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Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
( Min-young Lee ),( Ju-seong Kang ),( Ryeo-eun Go ),( Yong-sub Byun ),( Young Jin Wi ),( Kyung-a Hwang ),( Jae-hoon Choi ),( Hyoung-chin Kim ),( Kyung-chul Choi ),( Ki-hoan Nam ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α) converting enzyme, which is the molecule responsible for the release of TNF-α. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of TNF-α release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative TNF-α related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II. The severity of the CIA was measured by traditional clinical scores and histopathological analysis of hind limb joints. A rota-rod test and grip strength test were employed to evaluate the severity of CIA based on losses of physical functions. The results indicated that Rhbdf2 mutant mice showed clear alleviation of the clinical severity of CIA as demonstrated by the significantly lower severity indexes. Moreover, a grip strength test was shown to be useful for the evaluation of physical functional losses by CIA. Overall, the results showed that the Rhbdf2 gene has a significant effect on the induction of CIA, which is related to TNF-α.
Collagen-Induced Arthritis Analysis in Rhbdf2 Knockout Mouse
Lee, Min-Young,Kang, Ju-Seong,Go, Ryeo-Eun,Byun, Yong-Sub,Wi, Young Jin,Hwang, Kyung-A,Choi, Jae-Hoon,Kim, Hyoung-Chin,Choi, Kyung-Chul,Nam, Ki-Hoan The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha ($TNF-{\alpha}$) converting enzyme, which is the molecule responsible for the release of $TNF-{\alpha}$. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of $TNF-{\alpha}$ release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative $TNF-{\alpha}$ related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II. The severity of the CIA was measured by traditional clinical scores and histopathological analysis of hind limb joints. A rota-rod test and grip strength test were employed to evaluate the severity of CIA based on losses of physical functions. The results indicated that Rhbdf2 mutant mice showed clear alleviation of the clinical severity of CIA as demonstrated by the significantly lower severity indexes. Moreover, a grip strength test was shown to be useful for the evaluation of physical functional losses by CIA. Overall, the results showed that the Rhbdf2 gene has a significant effect on the induction of CIA, which is related to $TNF-{\alpha}$.
Influence of smoking and fighter flight on the lung; low-dose computed tomography study
( Dong-ho Bang ),( Young-wook Jeon ),( Seong Hoon Park ),( Joon Beom Seo ),( Namkug Kim ),( Ok-man Jeong ),( Wi-sub Hwang ),( Seonhyeok Kang ) 국군의무사령부 2014 대한군진의학학술지 Vol.45 No.1
Objectives: to compare low-dose chest computed tomography (LDCT) findings between fighter pilots and nonflying personnel. Methods: A total of 235 participants without any fighter flight experience and 185 fighter pilots with > 1,000 flight hours who underwent LDCT imaging were included in our study. The subjects were further divided into a smoking group and a nonsmoking group. The prevalence of each LDCT finding was compared by univariate analysis. Logistic regression analysis was performed with variables suspected of being significant in the univariate analysis and controlled by age > 50 years, smoking status, and fighter flight. The diameters of the pulmonary artery (PA) and the ascending aorta (AA) were measured and the PA:AA ratio were calculated. Results: Among the nonsmokers, subsegmental atelectasis was rare in the fighter pilots. Among the smokers, bronchiectasis was rare in the fighter pilots, but paraseptal emphysema was common. Paraseptal emphysema was prevalent in the smokers. Fighter flight had no significant influence on the lung. The diameters of PA and AA and PA:AA ratio were not significantly different between the two groups. Conclusion: The results suggest that a combination of fighter flight and smoking may have effects on the chest, particularly regarding the development of paraseptal emphysema.
( Dong-ho Bang ),( Seong Hoon Park ),( Joon Beom Seo ),( Namkug Kim ),( Sang-min Lee ),( Young-wook Jeon ),( Ok-man Jeong ),( Wi-sub Hwang ),( Seonhyeok Kang ) 국군의무사령부 2014 대한군진의학학술지 Vol.45 No.1
Purpose: to compare pulmonary morphology between fighter pilots and nonflying personnel using low-dose chest CT (LDCT) quantification. Methods: A total of 36 military fighter pilots and 36 nonflying personnel who were non-smoker in our institute from April to July 2013 were included in our study. The LDCT images were reviewed and the prevalence of each LDCT finding was compared by univariate analysis. The diameters of the pulmonary artery (PA) and the ascending aorta (AA) were measured and the PA: AA ratio were calculated and they were compared between the military fighter pilots and nonflying personnel. Quantification with LDCT images using in-house software based on the fullwidth- half-maximum method was performed. Lung volume, emphysema index, mean lung density, airway diameter and airway luminal area of subsegmental bronchus were also obtained and compared between the two groups using paired-t-test. Results: There was no statistically significant difference in the prevalence of LDCT findings between the two groups. AA, PA, and PA:AA ratio of the subjects did not show any statistically significant difference between the two groups. The mean airway diameter (mm) and airway luminal area (mm2) were significantly larger than that of the nonflying personnel (3.50 0.34 vs 3.21 0.44 and 11.29 2.84 vs 9.26 2.93, respectively) but lung volume, emphysema index, and mean lung density were not significantly different between the two groups. Conclusion: The occupational exposure to fighter flight might have influence on the lung, especially, airway dilatation.