Mongolian Gerbil as a Novel Animal Model for Ligature-induced Periodontitis

Sungil Jang,Eun-Jung Bak 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4

Inflammation from chronic and acute infections of distal organs and tissues such as periodontitis is a risk factor for atherosclerotic vascular processes. Recently, a new model of atherosclerosis with vascular pathologies was developed in the Mongolian gerbil. In this study, we attempted to develop a model of ligature-induced periodontitis in gerbils and compared the characteristics of that periodontitis model with that in rats and mice. Each gerbil, rat, and mouse was randomly assigned to groups of control and periodontitis. A thread was placed around the cervix of the right and left first molars in the mandible with knots placed on the mesial side of each molar. At day 14 after the ligation, the animals were sacrificed and their mandibles were dissected. To measure alveolar bone loss along with inflammation, histopathological and micro-CT analyses were carried out. Gerbils showed tooth characteristics of deeper gingival crevice, longer cusp, longer root trunk and shorter root than those of rats and mice. The increased CEJ-ABC distance in distal and PDL area in furcation was also observed in ligated gerbils. An inflammatory response in the connective tissue under the junctional epithelium was also shown in all the animals. As a result, we confirmed the induction of periodontitis by ligature in the gerbils. We therefore consider the gerbil to be a useful model for investigating relationship between periodontitis and vascular disease in the same animal.

Wogonin inhibits osteoclast formation induced by lipopolysaccharide

Jang, Sungil,Bak, Eun Jung,Kim, Minyoung,Kim, Jin Moon,Chung, Won-Yoon,Cha, Jeong-Heon,Yoo, Yun-Jung John Wiley Sons, Ltd. 2010 Phytotherapy research Vol.24 No.7

<P>To evaluate the inhibitory activity of wogonin against lipopolysaccharide (LPS)-induced bone resorption, we investigated the effect of wogonin on osteoclastogenesis induced by LPS. Wogonin inhibited LPS-induced osteoclastogenesis in co-cultures of mouse calvaria-derived osteoblasts and bone marrow-derived pre-osteoclasts. Wogonin also suppressed osteoclastogenesis in LPS-injected mouse calvaria. In osteoblasts, the upregulation of receptor activator of nuclear factor-&kgr;B (RANKL) expression and the downregulation of osteoprotegerin (OPG) expression by LPS were inhibited by wogonin. Wogonin and NS-398, a COX-2 inhibitor, suppressed LPS-stimulated PGE<SUB>2</SUB> production in osteoblasts. NS-398 inhibited the effect of LPS on RANKL and OPG expression in osteoblasts. These results suggest that wogonin acts as an inhibitor of LPS-induced osteoclastogenesis through downregulation of RANKL and upregulation of OPG expression via blockage of PGE<SUB>2</SUB> production. Based on these results, wogonin has potential for use as a therapeutic agent in bacteria-induced bone resorption. Copyright © 2009 John Wiley & Sons, Ltd.</P>

동역학 시스템을 위한 DNN 메타모델 기반의 시스템 보정 네트워크

장성일(Sungil Jang),최주환(Juhwan Choi),한성지(Seongji Han),김진균(Jin-Gyun Kim),최진환(Jin Hwan Choi) 대한기계학회 2023 대한기계학회 춘추학술대회 Vol.2023 No.11

Modeling and simulation of dynamic systems are widely used in mechanical system design and control. System identification, a process of correlation with experimental data or target data, is essential for the reliability of the implemented model. The process is possible when the relationship between various variables that affect the responses of the system can be understood. Since various assumptions and approximations are considered in the modeling process of a nonlinear system such as a multibody dynamics system, it is difficult to directly understand the relationship between variables. Therefore, a surrogate model is needed to understand the system. In this study, we propose a system identification framework using deep neural networks. This framework consists of two processes: System metamodel and System identification network. System metamodel that is trained by the nonlinear relationship between the changing output responses to the input variables of the system using a deep neural network is introduced. The data required for training the neural network is obtained from the numerical model of the system. The loss minimization process for initializing a new neural network, which is a system identification network to find an input that produces a target output is proceeded.

