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Mycobacterium mageritense에 의한 당뇨병성 족부 감염증 1예
김충종,김낙현,김문석,김계형,전재현,박문석,박경운,박완범,박상원,김홍빈,김남중,오명돈,최강원 대한감염학회 2008 감염과 화학요법 Vol.40 No.6
Diabetic foot infection is one of the important complications in patients with advanced diabetes mellitus. Limb threatening infections such as osteomyelitis, abscess, and necrotizing fasciitis are frequently accompanied by the disease. Non-tuberculous mycobacterium (NTM) is a rare causative organism of diabetic foot infection. Thus, if one is not suspicious or meticulous, infection due to NTM will be easily overlooked and this will result in delayed diagnose and treat. Therefore, it is necessary to consider NTM as the causative organism if the wound does not respond to the conventional antibiotic treatment and the culture from the adequately obtained specimen reveals atypical acid-fast bacilli. We present a case of diabetic foot infection with osteomyelitis and abscess due to Mycobacterium mageritense, one of the rapid growing mycobacteria, that was successfully treated with surgical debridement and appropriate antibiotic treatment.
토양으로부터 항세균성 물질을 생산하는 Streptomyces sp. 의 분리
오현정,정완석,김세재,김창진,고영환 제주대학교 생명과학연구소 1999 제주생명과학연구 Vol.2 No.-
제주도의 토양에서 분리된 방선균 307주를 대상으로, paper disc법과 시험관 희석 배양법을 사용하여 항세균성 물질을 생산하는 균주를 선별하였다. 약 3.3%에 상당하는 분리주들이 Escherichia coli 8749, Staphylococcus aureus 6538 그리고 Pseudomonas solanacearum 10692에 대해 항균효과를 나타냈고, 그 중에서 가장 높은 항균활성을 나타내는 BL93 균주를 최종선별하여 동정하였다. BL93 균주의 배양학적, 형태학적, 생리학적, 생화학적 그리고 화학분류학적 특성을 기준으로 볼 때 Streptomyces violaceus와 유사하였기에, Streptomyces sp. BL93으로 명명하였다. 이 균주가 생산하는 항세균성 물질은 butanol보다도 물에 더 잘 녹는 극성화합물로 chloroform이나 ethylacetate에는 거의 용해되지 않았다. 100℃에서 30분간 가열 처리해도 활성의 소실이 거의 없었고, pH 3∼9범위에서 안정하였다. 분리균주 BL93은 aspartocin을 생산하는 Streptomyces violaceus와 유사함으로, BL93이 생산하는 항세균성 물질의 동정 및 aspartocin과의 비교 검토가 선행되어야 할 것이다. Three hundred and seven isolates of Actinomycetes were isolated and purified from soil samples in Cheju Is. to screen antibacterial compounds. About 3.3% of the isolates showed antibacterial activity, and one of them, BL93, showed relatively higher antibacterial activity against Escherichia coli 8749, Staphylococcus aureus 6538 and Pseudomonas solanacearum 10692 by both paper disc method and tube dilution incubation method. The isolate BL93 was similar to Streptomyces violaceus based upon its cultural, morphological, physiological, biochemical and chemotaxanomic characteristics. It was designated as Streptomyces sp. BL93. The antibacterial substance produced by the isolate BL93 had higher affinity for water than butanol and was insoluble in chloroform or ethylacetate. Most of its antibacterial activity was retained even after heating at 100℃ for 30min and was stable at pH ranges 3 to 9. As the isolate BL93 was tentatively identified to be Streptomyces violaceus, the antibacterial substance preferentially need to be identified and compared with aspartocin, an antimicrobial compound produced by Streptomyces violaceus.
