Comparison of Melanoma Subtypes among Korean Patients by Morphologic Features and Ultraviolet Exposure

( Hong Sun Jang ),( Jee Hung Kim ),( Kyu Hyun Park ),( Jae Seok Lee ),( Jung Min Bae ),( Byung Ho Oh ),( Sun Young Rha ),( Mi Ryung Roh ),( Kee Yang Chung ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.4

Background: Genetic alterations have been identified in melanomas according to different levels of sun exposure. Whereas the conventional morphology-based classification provides a clue for tumor growth and prognosis, the new classification by genetic alterations offers a basis for targeted therapy. Objective: The purpose of this study is to demonstrate the biological behavior of melanoma subtypes and compare the two classifications in the Korean population. Methods: A retrospective chart review was performed on patients found to have malignant melanoma in Severance Hospital from 2005 to 2012. Age, sex, location of the tumor, histologic subtype, tumor depth, ulceration, lymph node invasion, visceral organ metastasis, and overall survival were evaluated. Results: Of the 206 cases, the most common type was acral melanoma (n=94, 45.6%), followed by nonchronic sun damage-induced melanoma (n=43, 20.9%), and mucosal melanoma (n=40, 19.4%). Twenty-one patients (10.2%) had the chronic sun-damaged type, whereas eight patients (3.9%) had tumors of unknown primary origin. Lentigo maligna melanoma was newly classified as the chronic sun-damaged type, and acral lentiginous melanoma as the acral type. More than half of the superficial spreading melanomas were newly grouped as nonchronic sun-damaged melanomas, whereas nodular melanoma was rather evenly distributed. Conclusion: The distribution of melanomas was largely similar in both the morphology-based and sun exposure-based classifications, and in both classifications, mucosal melanoma had the worst 5-year survival owing to its tumor thickness and advanced stage at the time of diagnosis. (Ann Dermatol 26(4) 485~490, 2014)

급성 포름알데히드 가스 흡입에 의한 흰쥐 후각상피의 형태학적 변화

백선용,전재기,문용석,황승영,노환중,고의경,왕수건 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

주물사업장에서 발생하는 호흡성분진의 농도 및 석영함유량에 관한 연구

박용선,노영만,김현욱,한진구,안연순,강성규,김정만 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

This study was performed to measure and evaluate the concentration of respirable dust and quartz content at molding and shakeout process in the foundry. The 129 samples in 30 foundries were collected using 10mm Dorr-Oliver nylon cyclone and analysed for quartz concent by Fourier Transform Infrared Spectroscopy. The average quartz concentrations in the respirable dust was 0.0273mg/㎡ and ranged from 0.0007 to 0.3757mg/㎥. The average quartz concentrations of shakeout process wsa significantly higher than that of molding in the foundry. The average of respirable dust in foundry 102129mg/㎡ and ranged from 0.1524 to 7.0428mg/㎥. But there is no significant difference between molding and shakeout processes. The average contents of quartz for OEL-MOL was 2025% and ranged from 0.05 to 32.79% The non-compliance rates for quartz were 22.96% in Korea-OEL and 34.01% in ACGIH-TLV and NIOSH-REL, and 35.03% in OSHA-PEL. The airbome dust in the foundry was effectively controlled when local exhaust ventilation and/or wetting system were operated. The result of this study therefore showed that the engineering controls and periodic environmental suveillance in foundry will be very important for preventing the health effects of workers exposed to quartz.

세라믹 정밀여과막 생물반응기를 이용한 매립지 침출수 처리

윤영재,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.2

The results that the membrane bioreactor allows the treatment of ammonia and part of the COD, with a limited production of sludges. The elimination yields observed on the membrane bioreactor are high, starting from a biologicaly equilibrated efflent, since the ratio C/N/P is slightly deficient in P. The Chemical Oxygen Demand and Total Organic Carbon are climinated more than 70%. The Nitrification rate nears 98% despite the important variability of the ammonia concentrations inside the raw leachate. The Suspended Solids are eliminated 100% thanks to the microfiltration membrane.

후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

儀式으로 본 通度寺 空間動線 조사 연구

오흥선,이영한,박기홍,문종만,노정선 서울産業大學校 1999 논문집 Vol.49 No.2

This study deals mainly with relationships between the spatial composition and the Buddhist rituals of monks at the Tongdosa temple. The results of study are summarized as followed. Many of rituals are performed in the Sangrohjun(上爐殿) and, in particular, handled in the Sulbujun(說法殿), but not performed in the Jungrohjun(上爐殿) and Harohjun(下爐殿) except for the time of Buddhist mass held in the every morning and night. The main activities of all rituals were based on the Kumkang Stupa in the past and such a tendency continues in the present time. The characteristics of temple space reflected by the movement of monks and believers who take advantage of the Kumkang Stupa's Structure in the significant rituals such as the entrance of priesthood, reception of Buddhist confirmation, Buddha's Birthday and establishment of Tongdosa Temple.

다환계 방향족 유기오염물을 함유한 폐수의 전기화학 처리

윤영재,강태구,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This work has concerned the possibility to apply both direct and indirect electrolysis process for the treatment of waste containing poliaromatic compounds. Two different kinds of electrode materials have been used: DSA-type anodes to carry out direct electrolysis and carbon felt cathodes to ferform indirect electrolysis. On the contrary, in the case of the tested wastewater especially containing naphthalen- and anthraquinon sulphonic compounds they do not seem to be very suitable materials. Better results have been achieved using the carbon felt cathodes. In this case the COD of the tested wastewater can be remarkably decreased using H_2O_2 as oxidation agent.