미국 국가안보 제도의 기원: 국가안전보장회의(NSC) 창설 과정에서 관료 조직 간 정치

장성일(Sungil Jang) 고려대학교 평화와민주주의연구소 2021 평화연구 Vol.29 No.1

본 연구는 국가안전보장법이 정한 최상위 국가안보 자문 기구이자 미국 국가안보 정책결정 제도의 핵심인 국가안전보장회의(NSC)의 기원을 분석한다. NSC는 미국 역사상 처음으로 외교정책과 군사정책을 통합하여 대통령에게 직접 자문하는 상설 조직이라는 점에서 미국 외교정책결정 제도를 이해하는 데 중요하지만 그 기원에 대한 연구는 충분히 이루어지지 않았다. NSC는 국가안보 정책의 효율성을 위한 노력의 결과라기보다 군부처 통합 논의를 둘러싼 대통령, 육군부 및 해군부 관료 조직 간 정치의 부산물이었다. 통합적인 국가안보 정책을 둘러싼 관료 조직 간 정치는 국무부 · 전쟁부 · 해군부 조정위원회(삼부조정위원회)까지 거슬러 올라간다. 따라서 본 연구는 NSC의 전신인 삼부조정위원회의 설치부터 국가안전보장법의 제정으로 NSC가 탄생한 1947년까지 관료 조직 간 정치에 주목하여 NSC의 기원을 분석한다. This paper examines the origin of the current U.S. national security institutions, focusing on the creation of the National Security Council. As a cabinet-level advisory coordination institution, the Council’s role is “to advise the President concerning the integration of domestic, foreign, and military policies relating to the national security.” The Council, which has been the cornerstone of the U.S. national security institutions to this date, was a by-product of the politics among the President, the Department of the Army, and the Department of the Navy over the unification plan of the two departments. To analyze the Council’s origin, I trace the evolution of the U.S. national security institutions from the establishment of the State-War-Navy Coordinating Committee to the creation of the Council. Though the Committee did not have any legal ground, it had paved the way for national security policy coordination between relevant departments.

외교정책 연구에서 ‘정책결정(Decision-making)’ 관점 재조명: 1967년 티란 해협 수송로 안보 위기 시 미국의 무대응 분석

장성일(Sungil Jang) 한국국제정치학회 2020 국제정치논총 Vol.60 No.2

This article aims to reassess the ‘Decision-making’ approach in foreign policy studies articulated by Snyder, Bruck, and Sapin in their seminal book in 1954. It also aims to analyze the U.S. inaction in the Straits of Tiran Crisis with the approach. Contrary to IR theories that assume a nation-state as a unitary analytical unit, the decision-making approach focuses on the activities of human decision-makers in explaining the nation’s external behavior. The approach has contributed to the development of subsequent foreign policy theories, such as the bureaucratic politics model. The decision-making approach has values as the approach makes it possible to investigate how international systemic variables and domestic variables, affect a nation’s foreign policy behaviors. Moreover, the approach is also contributing to uncovering underlying foreign policy decisions and implementations in ‘non-event’ cases. This article applies the decision-making approach to the U.S. inaction in the Straits of Tiran Crisis before the Six-Day War and uncovers decisions and implementations of policy-makers in responding to the crisis. By focusing on the decision-making process, researchers can find empirical evidence on the factors that have contributed to the U.S. inaction in the face of the crisis.

생활밀착형 작은도서관 - 스마트도서관

장성일 ( Sungil Jang ) 한국디지틀도서관포럼 2016 디지틀 도서관 Vol.83 No.-

Recently, the government and local administrations have opened new libraries, built small libraries, and supported a variety of policies such as e-book system, inter-library loan, and online book service. The current policies earn positive responses from their citizens. Nevertheless, the reality is that the reading rate is getting on the decline in Korea. It is critical to build up the circumstances under which people are easily exposed to books in daily routines. Book rental system in public places, for example, subway stations, bus stops, and shopping malls, will make reading rate higher through enhancing people to borrow and read books in convenient ways. This study aims at investigating smart library as an automatic system of unmanned library which can be run in terms of low-cost and high-efficient management. Moreover, potential readers have easy accesses to smart library in terms of both loan and return of books.

아세안 경제통합의 진행상황 평가와 한국의 대응 방향: TBT와 SPS를 중심으로

곽성일 ( Sungil Kwak ),신민금 ( Mingeum Shin ),김제국 ( Jegook Kim ),장용준 ( Yong Joon Jang ),최보영 ( Bo-young Choi ) 대외경제정책연구원 2023 연구보고서 Vol.2023 No.-

고출력 형광체변환 백색 LED 패키지의 가속시험

천성일(SungIl Chan),윤양기(YangGi Yu),장중순(JoongSoon Jang) 한국신뢰성학회 2010 신뢰성응용연구 Vol.10 No.2

This study deals with the accelerated life test of high power phosphor converted white Light Emitting Diodes (High power LEDs). Samples were aged at 110 ℃/85% RH and 130℃/85% RH up to 900 hours under non-biased condition. The stress induced a luminous flux decay on LEDs in all the conditions. Aged devices exhibited modification of package silicon color from white to yellowish brown. The instability of the package contributes to the overall degradation of optical lens and structural degradations such asgenerating bubbles. The degradation mechanisms of lumen decay and reduction of spectrum intensity were ascribed to hygro-mechanical stress which results in package instabilities.

