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특발성 맥락막신생혈관병증으로 오진된 시신경유두연접 망막모세혈관종 1예
박태관 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
PURPOSE : To report a case of Retinal capillary hemangioma initially misdiagnosed to idiopathic choroidal neovascularization CASE REPORTS : A 23-year-old female with a 6-month history of decreased vision in the left eye was referred to our hospital on June 17, 2003. A dilated fundus examination of the left eye was revealed a juxtapapillary subretinal lesion with adjacent exudative retinal detachment and retinal folds. A fluorescein angiogram demonstrated early hyperfluorescence and late leakage of the dye. Based on these results, a diagnosis of Idiopathic choroidal neovascularization was made. No treatment was performed. But, a new lesion of capillary hemangioma was found in the fundus examination on April 9,2004. Therefore, we confirmed the juxtapapillary subretinal lesion to a juxtapapillary capillary hemangioma. Medical investigations revealed no systemic involvement. Treatment with laser photocoagulation to the peripheral capillary hemangioma was performed. CONCLUSION : Juxtapapillary capillary hemangioma usually growths exophytically, and an endophytic form of juxtapapillry capillary hemnagioma has not been reported in Korea. However, the endophytic juxtapapillary capillary hemangioma as this case can be misdiagnosed to a choroidal neovascularization.
Telomerase activity in pterygeal and normal conjunctival epithelium
Tae Kwann Park,Kyung Hyun Jin 대한안과학회 2000 Korean Journal of Ophthalmology Vol.14 No.2
All pterygia have similar histologic features of solar degeneration seen in the skin such as acanthosis, keratosis, or hyperkeratosis. Although the pathogenesis of pterygia is still unclear, an association with solar exposure, in particular with UV radiation, has been reported. Telomerase activity has been found to be higher in some degenerative, precancerous, and cancerous skin lesions. We investigated telomerase activity in the epithelium and the stromal tissues of the pterygium. Pterygeal tissues were obtained from 30 patients. Telomerase activity was measured with TRAPeze-ELISA kit. Three of the 28 (10.7%) pterygeal stromal tissues demonstrated positive telomerase activity. Fourteen of the 27(51.9%) epithelial tissues were positive in telomerase activity, whereas telomerase activity was positive in only 3 of 9 normal epithelia (33.3%). Telomerase activity in the pterygium-covered epithelium was increased as compared with that seen in the normal epithelium, but the increase was not statistically significant. In conclusion, telomerase activity was somewhat increased in pterygeal tissues. Telomerase activity may be involved in the pathogenesis of pterygium.
레이저 레인지 센서를 이용한 모바일 로봇의 실내 공간에서의 위치인식 시스템
박종관(Jong-Kwann Park),박태형(Tae-Hyeong Park) 제어로봇시스템학회 2014 제어로봇시스템학회 각 지부별 자료집 Vol.2014 No.11
This paper presents a localization system of mobile robot using LRF(laser range finder) in indoor environment. The system is composed of three main procedures: data pre-processing, laser scan data segmentation, searching target object, and localization. Basic level data organization are used in data pre-processing. Breakpoint detection and edge detection are used for laser scan data segmentation. Breakpoint detection is used to determine sequence of measurements. Edge detection decides edge in segmented measurements. Extended IEPF(Iterative Endpoint Fit) algorithm is that used in the part. Each breakpoint and edge is used for searching three target objects.
Choi, Je-Min,Ahn, Mi-Hyun,Chae, Wook-Jin,Jung, Yung-Gook,Park, Jae-Chul,Song, Hyun-Mi,Kim, Young-Eun,Shin, Jung-Ah,Park, Choon-Sik,Park, Jung-Won,Park, Tae-Kwann,Lee, Jung-Hoon,Seo, Byung-Fhy,Kim, Kyu Nature Publishing Group 2006 Nature medicine Vol.12 No.5
CTLA-4 is a negative regulator of T-cell activation, and its inhibitory effects can be accomplished either by competition with CD28 or by transmitting negative signals through its intracellular domain. To utilize the cytoplasmic domain of CTLA-4 to suppress allergic inflammation, we fused it to a novel protein-transduction domain in the human transcriptional factor Hph-1. Transduction efficiency was verified in vitro and in vivo after ocular, intranasal and intradermal administration. After transduction into T cells, the Hph-1–ctCTLA-4 fusion protein inhibited the production of interleukin (IL)-2, and downregulated CD69 and CD25. Intranasal administration of Hph-1–ctCTLA-4 resulted in markedly reduced infiltration of inflammatory cells, secretion of T helper type 2 (T<SUB>H</SUB>2) cytokines, serum IgE levels and airway hyper-responsiveness in a mouse model of allergic airway inflammation. These results indicated that Hph-1–ctCTLA-4 constitutes an effective immunosuppressive protein drug for potential use in the treatment of allergic asthma, via nasal administration.
