항정신병약물에 대한 정신분열병 환자의 치료반응과 혈장 Homovanillic Acid 농도변화에 관한 연구

서해숙,김철응,강민희 대한신경정신의학회 1999 신경정신의학 Vol.38 No.1

연구목적 : 정신분열병 환자의 halopidol 투여에 따른 치료반응을 구분할 수 있는 생물학적 지표를 찾기 위해 haloperidol 투여 전과 투여 후 6주까지 혈장 HVA 농도의 변화를 보고자하였다. 방 법 : 항정신병 약물을 최소 3개월 이상 사용하지 않았던 정신분열병 환자를 대상으로 하여 약물 투여전과 약물투여후 6주까지 매주 간격으로 HPLC을 사용하여 혈장 HVA농도를 측정하고 간이정신상태 검사 총점수가 치료 6주 후 기저치에 비해 25%이상 감소된군을 호전군, 그 미만의 군을 비호전군으로 구분하여 각군의 혈장 HVA농도의 변화 양상을 조사하였다. 결 과 : 1) Haloperidol 치료로 임상적으로 호전된 군은 사회인구학적 특성에서 발병 연령이 유의하게 높았다. 2) Haloperidol 투여에 따른 형장 HVA의 농도는 전체 대상환자에서 치료 6주동안 통계적으로 유의한 변화를 보이지 않았으나 비호전군은 연속적 비교에서 치료 3일째와 1주째의 혈장 HVA 농도가 이전치에 비해 유의하게 낮았다. 3) 혈장 HVA 농도와 임상평가 척도 사이에는 haloperidol 투여 전, 투여 후 어느 시점에서도 유의한 상관관계를 보이지 않았다. 결 론 : 본 연구 결과는 haloperidol 투여에 따라 혈장 HVA의 변화 양상이 다른 아군이 존재한다는 사실은 시사하나 혈장 HVA 농도의 변화가 정신분열병 환자의 임상척도 또는 치료에 대한 반응을 나타낸다는 결론은 도출할 수 없었다. Objectives : Changes in plasma homovanillic acid(HVA) were investigated in neuroleptic responsive and non-responsive schizophrenics in order to delineate parameters of dopamine regulation, which may underlie difference in neuroleptic responsivity. Method : Twenty newly admitted acute schizophrenic patients were treated with haloperiodol for 6 weeks. HVA was sampled at baseline, 3 days after initial neuroleptic dose, and after 1, 2, 3, 4, 6 weeks of treatment. Nine patients were classified as responders in this prospective haloperidol treatment trial. They had a score of change in the BPRS total scores of 25% or greater. Eleven patients were classified as nonresponders, based on a score of changes in the BPRS total scores of less than 25%. Results : 1) The age of onset in respnder was older than nonresponder 2) There were no significant change in plasma HVA levels in total patients during 6 weeks haloperidol treatment period, but the nonreponders had a robust decrease in HVA level from baseline to 3 days and ones week after haloperidol treatment in successive comparison. 3) There were no significant correlations between plasma HVA level and total scores of BPRS. Conclusion : This study suggested that neuroleptic non-responsive schizophrenics had a difference plasma HVA concentration during haloperidol treatment but could not provide support to the that change in plasma HVA in response to neuroleptics can predict eventual clinical response to treatment. Further study is required in order to better characterize the change in dopamine turnover in subgroups of schizophrenics.

알콜리즘 환자의 혈액학적 생화학적 이상 소견

강민희 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

The author studied the clinical characteristics and hematological, biochemical abnormalities of 60 alcoholic patients who had been admitted in the psychiatric ward of the Chungnam National University Hospital from January 1992 to August 1995. The results were as follows : 1) Mean age of the patients was 47.2±10.6 years old, and 63.3% of them were in their forties or fifties. 2) Most of the patients lived in large cities, were educated in high school, and were married. 3) 48.3% of the patients had family histories of the alcoholism, and most of them were patients' fathers. 4) 50.0% of the patients had previous admission histories due to alcoholism. 5) Mean age of the first excessive drinking was 24.2±6.53 years old, and mean duration of excessive drinking was 22.0±11.6 years. Mean amount of drinking was 2.78±1.23 bottles of So-ju a day. 6) Most of the patients were diagnosed as alcohol dependence. Most frequent alcohol-induced organic mental disorders were uncomplicated alcohol withdrawl, withdrawl delirium, dementia. 7) Almost all of the patients had physical illnesses. 8) 80% of the patients were dropped out before 5 sessions of outpatient follow up after discharge. 9) Significant increases of MCV, GOT, GPT, rGTP were found in alcoholic patients

Meningoencephalitis in Dachshund Dog with Canine Distemper Virus Infection: 1.5 T and 7.0 T MRI Findings

강민희,박희명 한국임상수의학회 2010 한국임상수의학회지 Vol.27 No.6

A 6-year-old, intact female Dachshund was presented with generalized seizure for 2 days. Based on the neurologic and physical examinations, intracranial diseases were suspected. 1.5T and 7.0T magnetic resonance imaging (MRI) of the brain were taken. The MRI results revealed diffuse hyperintense lesions in the area of the diencephalon to the medulla oblongata in the T2-weighted images. Canine distemper virus-induced meningoencephalitis was confirmed by the result of RT-PCR of the cerebrospinal fluid (CSF). The dog was euthanized 7 days after diagnosis due to poor prognosis and clinical deterioration. Postmortem histopathologic examination was consistent with the MRI findings. This is the first case report using 1.5T and 7.0T MRI to compare the virus-induced intracranial lesions in meningoencephalitis.

