Chitinase를 생산하는 Pseudomonas sp. YS-542의 분리 및 특성

강신욱,이준우,방광웅,최희상 慶北專門大學(영주경상전문대학) 2002 慶北專門大學 論文集 Vol.21 No.-

A chitinase-producing bacterium was isolated from soil by selective enrichmentment culture medium. The bacterium was identified as Pseudomonas sp. based on the data obtained from its morphological, cultural and biochemical characteristics. The isolated strain was named Pseudomonas sp. YS-542. The medium for the production of chitinase was consisted of colloidal chitin 1.0%, tryptone 1.0%, MgS04·7H2O 0.2%, K2HP04 0.1%. The optimum cultural temperature, initial pH and time for the best production of chitinase were 25℃, 48hrs and pH 8.0, respectively.

地域産業振興政策을 위한 分析의 틀(Framework)에 관한 硏究 : 日本의 事例硏究와, Nutt와 Backoff의 第3섹터에 관한 管理戰略을 中心으로

康榮勳,金性俊 濟州大學校 法과 政策硏究所 1997 法과 政策 Vol.- No.3

우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

SCM420 기어의 表面處理 效果에 關한 硏究

姜昌鎬,李鎭伊,柳晟基,朴俊哲 慶尙大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.15 No.-

This study deals with effects of surface treatment on the bending fatigue strength of SCM420 spur gears. We manufactured gears using manufacture processes that are currently used in most gears manufacturing companies, we applied heat-treatment, and then we applied shot peening. In addition, we investigated the effect these surface-treatments had on hardened layer and compression residual stress in the risk section of the teeth. The fatigue test at a constant stress amplitude is performed by using an electrohydraulic serve-controlled pulsating tester. The S-N curves are obtained and illustrated. We investigated the effect of surface-treatment on fatigue strength and the position of crack of gear teeth.

스포츠 인문분야 정보화를 위한 교육 방안

강준상 남서울대학교 2005 남서울대학교 논문집 Vol.11 No.2

The objects of this study are investigating the important educating points and systematic step of education in e-business time. I examined the most important parts and priority of education in the curriculum of management information, management science, and management information of the business administration department. As a result, electronic business transactions, construction of global database, management system, and system environment by prototyping method are considered the most suitable information of management industry. The education of informed sports industry management is important in the meaning of hardware as well as software. So I suggest the following staged education methods. First, systematic establishment of structural base in the information-oriented sports management Second, understanding of tool for the information-oriented sports management Third, education that is related with the application of basic program which is most commonly usee in computer system Fourth, application of package program that is based in global database Fifth, development of basic software Sixth, organization of contents that is used the developed software in internet All the while education of sports management information is concentrated to equipment, sports products, hardware, so competitive power of software was low For the continuous development of sports management information, insurance of consumer relationship management(CRM) that include win-win-win strategy as well as development of hardware should be used.

중독한 추체로 증상을 보인 cyclosporine에 의한 뇌증 1예

강정현,곽승근,신현영,김성은,이정호,이정찬,곽상혁,윤환중,조덕연,김삼용,김제,송창준 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

The use of cyclosporine(CsA), a potent immunosuppressive agent, is associated with numerous side effects. Neurotoxicity was earlier less well known, but with growing experience central nervous system side effects are now reported up to 40% of patients. Among various CsA-induced neurotoxicities, tremor is most common and posterior leukoencephalopathy is well characterized. An encephalopathy presenting with pyramidal weakness, however, seems to be rare and poorly documented. We report here a case of encephalopathy presenting with multiple generalized seizures followed by fluctuating quadriparesis developed a few days after starting CsA and resolved spontaneously after withdrawal of the drug . A 48-year-old woman with aplastic anemia was placed upon immmunosuppressive treatment consisting of antithymocyte globulin(ATG), CsA, and methylprednisolone. Two days after starting the therapy, she developed a generalized seizure. The next day she developed 2 more episodes of seizure and the therapy was stopped. Computed tomogram of the brain was normal. Six days after starting therapy, she developed mild motor weakness and paresthesia of both lower extremities, which progressed to a definite quariparesis confining her to a bed in 3 days. Magnetic resonance imaging(MRI) of the brain revealed asymmetric, bilateral high-signal abnormalites in the subcortical white matter of fronto-temporal areas. After reaching to a maximum with some fluactuation(14 days after starting the therapy) the motor weakness started to be resolved. She was discharged with a almost complete resolution of the weakness 45 days after starting the therapy. Five months later she did well and brain MRI was negative.

