200 GeV/핵자 유황이온과 핵건판핵의 충돌에 의해 생성된 헬륨 파쇄핵의 극한파쇄 연구

김동철,송진섭,윤천실,정성헌,박인곤,김종오,김철수,김태연,이승희,조재희,천병구,김재률,김준원,김태익,박명렬,장한일,임인택 慶尙大學校 기초과학연구소 1992 基礎科學硏究所報 Vol.8 No.-

고에너지 중이온 원자핵과 핵건판의 충돌에서, 200GeV/핵자 유황이온에 의해 생성된 파쇄 헬륨핵(Z=2)의 실험실계의 방출각 분포는 표적핵에 무관한 회귀공식. dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)]로 잘 표현된다. 여기에서 의사신속도 η=-ln[tan(θ/2)]이고, y_b는 실험실계의 입사입자(^32S)의 신속도이다. 이 공식에 의한 적합에서 k=-0.057±0.008로 얻어진다. 즉, 핵건판과 고에너지 중이온의 충돌에서 파쇄 헬륨핵의 exp(η-y_b)의 분포는 "극한파쇄" 현상을 잘 설명하고 있다. The angular distribution of emission angle θ of helium (Z=2) produced in the collisions of incident particles of 200 GeV/nucleon ^32S in nuclear emulsion is well expressed by dN=exp[a+k exp(η-y_b)]d[exp(η-y_b)] where the pseudorapidity is η=-ln[tan(θ/2)], the laboratory system primary rapidity is y_b, and k=-0.057+0.008. The shape of this frequency of occurrence distributions in terms of exp(η-y_b) attests to the validity of the concept of "limiting fragmentation" for helium projectile fragments produced in the projectile fragmentation regions of heavy ion collisions in nuclear emulsion.

TGF-β signaling plays an important role in resisting γ-irradiation

An, Y.S.,Kim, M.R.,Lee, S.S.,Lee, Y.S.,Chung, E.,Song, J.Y.,Lee, J.,Yi, J.Y. Academic Press 2013 Experimental cell research Vol.319 No.4

Transforming growth factor-β1 (TGF-β1) regulates various biological processes, including differentiation, bone remodeling and angiogenesis, and is particularly important as a regulator of homeostasis and cell growth in normal tissue. Interestingly, some studies have reported that TGF-β1 induces apoptosis through induction of specific genes, whereas others suggest that TGF-β1 inhibits apoptosis and facilitates cell survival. Resolving these discrepancies, which may reflect differences in cellular context, is an important research priority. Here, using the parental mink lung epithelial cell line, Mv1Lu, and its derivatives, R1B and DR26, lacking TGF-β receptors, we investigated the involvement of TGF-β signaling in the effects of γ-irradiation. We found that canonical TGF-β signaling played an important role in protecting cells from γ-irradiation. Introduction of functional TGF-β receptors or constitutively active Smads into R1B and DR26 cell lines reduced DNA fragmentation, Caspase-3 cleavage and γ-H2AX foci formation in γ-irradiated cells. Notably, we also found that de novo protein synthesis was required for the radio-resistant effects of TGF-β1. Our data thus indicate that TGF-β1 protected against γ-irradiation, decreasing DNA damage and reducing apoptosis, and thereby enhanced cell survival.

Comparison of helper component-protease RNA silencing suppression activity, subcellular localization, and aggregation of three Korean isolates of Turnip mosaic virus

Han, J. Y.,Chung, J.,Kim, J.,Seo, E. Y.,Kilcrease, J. P.,Bauchan, G. R.,Lim, S.,Hammond, J.,Lim, H. S. Springer Science + Business Media 2016 Virus genes Vol.52 No.4

<P>In 2014, we performed a nationwide survey in Korean radish fields to investigate the distribution and variability of Turnip mosaic virus (TuMV). Brassica rapa ssp. pekinensis sap-inoculated with three isolates of TuMV from infected radish tissue showed different symptom severities, whereas symptoms in Raphanus sativus were similar for each isolate. The helper component-protease (HC-Pro) genes of each isolate were sequenced, and phylogenetic analysis showed that the three Korean isolates were clustered into the basal-BR group. The HC-Pro proteins of these isolates were tested for their RNA silencing suppressor (VSR) activity and subcellular localization in Nicotiana benthamiana. A VSR assay by co-agroinfiltration of HC-Pro with soluble-modified GFP (smGFP) showed that HC-Pro of isolate R007 and R041 showed stronger VSR activity than R065. The HC-Pros showed 98.25 % amino acid identity, and weak VSR isolate (R065) has a single variant residue in the C-terminal domain associated with protease activity and self-interaction compared to isolates with strong VSR activity. Formation of large subcellular aggregates of GFP: HC-Pro fusion proteins in N. benthamiana was only observed for HC-Pro from isolates with strong VSR activity, suggesting that R065 'weak' HC-Pro may have diminished self-association; substitution of the variant C-terminal residue largely reversed the HC-Pro aggregation and silencing suppressor characteristics. The lack of correlation between VSR efficiency and induction of systemic necrosis (SN) suggests that differences in viral accumulation due to HC-Pro are not responsible for SN.</P>

