의료인과 비의료인의 정신질환에 대한 태도 비교연구

이강오,최선화 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1

The purpose of this study was to find out the medical personnel and the non-medical personnel attitudes toward mental illness. Data collection was done from the 1st to the 30th of August, 1986 by means of a questionnaire. Subjects in this study were 210 medical personnel and 210 non-medical personnel in Chunnam and it's neighboring districts. The instrument used for mensuring attitudes was a questionnaire developed by Star and it's made up to 9 items. Data were analized by computer using S.P.S.S (statistical package for the social science). Frequencies and percentages were used to examine the general characteristics of the subjects. Chi-Square test was used to test the characteristics and attitudes toward mental illness between groups. The finding of this study were as follows : 1) Items for the recognition and attitudes toward mental illness. a. More positive attitudes toward mental illness found in the medical personnel and were showed statistically significant differences. (p <. 05) b. Attitude about neurosis were not showed statistically significant differences in medical and non-medical personnel. c. Prejudice about mentally ill patients. (1) Medical personnel's responses were more negative when the member of a family admitted to the hospital and showed statistically significant differences. (p < .05) (2) Medical personnel and non-medical personnel were positive when the member of a family had a mental illness and were not showed statistically significant differences. d. More positive attitudes about the prognosis of mental illness were found in the non-medical personnel and were showed statisticallysignificant differences. (P < .05) 2) Items for a mental hospital. a. More negative opinions about cure for the mentally ill patients were found in the medical personnel and were showed statistically significant differences. (P < .05) b. More positive attitudes about home based treatment were found in the medical personnl but were not showed statistically significant differences. c. More positive attitudes about the function of mental hospital were found in the medical personnel and were showed statistically significant differences. (p < .05) d. More positive attitudes about the open ware were found in the medical personnel and were showed statistically significant differences. (p < .05)

해수에서 출생하여 적응된 Guppy(Lebistes reticulatus) 신장의 proximal tubule의 미세구조

김한화,강화선 최신의학사 1992 最新醫學 Vol.35 No.1

정신장애인 치료에 중요 역할 담당자의 정신질환에 대한 태도조사

김병후,정선욱,강연화,김윤,김창엽,홍진표,한오수,조맹제,김용익 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

Objectives : Attitudes of families of mentally ill, health personnels and community leaders to the mentally ill after the development and utilization of the community mental health program and reintegration of the chronically ill patients into society. This study was designed to compare the attitudes toward the mentally ill patient of the persons who have important role in treating the mentally ill and to find the variables influencing the attitudes. Methods : We measured attitudes toward mental illness in psychotic patients' families(N=139), community leaders(N=180) and health personnels(N=324) including mental health personnels before the implementation of community mental health services in Yonchon county and Seodaemun district area. The instrument used to measure attitudes was Opinion about Mental Illness(O. M. I.) scale. Results : 1) Health personnel showed lower Authoritarianism(Factor A) and higher Benevolence(Factor B) scores on the average than community leaders and psychotic patients families. 2) Current residence affect the attitudes in psychotic patients' families, not in community leaders and health personnels. Families in urban area showed lower Authoritarianism(Factor A) and Social Restrictiveness(Factor D) and higher Benevolence(Factor B) scores than in the rural areas. 3) Many patient variables were correlated to the attitudes of families. Duration of illness, number of recurrence, number of admission, age of patient and family burden were positively correlated mainly to Social Restrictiveness(Factor D). 4) Sex and religion of respondents showed no or weak relationship with the factor scores. Conclusions : Education for community leaders and families is required to achieve successful community mental health services. Community support program should be developed for chronic, recurrent and burdensome psychiatric patients in the first place.

