신경세포 이주장애에 관한 연구

이건수,안인철 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

25 cases under 15 years of age with neuronal migration disorders were observed at the department of Pediatrics at Chungnam National University Hospital during a period of 6 years from January, 1992 to December, 1997. The results were as follows: 1. The peak incidence of age was 5 to 10 years(40.3%). The sex ratio of male to female was 1.8 : 1. 2. The types of neuronal migration disorders were cortical dysplasia (36%), lissencephaly(28%), schizencephaly(16%), heterotopia(12%) and megalencephaly(8%) in order of frequency. 3. The clinical findings were seizure(76%), delayed development(48%), delayed speech(32%), mental retardation(24%) and motor deficit(20%) in order of frequency. 4. The locations of disorder were frontal lobe(72%), parietal lobe(60%), temporal lobe(40%) and occipital Iobe(32%) in order of frequency. 5. The abnormal EEG findings were 17 cases(68%). Among these cases, focal abnormalities were 5 cases(29.4%), general abnormalities were 11 cases(64.7%) and abnormal background was 1 case(5.9%). 6. The seizure types were generalized seizure(63.2%), partial seizure (31.6%) and mixed seizure (5.3%) in order of frequency. 7. The patients with larger size of lesions had more delayed development, delayed speech and mental retardation.

간질 환아의 혈청 지질에 관한 연구

이건수,안인철 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Purpose : To assess the changes of treatment of phenobarbital, carbamazepine, valproic acid and polytherapy on serum lipids in epileptic children. Method : We determined serum levels of total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), and triglycerides in 50 healthy children and in 80 children with epilepsy who had been receiving phenobarbital(9 patients), carbamazepine(20 patients), valproic acid(30 patients), or polytherapy (21 patients) Results : In the group receiving phenobarbital, mean TC, HDL-C and LDL-C levels were significantly higher than in the control group. In the group receiving carbamazepine, mean TC levels were significantly higher than in the control group. In the group receiving valproic acid, mean triglyceride and HDL-C levels were significantly lower than in the control group, but mean LDL-C/HDL-C ratio were significantly higher than in the control group. In the group receiving polytherapy, mean TC and LDL-C levels were significantly higher than in the control group. In neither group did mean TG/HDL-C ratio differs significantly from the corresponding control groups. Conclusion : Our results suggest long-term treatment of anticonvulsants significantly modify serum lipids in epileptic children.

Floppy Infant에 관한 연구

이건수,안인철 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

16 cases with floppy infant syndrome were observed at the department of Pediatrics at Chungnam National University Hospital during a period of ll years from January, 1986 to December, 1996. The results were as follows: 1. The incidences of disease were Werdnig-Hoffman disease(W-H-D, 7 cases), Guillain-Barre syndrome(GBS, 3 cases), congenital muscular dystrophy(2 case), congenital myasthenia gravis (2 cases), congenital myotonic dystrophy(1 case) and neonatal myasthenia gravis(1 case) in order of frequency. 2. The sex ratio of male to female was 1.3 : 1. 3. The main symptoms and signs were decreased muscle tone(93.8%), decreased tendon reflex (75%), dysphagia(75%), respiratory distress(75%), abnormal traction response(68.8%), abnormal vertical response(68.8%), weak crying(62.5%), poor head control(62.5%), frog leg posture(62.5%) and fasciculation(31.3%) in order of frequency. 4. The EMG findings of W-H-D and GBS were increased amplitude and duration. The EMG findings of congenital muscular dystrophy and congenital myasthenia gravis were reduced amplitude and duration. The EMG findings of congenital myotonic dystrophy and neonatal myasthenia gravis were normal. 5. The ceatine kinase(CK) levels of W-H-D, GBS, congenital myasthenia gravis and neonatal myasthenia gravis were normal. The CK levels of congenital muscular dystrphy and congenital myotonic dystropohy were increased.

항경련제 투여 환아의 간기능 변화

황치관,이건수,안인철 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

Routine liver function test is done in epileptic children receiving antiepileptic drugs to prevent hepatotoxicity induced by these drugs. The abnormalities of liver function test are rarely seen, but these abnormalities accompanied by the clinical manifestation of hepatotoxicity are seldomly seen. This study carried out in order to assess the efficacy of routine liver function test in epileptic children. We examed the changes of the serum level of aspartate transferase(AST), alanine aminotransferase(ALT), total bilirubin, total protein, albumine, alkaline phosphatase(ALP) before and after antiepileptic drug medication in 60 epileptic children who had been receiving valproic acid(n=25명), ethosuximide(n=6명), carbamazepine(n=4명), valproic acid and carbamazepine(n= 14명), and other polytherapy(n=11명) for 3months or more. Results are as follows ; 1) The difference in each groups according to age, duration of treatment, and drug plasma concentration was not found. 2) AST was within normal range in any group, but decreased after valproic acid, ethosuximide, carbamazepine, and other polytherapy treatment. 3) ALT was within normal range in any group, but decreased after valproic acid treatment. 4) Total bilirubin, total protein, albumin, and ALP were within normal range in any groups. 5) Y-GT was within normal range, but the values were increasing tendency in polytherapy groups. 6) No clinical significant menifestations had developed during study period in any groups. The result suggest that the routine liver function test itself can not be the indicator of hepatotoxicity, and that the liver function test exammed when the clinical symptoms appear is more effective than the routine liver function test.

