Silence and Noise: The Unreliable Narration of “Bartleby, the Scrivener: A Story of Wall-Street”

Xu, Xuan 신영어영문학회 2021 신영어영문학 Vol.79 No.-

This paper calls attention to the disturbing narrative effects issuing from both silence and noises by tackling the issue of the narrator’s unreliability in Herman Melville’s “Bartleby, the Scrivener: A Story of Wall-Street.” In the story, the narrator’s ostensibly trustworthy and harmonious telling has been damaged by the silence and noises in his former premises. By listening carefully to the implied Melville, readers recognize that the narrator has deviated from the implied Melville’s account and must, therefore, question the narrator’s credibility. In addition to these two acoustic textual clues, another important signal (friendship) is embedded to indicate the narrator’s unreliability. These three textual clues integrally influence readers’ ethical judgment of the narrator. Indeed, the implied Melville intends to conceal that behind the narrator’s unreliability hides his flawed value system.

Effects of Multiple-target Anti-microRNA Antisense Oligodeoxyribonucleotides on Proliferation and Migration of Gastric Cancer Cells

Xu, Ling,Dai, Wei-Qi,Xu, Xuan-Fu,Wang, Fan,He, Lei,Guo, Chuan-Yong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Backgrounds: To investigate the inhibiting effects of multi-target anti-microRNA antisense oligonucleotide (MTg-AMOs) on proliferation and migration of human gastric cancer cells. Methods: Single anti-microRNA antisense oligonucleotides (AMOs) and MTg-AMOs for miR-221, 21, and 106a were designed and transfected into SGC7901, a gastric cancer cell line, to target the activity of these miRNAs. Their expression was analyzed using stem-loop RT-PCR and effects of MTg-AMOs on human gastric cancer cells were determined using the following two assay methods: CCK8 for cell proliferation and transwells for migration. Results: In the CCK-8 cell proliferation assay, $0.6{\mu}mol/L$ was selected as the preferred concentration of MTg-AMOs and incubation time was 72 hours. Under these experimental conditions, MTg-AMOs demonstrated better suppression of the expression of miR-221, miR-106a, miR-21 in gastric cancer cells than that of single AMOs (P = 0.014, 0.024; 0.038, respectively). Migration activity was also clearly decreased as compared to those in randomized and blank control groups ($28{\pm}4$ Vs $54{\pm}3$, P <0.01; $28{\pm}4$ Vs $59{\pm}4$, P < 0.01). Conclusions: MTg-AMOs can specifically inhibit the expression of multiple miRNAs, and effectively antagonize proliferation and migration of gastric cancer cells promoted by oncomirs.

Part one: Research in Korea : Pozzolanic-based Stabilization/Solidification of Lead Contaminated Firing Range Soils

( Xuan Feng Xu ),( Deok Hyun Moon ),( Dimitris Dermatas ),( Dae Yewn Shin ),( Oh Jin Jung ),( Hyung Il Choi ),( Kyung Hun Jung ) 한국환경보건학회(구-한국환경위생학회) 2004 Current Challenges and Advances in Environmental H Vol.- No.-

Polymorphisms in Epigenetic and Meat Quality Related Genes in Fourteen Cattle Breeds and Association with Beef Quality and Carcass Traits

Xuan Liu,Tahir Usman,Yachun Wang,Zezhao Wang,Xianzhou Xu,Meng Wu,Yi Zhang,Xu Zhang,Qiang Li,Lin Liu,Wanhai Shi,Chunhua Qin,Fanjun Geng,Congyong Wang,Rui Tan,Xixia Huang,Airong Liu,Hongjun Wu,Shixin Ta 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.4

