV/RG, UV/FO, UV/RG/FO(low), UV/RG/FO(high)]and orally administered three times a week respectively. UV radiation was applied to the backs of the mice three times a week for 8 weeks. Expressions of matrix metalloproteinase (MMP)-3, MMP-13 and tissue inhibitor matrix metalloproteinase (TIMP)-1 in skin were measured by immunohistochemical staining. Results : In this study, UVB-induced epidermal hypertropy was diminished by RG group or FO group or complex group of RG and FO. Expression levels of MMP-3 and MMP-13 were reduced and expression level of TIMP-1 was increased by RG group or FO group or complex group of RG and FO. Especially MMP-3 and MMP-13 were markedly reduced by diet of FO and complex diet of RG and FO compared with untreated group. Conclusions : This results suggest that complex diet of RG and FO have a anti-wrinkle activity on UV-induced photo-aging and intrinsic aging.
문연자,임난영,이성원,강대길,백순기,우원홍,Mun Yeun-Ja,Lim Nan-Young,Lee Sung-Won,Kang Dae-Gill,Baik Soon-Ki,Woo Won-Hong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2
This study was performed to investigate the effects of fermented extract of Pinus densiflora (FPD) on oxygen radicals and $H_2O_2$-induced damage. The results are as follows: 1. The 1.1-diphenyl-2-picrylhydrazyl (DPPH) free radicals were considerably reduced by FPD and $IC_{50}$ value was showed the concentration of 20 ㎍/㎖. 2. The cytotoxicity did not observe by FPD treatment in A548 cells. 3. The $H_2O_2$-induced cell damage was recovered by FPD pretreatment in A549 cells. These results suggest that FPD, as a natural antioxidant, has scavenging effect of free radicals and protection effect from $H_2O_2$-induced cytotoxicity.
A549 폐암세포주에 대한 蘇本 水抽出物의 세포고사 유도효과
문연자,남용재,이광규,최두호,이성원,안성훈,최민규,우원홍 대한동의생리학회,대한동의병리학회 2002 동의생리병리학회지 Vol.16 No.3
The Caesalpinia sappan is widely used in the traditional oriental herbal medicine for anti-inflammatory, antioxidant effects. The effects of water extract of C. sappan on the cell viability and induction of apoptosis were investigated in human lung cancer cell line A549. The water extract of C. sappan produced apoptotic cell death and DNA fragmentation and nucleus chromatin condensation in A549 cells. The enzyme activity of caspase-3 and protein level of actived caspase-3 were markedly increased in A549 cells treated with the water extract of C. sappan. In addition, the extract of C. sappan induced cleavage of Poly (ADP-ribose) polymerase (PARP), a known substrate for caspase-3, and dropped in cellular ATP levels. These results suggest that the extract of C. sappan exerts anticancer activity by induction of apoptosis via activation of caspase-3, cleavage of PARP protein, and depletion of cellular ATP levels in A549 cells.