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Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>
Mutational signatures according to the stage of lung adenocarcinoma in Korea
( Young Kim ),( Sung Yong Lee ),( Eun Joo Lee ),( Gyu Young Hur ),( Sang Yeub Lee ),( Jae Jeong Shim ),( Kwang Ho In ),( Kyung Ho Kang ),( Se Hwa Yoo ),( Chi Young Kim ),( Byeong Ki Kim ),( Seung Heon 대한결핵 및 호흡기학회 2018 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.126 No.-
Purpose: There are many somatic mutations in lung cancer, and many biological processes that cause mutations in somatic cells leave a mutational signature. The purpose of this study is to identify the mutational signature according to the stage of lung adenocarcinoma in Korea. Methods: A total of 103 specimens from patients diagnosed with lung adenocarcinoma were obtained and NGS based repeated deep sequencing was performed. The single nucleotide variation detected by the test was converted to maf.file and mutational signatures according to the stage of lung cancer analyzed by applying a computational framework for mutational signature model proposed by Alexandrov et al. The mutational signature nomenclature is that used in the Catalogue of Somatic Mutations in Cancer (COSMIC). Results: As a result of mutational signature analysis with stage I lung cancer, signature 5 (cosine similarity=0.656, unknown etiology) was the most significant result. With stage II lung cancer, signature 7 (cosine similarity=0.742, UV exposure) was the most significant result and with stage III lung cancer, signature 30 (cosine similarity=0.777, unknown etiology) was the most significant result. In this study, the number of patients with stage IV lung cancer was small and there were no significant results. Conclusions: The risk factors for lung cancer other than smoking,the exact cause has not been clarified, they are presumed to have left a mutational signature. In addition, the mutational signatures according to the stage of lung adenocarcinoma in Korean patients showed different result.
Gyu-Young Hur,박해심,박한정,이현영,고동희,이병재,최길순,김승현,예영민 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.3
Purpose: Our previous study indicated that the presence of wheat-specific IgG1 and IgG4 antibodies was associated with work-related symptoms in workers exposed to wheat flour. We performed this study to investigate the genetic polymorphisms of β_2-adrenergic receptors and wheat-specific antibodies in association with the clinical parameters of baker’s asthma. Materials and Methods: In total, 379 subjects working in a single industrial bakery were enrolled in this study. The skin prick test was performed with common inhalant allergens and wheat flour extract. The presence of serum-specific IgE, IgG1, and IgG4 antibodies to wheat flour were determined by ELISA. Whole blood samples were obtained for genotype analysis. Subjects were genotyped with regard to five candidate single nucleotide polymorphisms (SNPs) of the β_2-adrenergic receptor gene (ADRB2; -47 T>C, 46 A>G, 79 C>G, 252 G>A, and 523 C>A) using a single-base extension method. Results: No significant associations were observed between the genotype/allele frequencies of any of the SNPs tested and any clinical parameters. The haplotype of ADRB2 (GAA composed of 46 A>G, 252 G>A, and 523 C>A) was significantly associated with work-related symptoms (p<0.05). Moreover, in subjects with the AG or GG genotype at 46 A>G and haplotype [GAA] of ADRB2, the prevalence rates of wheat-specific IgG1 antibodies and lower respiratory symptoms increased significantly with exposure intensity (both p<0.05). Conclusion: The findings of the present study suggest that ADRB2 genetic polymorphism may contribute to the development of work-related symptoms in workers exposed to wheat flour, which can lead to baker’s asthma.
