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A 2.7Gbps & 1.62Gbps Dual-Mode Clock and Data Recovery for DisplayPort in 0.18㎛ CMOS
Lee, Seung-Won,Kim, Tae-Ho,Lee, Suk-Won,Kang, Jin-Ku 한국전기전자학회 2010 전기전자학회논문지 Vol.14 No.1
This paper describes a clock and data recovery (CDR) circuit that supports dual data rates of 2.7Gbps and 1.62Gbps for DisplayPort standard. The proposed CDR has a dual mode voltage-controlled oscillator (VCO) that changes the operating frequency with a "Mode" switch control. The chip has been implemented using CMOS process. Measured results show the circuit exhibits peak-to-peak jitters of 37ps(@2.7Gbps) and 27ps(@1.62Gbps) in the recovered data. The power dissipation is 80mW at 2.7Gbps rate from a 1.8V supply.
( Won Ku Lee ),( Jeong Min Kim ),( Gun Wook Kim ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ),( Je Ho Mun ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Choristoma is a tumor-like mass composed of histologically normal cells or tissues occurring in an abnormal location. Cartilaginous choristoma, composed of ectopic cartilaginous tissue, is mostly located in the hands and feet and very rare in the oral mucosa. Lip involvement is extremely rare and only two cases are reported worldwide. We describe a 53-year-old manpresented with a 6-month history of an asymptomatic mass on the lower lip. Intraoral examination revealed a firm, well-circumscribed, and mobile submucosal mass (15x8x15 mm) within normal mucosa. Ultrasonography showed ovoid, heterogeneous echoic nodule with hypoechoic rim in the lower lip. The patient underwent surgical excision of the mass and the whitish mass covered with a thin membrane was removed easily. Histopathologic examination revealed a cartilaginous lesion surrounded by fibrous connective tissue and well-circumscribed aggregation of hyaline cartilage tissue arranged in a lobular pattern. Because no tumorous characteristics or malignant changes were evident microscopically in the lesion, the pathologic diagnosis was confirmed as cartilaginous choristoma. The patient’s postoperative course was uneventful, and there has been no recurrence for 10 months after surgery. We describe a rare case of cartilaginous choristoma with clinical, histopathologic, and ultrasonographic findings of which is the first reported case in dermatology literature.
Single Oral Dose Toxicity Test of Platycodin D, a Saponin from Platycodin Radix in Mice
Won-Ho Lee,Cheol-Ou Gam,Sae-Kwang Ku,Seong-Hun Choi 한국독성학회 2011 Toxicological Research Vol.27 No.4
The object of this study was to evaluate the single oral dose toxicity of platycodin D, a saponin from the root of Platycodon grandiflorum in male and female mice. Platycodin D was administered to female and male mice as an oral dose of 2000, 1000, 500, 250 and 125 mg/kg (body wt.). Animals were monitored for the mortality and changes in body weight, clinical signs and gross observation during 14 days after treatment, upon necropsy, organ weight and histopathology of 14 principle organs were examined. As the results, no platycodin D treatment related mortalities, clinical signs, changes on the body and organ weights, gross and histopathological observations against 14 principle organs were detected up to 2000 mg/kg in both female and male mice. Therefore, LDsub{50} (50% lethal dose) and approximate LD of playtcodin D after single oral treatment in female and male mice were considered over 2000 mg/kg ? the limited dosages recommended by KFDA Guidelines [2009-116, 2009], respectively.
Tumors associated with nevus sebaceus of Jadassohn
( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Nevus sebaceus is commonly associated with the development of secondary neoplasms. The proportion of malignant tumors occurring on nevus sebaceus is highly variable in published reports. Objectives: We retrospectively analyzed the distribution of secondary neoplasm in nevus sebaceus. Methods: An analysis of all cases of nevus sebaceus diagnosed at Pusan National University Hospital and Yangsan Pusan National University Hospital from 2008.1 through 2018.7 was conducted. Results: A total of 531 patients were included in the study. Secondary tumors were found in 29 cases. Trichoblastoma and syringocystadenoma papilliferum were the most frequent benign tumor (n = 4, 0.8%). Malignant tumors were present in 2.6% of the specimens with basal cell carcinoma being the most common (n = 6, 1.2%) followed by squamous cell carcinoma (n = 4, 0.8%). The incidence of secondary neoplasm was statistically related to age and anatomic site (P<0.05). Almost all malignant tumors were seen in adults. Conclusion: The rate of malignant tumors arising on nevus sebaceus was very low. As no malignant tumors were seen in children, we believe it is reasonable to delay surgical management until adolescence.
( Won Ku Lee ),( Jeong Min Kim ),( Gun Wook Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Eruptive melanocytic nevi (EMN) are characterized by the sudden onset of numerous melanocytic nevi on previously uninvolved sun-exposed area. The mechanisms of the EMN are not well understood, but have been associated with systemic immunosuppression, bullous dermatoses, and a melanocytic stimulation drug. We report a 5-year-old girl with multiple hyperpigmented maculopapules on whole body. These lesions had first appeared on the chest at 1 year old, and hundreds of lesions covering her entire skin surface had developed over the next 1 year. They were 0.5 to 3 mm in diameter, and did not look like atypical nevi clinically and dermoscopically. BRAF mutation was not found from the nevi of the patient. The patient developed EMN with the absence of associated defined, noncutaneous abnormalities. Second patient with EMN was a 42-year-old man with widespread eruptive melanocytic nevi. He had been treated for imatinib-resistant chronic myeloid leukemia with radotinib, a selective BCR-ABL1 tyrosine kinase inhibitor. Three months after treatment with radotinib, 1-4 mm sized multiple pigmented papules developed on whole body, which were diagnosed as EMN. We describe two cases with EMN in a healthy child and a chronic myeloid leukemia, who is the first reported case treated with radotinib.
