당뇨병을 동반한 한국인 고지혈증 환자에서의 atorvastatin의 유효성 평가

최동섭,김덕규,김성연,남문석,박용수,손호상,안철우,이관우,이기업,이문규,정춘희,차봉연,김두만 대한당뇨병학회 2006 Diabetes and Metabolism Journal Vol.30 No.4

연구배경: NCEP ATP III 가이드라인에 의하면 당뇨병을 관상동맥질환 위험인자로 분류하여, 당뇨병을 동반한 고지혈증 환자의 적극적 치료를 권장하고 있다. 이에 시판 후 조사를 통해 당뇨병을 동반한 고지혈증 환자에서의 atorvastatin의 유효성과 안전성을 평가하기 위해 본 연구를 시행하였다.방법: 2004년 3월부터 2004년 9월까지 내분비내과를 방문한 고지혈증 환자 중 atorvastatin을 처음 투여 받은 환자를 대상으로 개방표지, 다기관, 비비교, 가변용량 연구를 실시하였다. 전국 66개 병원에서 96명의 내분비 전문의가 본 연구에 참여하였다. 총 2,182명의 환자가 등록되었으며, 이 중 당뇨병을 동반한 환자는 1,514명이었다. 유효성 평가는 atorvastatin을 4주 이상 복용하고, 기초 및 4주 이후에 총콜레스테롤 수치가 측정된 환자를 대상으로 이루어졌고, 안전성 평가는 atorvastatin을 1회 이상 투여한 모든 환자를 대상으로 이루어졌다. 연구자들은 환자 등록 시점에 당뇨병 동반 여부를 확인하였다. Atorvastatin을 최소 4주 이상 투여한 후, 총콜레스테롤, 중성지방, 고밀도지단백 및 저밀도지단백 콜레스테롤을 측정하도록 하였으며, 투여 전후의 각 수치의 변화율로부터 유효성을 평가하였다. 저밀도지단백 콜레스테롤의 치료목표인 100 mg/dL 미만을 달성한 환자의 비율도 분석하였다. 또한 이상반응 발현 여부 및 임상검사치의 이상 여부로부터 안전성을 평가하였다.결과: Atorvastatin 투여 후 당뇨병성 고지혈증 환자에서 총콜레스테롤, 중성지방, 저밀도지단백 콜레스테롤의 수치가 각각 26.6%, 12.0%, 34.8%의 높은 감소율을 나타냈으며, 100 mg/dL 미만의 저밀도지단백콜레스테롤을 가진 환자도 2.8%에서 52.6%로 크게 증가하였다. 총 2,182명의 환자 중에서 32명의 환자가 이상약물반응을 보고하여 1.5%의 발현율을 보였으며 매우 안전한 것으로 생각되었다. -Background: NCEP ATP III Guideline recommends aggressive treatments of diabetic dyslipidemia, recognizing diabetes mellitus as CHD risk equivalents. This study was conducted to evaluate the effectiveness and safety of atorvastatin in hyperlipidemic patients with Type 2 diabetes mellitus through post-marketing drug use investigation of atorvastatin.Methods: An open, multi-center, non-comparison, titrated dosage study was conducted in hyperlipidemic patients, who were treated with atorvastatin at first visiting hospitals from Mar. 2004 to Sep. 2004. 96 endocrinologists participated from 66 centers in this study. Total 2,182 hyperlipidemic patients were enrolled and 1,514 patients among them were accompanied by diabetes mellitus. Efficacy was evaluated at later than 4-week treatment by % change of total cholesterol, triglycerides, HDL-cholesterol and LDL-cholesterol from baseline. Percent of patients reaching LDL-cholesterol level less than 100 mg/dL was also analyzed.접수일자: 2006년 4월 24일, 통과일자: 2006년 7월 5일, 책임저자: 최동섭, 고려대학교 의과대학 내분비내과* 이 연구는 한국화이자제약㈜의 연구비 지원으로 이루어졌음.The adverse events incidence and abnormalities of clinical laboratory values were evaluated for safety monitoring.Results: Total cholesterol, triglycerides, and LDL-cholesterol level were reduced by 26.6%, 12.0%, and 34.8%, respectively, in diabetic hyperlipidemic patients after atorvastatin treatment. The patients with LDL-cholesterol level of less than 100 mg/dL were increased from 2.8% to 52.6%. Atorvastatin was considered to be safe because adverse drug reactions were reported in 32 patients (1.5%) of total 2,182 patients.Conclusion: Atorvastatin was effective and safe in hyperlipidemic patients with type 2 diabetes mellitus. (J Kor Diabetes Assoc 30:292~302, 2006)

