http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ryu, Ji-Kan,Cho, Chung-Hyun,Shin, Hwa-Yean,Song, Sun U.,Oh, Seung-Min,Lee, Minhyung,Piao, Shuguang,Han, Jee-Young,Kim, In-Hoo,Koh, Gou Young,Suh, Jun-Kyu Elsevier 2006 MOLECULAR THERAPY Vol.13 No.4
<P><B>Abstract</B></P><P>Hypercholesterolemia-related endothelial cell dysfunction and decreased endothelium-derived nitric oxide formation may account for impaired angiogenesis and subsequent erectile dysfunction. Angiopoietin-1 (Ang1) is a critical angiogenic factor for vascular maturation and enhances vascular endothelial growth factor (VEGF)-induced angiogenesis in a complementary manner. We hypothesized that combined adenovirus-delivered human Ang1 (ad-Ang1) and VEGF165 (ad-VEGF165) gene transfer might promote angiogenesis cooperatively in a rat model of hypercholesterolemic erectile dysfunction and result in a recovery of erectile function. Ad-Ang1 and ad-VEGF165 were injected either alone or in combination into the corpus cavernosum of the penis. Combined gene transfer of both ad-Ang1 and ad-VEGF165 significantly increased cavernous angiogenesis, eNOS phosphorylation, and cGMP expression compared with that in the groups treated with either therapy alone. Erectile function, as evaluated by electrical stimulation of the cavernous nerve 2 and 8 weeks after treatment, was completely restored in the combined treatment group, whereas intracavernous injection of either ad-Ang1 or ad-VEGF165 alone elicited partial improvement. The results indicate that combined application of angiogenic factors may enhance cavernous angiogenesis cooperatively by reinforcing the endothelium both structurally and functionally, which results in an additive effect on erectile function in hypercholesterolemic rats.</P>
박영민(Young Min Park),김지영(Ji Young Kim),천연진(Yean Jun Chung),노재열(Jai Youl Ro) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.6
Background: We reported that the single glycoprotein alprogen extracted from Aloe strongly inhibited the mediator releases caused by the activation of guinea pig lung mast cells. We purified another compound alprogen II α from Aloe vera. Therefore, this study aimed to assess the effects of Aloe single component (alprogen II α) on the mechanism of mediator releases caused by the mast cell activation, Materials and methods : We purified Aloe extracts by using various columns. #We also purified mast cells from guinea pig lung tissues by using enzyme digestion, the rough and discontinuous density percoll gradient method. Mast cells were sensitized with IgG> (anti-Ox-HDM) and challenged with Ox-HDM. Histamine was assayed by using fluorometric analyzer. leukotrienes by radioimmunoassay. Intracellular Ca++ level was analyzed by using a confocal laser scanning microscope. Protein kinase C (PKC) activity was determined by the protein phosphorylated with [γ-32P]ATP. The phospholipase D (PLD) activity was assessed by the labeled phosphatidylalcohol. PLA2 activity was determined by measuring the lyso-phosphatidylcholine released from the labeled phospholipids. Results: Alprogen IIα significantly decreased histamine, leukotriene, and TNFα releases, and blocked completely Ca++ influx during mast cell activation. The PLD and PKC activities were dec reased in a dose-dependent manner. Alprogen IIα inhibited the PLA2 activity during mast cell activation. Conclusion: The data suggest that alprogen IIα purified from Aloe vera inhibit mediator release by blocking the initial signal cascade of activation of mast cell stimulated with Ox-HDM/anti- Ox-HDM antibody reaction. (l Asthma Allergy Clin Immunol 20: 943-59, 2000)