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The protective effect of resveratrol on vascular aging by modulation of the renin–angiotensin system
Kim, Eun Nim,Kim, Min Young,Lim, Ji Hee,Kim, Yaeni,Shin, Seok Joon,Park, Cheol Whee,Kim, Yong-Soo,Chang, Yoon Sik,Yoon, Hye Eun,Choi, Bum Soon Elsevier Scientific Publ. Co 2018 Atherosclerosis Vol.270 No.-
<P><B>Abstract</B></P> <P><B>Background and aims</B></P> <P>This study evaluated the effects of resveratrol on arterial aging and the renin–angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs).</P> <P><B>Methods</B></P> <P>Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and the expression of AMP-activated protein kinase (AMPK), silent information regulator T1 (SIRT1), peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α), and anti-oxidative enzymes was measured in thoracic aortas of 24-month-old mice. The effect of resveratrol on fibrosis, cell senescence, and RAS components was also investigated in VSMCs stimulated by angiotensin (Ang) II.</P> <P><B>Results</B></P> <P>Aorta media thickness, inflammation, fibrosis, and oxidative stress were significantly lower in the resveratrol group than in the control group. Resveratrol treatment decreased serum Ang II level and the aortic expression of prorenin receptor (PRR) and angiotensin converting enzyme (ACE), and increased serum Ang-(1–7) level and the expression of ACE2, Ang II type 2 receptor (AT2R), and Mas receptor (MasR). Resveratrol increased the expression of phosphorylated AMPK, SIRT1, PGC-1α, phosphorylated endothelial nitric oxide synthase and superoxide dismutase 1 and 2, and decreased that of NADPH oxidase 2 and 4. In Ang II-stimulated VSMCs, resveratrol treatment markedly decreased the number of senescence associated β-galactosidase stained cells and pro-fibrotic protein expression and increased the expression of AT2R and MasR.</P> <P><B>Conclusions</B></P> <P>Resveratrol protects against arterial aging and this effect is associated with reduced activity of the PRR–ACE–Ang II axis and stimulation of the ACE2–Ang-(1–7)–ATR2–MasR axis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Resveratrol protected against arterial aging by attenuating inflammation and oxidative stress. </LI> <LI> Resveratrol reduced the activity of the prorenin receptor-angiotensin converting enzyme-angiotensin II axis in aorta of aging mice. </LI> <LI> Resveratrol stimulated the activity of the angiotensin converting enzyme 2-angiotensin-(1–7)-angiotensin II type 2 receptor-Mas receptor axis both<I>in vivo</I> and <I>in vitro</I>. </LI> </UL> </P>
Computer Integrated Surgical Robot System for Spinal Fusion
Kim Sungmin,Chung Goo Bong,Oh Se Min,Yi Byung-Ju,Kim Whee Kuk,Park Jong Il,Kim Young Soo The Korean Society of Medical and Biological Engin 2005 의공학회지 Vol.26 No.5
A new Computer Integrated Surgical Robot system is composed of a surgical robot, a surgical planning system, and an optical tracking system. The system plays roles of an assisting surgeon and taking the place of surgeons for inserting a pedicle screw in spinal fusion. Compared to pure surgical navigation systems as well as conventional methods for spinal fusion, it is able to achieve better accuracy through compensating for the portending movement of the surgical target area. Furthermore, the robot can position and guide needles, drills, and other surgical instruments or conducts drilling/screwing directly. Preoperatively, the desired entry point, orientation, and depth of surgical tools for pedicle screw insertion are determined by the surgical planning system based on CT/MR images. Intra-operatively, position information on surgical instruments and targeted surgical areas is obtained from the navigation system. Two exemplary experiments employing the developed image-guided surgical robot system are conducted.
Novel production of natural bacteriocin via internalization of dextran nanoparticles into probiotics
Kim, Whee-Soo,Han, Geon Goo,Hong, Liang,Kang, Sang-Kee,Shokouhimehr, Mohammadreza,Choi, Yun-Jaie,Cho, Chong-Su Elsevier 2019 Biomaterials Vol.218 No.-
<P><B>Abstract</B></P> <P>Recently, probiotics has drawn much attention as an alternative of antibiotics because overuse use of antibiotics has caused widespread bacterial resistance. Given that prebiotics enhance the activity of probiotics, we prepared phthalyl dextran nanoparticles (PDNs) by conjugation of phthalic anhydride with dextran to form a prebiotic and checked its effects on the cellular and antimicrobial properties of the probiotics. First, we found that the internalization of PDNs by probiotics was dependent on temperature, time, and glucose transporters. Internalization of PDNs enhanced the production of antimicrobial peptides by probiotics through self-defense mechanism and resulted in higher antimicrobial activities against Gram-positive and -negative pathogens compared to probiotics themselves. Moreover, pediocin produced by PDN-internalized probiotics was able to suppress pathogenic gut infections and alter the population of gut microbiome <I>in vivo</I>. The enhanced antimicrobial property of <I>Pediococcus acidilactidi</I> internalized with PDNs could decrease the number of pathogens and increase beneficial bacteria species in mice. Furthermore, the composition of gut microbiome was changed, and resulted in preventing reduction of the diversity of the microflora. Our results indicate that PDNs as a new type of prebiotic can regulate probiotic bacterial metabolism, suggesting a new avenue for probiotic modulation and their use in addressing the challenge of bacterial resistance.</P>
Oral Delivery of Probiotics Using pH-Sensitive Phthalyl Inulin Tablets