精神科에 諮問依賴된 患者에 對한 臨床的 考察

姜民熙 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

A clinical study was done with 63 inpatients consulted to department of Psychiatry in Chungnam National University Hospital for last 8 months. Characteristics of demographic data were old age, low educational level, and low socioeconomic status. Most common source of referral was department of internal medicine. Most frequent cause of consultation was subjective physical symptoms in spite of negative physical examination and laboratory tests. Common psychiatric diagnosis was neurosis including depressive neurosis. The rate of acceptance of psychiatric diagnosis was 37.5%, otherwise the rate of acceptance of recommended psychotropic drugs was 85.7%. These data appeared to reflect tendency of physicians not to accept the opinions of psychiatrist except psychotropic drugs.

[토론문] “구술없는 시대의 장애사, 무엇을 어떻게 서술할까”에 대한 토론문

강민희 한국장애학회 2019 한국장애학회 학술대회 자료집 Vol.2019 No.1

정신과 외래환자의 인격장애 척도에 관한 고찰

강민희 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

During a 2 month period from September 1, 1985 to October 31, 1985, the author performed the Personality Deviance Scale on 80 psychiatric out-patients. The tested group were composed of 40 male patients and 40 female patients with diagnosis of anxiety disorder (33), somatoform disorder (12), other neurotic disorders (2), affective disorder (26), adjustment disorder (5), tension headache (2). The author obtained following results. 1. The mean PDS scores for total out-patient group were Extrapunitive scale25.3, Intropunitive scale 26.9, Dominance scale 25.3. 2. The mean PDS scores for male out-patient group were Extrapunitive scale 25.7, Intropunitive scale 27.2, Dominance scale 26.1. 3. The mean PDS scores for female out-patient group were Extrapunitive scale 24.9, Intropunitive scale 26.7, Dominance scale 24.5. 4. In female group, the difference between Extrapunitive scale and Intropunitive scale was statistically significant. The difference between Intropunitive scale and Dominance scale also was also statistically significant.

Tegretol-CR의 抗 躁症 효과에 관한 임상적 연구

강민희,왕성근,신석철 최신의학사 1993 最新醫學 Vol.36 No.7

사인이 위염 및 H.pylori에 미치는 효과

강민희,정춘식 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1

The present study was carried out for the development of a new gastroprotective supplementary product. Five herbs that have GI protective property were selected from Dongeuibogam to be evaluated for anti-bacterial activity against Helicobacter pylori. The material used in the test were water extract of Alpinia oxyphylla (AO), Astragalus membranaceus (AM), Cinnamomum loureirii (CL), Citrus aurantium (CA) and Amomum villosum (AV). They were tested individually on HCl·ethanol-induced gastric lesions in rats, AV, CL, AO showed the most significant effectiveness, respectivly. Amomum villosum (AV) ethanol extract was fractionated with hexane, chloroform, butanol and water. The most active fraction was butanol that was investigated by a HCl·ethanol-induced gastric model. Data suggests that Amomum villosum (AV) can be applied as treatment of gastritis and Helicobacter pylori.

Successful Management of Feline Infectious Peritonitis with Human Recombinant Interferon-alpha and Pentoxifylline in a Cat

강민희,박희명 한국임상수의학회 2011 한국임상수의학회지 Vol.28 No.4

A 6-month-old intact female, domestic short hair cat was presented with dyspnea and anorexia for 2 days. Physical examination revealed muffled heart sound with labored breaths. Hyperproteinemia and hyperglobulinemia with polyclonal gammapathy was revealed. Pleural effusion was non-septic exudates, it also had hyperglobulinemia with decreased albumin:globuline ration. In addition, effusion RT-PCR for feline coronavirus was positive in this cat. Feline infectious peritonitis (FIP) was strongly suspected and aggressive treatments with human interferon-alpha, pentoxifylline, and glucocorticoids were initiated. The cat remained healthy without recurrence of pleural effusion during 5 months follow-up periods. To the author’s knowledge, this is the first case report describing successful management of FIP with human interferon-alpha and pentoxifylline in Korea.

우울증 환자에 대한 Amineptine Hydrochloride의 임상 효과

강민희,신석철,왕성근,신윤오 최신의학사 1990 最新醫學 Vol.33 No.7