Improvement for carcass traits related to beef quality is the key concern in beef production. Recent reports found that epigenetics mediates the interaction of individuals with environment and nutrition. The present study was designed to analyze the genetic effect of single nucleotide polymorphisms (SNPs) in seven epigenetic-related genes (DNMT1, DNMT3a, DNMT3b, DNMT3L, Ago1, Ago2, and HDAC5) and two meat quality candidate genes (CAPN1 and PRKAG3) on fourteen carcass traits related to beef quality in a Snow Dragon beef population, and also to identify SNPs in a total of fourteen cattle populations. Sixteen SNPs were identified and genotyped in 383 individuals sampled from the 14 cattle breeds, which included 147 samples from the Snow Dragon beef population. Data analysis showed significant association of 8 SNPs within 4 genes related to carcass and/or meat quality traits in the beef populations. SNP1 (13154420A>G) in exon 17 of DNMT1 was significantly associated with rib-eye width and lean meat color score (p<0.05). A novel SNP (SNP4, 76198537A>G) of DNMT3a was significantly associated with six beef quality traits. Those individuals with the wild-type genotype AA of DNMT3a showed an increase in carcass weight, chilled carcass weight, flank thicknesses, chuck short rib thickness, chuck short rib score and in chuck flap weight in contrast to the GG genotype. Five out of six SNPs in DNMT3b gene were significantly associated with three beef quality traits. SNP15 (45219258C>T) in CAPN1 was significantly associated with chuck short rib thickness and lean meat color score (p<0.05). The significant effect of SNP15 on lean meat color score individually and in combination with each of other 14 SNPs qualify this SNP to be used as potential marker for improving the trait. In addition, the frequencies of most wild-type alleles were higher than those of the mutant alleles in the native and foreign cattle breeds. Seven SNPs were identified in the epigenetic-related genes. The SNP15 in CAPN1 could be used as a powerful genetic marker in selection programs for beef quality improvement in the Snow Dragon Beef population.

Harvesting schedule effects on forage yield and nutritive values in low-lignin alfalfa

( Xuan Xu ),( Doohong Min ) 한국축산학회 2022 한국축산학회지 Vol.64 No.2

Under the four-cut system, low-lignin alfalfa (Medicago sativa L.) may extend harvesting intervals improving harvest management flexibility and producing forage products with higher nutritive values. The objective of this study was to compare forage yield and nutritive values of low-lignin and conventional alfalfa varieties when applied to six different harvest schedules in the first (2016) and second (2017) production years. There were 12 treatments of two alfalfa varieties as whole plots and six harvest schedules as subplots. Across harvest schedules, there were four cuttings in two production years. Three harvest intervals including “Standard” (high quality, HQ), “Standard+5-day” (medium quality, MQ), and “Standard+10-day” (high yield, HY) were chosen for the first cutting, and 30-day (HQ) and 35-day (HY) for the second cuttings. The third and fourth cuttings in 2016 were timed near final harvest date and in 2017 occurred at 35-day (MQ) and 40-day (HY). Variety by harvest schedule interaction was not significant, but the whole plot and sub-plot effects were significant. Hi-Gest 360 was consistently higher in nutritive value and with a similar yield as Gunner. Harvest schedules did not consistently differ in forage yield and nutritive values. HS-1 (“Standard” + 35-day + Medium Quality + High Yield) with shorter first two cutting intervals provided lower acid detergent fiber (ADF), neutral detergent fiber (NDF), higher relative feed value (RFV), and similar forage yield compared to other schedules. HS-1 had the highest economic incomes when considering RFV and yield among the six different harvest schedules.

Effects of harvest intervals and seeding rates on dry matter yield and nutritive value of alfalfa cultivars