지방 공공부문 분류체계 개선을 위한 탐색적 연구

장석준(Jang, Seokjun),윤성일(Yoon, Sungil) 서울행정학회 2018 한국사회와 행정연구 Vol.29 No.2

행정환경의 급속한 변화와 새로운 행정수요의 지속적 증가에 대응하여 전통적인 정부조직 밖에서 공공 서비스기능을 수행하는 준정부(Quasi-government)를 중심의 공공부문이 전세계적으로 확장되고 있다. 우리나라도 본격적인 지방자치 부활 이후 지방 공공부문 내지 지방 공공기관의 규모와 비중이 지속적으로 확대되어 왔다. 그러나 지방 공공부문을 규율하는 이원적인 법률 체계는 지방 공공부문을 이해하고 관리하는데 있어 명확한 법적 개념과 체계가 부족한 측면이 있다. 따라서 본 연구는 공공부문의 분류의 이론적 논의와 선진국의 실제 공공부문 분류체계에 대한 탐색을 토대로 우리나라 지방 준공공부문 분류 체계 개선을 위한 합리적 수준의 대안을 제안하는데 초점을 두고 있다. 기존의 지방 공공부문 개념과 분류체계에 관한 선행연구를 바탕으로 지방 준공공부문 분류 체계 개선을 위한 두 가지 대안을 제시하였다. 첫째, 지방 공공기관의 법적개념을 도입하여 현행 지방공기업법과 지방출자・출연법을 통합적으로 규율하여 (가칭)지방공공기관에 관한 법률을 제정하고, 지방직영기업은 별도의 (가칭)지방직영기업법을 제정하는 대안이다. 둘째, 현행 지방공기업법과 지방출자・출연법을 통합적으로 규율하여 (가칭)지방공공기관에 관한 법률을 제정하고, 지방직영기업은 지방책임운영기관 형태로 전환하여 별도의 (가칭)지방책임운영기관에 관한 기본법을 제정하여 관리하는 대안이다. In response to the rapid change in administrative environment and the continuing increase in new administrative demand worldwide, the public sector, mainly the quasi-government, which carries out public service functions outside traditional government organizations, has been expanded. Since the implementation of full-fledged local autonomy in South Korea, the size and the weight of the local sector or local public agencies has continuously expanded. However, due to a dual legal system that regulates the local public sector, there are aspects that are insufficient to understand and manage the local public sector. Therefore, in this research, based on the theoretical discussion of classification of the public sector and the analysis of the actual public sector classification system of developed countries, we proposed alternative to improve the classification system of the local public sector. Based on previous studies on existing concepts and classification system of local public sector, this research presented the following two alternatives for improvement of the local public sector classification system.

Operation Command에 따른 스마트 TV 입력방식 연구

조성일(Sungil Cho),홍사윤(Sayoon Hong),홍지영(Jiyoung Hong),양경인(Kyungin Yang),장구앙(Jay Jang),최진해(Jinhae Choi) 한국HCI학회 2012 한국HCI학회 학술대회 Vol.2012 No.1

스마트 TV 는 풍부한 컨텐츠의 소비, 다양한 서비스를 구현해야 하기 때문에 기존 TV 에서 사용되었던 버튼 입력방식만으로는 풍부한 사용자경험을 충족할 수 없다. 이에 본 연구에서는 스마트 TV 사용에 있어 Operation Command 별로 적절한 입력방식이 존재할 것이라는 가설 하에 사용자 Core Control Scene 을 정의하고 실험을 통하여 검증함으로써 사용자 중심의 스마트 TV 입력방식을 제안하였다. 연구 결과 순간적인 일회성 Command 에 해당하는 전원, 취소, 메뉴실행, 순간저장과 예외적인 성격을 갖는 볼륨은 버튼 입력방식이 사용이 편리한 것으로 검증되었으며 연속성 Command 에 해당하는 스크롤, 채널, 줌, 지정, 입력은 제스쳐 입력방식이 편리한 것으로 검증되었다. 본 연구를 통한 결과물은 인터랙티브한 스마트 TV 에 활용되어 사용자에게 최적화된 입력장치로 활용 될 수 있을 것이다. Conventional button input method for TV that has been used for many years is not able to provide abundant user experience since Smart TV requires use of various contents and services. Hence, this study is postulated on that appropriate input method exists for each operation command for Smart TV and suggests user centered Smart TV input method by defining and experimenting Core Control Scenes. As a result of the experiment, button input is proved to be convenient for onetime commands including power on/off, cancel, menu, capture and volume up/down whereas gesture input is proved to be convenient for continual commands such as scroll, channel, zoom, pointing and writing/drawing. Findings from this study can be applied to interactive Smart TV along with optimized input method.