모 컴퓨터 회사 근로자 건강증진 사업 전개를 위한 수요조사
임현우,안병용,최환석,박정일,김경수,이강숙,김정아,구정완 가톨릭대학산업의학쎈타 산업의학연구소 1997 韓國의 産業醫學 Vol.36 No.4
Before conducting the health promotion program, we surveyed the health risk appraisal(HRA) of 210 workers (186 men and 24 women) in a computer company, for the need assessment, selection of target population, priority setting, and as a standard for comparision after performing the program. The smokers were 115(88.6%), and drinkers (over 1 bottle of Soju per week) were 91(44.8%) in men. Entire women and 148(78.0%) men never or irregularly exercise. Type A personality were 73(39.2%) in men, 8(33.3%) in women, and 26(14.0%) of men and 6(25.0%) of women were high stress risk group. 53(25.2%) of men and 2(8.3%) of women were obese (BMI ≥25kg/m²), and workers who consumed exess of total calory compared with recommendation were 142(76.3%) in men and 18(75%) of women. By the health risk appraisal, it was suggested that smoking cessation program, drinking counselling, exercise prescription, stress management, and weight control program should be conducted effectively for the high risk group.
PWM 인버터 시스템에서의 전도노이즈 저감을 위한 출력필터 설계에 관한 연구
金利勳,朴奎炫,元忠淵,金榮石,崔世琓 성균관대학교 2002 학술회의지원논문목록집 Vol.2002 No.-
본 논문에서는 PWM 인버터-유도전동기 구동시스템의 전도노이즈 저감을 위한 출력필터 설계에 관한 연구를 수행하였다. 전도 노이즈는 고전압 압력, 고용량 구동시스템, 그리고 긴 전동기 터미널 등의 경우에서 크게 문제가 된다. 고압력을 갖는 시스템에서는 높은 압력에 비례한 직류 링크 전압을 갖고 이에 따라 스위칭 시 dv/dt가 순간 최대 CM 접지전류를 발생시킨다. 그러므로 이에 대한 대책에 필요하다. 따라서 최근 산업 현장에서 많이 사용되고 있는 PWM 인버터를 설계 제작하여 유도전동기를 구동하고 이에 따라 발생되는 전도노이즈 성분을 감쇠 시킬 수 있는 출력필터를 설계하였고 제작 및 실험을 통하여 그 타당성을 입증하였다. In this paper, filtering techniques to reduce the adverse effects of motor leads on high-frequency PWM inverter fed AC motor drives are presented. The filter was designed to keep the motor terminal from the cable surge impedance to reduce overvoltage reflections, ringing, and the dv/dr, di/dt, at the motor terminals. Specially, the output filter is used to limit the rate of the inverter output voltage and reduce common mode noise to the motor. The performance of the output filter is evaluated through simulations and experiment on PWM inverter-fed AC motor drive. An experimental PWM drive system reduction of conducted EMI was implemented on an available TMS320C31 micoprocessor controd board. Finally, experimental result shows inverter output filter reduces more common mode voltage than low pass filter also reduce overvoltage and ringing at the motor terminal.
Differentiation of embryonic stem cells into cardiomyocytes in a compliant microfluidic system.
Wan, Chen-rei,Chung, Seok,Kamm, Roger D Pergamon Press [etc.] 2011 Annals of biomedical engineering Vol.39 No.6
<P>The differentiation process of murine embryonic stem cells into cardiomyocytes was investigated with a compliant microfluidic platform which allows for versatile cell seeding arrangements, optical observation access, long-term cell viability, and programmable uniaxial cyclic stretch. Specifically, two environmental cues were examined with this platform--culture dimensions and uniaxial cyclic stretch. First, the cardiomyogenic differentiation process, assessed by a GFP reporter driven by the α-MHC promoter, was enhanced in microfluidic devices (?FDs) compared with conventional well-plates. The addition of BMP-2 neutralizing antibody reduced the enhancement observed in the ?FDs and the addition of exogenous BMP-2 augmented the cardiomyogenic differentiation in well plates. Second, 24 h of uniaxial cyclic stretch at 1 Hz and 10% strain on day 9 of differentiation was found to have a negative impact on cardiomyogenic differentiation. This microfluidic platform builds upon an existing design and extends its capability to test cellular responses to mechanical strain. It provides capabilities not found in other systems for studying differentiation, such as seeding embryoid bodies in 2D or 3D in combination with cyclic strain. This study demonstrates that the microfluidic system contributes to enhanced cardiomyogenic differentiation and may be a superior platform compared with conventional well plates. In addition to studying the effect of cyclic stretch on cardiomyogenic differentiation, this compliant platform can also be applied to investigate other biological mechanisms.</P>