표면탄성파 소자 응용을 위한 $LiTaO_3$ 단결정 성장

정대식,노용래,박병학,김유성,Chung, D.S.,Roh, Y.R.,Park, B.H.,Kim, Y.S. 한국결정성장학회 1994 한국결정성장학회지 Vol.4 No.2

$LiTaO_3 (LT)$ single crystals (Y, X-axis) were grown from the congruent composition, 48.65 mole %, $Li_2O$ for SAW (Surface Acoustic Wave) applications. Basic SAW filters were fabricated on the RIST prepared LT wafers (Y-cut) using phtolithography. SAW filter performance was evaluated. The results were compared of the SAW characteristics between RIST prepared LT wafer (Y-cut) and commercial Yamaju wafer (Y-cut). The SAW filter prepared on the RIST grown LT wafer was shown better SAW performances than that of Yamaju wafer.

H∞최적 제어기법을 이용한 전력계통의 안정화에 관한 연구

정형환,이정필,허동렬,왕용필 東亞大學校 海洋資源硏究所 1998 硏究論文集 Vol.11 No.1

In this paper, we are considered various possible disturbance conditions in order to design controller, H ∞ optimal controller is successfully designed to control in such as situations. To do this, we are determined weighting function and design parameter γ to method of trial and error by Glover-Doyle algorithm. To compare with H∞-PSS and conventional-PSS which is applied in nominal system and load variations, the dynamic characteristics of H∞-PSS controller was verified which has a good response.

REMiner: A tool for unbiased mining and analysis of repetitive elements and their arrangement structures of large chromosomes

Chung, B.I.,Lee, K.H.,Shin, K.S.,Kim, W.C.,Kwon, D.N.,You, R.N.,Lee, Y.K.,Cho, K.,Cho, D.H. Academic Press 2011 Genomics Vol.98 No.5

Repetitive elements (REs) constitute a substantial portion of the genomes of human and other species; however, the RE profiles (type, density, and arrangement) within the individual genomes have not been fully characterized. In this study, we developed an RE analysis tool, called REMiner, for a chromosome-wide investigation into the occurrence of individual REs and arrangement of clusters of REs, and REMiner's functional features were examined using the human chromosome Y. The algorithm implemented by REMiner focused on unbiased mining of REs in large chromosomes and data interface within a viewer. The data from the chromosome demonstrated that REMiner is an efficient tool in regard to its capacity for a large query size and the availability of a high-resolution viewer, featuring instant retrieval of alignment data and control of magnification and identity ratio. The chromosome-wide survey identified a diverse population of ordered RE arrangements, which may participate in the genome biology.

임신기간중 혈장 Fibronectin 농도변화를 이용한 임신성 고혈압 발생의 예측 가능성에 관한 연구

정두용,최종현,최경남,김민철,승경록 건국대학교 의과학연구소 1995 건국의과학학술지 Vol.5 No.-

Preeclampsia is classically defined as the triad of pregnancy induced hypertension(PIH) with generalized edema and proteinuria, and constitutes a deadly triad of maternal death. Recent studies suggest that drugs affecting prostacyclin and thromboxane production may be able to affect the development of preeclampsia(PE). In order to use these agents effectively, a woman at high risk should be selected properly before the clinical illness manifests. As the pathophysiologic mechanism of PE., endothelial damage is thought to play a major role in these days. Many investigators have suggested that plasma fibronectin(FN), a good indicator of vascular endothelial damage, is markedly elevated at least 4 weeks before clinical manifestations of PE and can be used as a sensitive predictor of PIH. To assess the clinical utility of plasma FN in predicting PIH, plasma FN concentrations of pregnant women over 28 weeks of gestation who visited Kon-Kuk University Hospital from June 1, 1994 to February 28, 1995 were assayed. The results were as follows: among 108 pregnancy specimens, 70 were in the normal blood pressure group and 38 were PIH group: 20, transient hypertension subgroup(PH), 8, mild PE subgroup(PM), 10, severe PE subgroup(PS). There was statistical significance in the mean birthweight between normal blood pressure group(3,205±68g) and PS subgroup(2,455±315g) (p<0.05). The mean concentrations of plasma FN were highest in the PS subgroup(412±68.9ug/㎖) and lowest in the normal blood pressure group(244±8.7ug/㎖), that is stastically significant. Plasma FN concentration in the normal pregnancy period showed fluctuation: from 29 weeks of gestation to 36 weeks, elevation and after 36 weeks, decline. The changes in the mean concentrations of plasma FN after delivery were noted in both groups, but those in normal blood pressure group(254±13→227±10㎍/㎖) and PS(405±22→318±51㎍/㎖)were stastically significant(p<0.05). There was negative linear correlation between the platelet count and concentration of plasma FN in the PS group [platelets(Y)=-0.20192×FN(X)+262.23257 r=0.69] (p<0.05). There was no linear correlation between the birthweight and plasma FN concentration in normal blood pressure group and PIH group. The changes in the plasma FN concentration in the normal blood pressure group and PIH group before clinical manifestation were not statistically significant.