송사리 상피의 미세구조적 연구

김한화,지영득,문영호,강화선 최신의학사 1988 最新醫學 Vol.31 No.12

해수에 적응시킨 Guppy(Lebistes reticulatus) 신장의 proximal tubule의 미세구조의 변화

김한화,지영득,문영화,강화선,한지원 최신의학사 1991 最新醫學 Vol.34 No.12

Antitumor Activity and Acquired Resistance Mechanism of Dovitinib (TKI258) in <i>RET</i>-Rearranged Lung Adenocarcinoma

Kang, Chan Woo,Jang, Kang Won,Sohn, Jinyoung,Kim, Sung-Moo,Pyo, Kyoung-Ho,Kim, Hwan,Yun, Mi Ran,Kang, Han Na,Kim, Hye Ryun,Lim, Sun Min,Moon, Yong Wha,Paik, Soonmyung,Kim, Dae Joon,Kim, Joo Hang,Cho, American Association for Cancer Research 2015 Molecular Cancer Therapeutics Vol.14 No.10

<P><I>RET</I> rearrangement is a newly identified oncogenic mutation in lung adenocarcinoma (LADC). Activity of dovitinib (TKI258), a potent inhibitor of FGFR, VEGFR, and PDGFR, in <I>RET</I>-rearranged LADC has not been reported. The aims of the study are to explore antitumor effects and mechanisms of acquired resistance of dovitinib in <I>RET</I>-rearranged LADC. Using structural modeling and <I>in vitro</I> analysis, we demonstrated that dovitinib induced cell-cycle arrest at G<SUB>0</SUB>–G<SUB>1</SUB> phase and apoptosis by selective inhibition of RET kinase activity and ERK1/2 signaling in <I>RET</I>-rearranged LC-2/ad cells. Strong antitumor effect of dovitinib was observed in an LC-2/ad tumor xenograft model. To identify the acquired resistance mechanisms to dovitinib, LC-2/ad cells were exposed to increasing concentrations of dovitinib to generate LC-2/ad DR cells. Gene-set enrichment analysis of gene expression and phosphor-kinase revealed that Src, a central gene in focal adhesion, was activated in LC-2/ad DR cells. Saracatinib, an src kinase inhibitor, suppressed ERK1/2 phosphorylation and growth of LC-2/ad DR cells. Taken together, these findings suggest that dovitinib can be a potential therapeutic option for <I>RET</I>-rearranged LADC, in which acquired resistance to dovitinib can be overcome by targeting Src. <I>Mol Cancer Ther; 14(10); 2238–48. ©2015 AACR</I>.</P>

mtDNA l1778위치의 돌연변이를 가진 Leber씨 유전성 시신경병증과 Leber's plus: 임상적 양상과 유전학적 연구

권순억,황정민,박혜원,강동화,구자성,이광우,노재규 대한신경과학회 1997 대한신경과학회지 Vol.15 No.2

Lateral Medullary Infarction with or without Extra-Lateral Medullary Lesions: What Is the Difference?

Kang, Hyun Goo,Kim, Bum Joon,Lee, Sang Hun,Kang, Dong-Wha,Kwon, Sun U.,Kim, Jong S. S KARGER AG 2018 Cerebrovascular Diseases Vol.45 No.3

