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      • KCI등재

        정준상관 행렬도와 군집분석을 응용한 KLPGA 선수의 기술과 경기성적요인에 대한 연관성 분석

        최태훈,최용석,Choi, Tae-Hoon,Choi, Yong-Seok 한국통계학회 2008 응용통계연구 Vol.21 No.3

        정준상관 행렬도(canonical correlation biplot)는 정준상관분석에서 두 변수 집단에 의해서 측정된 다변량 자료에서 변수 집단 간의 관계와 개체들의 관계를 탐색하기 위한 2차원 그림이다. 이는 일반적으로 최용석 (2006, 1장)의 한 변수 집단에 의한 행렬자료에 대한 일반적인 행렬도를 두 변수 집단에 의한 행렬자료로 확장한 것으로 볼 수 있다. 최근에 Choi와 Kim (2008)은 개체들이 많은 대용량 자료에서 행렬도의 해석상 힘든 문제점을 지적하고 이를 극복하는 데 군집분석을 활용하는 방법을 제시하고 있다. 일반적인 행렬도에서 발생하는 대용량 자료에 대한문제는 정준상관 행렬도에서도 동일하게 발생하곤 한다. 본 연구에서는 2006년도 KLPGA 선수 중 상금 순위 상위 50명을 대상으로 정준상관 행렬도를 통해 기술요인변수군(평균 퍼팅수. 그린 적중율, 파 세이브율, 파 브레이크율)과 경기성적요인변수군(상금, 평균 타수)간의 관련성을 살펴보고 군집분석을 활용하여 각 선수들의 군집을 시도하려한다. Canonical correlation biplot is 2-dimensional plot for investigating the relationship between two sets of variables and the relationship between observations and variables in canonical correlation analysis graphically. In general, biplot is useful for giving a graphical description of the data. However, this general biplot and also canonical correlation biplot do not give some concise interpretations between variables and observations when the number of observations are large. Recently, for overcoming this problem, Choi and Kim (2008) suggested a method to interpret the biplot analysis by applying the K-means clustering analysis. Therefore, in this study, we will apply their method for investigating the relationship between skill and competition score factors of KLPGA players using canonical correlation biplot and cluster analysis.

      • T 세포활성항원 CTLA-4의 기능에 관한 연구 : T 세포에서 표적세포 살해능과 CTLA-4 발현과의 연관성 Target Cytotoxicity of T Cell Correlates with CTLA-4 Production

        노만택,조양자,김용식,최용,조보현,최장원,정용훈 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4

        CTLA-4, a T cell activation antigen and a homologue of CD28, was originally identified as a gene by a series of reverse genetic approaches. While CD28 molecule has been characterized well as a stimulator of T-cell function via enhanced lymphokines production and stablilization of those mRNA, most of the functions of CTLA-4 remain unknown. It has been widely accepted that CTLA-4 functions as an immune suppressor which is down-regualting the function of CD28. We previously showed that 34 KD form of this antigen mainly expressed CD8+ subset, a cytotoxic or suppressor, of activated peripheral blood lymphocyte. Based on our previous finding this study was conducted to further characterize immunological function of CTLA-4 especially in terms of involvement of this molecule in T-cell effector function mediating target cell cytotoxicity. 4 human T cell clones with different target cytotoxicities were employed in this study. NBL46 (CD4+) and NBL77 (CD8+) were cytotoxic and NBL32 (CD4+) and NBL58 (CD 8+) were non-cytotoxic to target LBF cell in target cell chromium release assay. And in Western blot assay 34 kD antigen was detected in NBL46 (CD4+) and NBL77 (CD8+) clones but not in NBL32 (CD4+) and NBL58 (CD8+) clones. It was summarized that expression of the CTLA-4 antigen was associated with cytotoxicity but not with subset phenotypes of T cells. In conclusion CD8+ T subset of PHA-stimulated PBL was major and only CTLA-4 producer and this molecule was induced during mid to late stage of T cell activation. The cytotoxicity of T cell clones to its target cell was directly correlated with its CTLA-4 production and vice versa. And it was highly suggested that primary function of CTLA-4 may involved in T cell effector function which mediates target cell killing.

      • SCOPUSKCI등재

        헬리코박터 파이로리 균 진단용 ^13C-요소 캅셀의 개발

        용철순,김용일,김지만,강성훈,권기철,이종달,김종국,사홍기,최한곤 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1

        The purpose of this study was to develop a new ^13C-urea- containing capsule for diagnosis of H. pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystalline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG, [^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG/citric acid (38/1.9/1.9 mg/cap)] had the maximum DOB value, about 16 at 20 mim, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable preparation for diagnosis of H. pylori.