韓國産 초파리集團의 遺傳 生化學的 硏究 : 노랑초파리의 alcohol dehydrogenase 因子와 α-glycerophosphate dehydrogenase 因子 頻度의 季飭的變化에 대하여 Seasonal Variations of Frequencies of Alcohol Dehydrogenase Alleles and α-Glycerophosphate Dehydrogenase Alleles

鄭瑢載,李允鈴,太希貞 梨花女子大學校 韓國生活科學硏究院 1982 韓國生活科學硏究院 論叢 Vol.30 No.-

한국산초파리집단의 유전적 특성을 생화학적으로 분석하여 분자유전학적측면에서 집단유전학적 체계를 수립하는 연구의 일환으로 노랑초파리의 두 자연집단(서울과 부천)을 대상으로 ADH와 α-GPDH allele의 계절적변화(1981년 8월∼11월)를 agarose gel 전기영동법으로 조사한 결과는 아래와 같다. 1. 신촌과 부천 자연 집의단에서 다같이 ADH와 α-GPDH allele이 상당한 다형현상을 이루고 있다. 2. Heterozygosity는 신촌과 부천 두 집단에서 ADH는 30∼35%이고 α-GPDH는 40∼45%이다. 3. ADH에서는 F인자가 S인자보다 두드러지게 높은 빈도를 보이지만 α-GPDH는 두 인자 빈도의 차이는 뚜렷하지 않다. 4. ADH와 α-GPDH allele 빈도가 다 같이 신촌과 부천 자연집단에서 현저한 규칙적인(clinal)변화는 보이지 않는다. The present work was undertaken, as a part of the biochemical genetic study on Drosophila populations in Korea, in an attempt to survey seasonal variations of ADH and α-GPDH alleles in two natural populaions (Sinchon-seoul and Bucheon-Kyungi) of D. melanogaster by agarose gel electrophoresis from August to November, 1981. The results are presented below: 1. Both of ADH and α-GPDH alleles are found to be considerably polymorphic for two electrophoretic variants in both natural populations in Sinchon and Bucheon. 2. Heterozygosity is calculated as 30∼35% for ADH and as 40∼45% for α-GPDH. 3. The F gene frequency of ADH is found to be higher than the S gene but the F gene frequency, to be roughly same as the S gene of α-GPDH. 4. No considerable and clinal variations of both ADH and α-GPDH alleles are observed in both natural populations in Simchon and Bucheon.

자궁경부암에서 Interleukin-6 전사조절부위 다형성의 임상적 의의

김연정,문혜성,정혜원,김승철,김형래 대한부인종양 콜포스코피학회 2001 Journal of Gynecologic Oncology Vol.12 No.4

액적의 증발에 미치는 수증기 농도의 영향

김용우,이명준,이상석,정성식,하종률 동아대학교 생산기술연구소 1999 生産技術硏究所硏究論文集 Vol.4 No.1

This study is to investigate the influences of water vapor on evaporation of single droplet. We obtained the time histories of droplet diameter from droplets image taken by a CCD camera. Droplets of water-soluble ethanol and water-insoluble paraffin hydrocarbon droplets were exposed in temperature, 473K and atmospheric pressure as the ambient condition. The following are results about evaporation of single droplet which exposure in the field of water vapor of high temperature. There is almost none which water vapor concentration affect on water droplet. But, ethanol droplet had significant influence. In the case of n-heptane has the boiling point which is lower than the boiling point of water, a evaporation rate increase with water vapor concentration. The evaporation rate of n-hexadecane which is higher than the boiling point of water and water-insoluble paraffin hydrocarbon droplet also increased in the high moisture environment.