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醫藥品의 安定性에 關한 硏究 (第3報) : Sulpyrin 水溶液의 安定性에 關하여 The Stability of Sulpyrin in Aqueous Solution
金鍾秀,金壽億,徐成勳 慶熙大學校 1983 論文集 Vol.12 No.-
The pharmacokinetic study of solution was conducted to determine the stability of sulpyrin. The powder was added with diluents and stored under three different conditions to determine the humiditification weight and degradation rate. The solution of sulpyrin indicated first order reaction and t_90 was 82 days at 25℃. When the powder was stored under the three different conditions, the avicel mixture showed the highest humiditification weight, while the only sulpyrin showed the highest degradation rate under the relative humidity of 75% and 92% followed by the avicel mixture. The starch and lactose mixture showed the lowest similar humiditification weight and degradation rate. Therefore, it seems that the stability of the main ingredient will be greatly influenced by the diluents.
썰린댁/β-싸이클로 덱스트린 包接化合物 및 썰린댁/폴리 비니르피로리돈 共沈物에 관한 硏究
金壽億 慶熙大學校 1987 論文集 Vol.16 No.-
To increase the solubility of Sulindac which is used widely as a non-steroidal anti-inflammatory drug, its inclusion complex and coprecipitate were prepared and studied in this paper. Inclusion complex of sulindac with β-cyclodextrin were prepared by the four different methods; neutralization method, freezedrying method, kneading method and solvent evaporation method. Also copreciptates of sulindac with polyvinylpyrrolidone K30 and T40 were preparcd by solvent method. Inclusion complex formation of sulindac with β-cyclodextrin and coprecipitate formation of sulindac with polyvinylpyrrolidone K30 and T40 were ascertained by X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. It was found that he inclusion complex formation prepared by freeze-drying method, ?? evaporation method and neutralization method were similar, Freeze-drying method seemed to suitable for preparation of complex with most higher dissolution rate but kneeding method seemed not to be suiable for complex formation. Coprecpitate formation of sulindac prepared with polyvinylpyrrolidone K30 and T40 were similar. Dissoluton behaviors of the inclusion complex and the coprecipitate were examined. As a result, the release of sulindac from the inclusion complex and the coprecipitate was significantly improved than that of infact sulindac. The dissolution rate of coprecipitate was found to be no different between sulindac-polyvinyl pyrrolidone K30 system and sulindac-polyvinylpyrrolidone T40 system.
金壽億,權昌鎬,洪南斗 慶熙大學校 1987 論文集 Vol.16 No.-
In order to investigate the pharmacological effects of the combined preparation of oriental crude drung, Taeeuminyuldahanso-Tang. It has been widely used for emesis, vomiting, diarrhea etc. Here we studied on the anticonvulsion, analgesic, antipyretic, isolated ileum and diuretic effect in mice, rats, guinea-pigs and rabbits. Following results were obtained; Anticonvulsive effect was noted on the convulsion induced by strychnine and picrotoxin. In acetic acid method analgesic action was noted. Antipyretic effect on the fever induced by typhoid vaccine was significantly recognized. Spontaneous mortility of the isolated ileum was suppressed and its contraction caused by Ach, Ba, Histamine was remarkablely nhibited. Diuretic action was significantly noted. According to the above results, effects based on oriental medical references approximate to the actual experimental results.
金在植,金壽億,徐成勳 慶熙大學校 1984 論文集 Vol.13 No.-
This experiment was conducted to investigate the release pattern of allantion from six kind of ointment bases. Release rate(K) of PEG ointment was 3.68 which was the most value in experimented ointment base, nest order was cold cream (K=1.42). In the case of additives, urea enhanced the release of allantion from six kind of ointment , PVP enhanced the release of allantoin from only Hydrophobic ointment bases. Addition of DMS retarded the release of allantion from six kind of ointments, the more concentration of DMS was increasing, the greater retarding effect became. But, in the case of PVP and urea, the greater concentration of additives became, the more release rate was increasing
漢方藥의 成分 및 藥效에 關한 硏究(第4報) : 매자나무 엑기스의 行動藥理學的 硏究 Behavioral Pharmacology of Berberis koreana Pilibin
徐成勳,金壽億 慶熙大學校 1985 論文集 Vol.14 No.-
The behavioral effects of Berberis korean Pilibin extracts which is used to insomnia, neurose and nervous prostration were compared with those of diazepam and chloropromazine as a comparison durg in mice and rate. Effect of Berberis korean Pilibin extracts on the central nervous depressive action were tested by spontaneous movement activity using photoelectrical method, smoked paper method, open field method, sloped plate method and extension of hypnosis time induced with sodium phenoborbital and sodium pentoborbital, and defense against convulsive action induced with picrotoxin and strychnine. Berberis korean Pilibin extracts was found to pharmacollgically expect above various action similar to those of diazepam and chloropromazine but action of sample weaker than that of diazepam and chloropromazine. Aquar extracts was definitely superior to the alcohal extracts in the central nervous depressive action.
