소세포 폐암의 갑상선전이 1예

장리라,최영식,박요한,문대성,김자경,김성은,최인수,유찬희,남성진 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.3

Metastasis to the thyroid gland is usually considered uncommon. The most frequent sites of the primary tumor include the kidney, breast and lung. Its presence often indicates poor prognosis. Metastases represent the advanced stage of the tumors and fine needle aspiration cytology is and important way of diagnosis in thyroid metastasis. we experienced a case of Metastatic Small cell Lung Carcinoma to the Thyroid Gland. A 58-year-old man with Graves' disease diagnosed pulmonary nodule in the left upper lung field on his chest X-ray film. The patient's thyroid gland was diffusely swollen, and elastic to hard. A thyroid ultrasonography showed 1cm sized hypodense nodule on the left thyroid gland. The patient underwent a ultrasonography guided fine needle aspiration cytology of the mass. Cytological diagnosis was a metastatic small cell carcinoma. Then Chemotherapy was administered to the patient. The authors report this rare case of metastatic small cell lung carcinoma to the thyroid with literature review.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

Ascorbic Acid와 2-Methoxyestradiol에 의한 내분비선 장애물질의 제거효율

성대동,이성식,최금찬,성낙창 동아대학교 환경문제연구소 2000 硏究報告 Vol.23 No.1

The removal efficiency of an environmental endocrine disrupter, 1,l-bis (4-chlorophenyl)-2,2,2-trichloroethane(CPT) has been studied using L-ascorbic acid(ACA) and 2-methoxyestradiol(MSD). l,l-Bis(4-chlorophenyI)-2,2,2-trichlorcethyl anion(CPT^( θ)) is formed by treatment of OH- ion to l,l-bis(4-chlorophenyl)-2,2,2-trichloroethane(CPT), l,l-Bis(4-chlorophenyl)-2,2,2-trichiorcethyl radical(CPT·) yields during the reaction of l,l-his(4-chlorophenyl)-2.2,2-trichloroethyl anion with iodine occurs. A high m v a l efficiency for l,l-bis(4-chlorophenyl-2,2,2-trichlorcethyl radical(CPT·) reveals in the case of L-ascorbic acid(ACA) used more than that of 2-methozyestradiol(MSD). This is in accord with the rate of yielding L-ascorbic acid radical(ACA·) is faster than the one of 2-methoxyestradiol radical(MSD·). The removal efficiency of 1,1-bis(4-chlorophen~l)-2,2,2-trichloroethyl radical(CPT·) is increased with increasing of solvent acidity and solvent hydrogen bonding degree.

국산 체외 충격파 쇄석기의 음향학적 특성 평가

최민주,이종수,김성삼,조성찬,양형석,손종수,천원기 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

In the study we measured and evaluated the acoustical property of a domestic spark gap type extracorporeal shock wave lithotripsy (ESWL). Altering the discharging medium between the electrodes of the shock wave generator (water, 1% an 10% NaCl electrolyte), we measured shock waveforms and sound pressure level (SPL). For the shock waves produced using the discharging medium, water, it was seen that the shock wave peak pressure went up to 70 MPa, and the SPL was in the range of 90 - 100 dB. As the concentration of NaCl increased in the electrolyte. the SPL did not change much and was shown to increase correlation with the discharging voltage. In the case of the discharging medium. 10% NaCl electrolyte, it was found that the shock amplitudes varied in a narrow range when being high in the concentration of NaCl and were large when being high in discharging voltages. While the stone fragmentation was in process, we measured the acoustic emission and compared their spectral properties.

서울시 사회복지시설 근무 사회복지사들의 직무스트레스 수준

최수찬,김상아,이정은,박웅섭 大韓産業醫學會 2007 대한직업환경의학회지 Vol.19 No.4

목적: 사회복지사의 직무스트레스 실태를 알아보고,복지시설 유형과 직업조건에 따른 직무스트레스의 차이를 조사하고자 하였다. 방법: 서울시 소재 681개 사회복지시설에 근무 중인 사회복지사를 대상으로 우편설문을 시행하였으며 ,최종 분석 사용된 설문지는 총 432부였다. 한국인 직무스트레스 측정도구(KOSS)의 단축형을 사용하여 직무스트레스를 측정하였고,빈도분석,t-test,ANOVA 분석을 실시하였다. 결과: 노인복지시설의 경우 타 기관에 비해 직무요구,직무자율성결여,보상부적절로 인한 스트레스 수준이 모두 높게 나타났다. 작업조건별로는 업무형태,근무시간, 정규휴식시간,직위에 따라 직무스트레스 수준에 차이가 있었다. 서비스와 행정을 둘 다 수행하는 경우에 직무스트레스총점,직무요구,관계갈등,직무불안정,조직체계,보상부적절, 직장문화 영역의 직무스트레스 수준이 높았고,근무시간이 10시간 이상인 경우에 직무요구 영역에서 ,일선 및 선엄사회복지사가 직무자율성결여 및 보상부 적절로 인한 직무스트레스 수준이 높게 나타났다,또한 정규휴식시간 유무에 따라서는 직무스트레스 총점 및 직무스트레스의 7개 하위 영역 모두에서 유의한 차이가 있었다. 결론: 사회복지사의 직무스트레스를 적절한 관리하기 위해서는 서비스와 행정업무 병행에 대한 조치 및 정규휴식시간 확보가 필요하고,특히 노인복지시설 사회복지사의 직무스트레스에 대한 적절한 관리가 필요하다. Objectives: To investigate the level and variation of job stress according to social welfare organizations and work conditions among social workers in Seoul. Methods: For this survey, a self-reported questionnaire was administrated to 1,000 social workers working in organizations for social welfare practice in Seoul. A total of 432 completed questionnaires were received (43.2% response rate). Results: Social workers working in welfare organizations for the aged had higher job stress in the areas of job demand, insufficient job control and lack of reward than those in other welfare organizations. In addition, higher job stress was found in those in charge of both service and administrational work, without regular time for rest, working over 10 hours, in the frontline and senior grade. Conclusions: This study confirms the importance of guaranteeing regular time for breaks in the work schedule and of considering the service and administrational work ratio in job arrangement in order to alleviate stress of social workers.