Generalized pustular psoriasis in a 1-month-old boy
( Won Ku Lee ),( Hyunju Jin ),( Hyang Suk You ),( Woo Haing Shim ),( Jeong Min Kim ),( Gun Wook Kim ),( Hoon Soo Kim ),( Byung Soo Kim ),( Moon Bum Kim ),( Hyun Chang Ko ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Generalized pustular psoriasis (GPP) is a rare type of psoriasis, and it is very rare in children. A safe and consistently effective treatment regimen has not been identified, although many treatment modalities have been suggested so far. To our knowledge, the earliest onset of GPP in childhood that has been reported in the literature is 1.5months. Herein, we report a case of GPP in a child with the earliest onset of age. A healthy 2-month-old boy developed diffuse erythematous scaly patch with tiny pustules on whole body starting at 4 weeks after birth. Pustules were pin head-sized, and the lesions had rapidly progressed to large exuding areas. The clinical findings and histopathological examinations were consistent with the diagnosis of GPP. With topical steroid, the lesions repeated improvement and deterioration resulting lost to follow-up. After 1.5 years, the patient revisited the clinic with severe flare of erythematous lesions and pustules on whole body. The pustular lesions almost disappeared with the treatment of methylprednisolone and cyclosporine. Generalized erythematous eruption in neonate can be the manifestation of various diseases such as atopic dermatitis, seborrheic dermatitis, Leiner disease, and Langerhans cell histiocytosis. We suggest GPP should also be considered in differential diagnosis for neonatal erythroderma.
Convergent Synthesis of PAMAM-like Dendrimers from Azide-functionalized PAMAM Dendrons
Lee, Jae-Wook,Kim, Jung-Hwan,Kim, Byung-Ku,Kim, Ji-Hyeon,Shin, Won-Suk,Jin, Sung-Ho,Kim, Myung-hak Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.11
The convergent synthesis of symmetric PAMAM-like dendrimers from azide-functionalized poly(amido- amine) (PAMAM) dendrons and two different multi-alkynes was investigated. The stitching method was based on the click chemistry protocol, i.e., the copper-catalyzed cycloaddition reaction between an alkyne and an azide.
Lee Jee Hyung,Kim Haeryoung,이상협,Ku Ja-Lok,Chun Jung Won,Seo Ha Young,Kim Soon Chan,Paik Woo Hyun,Ryu Ji Kon,Lee Sang Kook,Lowy Andrew M.,Kim Yong-Tae 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.4
Background/Aims: Three-dimensional cultures of human pancreatic cancer tissue also known as “organoids” have largely been developed from surgical specimens. Given that most patients present with locally advanced and/or metastatic disease, such organoids are not representative of the majority of patients. Therefore, we used endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) to collect pancreatic cancer tissues from patients with advanced pancreatic cancer to create organoids, and evaluated their utility in pancreatic cancer research. Methods: Single-pass EUS-FNA samplings were employed to obtain the tissue for organoid generation. After establishment of the organoid, we compared the core biopsy tissues with organoids using hematoxylin and eosin staining, and performed whole exome sequencing (WES) to detect mutational variants. Furthermore, we compared patient outcome with the organoid drug response to determine the potential utility of the clinical application of such organoid-based assays. Results: Organoids were successfully generated in 14 of 20 tumors (70%) and were able to be passaged greater than 5 times in 12 of 20 tumors (60%). Among them, we selected eight pairs of organoid and core biopsy tissues for detailed analyses. They showed similar patterns in hematoxylin and eosin staining. WES revealed mutations in KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 which were 93% homologous, and the mean nonreference discordance rate was 5.47%. We observed moderate drug response correlations between the organoids and clinical outcomes in patients who underwent FOLFIRINOX chemotherapy. Conclusions: The established organoids from EUS-FNA core biopsies can be used for a suitable model system for pancreatic cancer research.
Lee, Ga-Young,Kim, Jin-Hyang,Jang, Han-Na,Won, Dong-Seon,No, Hyo-Jin,Lee, Ju-Yeon,Rhee, Bum-Ku,Choi, Hee-Dok Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.3
1-{2,4-Di-(2-hydroxyethoxy)phenyl}-2-(2-thienyl)ethene (5) was prepared and condensed with terephthaloyl chloride to yield polyester (6). Polymer 6 was reacted with tetracyanoethylene to give novel Y-type polyester (7) containing 1-(2,4-dioxyethoxy)phenyl-2-{5-(2,2,3-tricyanovinyl)-2-thienyl)}ethenyl groups as NLO-chromophores, which are parts the polymer backbones. Polymer 7 is soluble in common organic solvents such as acetone and N,N-dimethylformamide. It showed thermal stability up to 300 ${^{\circ}C}$ in thermogravimetric analysis with glasstransition temperature obtained from differential scanning calorimetry near 134 ${^{\circ}C}$. The second harmonic generation (SHG) coefficient ($d_33$) of poled polymer film at the 1560 nm fundamental wavelength was around 6.74 x $10^{-9}$ esu. The dipole alignment exhibited high thermal stability up to the glass-transition temperature ($Tg$), and there was no SHG decay below 135 ${^{\circ}C}$ because of the partial main-chain character of polymer structure, which is acceptable for NLO device applications.