골반경수술의 임상적 고찰

강민창,조혜진,최상준,한세준,정혁 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Objective: Pelviscopic surgery has been used in the treatment of some gynecologic disease. And now, it is applied in almost all cases of gynecologic disease. This study is performed to evaluate the clinical advantages of pelviscopic surgery and current circumstance of ORGY of chosun university hospital. Methods: From March, 2000 to February 2003, total 437 cases were received laparoscopic surgery on department of ORGY of Chosun University hospital. We reviewed the chart and analyzed these cases according to age, parity, clinical indication, operation type, duration of hospitalization, operation time and complication. Results: The results are summarized as follows, The mean age of patients was 42.5 years old with ranges between 15 and 61 years old and mean parity of the patients was 1.95. The common indications were uterine myoma (45.1%) , ovarian tumor (15.3%) and ectopic pregnancy (7.3%) and frequent types of surgery were laparoscopic assisted vaginal hysterectomy (LAVH) (46.9%) , salpingectomy (8.5%), oophorectomy (8.5%). The operation time was variable according to types of operation and difficulty and the mean duration of hospitalization was 4.27 days. The most frequent complication was hemorrhage at the trocar site. Conclusion: Pelviscopic surgery is useful and recommended for the treatment of gynecologic disease, because this is safe and has many advantages. So, we expect the number and indication of pelviscopic surgery will be increased in future. 목적 : 진단목적으로 시행되어오던 골반경 수술이 부인과 질환의 거의 모든 영역에서 적용되어있다. 이에 골반경 수술의 임상적 이점에 대해 알아보고자 본 연구를 시행하였다. 연구방법 : 2000년 3월부터 2003년 2월가지 조선대학교 병원 산부인과에서 골반경 수술을 시행 받은 437명의 외래 및 입원기록을 검토하여 환자의 연령, 출산력, 골반경수술의 적응증, 수술종류 및 시간, 입원기간, 합병증을 분석하였다. 결과 : 2000년 3월부터 2003년 2월까지 시행한 437예의 골반경수술을 분석하여 다음과 같은 결과를 얻었다. 환자들의 평균연령분포는 15세에서 61세 사이였고 평균 연령은 42.5세이었다. 평균 출산력은 1.95회이었다. 골반경 수술은 LAVH가 205예 (46.9%) 로 가장 많았고, 난관 절제술이 37예 (8.5%), 난소 적출술이 35예 (8.%), 난소부분절제술이 28예(6.4%) 이었다. 골반경 수술의 적응증은 자궁외 임신이 43예(86%), 자궁근종이 197예(61.2%), 난소종양이 82예(52.6%) 이었다. 수술시간은 수술의 종류 및 난이도에 따라 다양하였다. LAVH의 경우 평균 38.2분, 난소난관 절제술의 경우 평균 31.9분, 난관 절제술의 경우 평균 30.7분이 소요 되었다. 평균 실혈량은 LAVH가 1.16g/dl, 난관절제술은 0.94g/dl, 난소난관 절제술의 경우는 0.97g/dl이었다. 입원기간은 대부분 1일에서 5일 사이였으며, 평균 4.27일 이었다. 가장 많은 합병증은 트로카 천공부위 출혈이었다. 결론 : 본 연구의 결과로 골반경 수술은 현재 부인과 질환의 진단과 치료에 있어서 매우 유용하며 개복 수술을 대치하는 상황으로 나아가고 있다.

