Sleep Duration and Cancer Risk: a Systematic Review and Meta-analysis of Prospective Studies

Zhao, Hao,Yin, Jie-Yun,Yang, Wan-Shui,Qin, Qin,Li, Ting-Ting,Shi, Yun,Deng, Qin,Wei, Sheng,Liu, Li,Wang, Xin,Nie, Shao-Fa Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

To assess the risk of cancers associated with sleep duration using meta-analysis of published cohort studies, we performed a comprehensive search using PubMed, Embase and Web of Science through October 2013. We combined hazard ratios (HRs) from individual studies using meta-analysis approaches. A random effect dose-response analysis was used to evaluate the relationship between sleep duration and cancer risk. Subgroup analyses and sensitivity analyses were also performed. Publication bias was evaluated using Funnel plots and Begg's test. A total of 13 cohorts from 12 studies were included in this meta-analysis, which included 723, 337 participants with 15, 156 reported cancer outcomes during a follow-up period ranging from 7.5 to 22 years. The pooled adjusted HRs were 1.06 (95% CI: 0.92, 1.23; P for heterogeneity =0.003) for short sleep duration, 0.91 (95% CI: 0.78, 1.07; P for heterogeneity <0.0001) for long sleep duration. In subgroup analyses stratified by cancer type, long duration of sleep showed an inverse relation with hormone-related cancer (HR=0.79; 95% CI: 0.65, 0.97; P for heterogeneity =0.009) and a greater risk of colorectal cancer (HR=1.29; 95% CI: 1.09, 1.52; P for heterogeneity =0.346). Further meta-analysis on dose-response relationships showed that the relative risks of cancer were 1.00 (95% CI: 0.99, 1.01; P for linear trend=0.9151) for one hour of sleep increment per day, and 1.00 (95% CI: 0.98, 1.01; P for linear trend=0.7749) for one hour of sleep increment per night. No significant dose-response relationship between sleep duration and cancer was found on non-linearity testing (P=0.5053). Our meta-analysis suggests a positive association between long sleep duration and colorectal cancer, and an inverse association with incidence of hormone related cancers like those in the breast. Studies with larger sample size, longer follow-up times, more cancer types and detailed measure of sleep duration are warranted to confirm these results.

SH2D4A regulates cell proliferation via the ERα/PLC-γ/PKC pathway

( Ting Ting Li ),( Wei Li ),( Jing Yu Lu ),( Hong Liu ),( Ying Hui Li ),( Yan Yan Zhao ) 생화학분자생물학회 2009 BMB Reports Vol.42 No.8

Enhancing antibacterial activity of geminized cationic amphiphilic polymer via structure control and self-assembly regulation

Ting Chen,Lianyu Zhao,Ziyuan Wang,Jishi Zhao,Yan Li,Hangyu Long,Ming Yang 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-

A novel geminized amphiphilic polymer containing double cationic head groups and hydrophobic tails ineach structural unit (denoted as PAGBn), has been prepared in our study. The self-assembly behavior onthe solid/liquid interface was investigated by quartz crystal microbalance with dissipation (QCM-D),steady-statefluorescence, dynamic light scattering (DLS) and transmission electron microscope (TEM). Atwo-regime buildup can be observed, where thefirst regime is attributed to the rapid adsorption ofpolymers, while a rearrangements of pre-adsorbed molecules and their aggregation on the surfacedominate the second regime, exhibiting a formation of aggregates in large sizes due to the effect of thecharge density and hydrophobes on the self-assembly process. It exhibits a drastically enhanced killingefficiency of99.9% against both of Staphylococcus aureus and Escherichia coli bacteria for PAGBncompared with other traditional single-chained polymers, through the reinforced synergistic effect ofelectrostatic and hydrophobic interactions, and the formation of large-sized polymer aggregates,encompassing and killing the bacteria more efficiency. Ourfindings reveal the antibacterial mechanismand the correlation between antibacterial activity and aggregates structure, providing a basis for thedevelopment of super-antibacterial materials in the infection resistant applications.

