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Plant‐expressed Fc‐fusion protein tetravalent dengue vaccine with inherent adjuvant properties
Kim, Mi Young,Copland, Alastair,Nayak, Kaustuv,Chandele, Anmol,Ahmed, Muhammad S.,Zhang, Qibo,Diogo, Gil R.,Paul, Matthew J.,Hofmann, Sven,Yang, Moonx2010,Sik,Jang, Yongx2010,Suk,Ma, Julian Kx20 BLACKWELL 2018 PLANT BIOTECHNOLOGY JOURNAL Vol.16 No.7
<P><B>Summary</B></P><P>Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi Pasteur Dengvaxia vaccine does not protect children under the age of nine, and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant expression to produce a humanized and highly immunogenic poly‐immunoglobulin G scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor‐targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralizing antibodies and evidence of cell‐mediated immunity. Furthermore, these molecules were able to prime immune cells from human adenoid/tonsillar tissue <I>ex vivo</I> as evidenced by antigen‐specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T‐cell proliferation, IFN‐γ and antibody production. The purified polymeric fraction of dengue PIGS (D‐PIGS) induced stronger immune activation than the monomeric form, suggesting a more efficient interaction with the low‐affinity Fcγ receptors on antigen‐presenting cells. These results show that the plant‐expressed D‐PIGS have the potential for translation towards a safe and easily scalable single antigen‐based tetravalent dengue vaccine.</P>
x5f20;琳(Zhang Lin) 조선대학교 국제문화연구원 2012 국제문화연구 Vol.5 No.2
중한 양국의 근현대고등교육은 다 19세기 중후기부터 시작된 것이다. 한국은 아주 짧은 시간 안에 고등교육을 보급시켰으며 고등교육국제화발전이 아시아에서 선두에 있게 되었다. 본문은 교사와 학생들이 국제간의 이동, 교육과정설치의 국제화 및 국제화 동반자 관계와 협력 세 가지 측면에서 한국의 고등교육국제화를 분석하여 우리나라의 고등교육발전에 좋은 참고가 되기를 바란다.
Probing the nature of high‐<i>z</i> short GRB 090426 with its early optical and X‐ray afterglows
Xin, Lix2010,Ping,Liang, Enx2010,Wei,Wei, Jianx2010,Yan,Zhang, Bing,Lv, Houx2010,Jun,Zheng, Weix2010,Kang,Urata, Yuji,Im, Myungshin,Wang, Jing,Qiu, Yux2010,Lei,Deng, Jinx2010,Song,Huang, Blackwell Publishing Ltd 2011 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.410 No.1
<P><B>ABSTRACT</B></P><P>GRB 090426 is a short‐duration burst detected by <I>Swift</I> (<IMG src='/wiley-blackwell_img/equation/MNR_17419_mu1.gif' alt ='inline image'/> s in the observer frame and <IMG src='/wiley-blackwell_img/equation/MNR_17419_mu2.gif' alt ='inline image'/> s in the burst frame at <I>z</I>= 2.609). Its host galaxy properties and some gamma‐ray‐related correlations are analogous to those seen in long‐duration gamma‐ray bursts (GRBs), which are believed to be of a massive star origin (so‐called Type II GRBs). We present the results of its early optical observations with the 0.8‐m Tsinghua University–National Astronomical Observatory of China Telescope (TNT) at Xinglong Observatory and the 1‐m LOAO telescope at Mt Lemmon Optical Astronomy Observatory in Arizona. Our well‐sampled optical afterglow light curve covers from <IMG src='/wiley-blackwell_img/equation/MNR_17419_mu3.gif' alt ='inline image'/> to 10<SUP>4</SUP> s after the GRB trigger. It shows two shallow decay episodes that are likely due to energy injection, which end at <IMG src='/wiley-blackwell_img/equation/MNR_17419_mu4.gif' alt ='inline image'/> and 7100 s, respectively. The decay slopes after the injection phases are consistent with each other (<IMG src='/wiley-blackwell_img/equation/MNR_17419_mu5.gif' alt ='inline image'/>). The X‐ray afterglow light curve appears to trace the optical, although the second energy‐injection phase was missed due to visibility constraints introduced by the <I>Swift</I> orbit. The X‐ray spectral index is <IMG src='/wiley-blackwell_img/equation/MNR_17419_mu6.gif' alt ='inline image'/> without temporal evolution. Its decay slope is consistent with the prediction of the forward shock model. Both X‐ray and optical emission are consistent with being in the same spectral regime above the cooling frequency (<IMG src='/wiley-blackwell_img/equation/MNR_17419_mu7.gif' alt ='inline image'/>). The fact that <IMG src='/wiley-blackwell_img/equation/MNR_17419_mu8.gif' alt ='inline image'/> is below the optical band from the very early epoch of the observation provides a constraint on the burst environment, which is similar to that seen in classical long‐duration GRBs. We therefore suggest that death of a massive star is the possible progenitor of this short burst.</P>