Hur, Gyu-Young,Choi, Gil-Soon,Sheen, Seung-Soo,Lee, Hyun-Young,Park, Han-Jung,Choi, Sung-Jin,Ye, Young-Min,Park, Hae-Sim Elsevier 2008 The Journal of allergy and clinical immunology Vol.122 No.4
<P><B>Background</B></P> <P>Although methylene diphenyl diisocyanate (MDI) may induce occupational asthma in the workplace, the pathogenic mechanisms are unclear.</P> <P><B>Objectives</B></P> <P>By using bronchoalveolar lavage fluid, we sought to identify proteins that were differentially expressed between subjects with MDI-induced occupational asthma (MDI-OA) and asymptomatic exposed controls (AECs).</P> <P><B>Methods</B></P> <P>To find proteins that were differentially expressed between the MDI-OA and AEC groups, 2-dimensional electrophoresis was performed by using bronchoalveolar lavage fluid obtained from subjects after MDI-specific inhalation challenge. The selected protein spots were then identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The clinical relevance of the differentially expressed spots was compared by ELISA using sera from the MDI-OA/eosinophilic bronchitis, AEC, and unexposed healthy control groups. Receiver operating characteristic curves were then plotted, and the sensitivity and specificity were determined.</P> <P><B>Results</B></P> <P>Twenty-three protein spots were identified that distinguished the subjects with MDI-OA from those in the AEC group. Among them, ferritin expression was downregulated whereas transferrin expression was upregulated in subjects with MDI-OA compared with AEC; these results were validated by ELISA using sera from the MDI-OA/EB and AEC groups. To identify subjects with MDI-OA, the optimal serum cutoff levels were 69.84 ng/mL for ferritin and 2.48 μg/mL for transferrin. When these 2 parameters were combined, the sensitivity was 71.43% and the specificity was 85.71%.</P> <P><B>Conclusion</B></P> <P>Serum ferritin and transferrin levels are associated with the phenotype of MDI-OA.</P>
Allergen immunotherapy for the treatment of respiratory allergies in the elderly
Hur, Gyu-Young,Lee, Ji-Ho,Park, Hae-Sim Lippincott, Williams and Wilkins 2017 Current opinion in allergy and clinical immunology Vol.17 No.4
<P>Elderly individuals with proven, clinically relevant immunoglobulin E sensitization to inhalant allergens may benefit from allergen immunotherapy for respiratory allergic diseases. Older patients without contraindications should therefore be considered for treatment, with the additional benefit of reduced medication and symptom scores.</P>
Hur, Gyu-Young,Koh, Dong-Hee,Kim, Hyoun-Ah,Park, Han-Jung,Ye, Young-Min,Kim, Kyoo-Sang,Park, Hae-Sim Elsevier 2008 Respiratory medicine Vol.102 No.4
<P><B>Summary</B></P><P><B>Background</B></P><P>Although baker's asthma (BA) is a common occupational asthma, there have been few reports on this disease in Korean subjects.</P><P><B>Objectives</B></P><P>We evaluated the prevalence of serum-specific IgE, IgG1, and IgG4 antibodies in relation to work-related respiratory symptoms in a single industrial bakery.</P><P><B>Methods</B></P><P>Three hundred and ninety-two bakery workers were administered and taken a questionnaire regarding respiratory symptoms. For symptomatic workers, the methacholine bronchial challenge test and specific bronchoprovocation tests with wheat extracts were carried out. Skin prick tests were performed and serum-specific IgE, IgG1, and IgG4 antibodies to wheat flour were detected. The IgE- and IgG4-binding components were identified by immunoblotting.</P><P><B>Results</B></P><P>Sixty-seven workers (17.1%) complained of work-related upper and lower respiratory symptoms. The prevalence of BA based on positive bronchoprovocation test results was 1.5%. The sensitization rate to wheat flour was 5.9% by skin prick test and 6.5% by ELISA, and was closely associated with the presence of atopy and work-related lower respiratory symptoms (<I>P</I><0.001 for both). IgE immunoblotting revealed six major IgE-binding components (27, 31, 36, 43, 54, and 72kDa). The presence of wheat-specific IgG1 and IgG4 antibodies was found to be significantly associated with exposure intensity (<I>P</I><0.05 for both).</P><P><B>Conclusions</B></P><P>The overall prevalence of wheat sensitization in a Korean bakery was 5.9%. We confirmed that an IgE-mediated response is the major pathogenic mechanism for the induction of work-related symptoms in wheat-exposed workers. Wheat-specific IgG antibodies may represent current or previous exposure to wheat dust.</P>