Gaseous signal molecule SO2 regulates autophagy through PI3K/ AKT pathway inhibits cardiomyocyte apoptosis and improves myocardial fibrosis in rats with type II diabetes

Zhao Junxiong,Wu Qian,Yang Ting,Nie Liangui,Liu Shengquan,Zhou Jia,Chen Jian,Jiang Zhentao,Xiao Ting,Yang Jun,Chu Chun 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Myocardial fibrosis is a key link in the occurrence and development of diabetic cardiomyopathy. Its etiology is complex, and the effect of drugs is not good. Cardiomyocyte apoptosis is an important cause of myocardial fibrosis. The purpose of this study was to investigate the effect of gaseous signal molecule sulfur dioxide (SO2) on diabetic myocardial fibrosis and its internal regulatory mechanism. Masson and TUNEL staining, Western-blot, transmission electron microscopy, RT-qPCR, immunofluorescence staining, and flow cytometry were used in the study, and the interstitial collagen deposition, autophagy, apoptosis, and changes in phosphatidylinositol 3-kinase (PI3K)/AKT pathways were evaluated from in vivo and in vitro experiments. The results showed that diabetic myocardial fibrosis was accompanied by cardiomyocyte apoptosis and down-regulation of endogenous SO2-producing enzyme aspartate aminotransferase (AAT)1/2. However, exogenous SO2 donors could up-regulate AAT1/2, reduce apoptosis of cardiomyocytes induced by diabetic rats or high glucose, inhibit phosphorylation of PI3K/AKT protein, up-regulate autophagy, and reduce interstitial collagen deposition. In conclusion, the results of this study suggest that the gaseous signal molecule SO2 can inhibit the PI3K/AKT pathway to promote cytoprotective autophagy and inhibit cardiomyocyte apoptosis to improve myocardial fibrosis in diabetic rats. The results of this study are expected to provide new targets and intervention strategies for the prevention and treatment of diabetic cardiomyopathy.

Effects of Gypenosides on Acute Stress in Mice

Ting Ting Zhao,이명구,Keon Sung Shin,최현숙 한국생약학회 2013 Natural Product Sciences Vol.19 No.4

The effects of gypenosides (GPS) on electric footshock (EF)-induced acute stress in mice were investigated. Mice were treated orally with GPS (30 - 400 mg/kg) once a day for 5 days. After 2 days of GPS treatment, mice were exposed to EF stimuli (intensity, 2 mA; interval, 10 s; duration, 3 min) for acute stress for 3 days. Spontaneous locomotor activity was increased by acute EF stress, which was decreased by treatment with GPS (100 and 400 mg/kg). In addition, the increased levels of dopamine and serotonin by acute EF stress in the brain were reduced by treatment with GPS (100 and 400 mg/kg). The serum levels of corticosterone increased by acute EF stress were also reduced by GPS (100 and 400 mg/kg). These results suggest that GPS shows the ameliorating effects on acute EF stress by modulating the activity of dopaminergic and serotonergic neurons, and the serum levels of corticosterone. Clinical trials of GPS need to be conducted further so as to develop promising anti-stress agents.

Effects of different culture systems on the culture of buffalo (Bubalus bubalis) spermatogonia stem cell-like cells in vitro

Ting-Ting Li,Shuang-Shuang Geng,Hui-Yan Xu,Ao-Lin Luo,Peng-Wei Zhao,Huan Yang,Xing-Wei Liang,Yang-Qing Lu,Xiao-Gan Yang,Ke-Huan Lu 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.1

Currently, the systems for culturing buffalo spermatogonial stem cells (SSCs) in vitro are varied, and their effects are still inconclusive. In this study, we compared the effects of culture systems with undefined (foetal bovine serum) and defined (KnockOut Serum Replacement) materials on the in vitro culture of buffalo SSC-like cells. Significantly more DDX4- and UCHL1-positive cells (cultured for 2 days at passage 2) were observed in the defined materials culture system than in the undefined materials system (p < 0.01), and these cells were maintained for a longer period than those in the culture system with undefined materials (10 days vs. 6 days). Furthermore, NANOS2 (p < 0.05), DDX4 (p < 0.01) and UCHL1 (p < 0.05) were expressed at significantly higher levels in the culture system with defined materials than in that with undefined materials. Induction with retinoic acid was used to verify that the cultured cells maintained SSC characteristics, revealing an SCP3+ subset in the cells cultured in the defined materials system. The expression levels of Stra8 (p < 0.05) and Rec8 (p < 0.01) were significantly increased, and the expression levels of ZBTB16 (p < 0.01) and DDX4 (p < 0.05) were significantly decreased. These findings provided a clearer research platform for exploring the mechanism of buffalo SSCs in vitro.