( Xuan Xu ),( Doohong Min ),( Iryna Mcdonald ) 한국축산학회 2021 한국축산학회지 Vol.63 No.5

Maturation process of alfalfa (Medicago sativa L.) could be prevented by the reduction of lignin content in terms of conventional breeding or transgenic technology. Alfalfa could exhibit higher leaf/stem ratio, with a concern of yield loss. The objective of this study was to compare forage yield and nutritive value of low lignin alfalfa and two reference varieties subjecting to two harvest intervals and three seeding rates. The experimental design was a randomized complete block in a split-split plot arrangement with four replicates, where harvest intervals (28-day and 35-day) were assigned to whole plots, seeding rates were subplots, and varieties were sub-subplots. The weighted mean nutritive value was applied to two production years of 2016 and 2017. Hi-Gest 360 (low lignin alfalfa) provided similar yield potential and increased nutritive value compared to two reference varieties. Over a two-year production period, alfalfa harvested at every 28-day interval provided more economic returns than those at 35-day interval. For the seeding year and first production year, five cuts made by the 28- day interval produced more yield than four cuts by the 35-day interval. Due to limited rainfall in May 2017, a sharp drop of the first cutting overturned the advantage of the five-cut system. Shorter intervals between harvests generally increased crude protein (CP) concentrations. The differences of relative feed value (RFV) between two harvest intervals tended to be great during the first and second cuttings. Overall, harvest interval had a large effect on nutritive value and a more significant effect on alfalfa dry matter yield than variety selection. Seeding rate did not affect alfalfa yield and nutritive value.

Comorbidity Relationship to Outcome of Radical Cystectomy in Chinese: a Single Institution Study with the ACE-27 Comorbidity Index

Xuan, Zhu,Zhong, Zhao-Hui,Zhang, Xuan-Zhi,Zhang, Lei,Zhao, Xiao-Kun,Lv, Chen,Xu, Ran,Ren, Wei-Gang,Li, Song-Chao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

To determine the relationship between comorbidity and outcome after radical cystectomy in Chinese patients by using the Adult Comorbidity Evaluation (ACE)-27 index. Two-hundred-and-forty-six patients treated with radical cystectomy at the Second Xiangya Hospital of Central South University, Hunan Province, China between 2000 and 2010 were retrospectively analyzed. Medical records were reviewed for age, gender, delayed time of radical cystectomy, urinary diversion type, pelvic lymphadenectomy status, TNM stage, and pathological grade. Comorbidity information was assessed by the ACE-27 index. The outcome measurement was overall survival. Univariate and multivariate Cox proportional hazards regression analyses were used to determine the association between comorbidity and outcome. The study population consisted of 215 (87.40%) males and 31 (12.60%) females with a mean age of $62{\pm}11$ years. Median duration of follow-up was $47{\pm}31$ months. A total of 151 (61.38%) patents died during follow-up. Of those, 118 (47.97%) had at least one comorbidity. According to the ACE-27 scores, 128 (52.03%) patients had no comorbidity, 79 (32.11%) had mild, 33 (13.41%) had moderate, and 6 (2.45%) had severe comorbidities. Multivariate analysis indicated that moderate (p=0.002) and severe (p<0.001) comorbidity was significantly associated with decreased overall survival. In addition, age ${\geq}70$ years (p=0.002), delayed time of radical cystectomy >12 weeks (p=0.044), pelvic lymphadenectomy status (p=0.014), and TNM stage >T3 (p<0.001) were determined to be independent risk factors of overall survival. Increasing severity of comorbidity statistically correlated with decreased overall survival after radical cystectomy.

Polymorphisms in Epigenetic and Meat Quality Related Genes in Fourteen Cattle Breeds and Association with Beef Quality and Carcass Traits

Liu, Xuan,Usman, Tahir,Wang, Yachun,Wang, Zezhao,Xu, Xianzhou,Wu, Meng,Zhang, Yi,Zhang, Xu,Li, Qiang,Liu, Lin,Shi, Wanhai,Qin, Chunhua,Geng, Fanjun,Wang, Congyong,Tan, Rui,Huang, Xixia,Liu, Airong,Wu, Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.4