單調增加荷重을 받는 平面 트러스의 複合 非線型 擧動에 關한 硏究

權寧煥,金和中,金明璇,魯德煥 경북대학교 산업기술연구소 1990 産業技術硏究誌 Vol.18 No.-

The object of this study is that develop computer program as being derive simple formula considering complex (material and geometric) nonlinear, and select the most useful truss in efficiency with the analysis Howe truss, Fink truss, Pratt truss and Warren truss. The complex nonlinear behavior is considered in this paper, so is acquired following results. 1. We developed program that could analyze complex nonlinear of plane truss. 2. In view of the results analyzied the numerical analysis example of plane truss, When Howe truss, Fink truss, Pratt truss, and Warren truss are equal to weight and span, and the same load is loaded. Among the trusses of same weight, Warren truss is the most useful in efficiency. And When height of warren truss is changed, the lower height of truss, the more useful in efficiency

운송업 종사 근로자의 건강가치 인식 및 건강증진 행위와 건강진단 결과와의 관련성

이선주,박정일,임현우,노영만,정치경 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.3

목 적 : 건강진단 결과 건강인과 요관찰자 및 일반질환자를 포함한 비건강인에서 건강가치인식 및 건강증진행위 실천정도를 알아보고, 건강인과 비건강인으로 층화한후 건강가치인식이 높은 군과 낮은 군에서 건강증진행위 실천에 차이가 있는지를 비교함으로써 바람직한 건강증진 프로그램 개발과 적용을 위한 기초자료를 제공하고자 수행되었다. 방 법 : 1998년도 건강진단을 받은 철도운송업 종사 근로자 4,919명중에서 자기기입식 설문에 응답한 건강인 233명, 요관찰자 172명, 일반질환자 160명을 연구대상으로 하였다. 결 과 . 삶의 가치 중 건강을 가장 가치있게 인식하고 있는 근로자가 건강인에서 37.3%, 비건강인에서 36.1%로 두 군간에 차이가 없었다. 건강증진 행위 실천에 있어 비 건강인이 건강인에 비하여 운동영역의 실천정도가 유의하게 낮았으며 대인관계 지지영역은 유의하게 높았다. 그 외의 영양, 스트레스관리, 자아실현 및 건강책임 관련 영역의 실천정도는 건강인과 비건강인 사이에 유의한 차이가 없었다. 건강인에서의 연령 변수를 제외하고 건강인 및 비건강인 모두 일반적 특성에 따른 건강가치 인식도에 차이가 없었다. 건강가치 인식도에 따른 건강증진행위 실천 정도는 건강인의 경우 건강가치 인식이 높은 군이 낮은 군에 비하여 자아실현 및 건강책임 영역의 실천 정도가 유의하게 높았으며, 비건강인의 경우 유의한 차이를 보이는 영역은 없었다. 결 론: 건강가치 인식, 건강증진행위 실천 정도와 건강진단 결과와의 관련성은 매우 낮게 나타나 건강증진 프로그램 개발과 적용에 있어 인식보다는 실천에 촛점을 두어야 될 것으로 판단된다. Objectives : This study was performed to compare health value cognition and health promotion behavior compliance between healthy group and not being healthy group, and to evaluate the difference of health promotion behaviors compliance between high group and low group in health value cognition. Methods . The subjecus of this study were 565 wor17ers, 233 healthy workers, 172 observation cases and 160 disease cases, selected from 4,919 transit coporation's workers. Results : In health promoting behavior compliance, not belng healthy group showed lower level than healthy group in exercise and showed higher level than healthy group in interpersonal support significantly. A worker who replied on "health" as the most value in life was consisted in 37.3% of healthy group and 36.1% of not belng healthy group, Health value cognition according to general characteristics showed no significant difference except only variable of age in healthy group. Health promoting behavior compliance according to cognition of health value showed in healthy group that a high level group of health value cognition was more significant difference than a low level group in self aclualization and health responsibility of health promoting behavior and didn't show difference significantly in not being healthy group. Conclusions : In conclusion, the relationship between health value cognition, health promotion behavior compliance and periodic health examination results showed weakly. Therefore, in order to develop and apply spontaneous health promotion program, it was considered that should emphasize compliance than cognition.

상아질에 대한 자가 산부식 접착제의 전단결합강도와 SEM 분석 비교

조영곤,노기선,김수미,이영곤,정진호,기영재 大韓齒科保存學會 2003 Restorative Dentistry & Endodontics Vol.28 No.3

The purpose of this study was to compare shear bond strength and interfacial pattern of composite bonded to dentin using self-etching adhesive systems. Sixty extracted human molars with exposed occlusal dentin were divided into four groups and bonded with four adhesives and composites: Single Bond/Filtek Z 250(SB), Tyrian SPE-One-Step Plus/Aelitefil(TY), Prompt L-Lpop/Filtek Z 250(LP), and one-Up Bond F/Palfique Toughwell(OU). The results of this study were as follows; 1. Shear bond strength for OU was significantly lowet than that of other groups(p<0.05). No significant difference was founded among SB, TY, and LP. 2. Failure modes to dentin showed adhesive and mixed for SB, TY, and LP, but them for OUT showed adhesive in all spceimens. 3. Dentin-resin interface showed close adaptation for SB, TY, and LP, but it showed gap for OU. 4. The hybrid layers for TY, LP, OU were thinner than that of SB. Adhesive layers were observed between composite and hybrid layer, which were 5 ㎛ thick for TY and 10 ㎛ thick for OU.