<P><B><I>Background:</I></B> Lateral medullary infarction (LMI) is not an uncommon disease. Although lesions are usually restricted to the lateral medullary area, some patients have additional infarcts in other parts of the brain. The clinical features and prognosis of isolated LMI (pure LMI, LMIpr) have been investigated. However, it remains unclear whether clinical characteristics, prognosis and factors associated with prognosis differ between patients with LMIpr and those with additional lesions (LMI plus, LMIpl). <B><I>Methods:</I></B> Patients with LMI identified by MRI were enrolled. The demographic and clinical characteristics, in-hospital outcome (intensive care unit [ICU] admission, pneumonia and modified Rankin scale [mRS] at discharge), and long-term residual symptoms (vertigo/dizziness, sensory disturbances, dysphagia) and outcomes (occurrence of stroke, acute coronary syndrome [ACS], death, and mRS at follow-up) were compared between LMIpr and LMIpl patients. Factors associated with poor functional outcome (mRS 2–6) at the follow-up were analyzed. <B><I>Results:</I></B> Among 248 LMI patients, 161 (64.9%) had LMIpr and 87 (35.1%) had LMIpl. During admission, patients with LMIpl more frequently experienced ICU care, pneumonia and had a higher discharge mRS (3 vs. 2; <I>p</I> < 0.001) than LMIpr patients. The occurrence of stroke, ACS, frequency of death and functional outcome was not different during follow-up. However, residual neurologic symptoms such as dizziness (<I>p</I> = 0.002), dysphagia (<I>p</I> = 0.04) and sensory symptoms (<I>p</I> < 0.001) were more frequent in LMIpr than in LMIpl patients. In LMIpr patients, the rostral location of LMI was associated with poor functional outcome (<I>p</I> = 0.041), whereas in LMIpl patients, the presence of medial posterior-inferior cerebellar artery lesion was associated with good functional outcome (<I>p</I> = 0.030). <B><I>Conclusion:</I></B> Although the short-term outcome is poorer in LMIpl than LMIpr patients, long-term residual symptoms are more common in LMIpr patients. The location of the LMI and extra-medullary lesion affects the long-term functional outcome of LMIpr and LMIpl patients respectively.</P>

敎養課程으로서의 「人口와 未來」開設 및 運營에 관한 實驗硏究 : 梨花女子大學校를 中心으로

康宇哲,徐洸善,田贊和,金在恩,蘇興烈 이화여자대학교 한국문화연구원 1979 韓國文化硏究院 論叢 Vol.33 No.-

This is a research report of the research that led to the opening of a population education course at Ewha Womans University. The research itself may be divided into the following four parts: planning for the research ; preparatory work for a population education course; opening of a population course; and evaluation of the population course. In the first stage of the research, the work, as usual, consisted of organizing the research team, setting up the research objectives, planning the research schedule, etc. The project began in the Fall of 1974, and concluded in the Fall of 1978. In the second stage of the research, the work was carried out for the preparation of a course in population education. Several sessions of faculty conference, in which more than 40 professors from various fields of specialization participated, were held in order to determine the specific objectives of the proposed course, to draw up a syllabus, and to prepare for a textbook for the course. When a rough sketch of the syllabus, and the contents of the course was made a student group was organized to examine and evaluate it. In the third stage of the research, a population education course titled "Population and Future" was opened as an elective course in the general education curriculum. This was in the Fall of 1875, and the course remained open every semester until now. An anthology with the same title as the course itself was used for reading, and the teaching was carried out as a team teaching by a team of 6-9 professors. In the fourth stage of the research, an evaluative study was taken up in order to evaluate the course with regard to its structure, textbook, teaching method, and its contents, as well as to assess the effectiveness of the course on terms of the students' change in their cognitive and emotive or attitudinal response to population problem.

Optical Properties of 1-Phenyl-3-Naphthyl-5-((Ethoxy)phenyl)-2-Pyrazoline Organic Nanoparticlesby Reprecipitation Method

Kang, Hyo Sim,Park, Mi Na,Kang, Young Soo,Oh, Sun Wha TaylorFrancis 2007 Molecular Crystals and Liquid Crystals Vol.463 No.1

<P> Nanoparticles of 1-phenyl-3-naphthyl-5-((ethoxy)phenyl)-2-pyrazoline with sizes ranging from tens to hundreds of nanometers were prepared by the reprecipitation method. Their excitonic transitions responsible for absorption and emission, as compared with those of diluted solution, have been investigated as a function of nanoparticle size. We found that pyrazoline nanoparticles possess an ambiguous size dependence on their optical properties. As the nanoparticle size decreased, the absorption peak of pyrazoline nanoparticles was observed to be shifted to the high-energy side due to size effect.</P>