갑상선기능 저하증의 진단과 치료

최동섭 약업신문사 1996 의약정보 Vol.1996 No.5

행정발전을 위한 제도 및 법령개선

최동섭 대한지방행정공제회 1984 地方行政 Vol.33 No.371

N/A

아토피성 피부염으로 인한 속발성 한국성 피부 Amyloidosis

최동섭,우태하,조길연 대한피부과학회 1973 大韓皮膚科學會誌 Vol.11 No.2

Secondary localized amyloidosis of the skin is occasionaly associated with keratoma, epithelioma, seborrheic keratosis, chronic dermatitis, etc. It was generally known that amyloidosis, especially lichen amyloidosis, is frequently seen in atopic disorders. But the exact mechanism and relationship of atopic disorders to the development of the amyloidosis is obscure still nowadays. This 72 years old male patient was suffered from itching sensation on the whole body which is suggested to be atopic dermatitis since about 35 years ago and pruritic lichenoicl papulonodular eruptions developed on the extensor surface of the lower extremity first since about 10 years ago and then occured gradually on the thigh and extensor surface of the arm and forearm in both side. The charateristic lesions seems to be lichen amyloidosis. But we suggest thc case is secondary localized amyloidosis of the skin probably due to atopic dermatitis in according to past history, physical examination and eosinophilia without other definitive diseases, The therapeutic results were not promissing, however itching and lichenoid papules were much disappeared during the treatment with steroid cream for occlusivc dressing therapy and oral use of steroid.

기술초대석II - STD(Strut Top Down) 이용한 지하층역타공법

최동섭,Choe, Dong-Seop 한국건축구조기술사회 2012 건축구조 Vol.19 No.2

2급 응급구조사의 성인외상환자에 대한 처치의 적절성 평가

장문수,어은경,김상현,김창섭,송근정,박한규,유지영,최동섭 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

In Korea, EMT have two classified subgroup of first and second degree : EMT-P, and EMT. For the beginning, authorization of the first EMT was made in this year through the EMT educational program. There are 8 items which EMT can perform the treatment without the supervision by a physician. But there was no previous report of pertinent assesment of treatment performed by the EMT. There upon authors have conducted review of assessment done by the EMT in EC setting, and proposed the following treatment application can be used by EMT at the field of accident. The study materials include adult trauma patient older than 15 years, and sustained trauma within 48 hours before visiting Ewha University DongDaeMoon Hospital Emergency Deparment. The duration of study was from Apr. 1 1995 to Aug. 31 1995. the study was conducted by 5 certified EMT. The EMT's performance was evaluated by the attending Emergency Medicine physician. The result were as followings ; 1. Among the total 5532 ED visiting patients during the study period, 1267 were adult trauma patients who recieved treatment within 48 hours of injury. 2. Among 1222 out of 1267 patients have completed performed survey. 3. Male to female ratio was 2.6 : 1, age distribution was from 15 to 87 years old and mean age was 34.6 years old. 4. The MOI showed : MVA (33.1%), blunt trauma (29.9%), slip down (16.8%), penetrating injury(15.4%), and miscellaneous (5.7 %), burn (3.1%), falling down injury(2.9 %), bite injury(1.1%) in order. 5. There were 437 cases of survey completed by the EMT. For assessment of mental status of 3 different method : AVPU, 5 scale mental status and GCS, were correlated with EM physician with 99.1%, 98.6%, 97.7 %, respectively. 6. For 320 out of 437 cases of survey completed, 319 patients recieved treatment by the EMT within 30 minute and 1 patient between 30 to 60 minute of an ED arrival. 7. For those 437 cases of survey completed, 266 patient (60.9%) had adequate treatment and 54 patients (12.4%) had inadequate treatment. 67 patient (15.3%) did not received treatment but it was adequate inway, and 50 patients (11.9%) did not received treatment even though patient required treatment. In cases of adult trauma patients, EMT's mental status assessment was correlated with EM physician's assessment. But treatment done by EMT without the supervision of EM physician was adequate only in 76.2 %. Therefore, continuous education and assessment of treatment performed by EMT in needed to improve field treatment by EMT future.

`76 지방행정 시책방향 `76 지방행정 정부시책방향

최동섭 대한지방행정공제회 1976 地方行政 Vol.25 No.269

N/A

한국행정의 과제

최동섭 한국행정학회 1992 한국행정학회 학술발표논문집 Vol.1992 No.-

UKPDS의 임상적 의의

최동섭 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.4

광화학적 Rhodamine B 제거를 위한 구슬형태의 TiO₂의 제조

최동섭,변상우,김지율,박일건,주지봉 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1

최근 수질오염문제가 대두되면서 수중 오염 물질 제거에 대한 관심이 높아지고 있다. 물 속에서 존재하는 Rhodamine B와 같은 유기염료를 제거하기 위한 여러 기술 중, TiO₂을 이용한 광촉매 기술이 주목 받고 있다. 분말형태의 TiO₂는 주로 물에 분산시켜 사용하기 때문에 높은 활성을 달성할 수 있으나, 수용액에 분산된 분말형태의 촉매를 회수하기 어렵다는 단점이 있다. 본 연구에서 이러한 단점을 극복하기 위해 알지네이트 화합물을 이용하여 'egg-box junction' 모델 반응을 통해 구슬형태의 TiO₂촉매를 합성하였다. 합성조건을 조절하여 입자의 크기 등의 물리적 특성을 조절할 수 있었다. 만들어진 구슬형태의 TiO₂를 사용한 회분식 및 연속식 반응기에서 Rhodamine B 염료분해 반응을 수행한 결과, Rhodamine B 염료분해 반응을 수행한 결과, Rhodamine B 의 양이 꾸준히 감소하는 것과, 입자의 안정성을 확인하였다.