胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮 충남대학교 대학원 1976 論文集 Vol.6 No.-

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975 The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern with clinical considerations The results obtained were as follows 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis wth other diseases (13.%) 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically 3) Sec distr bution of stomach cancr was 20 malse (65%), and 14 females (35%) having 1 9 ratio Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases (57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%) Age distribution was the highest in both 4th decade 12 cases (30.8%) and 12 cases(30.8%) in 5th decade 5) The average diameter of malignant ulcers was 3.0-3.9 ㎝ in 14 cases (35.0%), and 6 cases were mort than 5.0㎝ in diameter In benign peptic ulcer mose frequent average size was 1.0-1.9 ㎝ in 16 cases (41.0%)and there was no case meauring over 5.0 ㎝ in diameter 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the greater curvature of the stomach The peptc ulcers also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 27.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperplasia.

胃의 癌 및 良性 疾患에 있어서 胃粘膜의 細胞學的 診斷

姜大榮,李泰淑 충남대학교 의과대학 지역사회의학연구소 1976 충남의대잡지 Vol.3 No.1

In order to evaluate cytologic diagnosis in benign and malignant lesions in the stomach, 91 unfixed gastrectomized specimen were studied, which were submitted to department of pathology, Chungnam National University School of Medicine from January 1975 to September 1975. The cytologic smears were taken from central portions and margins of the ulcer of the lesions, and compared with that of histologic pattern, with clinical considerations. The results obtained were as follows: 1) 91 cases were consisted of 40 carcinomas (44.0%), 39 benign peptic ulcers(42.9%) and 12 gastritis with other diseases(13.1%). 2) Among gastric carcinomas there were noted 4 early gastric cancers originated from primary chronic peptic ulcers, which were not detected clinically. 3) Sex distribution of stomach cancer was 20 males(65%), and 14 females (35%) having 1.9:1 ratio. Age distribution of stomach cancer was showing the highest in 6th decade, 23 cases(57.5%), 5th decade, 10 cases (25.0%) and more than 80% were noted from 40 year to 60 year-old age groups. 4) Sex distribution of chronic peptic ulcer was consisted mainly of male cases showing 37 cases of a total 39 patients (94.9%). Age distribution was the highest in both 4th decade 12 cases (30.8%), and 12 cases (30.8%) in 5th decade. 5) The average diameter of malignant ulcers was 3.0∼3.9cm in 14 cases (35.0%), and 6 cases were more than 5.0cm in diameter. In benign peptic ulcer, most frequent average size was 1.0∼1.9cm in 16 cases (41.0%) and there was no case measuring over 5.0cm in diameter. 6) The most malignant ulcers were located along the lesser curvature of the antrum in 33 cases (82.5%), and 5 cases (12.5%) were along the grater curvature of the stomach. The peptic ulcers, also, were located most frequently along the lesser curvature of the antrum in 32 cases (82.1%). 7) Cytologic diagnosis smeared from center and margins of the malignant ulcers was positive in 85%, but that smeared from peripheral portions of the lesion was positive only in 25.5% of cases. 8) The positive diagnosis in well differentiated and moderately differentiated type of the stomach cancer was 100%, and showed one case of pseudonegative in 18 cases of poorly differentiated type. 9) The doutful cytological diagnosis in chronic peptic ulcers was 16 cases (41.0%), and those were associated with chronic gastritis or with marked inestinal metaplasia with atypical glandular hyperlasial.

해적판 서적의 제작ㆍ유통과정 추적

강대영 세계평화교수협의회 1987 廣場 Vol.173 No.-

睾丸에 原發한 橫紋筋肉腫의 1例

姜大榮,金在權,李泰淑 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Rhabdomyosarcoma of testis is a very rare and highly malignant tumor. We have experienced a case of rhabdomy osarcoma originating from the testis of a fifteen year old Korean boy, with the chief complaint of a swollen mass in the scrotum. So we present this case report with the article review.

