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Yun-Sook Lim,Men T.N. Nguyen,Thuy X. Pham,Trang T.X. Huynh,Eun-Mee Park,Dong Hwa Choi,Sang Min Kang,Dongseob Tark,Soon B. Hwang 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.3
Hepatitis C virus (HCV) is a major cause of chronic liver disease and is highly dependent on cellular proteins for viral propagation. Using protein microarray analysis, we identified 90 cellular proteins as HCV nonstructural 5A (NS5A) interacting partners, and selected telomere length regulation protein (TEN1) for further study. TEN1 forms a heterotrimeric complex with CTC and STN1, which is essential for telomere protection and maintenance. Telomere length decreases in patients with active HCV, chronic liver disease, and hepatocellular carcinoma. However, the molecular mechanism of telomere length shortening in HCV-associated disease is largely unknown. In the present study, protein interactions between NS5A and TEN1 were confirmed by immunoprecipitation assays. Silencing of TEN1 reduced both viral RNA and protein expression levels of HCV, while ectopic expression of the siRNA-resistant TEN1 recovered the viral protein level, suggesting that TEN1 was specifically required for HCV propagation. Importantly, we found that TEN1 is re-localized from the nucleus to the cytoplasm in HCV-infected cells. These data suggest that HCV exploits TEN1 to promote viral propagation and that telomere protection is compromised in HCV-infected cells. Overall, our findings provide mechanistic insight into the telomere shortening in HCV-infected cells.
Enhanced Light Outcoupling in Organic Light-Emitting Diodes Using Phase Separated Polymer Films
Juhee Hong,Joo Won Han,Trang T. K. Tu,Soyeon Kim,Dongchan Lim,Sung Bin Park,Souk Yoon Kim,Jung Ha Kim,Dong Woo Kim,Jonghee Lee,Kwon Taek Lim,김용현 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.4
We report high performance internal light outcoupling films based on phase separation polymer for indium tin oxide-free organic light emitting diodes (OLEDs). The two immiscible polymers of poly(amic acid) and polyimide in a blend film result in nanoporous structures after spin-coating by self-assembly process. The OLEDs are prepared by solution process including phase separation films and transparent electrodes, allowing for low-cost and high-speed manufacturing. The phase separation films prepared between the glass substrate and the poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) transparent electrode remarkably improve the outcoupling performance of OLEDs. The poly(methyl methacrylate) (PMMA)-assisted phase separation films significantly improve the external quantum efficiency and power efficiency of OLEDs by a factor 1.88 and 1.87, respectively, compared to the reference device without any outcoupling structure. Our results demonstrate that phase separation films developed here offer new opportunities in improving the outcoupling efficiency in OLEDs.
Tran Xuan Ngoc Huy, Ched Nicole Turbela Aguilar, Trang Thi Nguyen, Said Abdi Salad, Hu Jang Lee, Jin Hur, Dong-Kwan Lee, Suk Kim 한국예방수의학회 2023 예방수의학회지 Vol.47 No.3
Extensive research and testing continue to be conducted for the development of vaccines targeting zoonotic diseases such as brucellosis. In this study, the potential of the DapB as a recombinant protein vaccine to effectively combat Brucella abortus 544 infection in BALB/c mice was evaluated. Western blotting assay results showed that recombinant protein DapB reacted with Brucella-positive serum, indicating its potential immunoreactivity. In vivo results showed that the peripheral blood CD4+ and CD8+ T cell population significantly increased in the DapB-immunized mice group after the first, second and third blood collection, compared to the control group that received PBS. Additionally, at the fourth blood collection, an increase in CD4+ T cell activation was observed in three vaccination groups compared to PBS negative control group. These results indicate the potential of DapB in stimulating cellular immunity. Fourteen days after infection, the bacterial load in the spleen was evaluated. The reduction in bacterial replication in the spleen by both DapB and RB51 highlights their protective efficacy against Brucella infection. These findings contribute to the ongoing efforts in developing effective vaccines against brucellosis and provide valuable insights for further research in this field.