Sun, Zhengwang,Park, Sang Yong,Hwang, Eunson,Zhang, Mengyang,Seo, Seul A.,Lin, Pei,Yi, Taex2010,Hoo John Wiley and Sons Inc. 2017 JOURNAL OF CELLULAR AND MOLECULAR MEDICINE Vol.21 No.2
<P><B>Abstract</B></P><P>Solar ultraviolet (UV) radiation‐induced reactive oxidative species is mainly responsible for the development of photoageing. Rosmarinic acid was one of the main bioactive components detected in <I>Thymus vulgaris</I> (TV) we extracted. In this study, UVB‐induced skin damages have been shown to be ameliorated by treatment with TV in hairless mice (HR‐1) skin, demonstrated by decreased matrix metalloproteinases (MMPs) and increased collagen production. However, the underlying molecular mechanism on which TV acted was unclear. We examined the photoprotective effects of TV against UVB and elucidated the molecular mechanism in normal human dermal fibroblasts. <I>Thymus vulgaris</I> remarkably prevented the UVB‐induced reactive oxygen species and lactate dehydrogenase. Dose‐dependent increase in glutathione, NAD(P)H: quinone oxidoreductase1 and heme oxygenase‐1, by TV was confirmed by increased nuclear accumulation of Nrf2. Furthermore, 5‐Methoxyindole‐2‐carboxylic acid was introduced as a specific inhibitor of dihydrolipoyl dehydrogenase (DLD). We demonstrated that Nrf2 expression was regulated by DLD, which was a tricarboxylic acid cycle‐associated protein that decreased after UVB exposure. Besides, TV significantly diminished UVB induced phosphorylation of mitogen activated protein kinases pathway, containing extracellular signal‐regulated kinase, Jun N‐terminal kinase and p38, which consequently reduced phosphorylated c‐fos and c‐jun. Our results suggest that TV is a potential botanical agent for use against UV radiation‐induced oxidative stress mediated skin damages.</P>
Solar Water Splitting with a Hydrogenase Integrated in Photoelectrochemical Tandem Cells
Nam, Dong Heon,Zhang, Jenny Z.,Andrei, Virgil,Kornienko, Nikolay,Heidary, Nina,Wagner, Andreas,Nakanishi, Kenichi,Sokol, Katarzyna P.,Slater, Barnaby,Zebger, Ingo,Hofmann, Stephan,Fontecillax2010,Ca John Wiley and Sons Inc. 2018 Angewandte Chemie Vol.57 No.33
<P><B>Abstract</B></P><P>Hydrogenases (H<SUB>2</SUB>ases) are benchmark electrocatalysts for H<SUB>2</SUB> production, both in biology and (photo)catalysis in vitro. We report the tailoring of a p‐type Si photocathode for optimal loading and wiring of H<SUB>2</SUB>ase through the introduction of a hierarchical inverse opal (IO) TiO<SUB>2</SUB> interlayer. This proton‐reducing Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase photocathode is capable of driving overall water splitting in combination with a photoanode. We demonstrate unassisted (bias‐free) water splitting by wiring Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase to a modified BiVO<SUB>4</SUB> photoanode in a photoelectrochemical (PEC) cell during several hours of irradiation. Connecting the Si|IO‐TiO<SUB>2</SUB>|H<SUB>2</SUB>ase to a photosystem II (PSII) photoanode provides proof of concept for an engineered Z‐scheme that replaces the non‐complementary, natural light absorber photosystem I with a complementary abiotic silicon photocathode.</P>
Zhang, Yongx2005,Jian,Kim, Keex2005,Yong,Park, Jungx2005,Hwan,Song, Choongx2005,Eui,Lee, Kyungae,Lah, Myoungx2005,Soo,Lee, Sang-gi WILEY-VCH Verlag 2005 Advanced synthesis & catalysis Vol.347 No.4
<P>The diastereomeric 1,4-diphosphine ligands, (S,S,S,S)-1a, (R,S,S,R)-1b and (R,S,S,S)-1c, with the imidazolidin-2-one backbone were synthesized, and utilized for an investigation of the effects of backbone chirality on the enantioselectivity in the Rh(I)-catalyzed hydrogenation of various functionalized olefinic substrates. It was found that the catalytic efficiencies are largely dependent on the configurations of the α-carbons to phosphine. Thus, the Rh complex of the pseudo-C<SUB>2</SUB>-symmetrical diphosphine, (R,S,S,S)-1c, showed excellent enantioselectivities (93.0–98.6% ees) in the hydrogenations of a broad spectrum of substrates, and especially in the hydrogenations of methyl α-(N-acetyamino)-β-arylacrylates (95.3–97.0% ees). However, the enantioselectivities obtained with the C<SUB>2</SUB>-symmetrical (R,S,S,R)-1b were largely dependent on the substrate (19.8–97.3% ees). The Rh complex of ligand 1a having the (S,S,S,S)-configuration showed the lowest catalytic efficiency for all of the substrates examined (0–84.8% ees).</P>