Vitamin A 및 E 투여가 Aflatoxin B_1의 종양 발생에 미치는 영향에 관한 연구

강대영 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

In an attempt to elucidate the pathological effects of vitamin A and E on chronic hepatic lesions induced by afatoxin B_1, the present study in male Sprague-Dawley rats was undertaken to evaluate the relation between the light microscopic changes of the liver and the electron microscopic changes. The control group animals were fed basal diet. The experimental group animals were fed the powdered basal diet containing 1 ppm aflatoxin B_1 and vitamin A 1 mmol for 10 months with three times administration of aflatoxin B_1(1mg/kg) by gastric tube. The aflatoxin B-1 was dissolved in peanut oil (1mg aflatoxin B_1 to 1ml peanut oil). The group 2 and 5 experimental animals were placed on diet containing 1 mmol vitamin A for 10 months. Each rat in the group 5 and 5 were orally administered vitamin E 20 IU two times per week for 10 months. All animals were sacrificed after 10 months. The results were as follows: 1. The incidence of hepatoma was 6.7%(2 cases) in the aflatoxin B_1, aflatoxin B_1+vitamin A, and aflatoxin B_1+vitamin E treated groups, and 10%(3 cases) in the vitamin A+E treated group. 2. Light microscopically, the normal hepatic lobular structure was distorted and replaced by the basophilic nodules, eosinophilic nodules, vacuolated nodules, hyperplastic areas and hepatoma of pseudoglandular and trabecular types. 3. Electron microscopically, the nodular and hepatocellular carcinoma cells showed variation in the size and form of mitochondria, shortened or depleted microvilli, proliferation or blebbing of smooth endoplasmic reticulum, irregular shape nuclei and nuclear membrane, and nucleolar segregation of fibrillar and granular elements. 4. The eosinophilic nodules were distinguished from other nodular lesions by the multiple concentric membranous bodies in the cytoplasm of nodular cells. The multiple concentric membranous bodies were also present in some hepatocellular carcinoma cells. 5. Light microscopically, the hyperplastic areas were distinct from the discrete basophilic, vacuolated, and eosinophilic nodules often compressing the surrounding parenchyma. There was a decrease in the intensity of the PAS staining in the nodules, compared with that of the control. The observations provided some evidence suggesting that the eosinophilic nodules, rather than the other nodules, may play a role in the development of malignancy in the rat liver. There was no evidence than vitamin A or vitamin E inhibits malignant transformation of live cells induced by aflatoxin B_1.

胃에 發生한 巨大한 平滑筋腫의 1例

姜大榮,金在權,朴成均 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.2

Benign tumor of stomach is relatively rare, and leiomyoma is about 26% in all benign tumors of stomach. It's true etiology is unknown, and it is more prevalent in male. Abdominal pain, gastrointestinal bleeding and a palpable mass were the main symptoms and signs. Although incorrect still, radiologic finding was a clue of diagnosis. Recently we have experienced a case of very large smooth muscle tumor. A brief review of literatures and a discussion concerning leiomyoma of stomach are presented in this paper.

Phenobarbital 前處置量이 Dimethylnitrosamine의 白鼠肝의 中毒性 病變에 미치는 影響에 關한 硏究

姜大榮 충남대학교 의과대학 지역사회의학연구소 1979 충남의대잡지 Vol.6 No.2

Dimethylnitrosamine, potent hepatotoxic and carcinogenic agent, is metabolized mainly in the liver, and its hepatotoxic action is influenced by the administration of phenobarbital which is thought as inducer of hepatic drug-metabolizing enzyme. In order to study the effects of phenobarbital pretreated dosage on the hepatotoxic changes of dimethylnitrosamine, phenobarbital were administered with 100mg every consecutive day to the male albino rats intraperitoneally, and then 60mg, 50mg, 40mg, and 30mg/kg of dimethylnitrosamine in physiologic saline solution were given by intraperitoneal injection. The mortality and histopathologic changes between control (dimethylnitrosamine only) and experimental groups were as follows: 1. Mortality in 60mg, 50mg, 40mg and 30mg injected rats indicated 80%, 50%, 40% and 15%, whereas phenobarbital 3 successive days' pretreated rats in corresponding group sustained 25%, 20%, 15%, and 5% of death rate, respectively, 6 successive days' pretreated rats 30%, 20%, 20% and 10%, 9 successive days' pretreated rats 75%, 70% and 17%. 2. The rats given 60mg, and 50mg of DMN, cause acute massive hemorrhage in the liver, and then the necrotic changes were more extensive and intensive in the early experimental days, and progressed with lessened thereafter. The phenobarbital 300mg pretreated groups were less intensive in their lesions and fastened their recovery than DMN-injected groups. The hemorrhagic necrotic changes in phenobarbital 600mg and 900mg phenobarbital groups, were less intensive on the first day of experiment, compared with 300mg pretreated groups, but after that more intensive and prolonged. 3. Necrotic changes in the 40mg and 30mg of DMN injected groups developed mild to moderate degree in the first experimental day, and became worse in successive 1-2 days, whereas in phenobarbital 300mg pretreated groups the lesions were more mild and shortened their course than those in DMN injected groups, but in phenobarbital 600mg and 900mg pretreated groups, necrotic changes were mild on the first day of experiment, but after that became more intensive and prolonged. 4. Hepatic fibrosis in both DMN-injected and phenobarbital pretreated groups developed around the date when necrotic changes were subsided, but in phenobarbital pretreated groups were less intensive and shorter course than each corresponding DMN-injected group. There are no specific relationships between necrotic or fibrotic change and phenobarbital pretreated dosage.

