http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Poster Session 2 : Transduction of human Grb7 mediated by HIV-1 Tat basic domain into skin cells
( So Young Kim ),( Jae Jin An ),( Dae Won Kim ),( Soo Hyun Choi ),( Hee Soon Choi ),( Sun Hwa Lee ),( Jin Seu Park ),( Sang Chul Lee ),( Har Young Poo ),( Hyung Joo Kwon ),( Tae Yoon Kim ),( Won Sik E 생화학분자생물학회 2005 생화학분자생물학회 춘계학술발표논문집 Vol.2005 No.-
Bio-Derived Poly(γ -Glutamic Acid) Nanogels as Controlled Anticancer Drug Delivery Carriers
( Hee Ho Bae ),( Mi Young Cho ),( Ji Hyeon Hong ),( Har Young Poo ),( Moon Hee Sung ),( Yong Taik Lim ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.12
We have developed a novel type of polymer nanogel loaded with anticancer drug based on bio-derived poly(γ- glutamic acid) (γ-PGA). γ-PGA is a highly anionic polymer that is synthesized naturally by microbial species, most prominently in various bacilli, and has been shown to have excellent biocompatibility. Thiolated γ-PGA was synthesized by covalent coupling between the carboxyl groups of γ-PGA and the primary amine group of cysteamine. Doxorubicin (Dox)-loaded γ-PGA nanogels were fabricated using the following steps: (1) an ionic nanocomplex was formed between thiolated γ-PGA as the negative charge component, and Dox as the positive charge component; (2) addition of poly(ethylene glycol) (PEG) induced hydrogen-bond interactions between thiol groups of thiolated γ-PGA and hydroxyl groups of PEG, resulting in the nanocomplex; and (3) disulfide crosslinked γ-PGA nanogels were fabricated by ultrasonication. The average size and surface charge of Dox-loaded disulfide cross-linked γ-PGA nanogels in aqueous solution were 136.3 ± 37.6 nm and -32.5 ± 5.3 mV, respectively. The loading amount of Dox was approximately 38.7 ?g per mg of γ-PGA nanogel. The Dox-loaded disulfide cross-linked γ-PGA nanogels showed controlled drug release behavior in the presence of reducing agents, glutathione (GSH) (1- 10 mM). Through fluorescence microscopy and FACS, the cellular uptake of γ-PGA nanogels into breast cancer cells (MCF-7) was analyzed. The cytotoxic effect was evaluated using the MTT assay and was determined to be dependent on both the concentration and treatment time of γ-PGA nanogels. The bio-derived γ-PGA nanogels are expected to be a well-designed delivery carrier for controlled drug delivery applications.
( Doo Jin Kim ),( Eun Jin Kim ),( Tae Young Lee ),( Ji Na Won ),( Moon Hee Sung ),( Har Young Poo ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.9
Conventional chemotherapeutic regimens often accompany severe side effects and fail to induce complete regression of chemoresistant or relapsing metastatic cancers. The need for establishing more efficacious anticancer strategies led to the development of a combined modality treatment of chemotherapy in conjunction with immunotherapy or radiotherapy. It has been reported that poly-gamma-glutamate (γ-PGA), a natural polymer composed of glutamic acids, increases antitumor activity by activating antigen-presenting cells and natural killer (NK) cells. Here, we investigated the antitumor effect of γ-PGA in combination with cyclophosphamide in a murine melanoma model. Whereas cyclophosphamide alone directly triggered apoptosis of tumor cells in vitro, γ-PGA did not show cytotoxicity in tumor cells. Instead, it activated macrophages, as reflected by the upregulation of surface activation markers and the secretion of proinflammatory factors, such as nitric oxide and tumor necrosis factor α. When the antitumor effects were examined in a mouse model, combined treatment with cyclophosphamide and γ-PGA markedly suppressed tumor growth and metastasis. Notably, γ-PGA treatment dramatically increased the NK cell population in lung tissues, coinciding with decreased metastasis and increased survival. These data collectively suggest that γ-PGA can act as an immunotherapeutic agent that exhibits a synergistic antitumor effect in combination with conventional chemotherapy.