Improvement for carcass traits related to beef quality is the key concern in beef production. Recent reports found that epigenetics mediates the interaction of individuals with environment and nutrition. The present study was designed to analyze the genetic effect of single nucleotide polymorphisms (SNPs) in seven epigenetic-related genes (DNMT1, DNMT3a, DNMT3b, DNMT3L, Ago1, Ago2, and HDAC5) and two meat quality candidate genes (CAPN1 and PRKAG3) on fourteen carcass traits related to beef quality in a Snow Dragon beef population, and also to identify SNPs in a total of fourteen cattle populations. Sixteen SNPs were identified and genotyped in 383 individuals sampled from the 14 cattle breeds, which included 147 samples from the Snow Dragon beef population. Data analysis showed significant association of 8 SNPs within 4 genes related to carcass and/or meat quality traits in the beef populations. SNP1 (13154420A>G) in exon 17 of DNMT1 was significantly associated with rib-eye width and lean meat color score (p<0.05). A novel SNP (SNP4, 76198537A>G) of DNMT3a was significantly associated with six beef quality traits. Those individuals with the wild-type genotype AA of DNMT3a showed an increase in carcass weight, chilled carcass weight, flank thicknesses, chuck short rib thickness, chuck short rib score and in chuck flap weight in contrast to the GG genotype. Five out of six SNPs in DNMT3b gene were significantly associated with three beef quality traits. SNP15 (45219258C>T) in CAPN1 was significantly associated with chuck short rib thickness and lean meat color score (p<0.05). The significant effect of SNP15 on lean meat color score individually and in combination with each of other 14 SNPs qualify this SNP to be used as potential marker for improving the trait. In addition, the frequencies of most wild-type alleles were higher than those of the mutant alleles in the native and foreign cattle breeds. Seven SNPs were identified in the epigenetic-related genes. The SNP15 in CAPN1 could be used as a powerful genetic marker in selection programs for beef quality improvement in the Snow Dragon Beef population.

刍论民事执行监督程序之立法修正 - 以法院自我监督模式为研究视角

서병훤(XU Bing xuan)(徐炳煊),이성총(LI Sheng cong)(李盛聪,) 원광대학교 법학연구소 2017 圓光法學 Vol.33 No.2

With the implementation of civil enforcement supervision procedures, laws and regulations have been introduced, the legislative amendments of the civil enforcement supervision procedures have gradually been concerned by the jurists and scholars. Provisions on civil enforcement supervision procedures have been optimized, but for the people s court at the same level of self-supervision procedures still have some problems in the relevant provisions and the application of justice in the practice is also very different in China. In order to enable the people s court to supervise itself under the sun , the relevant legislation should be improved, at the same time, we also need to consider the drawbacks of my supervision made from the court, we should focus on solving the following two issues: firstly, after the Executive Board achieves walking on two legs , how to curb the breeding of corruption. Secondly, the question of the insufficient number of judges in the implementation of the staffing system. The introduction of the escort supervisor system will be a new initiative to solve the above two problems. 随着有关民事执行监督程序的法律、法规的相继出台, 民事执行监督程序之立法修正也逐渐进入法学家及学者们的视野, 并受到了各界的广泛关注。就目前的立法现状来看, 我国已对民事执行监督程序作出了较为详细的规定, 但对于本级人民法院自我监督程序的相关规定尚存在漏洞, 各地在司法实践中的适用也大相径庭。为了使人民法院自身监督程序能够在“阳光”下运行, 在完善相关立法的同时, 还需考虑法院自我监督模式存在的弊端, 应当着重解决以下两个问题:第一, 执行局实现“两条腿走路”后, 应如何抑制腐败滋生的问题。第二, 员额制执行法官人数不足的问题。引入“陪执监督”制度将成为解决以上两个问题的新举措。

Connectivity-preserving-based Distributed Synchronized Tracking of Networked Uncertain Underactuated Surface Vessels with Actuator Failures and Unknown Control Directions

Yujing Xu,Chaoli Wang,Gang Wang,Xuan Cai,Luyan Xu,Chonglin Jing 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.12

When the actuator faults and the control directions are unknown, the difficulty of the asymptotically tracking control of the surface vessel will increase. In this paper, for actuator failures and unknown control directions, a distributed adaptive asymptotically synchronous tracking control law for multiple uncertain underactuated surface vessels (USVs) is proposed, which can achieve network connectivity and good tracking performance in a limited communication range. First, a distributed nonlinear error surface is introduced to achieve synchronous tracking between USVs and maintain the initial connectivity patterns. Second, a conditional inequality is proposed to solve the problems of unknown actuator failures and unknown control directions. Then, combined with the derived technical lemmas and Barbalat’s lemma, the stability of the closed loop system is proved by the Lyapunov method. Finally, a simulation example verifies the theoretical results.