A Coaxial and Off-axial Integrated Three-mirror Optical System with High Resolution and Large Field of View

Zhe Chen,Junqing Zhu,Jiantao Peng,Xingxiang Zhang,Jianyue Ren 한국광학회 2016 Current Optics and Photonics Vol.20 No.1

A novel optical design for high resolution, large field of view (FOV) and multispectral remote sensingis presented. An f/7.3 Korsch and two f/17.9 Cook three-mirror optical systems are integrated by sharingthe primary and secondary mirrors, bias of the FOV, decentering of the apertures and reasonable structurearrangement. The aperture stop of the Korsch system is located on the primary mirror, while those ofthe Cook systems are on the exit pupils. High resolution image with spectral coverage from visible tonear-infrared (NIR) can be acquired through the Korsch system with a focal length of 14 m, whilewide-field imaging is accomplished by the two Cook systems whose focal lengths are both 13.24 m. The full FOV is 4°×0.13°, a coverage width of 34.9 km at the altitude of 500 km can then be acquiredby push-broom imaging. To facilitate controlling the stray light, the intermediate images and the real exitpupils are spatially available. After optimization, a near diffraction-limited performance and a compactoptical package are achieved. The sharing of the on-axis primary and secondary mirrors reduces the costof fabrication, test, and manufacture effectively. Besides, the two tertiary mirrors of the Cook systemspossess the same parameters, further cutting down the cost.

Microvibration analysis of a cantilever configured reaction wheel assembly

Zhang, Zhe,Aglietti, Guglielmo S.,Ren, Weijia,Addari, Daniele Techno-Press 2014 Advances in aircraft and spacecraft science Vol.1 No.4

This article discusses the microvibration analysis of a cantilever configured reaction wheel assembly. Disturbances induced by the reaction wheel assembly were measured using a previously designed platform. Modelling strategies for the effect of damping are presented. Sine-sweep tests are performed and a method is developed to model harmonic excitations based on the corresponding test results. The often ignored broadband noise is modelled by removing spikes identified in the raw signal including a method of identifying spikes from energy variation and band-stop filter design. The validation of the reaction wheel disturbance model with full excitations (harmonics and broadband noise) is presented and flaws due to missing broadband noise in conventional reaction wheel assembly microvibration analysis are discussed.

Sentiment analysis and product personalization - An emotional design approach to AI technology

Yu-Zhe Qi,Kie-Su Kim,Hong-Yan Ren,Xu Sun,Jiang-Yue Han,Xiang Zhang 한국콘텐츠학회 2023 한국콘텐츠학회 ICCC 논문집 Vol.2023 No.12

Optimal Design for Cooling System of Batteries Using DOE and RSM

Zhen-Zhe Li,Yun-De Shen,Tai-Hong Cheng,Dong-Ji Xuan,Ming Ren,Gui-Ying Shen 한국정밀공학회 2012 International Journal of Precision Engineering and Vol. No.

A hybrid power composed of fuel cell and batteries has become the good strategy for HEV. On the contrary, the produced heat of batteries can affect to the total performance of HEV significantly. In this study, simulation methods with optimization were developed for obtaining the high performance cooling system of batteries. At first, a numerical method for obtaining the temperature distribution of batteries was developed by using CFD. In the following step, several parameters were investigated for selecting design variables with the important effect on the performance of the cooling system of batteries. Finally, an optimization method based on DOE and RSM was obtained through a real optimal design. There was 21.1% reduction on the view of the root mean square temperature between batteries as shown in the optimization result. The developed analysis with optimization can be used to improve the performance of the cooling system of batteries, and these works have made the theoretical basis for simulation and optimization of the cooling system of batteries.

Finite-time L2-L∞ Filtering for Nonlinear Stochastic Systems Based on a Novel Stochastic Finite-time Stability Theorem

Ming-Zhe Hou,Ai-Guo Wu,Guang-Ren Duan 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.2

This paper presents a novel stochastic finite-time stability theorem and gives its application in the finitetimeL2 L¥ filter design for nonlinear stochastic systems. Different form the frequently-used stochastic finitetimestability result, the proposed one does not require that all the states have the same fractional order exponent. Based on this result, a sufficient condition is given for nonlinear stochastic systems to possess the finite-time L2 L¥ performance with a prescribed gain. Further, an existence condition of the finite-time L2 L¥ filter with aprescribed disturbance attenuation level is given for nonlinear stochastic systems with external disturbance inputs. The effectiveness of the obtained results is illustrated by an example.

Robust Adaptive Dynamic Surface Control of Uncertain Nonlinear Systems

Ming-Zhe Hou,Guang-Ren Duan 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.1

This paper studies the robust adaptive dynamic surface control of a class of nonlinear systems with unmatched uncertainties. The unmatched uncertainties consist of not only the linearly parameterized terms but also the nonlinearly parameterized terms. The bound of each nonlinearly parameterized uncertainty term is supposed to be expressed by a known nonnegative function multiplied by a constant called bound parameter. According to whether the bound parameters are known or not, two different kinds of robust adaptive dynamic surface control algorithms are proposed. It is proved that in each case all the states of the closed-loop system are kept uniformly ultimately bounded, and the output is driven to track a feasible desired output trajectory with an arbitrarily small error. An example is also employed to indicate the effect of the proposed methods.