2007년 대한감염학회 권장 성인 예방접종 권장안

강진한,김홍빈,손장욱,이상오,정문현,정희진,최영화,최정현,최준용,최희정 대한감염학회 2008 감염과 화학요법 Vol.40 No.1

In 2007, the Korean Society of Infectious Diseases recommended an immunization schedule for adults residing in Korea. This recommendation includes four categories: standard immunization for healthy persons, supplementary immunization for persons with underlying illnesses, recommendations for health-care personnel and for international travelers. The Standard Immunization Schedule consists of universal vaccination (tetanus-diphtheria/tetanus-diphtheria-pertussis (Td/Tdap); hepatitis A vaccine for persons aged 20s; human papilloma virus vaccine for women under 26 years old; meningococcal vaccine for military recruits and college students in dormitories; influenza vaccination for persons aged 50 years or more and pregnant women; and pneumococcal vaccination for persons aged 65 years or more) and catch-up vaccination (hepatitis A vaccine for persons aged 30s; hepatitis B vaccine, varicella and MMR vaccines for persons who have uncertain specific immunities). The Supplementary Immunization Schedule recommends 4 vaccines, i.e., pneumococcal, influenza, meningococcal, and Haemophilus influenzae type b, appropriate to the underlying illnesses, and confirmation of the presence of antibodies to hepatitis A and hepatitis B. The Recommendation for Health-Care Personnel includes universal vaccination (influenza and pertussis) and catch-up vaccination (hepatitis B, measles-mumps-rubella and varicella for seronegative health-care personnel). The Recommended Immunization for International Travelers focuses reinforcement of vaccinations for healthy persons and includes certain immunizations necessary for international travel (yellow fever, meningococcal, plaque, tick-borne encephalitis, and cholera). These guidelines can be seen at www.ksid.or.kr.

태풍 Vera 통과시 남해에서의 파랑추정

전기천,강시환,박광순,김상익 경남대학교 환경문제연구소 1990 환경연구 Vol.12 No.-

최근 한반도를 통과했던 태풍 중 그 규모가 커서 海上에서 발생된 颱風波浪에 의해 특히 남해안 지역에 큰 재해를 준 1986년 태풍 Vera(8613)호 통과시에 南海의 거문도와 거제도 海上에서 동시에 태풍파랑을 관측하였다. 관측된 태풍파랑의 재현을 위하여 유럽의 북해를 대상으로 최근 연구개발된 Hybrid Parametric Wave Model(HYPA)을 적용하여 Vera 통과시의 파랑분포를 수치적으로 계산하였으며, 그 계산결과를 관측치와 비교하였다. 또한 태풍파랑의 추정에 주로 사용되어온 Wilson모델의 결과와도 비교하여으며, HYPA모델의 결과가 Wilson모델에 비해 훨씬 관측된 파랑자료에 근접함을 보였다. 따라서 본 연구를 통해서 한반도 근해상에서 발생되는 태풍파랑의 예측과 추정에 있어 HYPA모델에 매우 정확함을 보여주었다. During the passage of Typhoon Vera(8613) which causes the heavy natural disasters, especially, on the southern coast of Korea, waves were simultaneously measured at two different locations of the South Sea, that is, near to the Geomun and the Geoje Islands. In order to reproduce the measured typhoen-waves, Hybrid Parameteric Wave Model(HYPA) which has been developed for the North Sea was adopted to calculate numerically the waves generated by the Typhoon Vera. The model results were jilter-compared with the measured waves, and also with the results of Wilson model which has been widely used for the hindcast of typhoon-waves. HYPA's results show in the closer ageement with the measured waves than those of Wilson's. Based on these comparisons, HYPA model can be used for more accurate forecast and hindcast of typhoon-waves in Korean Seas.