Moxibustion for medical personnel with negative emotion and insomnia during COVID-19 pandemic: A randomized, controlled trial

Li Xiying,Li Xiaojuan,Wang Xian,Yin Xuan,Li Shanshan,Wu Junyi,Ren Xiumei,Zhang Wei,Mi Yiqun,Xu Shifen 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3

Background: We conducted this randomized controlled trial (RCT) to evaluate the effectiveness and safety of moxibustion at Sanyinjiao (SP6) acupoint for treatment of negative mood and sleep quality in healthcare workers during the 2019 coronavirus disease (COVID-19). Methods: A total of 180 participants were divided in a 1:1 ratio into two groups, the treatment group (for moxibustion) and the control group (for no treatment). The treatment group had a 30-minute moxibustion therapy once a day for two weeks, followed by a two-week follow-up. The Hamilton Anxiety Scale (HAMA) was used to assess the degree of the participants' anxiety, and the Patient Health Questionnaire-9 (PHQ-9) was utilized to examine their depressed condition. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to measure the level of burnout among healthcare workers. To determine the severity of insomnia, the Sleep Dysfunction Rating Scale (SDRS) was utilized. At baseline, week 2, and week 4, all scales were evaluated. Results: Compared to the control group, The treatment group improved more significantly in the HAMA at week 2 (MD = -19.01, 95% CI: -21.89 to -16.14; P<0.001) and at week 4 follow-up visits (MD = -8.96, 95% CI: -11.19 to -6.73; P<0.001). A subgroup study of HAMA scores revealed that position and education had significant impact on treatment effectiveness. During the 2-week intervention period, the treatment group showed more significant improvements in depressive symptoms measured by PHQ-9 (13.00±2.41 vs. 15.60±3.65; P<0.001), work burnout symptoms measured by MBI-GS (MD = -11.88, 95% CI, -15.73 to -8.03; P<0.001), and insomnia symptoms measured by SDRS (MD = -2.45, 95% CI, -4.24 to -0.66; P<0.01). There were no significant adverse effects reported. Conclusion: Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19.

Analysis of the Relationship between MHC-DRB1 Gene Polymorphism and Hydatidosis in Kazakh Sheep

Li, Ren-Yan,Jia, Bin,Zhang, Wen-Ju,Zhao, Zong-Sheng,Shi, Guo-Qing,Shen, Hong,Peng, Qiang,Lv, Li-Min,Zhou, Qi-Wei,Du, Ying-Chun Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.9

The objective of this work was to analyze the relationship between ovine major histocompatibility complex (MHC) DRB1 gene polymorphism and genetic resistance to hydatidosis in Kazakh sheep. The Ovar (ovine MHC) class II DRB1 second exon was amplified by polymerase chain reaction (PCR) from DNA samples of 702 Kazakh sheep, including 302 sheep with hydatidosis and 400 health controls. PCR products were characterized by the restriction fragment length polymorphism (RFLP) technique using five restriction enzymes, i.e., MvaI, HaeIII, SacI, SacII and Hin1I, yielding 14 alleles and 28 genotypes. Comparing the frequency of genotypes in hydatidosis sheep with the control group, it was found that the genotype frequencies of MvaIbc, Hin1Iab, SacIIab, HaeIIIde, HaeIIIdf and HaeIIIdd in control sheep were significantly (p<0.01) higher than in hydatidosis sheep, indicating that a significant correlation existed between these genotypes and resistance to hydatidosis. Genotype frequencies of MvaIbb, SacIIaa, Hin1Ibb and HaeIIIef in sheep with hydatidosis were extremely significantly (p<0.01) higher than in the control group, and the genotype frequency of HaeIIIab was significantly higher (p<0.05), indicating that a marked correlation existed between these genotypes and susceptibility to hydatidosis. By way of analyzing haplotype with these resistant genotypes, the hydatidosis resistant haplotype MvaIbc-SacIIab-Hin1Iab of Kazakh sheep was screened out, and then verified through artificial hydatid infection in sheep. The results indicated that the infection rate of sheep with the resistant haplotype of hydatidosis was significantly lower (p<0.01) than without this resistant haplotype. It showed that the genic haplotype MvaIbc-SacIIab-Hin1Iab of Ovar-DRB1 exon 2 was the resistant haplotype of hydatidosis in Kazakh sheep.

Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing

Li Shi-Dan,Xing Wei,Wang Shao-Chuan,Li You-Bin,Jiang Hao,Zheng Han-Xuan,Li Xiao-Ming,Yang Jing,Guo De-Bin,Xie Xiao-Yu,Jiang Ren-Qing,Fan Chao,Li Lei,Xu Xiang,Fei Jun 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-

Bone fracture remains a common occurrence, with a population-weighted incidence of approximately 3.21 per 1000. In addition, approximately 2% to 50% of patients with skeletal fractures will develop an infection, one of the causes of disordered bone healing. Dysfunction of bone marrow mesenchymal stem cells (BMSCs) plays a key role in disordered bone repair. However, the specific mechanisms underlying BMSC dysfunction caused by bone infection are largely unknown. In this study, we discovered that Fibulin2 expression was upregulated in infected bone tissues and that BMSCs were the source of infection-induced Fibulin2. Importantly, Fibulin2 knockout accelerated mineralized bone formation during skeletal development and inhibited inflammatory bone resorption. We demonstrated that Fibulin2 suppressed BMSC osteogenic differentiation by binding to Notch2 and inactivating the Notch2 signaling pathway. Moreover, Fibulin2 knockdown restored Notch2 pathway activation and promoted BMSC osteogenesis; these outcomes were abolished by DAPT, a Notch inhibitor. Furthermore, transplanted Fibulin2 knockdown BMSCs displayed better bone repair potential in vivo. Altogether, Fibulin2 is a negative regulator of BMSC osteogenic differentiation that inhibits osteogenesis by inactivating the Notch2 signaling pathway in infected bone.

한국에서 출토된 목인(木印) 문자 고석(考釋)

런리웨이 ( Li Wei Ren ) 慶南大學校 人文科學硏究所 2009 人文論叢 Vol.23 No.-

关于韩国放送大学教材《实用中国语》的几点意见

任立?(Ren Li-wei) 대한중국학회 2007 중국학 Vol.28 No.-

  이 문장은 한국 방송통신대학 교재 《실용중국어》를 대상으로 작성된 것이다. 필자는 이 교재에서 인용한 중국어 예문에 존재하는 의미의 부정확성, 어법의 착오, 어휘사용의 부적합성, 문장부호의 오류, 오자 그리고 중국 언어습관에 위배되는 문제에 대하여 본인의 관점을 피력하고, 수정할 수 있는 방법을 제공하고자 한다. 이러한 의견과 건의는 향후 저자가 교재를 바로 잡는데 참고가 되고, 이 책을 사용하는 교사와 학생들의 실제수업에서 유용하게 활용 될 수 있을 것이다.

천고의 역로 문화 추적 -중국 북송(宋) 사요시(使遼詩)에 나타난 지리 문화에 관한 고찰

런리웨이 ( Li Wei Ren ) 慶南大學校 人文科學硏究所 2009 人文論叢 Vol.24 No.-

연구논문 : 중국 도시 발달의 현황과 전략

렌리웨이 ( Ren Li Wei ) 경남대학교 인문과학연구소 2011 人文論叢 Vol.27 No.-

급속한 경제 발전에 의해 중국에서는 도시화 현상 역시 빠른 속도로 진행되고 있다. 도시화의 규모면에서만 보면 경제력, 인구의 증가 속도에서 중국은 이미 세계 제1위의 위치를 차지하였다고 할 수 있다. 즉, 급속한 경제 발전이 야기한 대규모 도시화 현상은 중국의 국제적 지위, 국민의 생활수준, 사회구조, 과학기술, 문화수준 제고 등에 큰 변화를 주었다. 하지만 동시에 일련의 문제점도 초래하였다. 즉, 도시화 속도와 질적인 수준면에서 상호 부조화를 일으키고 있다는 것이다. 도시화 과정 중에 자원의 낭비, 환경오염 문제를 일으킨 것은 물론이고 산업 구조의 불안정화 및 도시 분포의 불합리화도 초래하였으며 도시 유입 인구를 수용할 수 있는 기본 시설의 부족 등 심각한 문제점을 안고 있다. 이에 중국의 도시화 발전 및 현황에 대해 국내 지도자, 학자들은 물론이고 세계의 전문가들도 중국의 도시화 과정을 주목하고 있다. 본고에서는 중국의 도시화의 기본적인 현황과 문제점에 대해 논하였다. 이미 이러한 경험을 겪은 한국 및 선진국의 경험을 통해 이러한 문제의 근본적인 원인이 무엇인지 살펴보았고 그 해결 방안 및 대책도 제시하였다. In modern China society, with the rapid economics development, the enlarging urban area, and expanding suburbs have made the rural area and small towns turn to parts of the cities. The map of the cities will have to be updated frequently. The cities in the economy developed areas as Southeast China, Central China, and Northeastern China, are expanding crazily like leavened bread. Some foreign friends who have been to China often said "Too fast! It changed too fast!" while they came back to China. This kind of change happened in the period of five or ten years, but only one year of half a year. The rapid economics development in China will change the urban and rural pattern the same as many developed countries. That is a kind of normal phenomenon during the change of a country`s economic development, which is called "urbanization". The current situation and strategy for the development of urbanization in China becomes a popular topic around the world, and made the thoughts of the people who can make decisions in China and scholars. This paper has describe the current situation of urbanization in China, and discusses the problems caused by the development, then tries to find out the causes and solution, so that the people who can make decisions in China may acknowledge the hidden danger in over-increasing development clearly, then find the solution to make better urbanization in China.

YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis

Su Wei,Guo Yingying,Wang Qianqian,Ma Lu,Zhang Qing,Zhang Yuhan,Geng Yiding,Jin Tongzhu,Guo Jiayu,Yang Ruoxuan,Niu Zhihui,Ren Lingxue,Wang Yanjie,Ning Zhiwei,Li Wenyue,He Wenxin,Sun Jian,Li Tianyu,Li Z 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-

The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic pulmonary fibrosis (IPF). Yes-associated protein 1 (YAP1) is essential for cell growth and organ development; however, the role of YAP1 in AT2 cells during pulmonary fibrosis is still unclear. YAP1 expression was found to be downregulated in the AT2 cells of PF patients. Deletion of YAP1 in AT2 cells resulted in lung injury, exacerbated extracellular matrix (ECM) deposition, and worsened lung function. In contrast, overexpression of YAP1 in AT2 cells promoted alveolar regeneration, mitigated pulmonary fibrosis, and improved lung function. In addition, overexpression of YAP1 alleviated bleomycin (BLM) -induced senescence of alveolar epithelial cells both in vivo and in vitro. Moreover, YAP1 promoted the expression of peroxiredoxin 3 (Prdx3) by directly interacting with TEAD1. Forced expression of Prdx3 inhibited senescence and improved mitochondrial dysfunction in BLM-treated MLE-12 cells, whereas depletion of Prdx3 partially abrogated the protective effect of YAP1. Furthermore, overexpression of Prdx3 facilitated self-repair of the injured lung and reduced ECM deposition, while silencing Prdx3 attenuated the antifibrotic effect of YAP1. In conclusion, this study demonstrated that YAP1 alleviates lung injury and pulmonary fibrosis by regulating Prdx3 expression to improve mitochondrial dysfunction and block senescence in AT2 cells, revealing a potential novel therapeutic strategy for pulmonary fibrosis.

The genome of the cucumber, Cucumis sativus L.

Huang, Sanwen,Li, Ruiqiang,Zhang, Zhonghua,Li, Li,Gu, Xingfang,Fan, Wei,Lucas, William J,Wang, Xiaowu,Xie, Bingyan,Ni, Peixiang,Ren, Yuanyuan,Zhu, Hongmei,Li, Jun,Lin, Kui,Jin, Weiwei,Fei, Zhangjun,Li Nature Publishing Group 2009 Nature genetics Vol.41 No.12

Cucumber is an economically important crop as well as a model system for sex determination studies and plant vascular biology. Here we report the draft genome sequence of Cucumis sativus var. sativus L., assembled using a novel combination of traditional Sanger and next-generation Illumina GA sequencing technologies to obtain 72.2-fold genome coverage. The absence of recent whole-genome duplication, along with the presence of few tandem duplications, explains the small number of genes in the cucumber. Our study establishes that five of the cucumber's seven chromosomes arose from fusions of ten ancestral chromosomes after divergence from Cucumis melo. The sequenced cucumber genome affords insight into traits such as its sex expression, disease resistance, biosynthesis of cucurbitacin and 'fresh green' odor. We also identify 686 gene clusters related to phloem function. The cucumber genome provides a valuable resource for developing elite cultivars and for studying the evolution and function of the plant vascular system.

Application of modified graphite felt as electrode material: a review

Yang Su,Na Chen,Hai‑lin Ren,Cheng‑wei Li,Li‑li Guo,Zhen Li,Xiao‑min Wang 한국탄소학회 2023 Carbon Letters Vol.33 No.1

Graphite felt is a felt-like porous material made of high-temperature carbonized polymers. It is widely used in electrode materials because of its good temperature resistance, corrosion resistance, large surface area and excellent electrical conductivity. In this paper, the surface functional group modification is of graphite felt electrodes (mainly nitrogen doping modification, nitrogen–sulfur or nitrogen–boron co-doping modification) and surface catalytic modification (metal/ion surface modification and metal oxide surface modification as Main). There are two main methods and research progresses to improve the performance of graphite felt electrodes, and the comprehensive performance of surface functional group-modified graphite felt electrodes and surface catalytically modified graphite felt electrodes are compared respectively. The results show that both surface functional group modification and surface catalytic modification can improve the comprehensive performance of graphite felt electrodes. In this paper, the future development direction of graphite felt activation modification is also prospected.