독성 및 약인성 간손상 - 병리소견 -

강대영 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.1(S)

복막유착의 원인 규명과 예방을 위한 실험적 연구

강대영,송규상,노승무,조준식,이태용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Postoperative peritoneal adhesion is the most common cause of intestinal obstruction, and intestinal obstruction is one of the most difficult problems in abdominal surgery. In this experimental study for developing peritoneal adhesion model and its prevention, we divided rats into 5 groups; the talc powder treated group, the cotton-fluff treated group, the talc+fluff treated group, the ischemia group and the control group. There were 16 rats in each group. We made incisions on the midabdomen of the rats and administered talc powder, cotton fluff and talc powder+fluff into the peritoneal cavity respectively. In the ischemia group, we clamped the root of superior mesenteric artery for two minutes to induce ischemia on the small bowel of the rat. We counted the number of the peritoneal adhesive sites in peritoneal cavity on the 7th, 14th , 21st and 42nd postoperative day after peritoneal adhesion induced operation, and observed the characters of the adhesion state. The average number of the peritoneal adhesions were 1.25 per one rat in the talc powder group, 1.44 in the fluff group, 1.31 in the talc+fluff group and 1.31 in the ischemia group compared with 0.94 per one rat in the control group performed sham operation. 91.6% of the all adhesions were observed on the peritoneum of the previous incision sites and only 8.4% of the adhesions were adhered to the peritoneal surface of non-incision sites. The data of this study suggest that peritoneal injury and inflammatory reaction is the major cause of peritoneal adhesion. Also this study indicates that foreign bodies can develop peritoneal adhesion, but the effect is much lower than that of peritoneal injury with inflammatoty reaction.

영지 버섯 투여가 Alcohol에 의한 급성 간 병변에 미치는 영향에 관한 연구

강대영,최정목 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

In order to elucidate the effects of Ganorderma lucidum(GL) on acute hepatotoxicity induced by ethanol, thirty Sprague-Dawley male rats, four weeks old, were fed ethyl alcohol and GL powder for 7weeks. The ethyl alcohol was reduced 10% by dilution with distilled water, and the GL was first pulverized and then mixed with a chemically pure diet. The rats were divided into 5 groups : The control group, the alcohol only group, the alcohol + 1% CL group, the alcohol + 2% GL group, and the alcohol + 4% GL group. The animals were sacrified after 7 weeks. All the livers were graded for the degree of fatty change : 1~5+ using the perentage of liver cells containing fat, i.e., < 10% = 1+ , < 10~25% = 2+, 25~50% = 3+, 50~75% = 4+, and > 75% = 5+. All data are shown as means±SD. A comparison among the individual groups was performed using Anova test by repeated measure. The results are summarized as follows: Light microscopically, the fatty change appeared diffusely around the central veins of the hepatic lobules throughout the periportal areas in the alcohol-only reated group(score: 4.0±0.89), while fatty change in the alcohol + 1% GL treated group(score; 2.67±0.52) was shown around the central veins(P<0.05). However, in the alcohol + 2% GL(score; 3.83±1.83) and alcohol + 4% GL (score: 4. 33±0.82) treated groups, the degree of fatty change in the liver was similar to that of the alcohol-only treated group(score; 4.0±0.89). The above results suggest that the GL exerted some beneficial effect in reducing the degree of fatty change in the liver. Thus, the GL must be effective for reducing the ethanol induced fatty change in the liver. However, more detailed biochemical or molecular studies are needed in the future.