성별, 연령 및 생리주기에 따른 대장 통과시간의 변이

이상전,이두한,송영진,최재운,장이찬 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.1

적외선열화상장치를 이용한 Buchanan plugger 표면의 온도상승 분석

최성아,김선호,황윤찬,윤창,오병주,최보영,정우남,정선와,황인남,오원만 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.4

This study was performed to evaluate the temperature rise on various position of the Buchanan plugger, the peak temperature of plugger's type and the temperature change by its touching time of heat control spring. The heat carrier system 'System B' (Model 1005. Analytic Technologies, USA) and the Buchanan's pluggers of F, FM, M and ML sizes are used for this study. The temperature was set to 200℃ which Dr. Buchanan's "continuous wave of condensation" technique recommended on digital display and the power level on it was set to 10. In order to apply heat on the Buchanan's pluggers, the heat control spring was touched for 1, 2, 3, 4 and 5 seconds respectively. The temperature rise on the surface of the pluggers were measured at 0.5 mm intervals from tip to 20 mm length of shank using the infraed thermography (Radiation Thermometer-IR temper, NEC San-ei Instruments, Ltd, Japan) and TH31-702 Data capture software program (NEC San-ei Instruments, Ltd, Japan). Data were analyzed using a one way ANOVA followed by Duncan's multiple range test and linear regression test. The results as follows. 1. The position at which temperature peaked was approximately at 0.5 mm to 1.5 mm far from the tip of Buchanan's pluggers (p<0.001). The temperature was constantly decreased toward the shank from the tip of it(p<0.001). 2. When the pluggers were heated over 5 seconds, the peak temperature by time of measurement revealed from 253.3±10.5℃ to 192.1±3.3℃ in a touch for 1 sec, from 218.6±5.0℃ to 179.5±4.2℃ in a touch for 2 sec, from 197.5±3.0℃ to 167.6±3.7℃ in a touch for 3 sec, from 183.7±2.5℃ to 159.8±3.6℃ in a touch for 4 sec and from 164.9±2.0℃ to 158.4±1.8℃ in a touch for 5 sec. A touch for 1 sec showed the highest peak temperature, followed by, in descending order, 2 sec, 3 sec, 4 sec. A touch for 5 sec showed the lowest peak temperature (p<0.001). 3. A each type of pluggers showed different peak temperatures. The peak temperature was the highest in F type and followed by, in descending order, M type, ML type. FM type revealed the lowest peak temerature (p<0.001). The results of this study indicated that pluggers are designed to concentrate heat at around its tip, its actual temperature dose not correlate well with the temperature which Buchanan's "continuous wave of condensation" technique recommended, and finally a quick touch of heat control spring for 1 sec reveals the highest temperature rise.

제주도 동남방 신천해안역 해수의 이화학적 특성과 저질분포

최영찬,고기원,김상현 제주대학교 해양연구소 1987 해양자원연구소연구보고 Vol.11 No.-

맞벌이 여부에 따른 직장-가정간 갈등과 직무만족도

최수찬,우종민,박웅섭,김상아 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.1

목적 본 연구에서는 기혼의 직장인들을 대상으로 직장 역할에 참여함으로서 가정역할 수행이 어려운 경우와 반대로 가정역할에 참여함으로서 직장 역할 수행이 어려운 경우에 발생하는 직장-가정 간 갈등과 같은 스트레스가 직무태도에 미치는 영향에 있어 맞벌이 여부에 따른 차별적 영향의 가능성을 고찰해보고자 하였다 방법 서울과 수도권에 거주하고 있는 직장인 1,000명을 대상으로 우편설문을 실시하여 44.0%의 회수율을 보였으며 본 연구의 주제인 맞벌이 여부에 맞도록 기혼상태로 보고한 236부의 설문지만을 최종 자료로 사용하였다 수집된 자료는 전산입력 후 SAS 10.0 프로그램을 사용하여 통계처리 하였다 결과 직무만족도를 종속변수로 이변량분석에서 유의한 변수들을 독립변수로 한 다중희귀분석수행결과 홑벌이에 있어서는 직장이 가정에 끼치는 갈등이 감소할수록 직무만족도가 유의하게 높았고(p<0.05) 맞벌이에서는 가정이 직장에 끼치는 갈등이 감소할수록 직무만족도가 유의하게 높았다(p<0.05) 결론 맞벌이 여부에 따라 경험하는 직장-가정과 관련된 스트레스의 내용에 차이가 있으므로 추후 기업 내에서 근로자들의 직무만족도를 향상시키기 위해서는 홑벌이와 맞벌이와 같은 가족형태에 따른 차별적 서비스를 제공할 필요가 있다 Objectives Work family conflict can arise from two opposite directions the experiences at work interfere with family life and the experiences in the family interfere with work life This study explored the effects of the presence of two income sources on the association between work-family conflict and Job attitude Methods Responses to structured survey questionnaires were received from 236 two-income families living in the Seoul Metropolitan Area Results A differential effect was observed between single income families and two-income families Higher job satisfaction was related with lower work interference with family (WIF) among single-income families and with lower family interference with work (FIW) among two-income families Conclusions Employee welfare programs need to be expanded to enhance job satisfaction for the increasing number of two-income families