Jinu Han(Jinu Han),Kwangsic Joo(Kwangsic Joo),Ungsoo Samuel Kim(Ungsoo Samuel Kim),Se Joon Woo(Se Joon Woo),Eun Kyoung Lee(Eun Kyoung Lee),Joo Yong Lee(Joo Yong Lee),Tae Kwann Park(Tae Kwann Park),San 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.2
Mutations in the RPE65 gene, associated with Leber congenital amaurosis, early-onset severe retinal dystrophy, and retinitispigmentosa, gained growing attention since gene therapy for patients with RPE65-associated retinal dystrophy is available inclinical practice. RPE65 gene accounts for a very small proportion of patients with inherited retinal degeneration, especiallyAsian patients. Because RPE65-associated retinal dystrophy shares common clinical characteristics, such as early-onset severenyctalopia, nystagmus, low vision, and progressive visual field constriction, with retinitis pigmentosa by other geneticmutations, appropriate genetic testing is essential to make a correct diagnosis. Also, fundus abnormalities can be minimal inearly childhood, and the phenotype is highly variable depending on the type of mutations in RPE65-associated retinal dystrophy,which makes a diagnostic difficulty. The aim of this paper is to review the epidemiology of RPE65-associated retinaldystrophy, mutation spectrum, genetic diagnosis, clinical characteristics, and voretigene neparvovec, a gene therapy productfor the treatment of RPE65-related retinal dystrophy.
( Joo Youn Park ),( Woo Ho Nam ),( Seung Hoon Kim ),( Sun Young Jang ),( Young Hoon Ohn ),( Tae Kwann Park ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.4
Purpose: To report on the anatomical and functional changes to the macula in nine patients suffering from commotio retinae not accompanied by any other types of traumatic retinopathy. Methods: Nine injured eyes with commotio retinae were evaluated soon after ocular trauma with ophthalmic examination, including Spectral-domain optical coherence tomography (SD-OCT). In 12 eyes of 6 patients, Humphrey visual field (HVF) and multifocal electroretinogram (mfERG) were performed. Re-examinations were periodically performed for a mean of 26 days. Data from 9 injured eyes were collected and compared to data collected from the 9 non-affected eyes of the same patients. Results: SD-OCT revealed no significant differences in the foveal thickness and total macular volume between traumatized and intact eyes in all 9 patients. Only 3 out of the 9 injured eyes showed abnormal findings in SD-OCT images such as discontinuity of the inner/outer segment (IS/OS) junction or abnormal hyper-reflectivity from the IS/OS and retinal pigment epithelium (RPE) lines in the macula. HVF and mfERG results did not show any functional deterioration in the injured eyes compared with intact eyes. During follow-up, the commotio retinae resolved in all 9 eyes. The changes to the outer retinal region detected in 3 patients by SD-OCT were also resolved. Conclusions: Acute retinal changes in commotio retinae, not associated with other retinal pathologies, were resolved without histological and functional sequelae. In a few cases of commotio retinae, SD-OCT revealed transient abnormalities mainly observed at the IS/OS and RPE complexes.
( Joo Youn Park ),( Seung Hoon Kim ),( Tae Kwann Park ),( Young Hoon Ohn ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.3
Purpose: To evaluate the changes in multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) after intravitreal bevacizumab injection in the treatment of age-related macular degeneration (AMD). Methods: Twenty-one eyes with choroidal neovascularization secondary to AMD were studied before and after intravitreal bevacizumab injection for best corrected visual acuity (BCVA), OCT, and mfERG. Results: The BCVA improved, while central macular thickness and total macular volume in OCT decreased after intravitreal bevacizumab injection (p=0.03, 0.01, and 0.01, respectively). In mfERG, the amplitude of P1, and implicit time of P1 and N1 indicated a statistically significant improvement of retinal response after intravitreal bevacizumab injection. Conclusions: There is a potential role for mfERG in evaluating the effect on retinal function of intravitreal bevacizumab injection.
급성골수구성백혈병에서 재발의 첫 임상증상으로 나타난 시신경유두 침범의 1예
박새미,박성규,박태관,Saemi Park,Seong-Kyu Park,Tae Kwann Park 대한안과학회 2011 대한안과학회지 Vol.52 No.2
Purpose: To present a case of leukemic infiltration of the optic nerve head as the initial manifestation of leukemic relapse. Case summary: A 65-year-old woman was diagnosed with acute myeloid leukemia. Complete remission was achieved after 4 complete courses of chemotherapy. She complained of a sudden decrease in visual acuity in her left eye. Fundus examination showed severe optic disc edema with peripapillary hemorrhage and serous retinal detachment. Visual acuity and fundus continued to aggravate and high-dose intravenous steroid therapy was instituted. Visual acuity and fundus deteriorated more after treatment. Brain magnetic resonance imaging and CSF study were normal but intrathecal chemotherapy and focal irradiation were performed on account of the suspected CNS involvement of leukemia. Morphologic improvement in the retinal structure was achieved, however, optic atrophy remained and her vision did not recover. Conclusions: The present case shows the involvement of the optic nerve head as the initial isolated manifestation for the relapse in a patient with complete remission. CNS involvement is rare in acute myeloid leukemia and in particular, the optic nerve is rarely reported as the initial isolated presentation for the relapse. Moreover, the disease progression relatively aggravated after treatment. In the atypical aspects of leukemic relapse, the present case was noticeable. J Korean Ophthalmol Soc 2011;52(2):250-254