[P3-09] Effect of roasting condition on the chemical composition and oxidative stability of perilla oil

Ting-Ting Zhao,Seung In Hong,In-Hwan Kim 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

Performance of the R-way Colposcopic Evaluation System in Cervical Cancer Screening

Zhao, Jian,Zhang, Xi,Chen, Rui,Zhao, Yu-Qian,Wang, Ting-Ting,He, Shan,Qiao, You-Lin Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Objective: To investigate the diagnostic value of the R-way colposcopic evaluation system (R-way system) in cervical cancer screening. Materials and Methods: Between August 2013 and August 2014, a total of 1,059 cases referred to colposcopy in Peking University First Hospital were studied using both the R-way system and conventional colposcopy. Our study evaluated and compared the diagnostic ability of the two methods in detecting high-grade lesions and cervical cancer (hereinafter called CIN2+). Evaluation indicators including sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), Youden index and the area under the curve (AUC) of the receiver operating characteristic (ROC) were calculated. Results: The R-way system had a slightly lower specificity (94.5%) than conventional colposcopy (96.0%) for CIN2+ detection (P=0.181). However, the sensitivity (77.8%) was significantly higher than with the conventional colposcopic method (46.6%) (${\chi}^2=64.351$, P<0.001). In addition, the AUC of the ROC for CIN2+ detection using the R-way system (0.839) was larger than that with conventional colposcopy (0.731) (Z=4.348, P<0.001). If preliminary result had been drawn from cervical exfoliated cytology before colposcopy referral, combination of the R-way system with cytology could increase the sensitivity to 93.9% for CIN2+ detection (excluding ASCUS\LSIL), confirmed by multipoint biopsy or ECC. Conclusions: The diagnostic value of the R-way evaluation system is higher than that of conventional colposcopic evaluation in cervical cancer screening. Moreover, taking the ease of use and standardized quality control management into account, the R-way system is highly preferable.

Effects of (-)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson's Disease

Ting Ting Zhao,신건성,이명구 한국생약학회 2016 Natural Product Sciences Vol.22 No.4

This study investigated the effects of (-)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson's disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (-)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD: (-)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-D-aspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (-)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (-)-sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.

North Korean Nuclear Issue in Association of Southeast Asian Nations (ASEAN) Diplomacy: A Study Based on PEST-SWOT Analysis

Ting Zhao,Aijiao Liu 한국국회학회 2021 한국과 세계 Vol.3 No.1

Since 1990s, despite the strong opposition of the international community, North Korea has frequently conducted nuclear weapons tests and missile tests, and the DPRK nuclear issue has become an important factor affecting the security and stability of the Asia-Pacific region. As an extremely important multilateral organization in the Asia-Pacific region, ASEAN has gradually increased its influence in the Asia- Pacific region with the advancement of integration in recent years. In order to further enhance its influence and enhance its participation in Asia-Pacific affairs, ASEAN has been trying to give its voice on the Korean nuclear issue. The ASEAN Regional Forum and ASEAN Summit are the most important platforms for ASEAN to express its position and views. Since the North Korean nuclear issue became prominent, the North Korean nuclear issue has been a key topic discussed in the ASEAN Regional Forum and ASEAN Summit. Judging from the conference documents produced by the conferences over the years, ASEAN s attitude towards the Korean nuclear issue is still being fine-tuned. Although the international community has repeatedly issued policies to condemn North Korea and impose economic sanctions, ASEAN is generally neutral and conservative in its attitude towards the DPRK nuclear issue, and it is also very cautious in its actions. Recently, with China and Russia following the United States, they began to impose severe economic sanctions on North Korea, and their words changed to severe condemnation, and ASEAN s attitude towards North Korea also changed subtly. To some extent, the changes of the Korean nuclear issue in ASEAN reflect the constant fine-tuning of ASEAN s foreign policy. This paper aims to find out the fine-tuning of ASEAN s foreign policy and its influence on ASEAN by combing the changes of ASEAN s Korean nuclear issue and the potential reasons behind the changes.