A novel differential bandpass filter with ultra‐wide band common‐mode suppression
Zhang, Xiaox2010,Yu,Wang, Yang,Lee, Jongx2010,Chul John Wiley Sons, Inc. 2019 MICROWAVE AND OPTICAL TECHNOLOGY LETTERS Vol.61 No.8
<P><B>Abstract</B></P><P>A compact differential filter with ultra‐wide band common‐mode (CM) suppression is proposed. Ultra‐wide band property is achieved by the frequency‐selecting coupling structure (FSCS), which generates three transmission zeros in the passband of differential‐mode (DM) as well as in the stopband of CM. Moreover, the position of the transmission zeros, the CM insertion loss and the DM return loss can be customized by designing the parameters of the FSCS. To verify the concept, a filter has been designed, simulated and measured. The proposed filter shows the center frequency of 2.45 GHz with a DM 3 dB fractional bandwidth of 51% and a CM 20 dB fractional bandwidth of 108.6%.</P>
Zhang, Wei,Shin, Eunx2010,Joo,Wang, Tongguang,Lee, Phil Ho,Pang, Hao,Wie, Myungx2010,Bok,Kim, Wonx2010,Ki,Kim, Seongx2010,Jin,Huang, Wenx2010,Hsin,Wang, Yongjun,Zhang, Wanqin,Hong, Jaux201 Federation of American Society for Experimental Bi 2006 The FASEB Journal Vol.20 No.14
<P>We investigated the neuroprotective property of analogs of dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify neuroprotective drugs for Parkinson's disease (PD). In vivo studies showed that daily injections with DM analogs protected dopamine (DA) neurons in substantia nigra pars compacta and restored DA levels in striatum using two different models for PD. Of the five analogs studied, 3-hydroxymorphinan (3-HM), a metabolite of DM, was the most potent, and restored DA neuronal loss and DA depletion up to 90% of the controls. Behavioral studies showed an excellent correlation between potency for preventing toxin-induced decrease in motor activities and neuroprotective effects among the DM analogs studied, of which 3-HM was the most potent in attenuating behavioral damage. In vitro studies revealed two glia-dependent mechanisms for the neuroprotection by 3-HM. First, astroglia mediated the 3-HM-induced neurotrophic effect by increasing the gene expression of neurotrophic factors, which was associated with the increased acetylation of histone H3. Second, microglia participated in 3-HM-mediated neuroprotection by reducing MPTP-elicited reactive microgliosis as evidenced by the decreased production of reactive oxygen species. In summary, we show the potent neuroprotection by 3-HM in LPS and MPTP PD models investigated. With its high efficacy and low toxicity, 3-HM may be a novel therapy for PD.</P>
Neural Network‐Based Analysis of Thiol Proteomics Data in Identifying Potential Selenium Targets
Lee, Jongx2010,Sik,Ma, Yongx2010,Beom,Choi, Kyoungx2010,Soo,Park, Soox2010,Yeon,Baek, Sunx2010,Hee,Park, Youngx2010,Mee,Zu, Ke,Zhang, Haitao,Ip, Clement,Hong Kim, Yeul,Park, Eunx2010,Mi MARCEL DEKKER, INC 2006 PREPARATIVE BIOCHEMISTRY AND BIOTECHNOLOGY Vol.36 No.1
<P>Generation of a monomethylated selenium metabolite is critical for the anticancer activity of selenium. Because of its strong nucleophilicity, the metabolite can react directly with protein thiols to cause redox modification. Here, we report a neural network-based analysis to identify potential selenium targets. A reactive thiol specific reagent, BIAM, was used to monitor thiol proteome changes on 2D gel. We constructed a dynamic model and evaluated the relative importance of proteins mediating the cellular responses to selenium. Information from this study will provide new clues to unravel mechanisms of anticancer action of selenium. High impact selenium targets could also serve as biomarkers to gauge the efficacy of selenium chemoprevention.</P>