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Effect of Ginkgetin from Ginkgo biloba Leaves on Cyclooxygenases and In Vivo Skin Inflammation
Kwak, Wie-Jong,Han, Chang Kyun,Son, Kun Ho,Chang, Hyeun Wook,Kang, Sam Sik,Park, Byung Kyu,Kim, Hyun Pyo 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Ginkgetin, a biflavone from Ginkgo biloba leaves, was previously reported to be a phospholipase A_2 inhibitor and this compound showed the potent antiarthritic activity in art adjuvant-induced arthritis as well as analgesic activity. This investigation was carried out to find effects on cyclooxygenase (COX)-1 and -2 including an in vivo effect. Ginkgetin (1 - 10 ??M) and the biflavonoid mixture(10-50 ㎍/ml), mainly a 1:1 mixture of ginketin and isoginkgetin, from G. blloba leaves, inhibited production of prostaglandin E_2 from lipopolysaccharide-induced RAW 264.7 cetls. This inhibition was mediated, at least in part, by down-regulation of COX-2 expression, but not by direct inhibition of COX-1 or COX-2 activity. Down-regulation of COX-2 by ginkgetin was also proved in the dorsal skin of ICR mouse treated by 12-0-tetradecanoylphorbol 13-acetate (TPA). At total doses of 1,000㎍/site on the dorsal skin (15mm × 15 mm), ginkgetin inhibited prostaglandin E_2 production by 65.6% along with a marked suppression of COX-2 induction. in addition, ginkgetin and the biflavonoid mixture(100-1,000 ㎍/ear)dose-dependently inhibited skin inflammation of croton oil induced ear edema in mice by topical application. The present study suggests that ginkgetion from G.blloba leaves down-regulates COX-2 induction in vlvo and this down-regulating potential is associated with an anti-inflammatory activity against skin inflammatory responses.
Structures of Two Acylated Flavonol Glucorhamnosides from Ginkgo biloba Leaves
Kang, Sam-Sik,Kim, Ju-Sun,Kwak, Wie-Jong,Kim, Ki-Hyup The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.2
The position of interglycosidic linkages of two acylated flavonol glucorhamnosides from Ginkgo biloba leaves was unambiguously determined as 1 $\longrightarrow$ 2 linkages rather than 1 $\longrightarrow$ 4 ones on the basis of spectroscopic and chemical evidence.
고속액체크로마토그라피에 의한 은행잎중 Flavonoid Glycoside 의 확인 및 정량
강삼식(Sam Sik Kang),김주선(Ju Sun Kim),곽의종(Wie Jong Kwak),김기협(Ki Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.2
Seven flavonol glycosides from the EtOAc fraction of Ginkgo biloba leaves were identified by high performance liquid chromatography. Separation by reversed phase chromatography on Lichrosorb RP-18 column was achieved by isocratic elution. The content of the major acylated flavonol glycoside, kaempferol 3-O-[6`-O-p-coumaroyl-β-D-glucosyl(1→2)-α-L-rhamnoside] was about 8.0% and 0.55% for EtOAc fraction and MeOH extract, respectively.
강삼식(Sam Sik Kang),김주선(Ju Sun Kim),곽의종(Wie-Jong Kwak),김기협(Ki-Hyup Kim) 한국생약학회 1990 생약학회지 Vol.21 No.2
Five biflavones and seven flavonol glycosides were isolated from the leaves of Ginkgo biloba. They were sciadopitysin(1), ginkgetin(2), isoginkgetin(3), bilobetin (4), amentoflavone(5), kaempferol 3-O-[6`-O-p-coumaroyl-β-D-glucopyranosyl(1→2)-α-L-rhamnopyranoside](6), quercetin 3-O-[6`-O-p-coumaroyl-β-D-glucopyranosyl(1→2)-α-L-rhamnopyranoside](8), rutinosides of kaempferol(7), isorhamnetin(9), quercetin (10), laricitrin(11), and kaempferol 3-O-(2, 6-α-L-dirhamnopyranosyl-β-D-glucopyranoside) (12). The structures were established by spectroscopic and chemical methods.
Protective Effect of S-Allyl Cysteine on Carbon Tetrachloride-induced Liver Injury in Rats
( Soo Nyun Choi ),( Il Hwa Hong ),( Sung Hye Bang ),( Wie Jong Kwak ),( Jin Kyu Park ),( Dong Wei Yuan ),( Ok Kyung Hwang ),( Jung Youn Han ),( Kyung Sook Hong ),( Ae Ri Ji ),( Mi Ran Ki ),( Kyu Shik 한국수의병리학회 2008 한국수의병리학회 학술발표논문집 Vol.12 No.2
Lee, Ming Hong,Kim, Jae Yeon,Yoon, Jeong Hoon,Lim, Hyo Jin,Kim, Tae Hee,Jin, Changbae,Kwak, Wie-Jong,Han, Chang-Kyun,Ryu, Jae-Ha Heyden & Son 2006 Phytotherapy Research Vol.20 No.9
<P>Activated microglia by neuronal injury or inflammatory stimulation overproduce nitric oxide (NO) by inducible nitric oxide synthase (iNOS) and reactive oxygen species (ROS) such as superoxide anion, resulting in neurodegenerative diseases. The toxic peroxynitrite (ONOO<SUP>−</SUP>), the reaction product of NO and superoxide anion further contributes to oxidative neurotoxicity. A butanol fraction obtained from 50% ethanol extracts of Opuntia ficus indica var. saboten (Cactaceae) stem (SK OFB901) and its hydrolysis product (SK OFB901H) inhibited the production of NO in LPS-activated microglia in a dose dependent manner (IC<SUB>50</SUB> 15.9, 4.2 µg/mL, respectively). They also suppressed the expression of protein and mRNA of iNOS in LPS-activated microglial cells at higher than 30 µg/mL as observed by western blot analysis and RT-PCR experiment. They also inhibited the degradation of I-κB-α in activated microglia. Moreover, they showed strong activity of peroxynitrite scavenging in a cell free bioassay system. These results imply that Opuntia ficus indica may have neuroprotective activity through the inhibition of NO production by activated microglial cells and peroxynitrite scavenging activity. Copyright © 2006 John Wiley & Sons, Ltd.</P>
Seo, Jin-soo,Joo, Yang-Hee,Yi, Jung-Bum,Lee, Eun-Ju,Lee, Nam-Kyu,Cho, Yong-Balk,Kwak, Wie-Jong,Hwang, Jong-Yeon,Jeon, Yong-Seog,Jeon, Hyun-Suk,Yoo, Sung-eun,Yoon, Cheol-Min,Dong, Mi-Sook,Gong, Young-D Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.6
2,2-Dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyran analogues (eg., 7 and 8) were identified as prolyl 4-hydroxylase inhibitors via a screening process using HSC-T6 and LI 90 cells that express an immortalized rat hepatic stellate cell line and as part of a test of the type I collagen contents employing the ELISA method. A subsequent lead optimization effort based on solid-phase parallel synthesis led to the identification of 2,2-dimethyl-3,4-dialkoxy-substituted 6-aminobenzopyrans as potent inhibitors of prolyl 4-hydroxylase.