http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
문미란,박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5
For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene]. the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.
마약길항제의 방출 제어형 제제 ( 제2보 ) : 나론속 이식제제의 생체적합성 및 약물속도론적 평가
문미란,박주애,이승진,김형국,김길수 ( Mi Ran Moon,Joo Ae Park,Seung Jin Lee,Hyung Kuk Kim,Kil Soo Kim ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.2
For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene], the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.
마약길항제의 방출 제어형 제제 (제2보): 나록손 이식제제의 생체적합성 및 약물속도론적 평가
문미란,박주애,이승진,김형국,김길수,Moon, Mi-Ran,Park, Joo-Ae,Lee, Seung-Jin,Kim, Hyung-Kuk,Kim, Kil-Soo 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.2
For the effective administration of narcotic antagonist, the application of sustained release implantable systems with biodegradable polyphosphazene was examined. Using poly[(diethyl glutamate)-co-(ethyl glycinate) phosphazene], the implantable devices containing naloxone hydrochloride were prepared and in vivo implantation studies were carried out subcutaneously in rat and rabbit with this preparation for the biocompatibility and pharmacokinetics. The histological finding in rats at initial time period was the inflammation that occurred focally around the implants, but they were showed subsequent mild and limited chronic inflammations and the irreversible changes such as necrosis and degeneration of the muscle or connective tissues were not observed. Therefore the placebo and naloxone implants are considered to be biocompatible formulations histologically. In pharmacokinetic studies, the release of naloxone from the naloxone implants into blood plasma was maintained in 192 hours, but the initial burst effect was observed. If this problem was solved, the application for the narcotic antagonist sustained release systems can be expected.
Pisolithus tinctorius菌에 의해 형성된 소나무류 外生菌根의 形態的 比較
文美蘭,吳光仁,鄭南澈 全南大學校 農業科學技術硏究所 1999 農業科學技術硏究 Vol.34 No.-
Pisolithus tinctorius菌을 곰솔(Pinus thunbergii), 소나무(P. densifora), 리기다소나무(P. rigida), 테에다소나무(P. taeda), 리기테다소나무(P. rigitaeda), 버지니아소나무(P. virginiana)에 人工接種하여 수종간 균근의 發達, 菌根型의 特異性, 外部形態的 特徵을 調査하였다. P. tinctorius菌이 接種된 소나무류의 菌根型은 線型(linear type), 頂端型(apical type), 棍棒型(clavate type), 塊根型(nodular type), 二次分枝型(dichotomy type), 念珠型(bead type), 長二次分枝型(long dichotomy type), 不均衡 二次分枝型(unbalanced dichotomy type), 二重二次分枝型(double dichotomy type), 不均衡二重二次分枝型(unbalanced double dichotomy type), 不均衡半二重二次分枝型(unbalanced semi-double dichotomy type), 珊瑚型(coralloid type)으로 識別되었다. 곰솔, 리기테다소나무의 均套표면은 노란색 Felt 형의 뚜렷한 菌套를 형성하였다. 그러나 리기다소나무, 소나무, 테다소나무, 버지니아소나무의 菌套表面은 부착 菌絲의 형성이 전혀 없는 매끄럽고 윤기있어 보이는 황갈색 velvety형 均套를 나타냈다. 소나무, 리기다소나무, 테다소나무, 버지니아소나무는 線型, 頂端型, 二次分枝型, 念珠型, 長二次分枝型들과 같은 단순한 형태들이 주로 나타났지만, 곰솔과 리기테다소나무는 二次分枝型, 變形들인 長二次分枝型, 不均衡二次分枝型, 二重二次分枝型, 不均衡二重二次分枝型, 不均衡半二重二次分枝型들이 많이 나타났고 안정형인 珊瑚型으로 發達하였다. The morphological characteristics of ectomycorrhizae in the seedlings of 6 different pines(Pinus. thunbergii, P. densiflora, P. rigida, P. teada, P. rigiteada and P. virginiana), inoculated with ectomycorrhizal fungi, Pisolithus tinctorius(Pers.) Coker & Couch, were analyzed. The types of ectomycorrhizal short roots among 6 pines could be categorized into 12 types; linear, apical, clavate, nodular, dichotomy, bead, long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, unbalanced semi-double dichotomy, and coralloid types. Whereas the sheaths of seedlings of P. thunbergii and P. rigiteada were covered with a mycellium bed of light yellowish white, those of the other pines were covered with the smooth and blight bed of yellowish brown without attached mycellium. The five major types(i.e, linear, apical, dichotomy, bead, and long dichotomy types) of the 12 types classified in this study were for P.densiflora, P.rigida,P.teada,and P.virginiana,respectively. However, P. thunbergii, and P. rigiteada of long dichotomy, unbalanced dichotomy, double dichotomy, unbalanced double dichotomy, and unbalanced semi-double dichotomy types were the major types, which were developed into a stable type such as coralloid type.