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元裕憲,金鍾勳,盧三赫 弘益大學校 科學技術硏究所 1995 科學技術硏究論文集 Vol.6 No.-
Disk arrays were proposed in the 1980`s as a way to allow parallelism between multiple disks to improve aggregate I/O performance. Today they appear in the product lines of most major computer manufactures. This paper gives a comprehensive overview of disk arrays and provides a framework in which to organize current and future work. First, this paper introduces disk arrays in general, and reviews the driving forces that have popularized disk arrays : performance and reliability. It discusses the two architectural techniques used in disk arrays, striping across multiple disks to improve performance and redundancy to improve reliability. Next, this paper describes 6 disk array architectures, namely RAID levels 0∼5. It goes on to discuss advanced research and implementation topics such as the way in which parity is distributed in a RAID, and the means of refining the basis RAID levels to improve performance. Finally, this paper describes software disk arrays which allow writing data redundantly across an array of disks in workstations distributed across the network.
Promoter DNA methylation contributes to human <i>β</i> -defensin-1 deficiency in atopic dermatitis
Noh, Yoo-Hun,Lee, Jaehyouk,Seo, Seong Joon,Myung, Soon Chul ZOOLOGICAL SOCIETY OF KOREA 2018 ANIMAL CELLS AND SYSTEMS Vol.22 No.3
<P><B>ABSTRACT</B></P><P>Atopic dermatitis (AD) is a chronic inflammatory skin disease caused by epidermal barrier dysfunction and dysregulation of innate and adaptive immunity. Epigenetic regulation of human <I>β</I>-defensin-1 (HBD-1) might be associated with a variety of defects in the innate immune system during AD pathogenesis. We investigated the possible mechanism of decreased <I>HBD-1</I> gene expression in AD and demonstrated the restoration of HBD-1 transcription in undifferentiated normal human epidermal keratinocyte cells after treatment with a DNA methyltransferase inhibitor. We also conducted an <I>in vitro</I> methylated reporter assay using a reporter containing 14 CpG sites. Methylation of the 14 CpG sites within the HBD-1 5′ region resulted in an approximately 86% reduction in promoter activity and affected HBD-1 transcriptional regulation. We then compared methylation frequencies at CpG 3 and CpG 4 between non-lesional and lesional epidermis samples of patients with severe AD and between these paired tissues and healthy control epidermis from normal volunteers without AD history. Bisulfite pyrosequencing data showed significantly higher methylation frequencies at the CpG 3 and 4 sites in AD lesional samples than in non-lesional AD skin and normal skin samples (<I>P</I> < 0.05). These results suggest that the DNA methylation signature of HBD-1 is a novel diagnostic/prognostic marker and a promising therapeutic target for the compromised stratum corneum barrier attributed to HBD-1 deficiency.</P>
Improvement of andropause symptoms by dandelion and rooibos extract complex CRS-10 in aging male
Yoo-Hun Noh,Do-Hee Kim,Joon Yub Kim,Jiae Park,Ok Hyeon Kim,Daeseok Han,Won-Yong Kim,Sung-Su Kim,Moo-Yeol Lee,Seok-Hyun Heo,Misook Kim,Won Bok Lee,Yoonhwa Jeong,Soon Chul Myung 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.6
Many aging male suffer various andropause symptoms including loss of physical and mental activities. This study evaluated the putative alleviative effects of CRS-10 dandelion and rooibos extract complex (CRS-10) on the symptoms of andropause. The survival rate of TM3 Leydig cells (TM3 cells) treated with CRS-10 was measured based on typical physiological stress. After daily intake of CRS-10 for 4 weeks, the level of testosterone, physical activity and both the number and activity of sperm in older rats (18 weeks) were measured. Furthermore, thirty males were surveyed with AMS (Aging Males" Symptoms) questionnaire after intake of 400 mg of CRS-10. Overall, CRS-10 protected TM3 cells from serum restriction and oxidative stress via activation of ERK and Akt pathways. The level of testosterone and activation of spermatogenesis in rats were significantly enhanced. In addition, physical locomotion was markedly improved. Daily intake of 400 mg of CRS-10 improved the quality of life among agingmale respondents, according to a clinical survey using the AMS. The results indicate the potential of CRS-10 as a safe and efficacious natural substance for reducing or alleviating andropause symptoms.