( Whee-soo Kim ),( Chong-su Cho ),( Liang Hong ),( Geon Goo Han ),( Bum Ju Kil ),( Sang-kee Kang ),( Dae-duk Kim ),( Yun-jaie Choi ),( Chul Sung Huh ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.2
Probiotics show low cell viability after oral administration because they have difficulty surviving in the stomach due to low pH and enzymes. For the oral delivery of probiotics, developing a formula that protects the probiotic bacteria from gastric acidity while providing living cells is mandatory. In this study, we developed tablets using a new pH-sensitive phthalyl inulin (PI) to protect probiotics from gastric conditions and investigated the effects of different compression forces on cell survival. We made three different tablets under different compression forces and measured survivability, disintegration time, and kinetics in simulated gastric-intestinal fluid. During tableting, there were no significant differences in probiotic viability among the different compression forces although disintegration time was affected by the compression force. A higher compression force resulted in higher viability in simulated gastric fluid. The swelling degree of the PI tablets in simulated intestinal fluid was higher than that of the tablets in simulated gastric fluid due to the pH sensitivity of the PI. The probiotic viability formulated in the tablets was also higher in acidic gastric conditions than that for probiotics in solution. Rapid release of the probiotics from the tablet occurred in the simulated intestinal fluid due to the pH sensitivity. After 6 months of refrigeration, the viability of the PI probiotics was kept. Overall, this is the first study to show the pH-sensitive properties of PI and one that may be useful for oral delivery of the probiotics.
B cell-associated immune profiles in patients with end-stage renal disease (ESRD)
Kim, Kyoung Woon,Chung, Byung Ha,Jeon, Eun Joo,Kim, Bo-Mi,Choi, Bum Soon,Park, Cheol Whee,Kim, Yong-Soo,Cho, Seok-Goo,Cho, Mi-La,Yang, Chul Woo Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.8
Most of the previous studies on immune dysregulation in end-stage renal disease (ESRD) have focused on T cell immunity. We investigated B cell subpopulations in ESRD patients and the effect of hemodialysis (HD) on B cell-associated immune profiles in these patients. Forty-four ESRD [maintenance HD patients (n = 27) and pre-dialysis patients (n = 17)] and 27 healthy volunteers were included in this study. We determined the percentage of B cell subtypes, such as mature and immature B cells, memory B cells, and interleukin (IL)-$10^+$ cells, as well as B cell-producing cytokines (IL-10, IL-4 and IL-21) by florescent activated cell sorting (FACS). B cell-associated gene expression was examined using real-time PCR and B cell producing cytokines (IL-10, IL-4 and IL-21) were determined using an enzyme-linked immunosorbent assay (ELISA). The percentage of total B cells and mature B cells did not differ significantly among the three groups. The percentages of memory B cells were significantly higher in the pre-dialysis group than in the HD group (P<0.01), but the percentage of immature B cells was significantly lower in the pre-dialysis group than in the other groups. The percentages of IL-10-expressing cells that were $CD19^+$ or immature B cells did not differ significantly (P>0.05) between the two subgroups within the ESRD group, but the serum IL-10 concentration was significantly lower in the pre-dialysis group (P<0.01). The results of this study demonstrate significantly altered B cell-associated immunity. Specifically, an imbalance of immature and memory B cells in ESRD patients was observed, with this finding predominating in pre-dialysis patients.
Jungmi Kim,Hwasoon Kim,Young Whee Lee,Ji Young Lim,Soo Hyun Kim 한국간호과학회 2021 한국간호과학회 학술대회 Vol.2021 No.10
Aim(s): This structural model study aimed to identify the factors affecting social readjustment of stroke patients, to propose a hypothetical model, and to test the developed model with empirical data. Method(s): The hypothetical model was developed based on Roy’s adjustment model (1991) and a review of previous literature on the topic. It consists of four exogenous variables (neurological damage, sex, age, and social support) and five endogenous variables (activities of daily living, acceptance of disability, depression, rehabilitation motivation and social readjustment). The subjects were 321 stroke patients. The data were analyzed using IBM SPSS/WIN 22.0 and AMOS 23.0. Result(s): The fit of the hypothetical model was χ2=222.902, χ2/df=2.533, CFI=.937, TLI=.902, RMSEA=.069, SRMR=.054, which indicates that the model is fairly suitable. 18 of the model’s 28 research hypotheses were supported, and explained 64.1% of stroke patients’ social readjustment. According to the findings, social readjustment is directly and significantly affected by age (SRW=-.379, p<.001), social support (SRW=.295, p<.001), activities of daily living (SRW=.335, p<.001), and depression (SRW=-.244, p<.01). On the other hand, neurological damage (SRW=-.062, p=.358), sex (SRW=.059, p=.282), acceptance of disability (SRW=-.100, p=.218), and rehabilitation motivation (SRW=.055, p=.391) did not have significant direct effect. Conclusion(s): Continuous assistance should be provided to stroke patients who require long-term rehabilitation and care on account of disabilities caused by sudden neurological damage, including active nursing intermediation in physical, psychological, and social aspects, so as to improve their social readjustment gradually. In order to improve stroke patients’ social readjustment, their activities of daily living should be increased, and enhanced social support should be provided to prevent depression.