      • KCI등재

        양극산화와 절연파괴로 형성한 인산칼슘 함유 티타늄 산화피막의 특성

        최원호,이용승,김동환,권용훈,배태성 大韓齒科器材學會 2003 대한치과재료학회지 Vol.30 No.1

        This study was performed to investigate the surface properties of electrochemically oxidized pure titanium by anodic spark deposition technique. Titanium plates of 10×10×1 ㎜ were polished sequentially from # 300 to # 1,000 emery paper. They were ultrasonically washed in ethyl alcohol and acetone for 5 min and dried in a desiccator. Titanium plates and titanium screw implants were anodized in an electrolytic solution that was dissolved calcium and phosphate in water. The electrolytic voltage was set in the range of 190-340 V and the current density was 30 ㎃/㎠. The surface oxide film was characterized by X-ray deffractometer(XRD), scanning electron microscope(SEM) and X-ray photoemission spectroscopy(XPS). The main crystal structure of the titanium oxide was anatase type as analyzed with thin-film X-ray diffractometery. The diameter of micropores increased with increasing the spark forming voltage. The porous coatings showed the growth of cell structure and more compact texture with increasing the spark forming voltage. Microcracks were examined in the coating formed at voltage of 340 V. Ca/P ratio in coatings was increased with increasing the voltage.

      • 헬리코박터 파이로리 균 진단용 ^13C-요소 캅셀의 개발

        용철순,김용일,김지만,강성훈,권기철,이종달,김종국,사홍기,최한곤 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

        The purpose of this study was to develop a new ^13C-urea-containing capsule for diagnosis of H.pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystaline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG,[^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG (38/1.9/1.9 mg/cap)] had the maximum DOB value. about 16 at 20 min, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable perparation for diagnosis of H. pylori.

      • KCI등재

        佛敎의 唯識思想과 分析精神治療 理論의 比較 試論

        崔焄東,李符永 大韓神經精神醫學會 1986 신경정신의학 Vol.25 No.1

        While there are many articles on the Son(Zen) Buddhism ad its psychotherapeutic implications in the Eastern and western countries, Yogacara Buddhism was rarely studied in the aspect of psychotherapy. The authors reviewed Yogacara theories and compared them with the theories of analytical psychotherapy, hoping to find out the possibilities to incorporate the Yogacara theories into the theories of psychotherapy. ?? (Store-consciousness) is a consciousness which is the foundation of all acts of thought. The impressions of the whole of past experience are stored up in it. ?? is comparable to the psychological concept of the unconscious. Especially it is very similar to the Jungian unconsciousness which has both personal and collective components. The process of turning avidya(ignorance) into vidya(enlightenment) is comparable to the insight-oriented psychotherapy. Therefore Yogacara Buddism might provide the expanding knowledge and the scope of psychotherapy and the philosophical basis of psychotherapists.

      • 회전축계 위치제어를 위한 비선형 마찰 보상

        최연선,장용훈 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.2

        Friction effects in rotor system with a brush type D. C. servo motor is explored for the precise position control based on experiments. The success of friction compensation depends on the accurate measurement of real friction torque. Experimental results have clearly shown that both static and dynamic friction have nonsymmetric characteristics. Estimated friction torque was used to linearize the system by feedforward compensator. In practice, overcompensation may cause another stability problem due to sampling time, gain, and modeling. Therefore, a compensation ratio was introduced for the elimination of the instability.

      • 알레르기성 자반증 환자에서 캡슐내시경으로 공장궤양을 진단한 1예

        이용강,오탁근,최아라,이지훈,김미나,홍성필 고신대학교의과대학 2012 고신대학교 의과대학 학술지 Vol.27 No.1

        Henoch-Schönlein purpura (HSP) is the most common form of systemic vasculitis in children. Palpable purpura, arthralgia, arthritis, abdominal pain and renal involvement are the major clinical manifestations. Gastrointestinal involvement is related with abdominal pain and bleeding. We described a 71 year-old female experienced acute exacerbation of HSP presented with gastrointestinal bleeding. She was hospitalized for hematemesis and diagnosed duodenitis by esophagogastroduonenoscopy (EGD). Duodenitis was improved at EGD checked in 7 days. She still complained of melena and abdominal pain. There were no abnormal findings at sigmoidoscopy. Jejunal ulcer and purpura were diagnosed by capsule endoscopy. Symptoms were relieved after administration of systemic steroid. But she needed renal replacement therapy for 3 months. Small bowel ulcer diagnosed by capsule endoscopy in patients with HSP was rarely described in Korean literature. This case suggests that capsule endoscopy have a role in diagnosis of small bowel ulcer and its severity in HSP with gastrointestinal symptom.

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