藥物의 吸收 排池에 關한 硏究(第6報) : 病態白鼠에서의 Sulpyrine 吸收에 대하여 Absorption of Sulpyrine in Pathological Rats
趙春宇,金壽億,徐成勳 慶熙大學校 1987 論文集 Vol.16 No.-
Studies on the gastrointestinal absorption of sulpyrine was examined by rats pretreated with alloxan on carbon tetrachloride(CCl_4). Gastric absorption was increased in proportion to pH addition Alloxan diabeted group was increased rather than control group but hepatic disorder group was repressed more or less. Intestinal absorption of sulpyrine by in situ recirculating perfusion was increased in alloxan diabetes group and was repressed in hepatic disorder group, too. Absorption half-life of control, alloxan diabetes and hepatic disorder groups was 54.57, 36.32 and 72.63 minutes in separate. The transmucosal fluid in the intestine of alloxan diabetic rats was abserlved to be increased but CCl_4 hepatic disorder's rats be depressed. But the rate of transmucosal fluid was not in proportion to absorption of drugs.
李鍾錫,徐成勳,金壽億 慶熙大學校 1990 論文集 Vol.19 No.-
The effect of two different particle sizes and three different of base on preparation of polyvinylpyrrolidone iodine suppositories were studies in this paper. The partcle size of povidone-iodine was divided into two parts(0.074㎛, 0.149㎛) by sieving method. Three types of base used in povidone iodine-suppositories were as follows : witepsol H-15 as a oleogeous base, cacao butter contained 1% of polysorbate 80 as a o/w type emulsified base and macrogols (macrogol 1000 : 1540, 1:4 w/w) as a water soluble base. Suppositories perpared with different particle sizes and base were examined for appearance and dispersion of drug. It was found that the apperance of suppositories with water soluble bases, macrogols, was better in color and dispersion than with the witepsol H-15 and the cacao butter. Each suppositories was tested for 8 weeks under the accelerated conditions(temp : 40。, RH : 75%) and room temperature (temp : 20。±3。, RH : 50±5%). The suppositories prepared with water soluble base were more stable in the content of povidone-iodine than with oleogeous base and o/w type emulsified base. The suppositories with 0.074㎛ of particle size were all the same to the suppositories with 0.149㎛ of particle size.
柳浩仁,徐成勳,金壽億 慶熙大學校 1989 論文集 Vol.18 No.-
To Increase the solubility of minoxydil which is used as an antihypertensive agent, its inclusion complex was prepared and studied in this paper. Inclusion complexes of minoxydil with β-cyclodextrin were prepared by three different methods; Coprecipitation method, kneading method and freezedrying method. Inclusion complex formation of minoxydil with β-cyclodextrin was ascertained by powder x-ray diffractometry, differential scanning calorimetry and IR spectroscopy. Inclusion complex of minoxydil with β-cyclodextrin in 1:3 molar ratio seemed to be suitable for the preparation of complex with higher purity, and its dissolution behavior in water was compared with that of intact minoxydil and physical mixture of minoxydil with β-cyclodextrin. The dissolution rate of minoxydil in water was found to be markedly increased by β-cyclodextrin complexation.
李賢淑,徐成勳,金壽億 慶熙大學校 1984 論文集 Vol.13 No.-
A rapid, reproducibile high-pressure liquid chromatographic system for the determination of Norethindrone and Mestranol in tablet was investigated in this paper. The results were as follows; 1. The condition of HPLC was a reversed phase column with a mobile phase of Acetonitrile: water(60:40) 2. Reproducibility of Norethindrone and Mestranol was 99.1% ± 1.002, 98.71% ± 1.079 respectively. The average recovery value of Norethindrone and Mestranol in preparation was 100.44% ± 1.241, 98.55% ± 1.919 respectively. 3. Content uniformity of Norethindrone and Mestranol in preparation was 93.19%∼103.91% ± 4.037∼4.827. 4. This assay method could be used for simultaneous determination and content uniformity of Norethindrone and Mestranol in tablet.
漢方製劑의 行動藥理學的 硏究 (第5報) : 柏子仁의 中樞抑制作用에 關하여 Central Depressive Action of Thujae Semen
李淑自,徐成勳,金壽億 慶熙大學校 1983 論文集 Vol.12 No.-
The behavioral effects of Thujae semen aqueous extracts which is used to insomnia, neuroses, nervous prostration in oriental medicine were compared with those of chlorpromazine and dizaepam as a comparison drug in mouse and rat. Effects of Thujae semen aqueous extracts on the central nervous depressive action were tested by spontaneous movement activity using photoelectrical method, smoked paper method and open field method, sloped plate method, extension of hypnosis time induced with phenobarbital-Na pentobarbital-Na and defense against convulsive action induced with picrotoxin, strychnine and electroshock. Thujae semen aqueous extracts was found to pharmacologically expect above various action similar to those of chlorpromazine Hcl and diazepam but action of sample was weaker than that of chlorpromazine and diazepam.