백금과 이리듐을 첨가한 zeolite촉매를 사용한 린번엔진으로부터의 질소산화물 제거

배재호,서해근,신병선,정석진 慶熙大學校 材料科學技術硏究所 1998 材料科學技術硏究論集 Vol.11 No.-

Under lean burn condition region, main hazard exhaust components are NOx and abundant hydrocarbons. Therefore, NOx abatement using hydrocarbon reductant was most desirable. During last twenty years, NO direct decomposition reaction by Cu-ZSM-5 was suggested with strong possibilities. However, at actual engine exhaust condition(i.e. hydrothermal atmosphere) that wasn't work its own function. In this paper, we tried in order to overcome these disadvantages, other precious metal, especially Pt, Ir, Rh ion exchanged zeolite catalysts were used for lean deNOx catalysis.

Hepatoblastoma

Suk-Bae Moon,Hyun-Baek Shin,Jeong-Meen Seo,Suk-Koo Lee 대한외과학회 2011 Annals of Surgical Treatment and Research(ASRT) Vol.81 No.2

Purpose: Hepatoblastoma is the most common malignant liver tumor in children. The aim of this study was to review our results of hepatoblastoma treatment and to determine the role of surgical treatment in hepatoblastoma. Methods: This is a retrospective clinical study. The medical records of patients with hepatoblastoma, treated between October 1994 and October 2009, were reviewed. The patients were classified according to the pretreatment extent of disease (PRETEXT) grouping system. The main outcome variable was survival. Secondary outcome variables were complete, partial and no response to chemotherapy and surgery, when indicated. Results: Twenty-seven patients were treated during the observation period. Eighteen were males. Five were PRETEXT group I, 8 group II, 13 group III and 1 group IV. Complete excision was achieved in all patients except in one case that underwent liver transplantation (group IV). Median follow-up and survival rate were 2.3 years and 100%, 6.6 years and 75%, 5.8 years and 92%, 7.7 years and 100%, for groups I to IV, respectively. Twenty patients are currently considered to be in complete response status and three patients are receiving postoperative chemotherapy. Four patients died; the causes of death were cytomegalovirus hepatitis, bone marrow suppression during adjuvant chemotherapy, primarynonfunction after the transplantation for recurrent tumor and metachronous rectal cancer, respectively. Conclusion: Favorable long-term outcome could be expected for hepatoblastoma with complete tumor excision and adjuvant chemotherapy.

육계에서 조직과 혈액의 enrofloxacin 및 대사성 ciprofloxacin 잔류 상관관계 조사 및 검사방법간의 비교

성명숙 ( Myung Suk Sung ),김미숙 ( Mi Suk Kim ),서희진 ( Hee Jin Seo ),배동록 ( Dong Rok Bae ),황지영 ( Ji Young Hwang ),김순태 ( Soon Tae Kim ),조종숙 ( Jong Suk Cho ),박홍제 ( Hong Je Park ),홍성희 ( Sung Hee Hong ),김경동 ( Gyu 한국동물위생학회 2013 韓國家畜衛生學會誌 Vol.36 No.4

The purpose of this study was to evaluate detecting methods and the relationship between tissues and blood for enrofloxacin and metabolic ciprofloxacin residues in broiler chickens. Two groups of broiler chickens were administrated via the drinking water with 50 μg/mL and 100 μg/mL of enrofloxacin for 5 days, respectively. The concentration of enrofloxacin and metabolic ciprofloxacin in tissues (muscle and kidney) and blood were measured during administration period (for 5 days) and withdrawal period (for 12 days) by high performance liquid chromatography (HPLC) method. Also, all samples were conducted for screening of residues by microbial method using E. coli for quinolone detection and immuno- chromatography method using Smart kit. The relationship between tissues (muscle and kidney) and blood for enrofloxacin and metabolic ciprofloxacin residues in broiler chickens was followed : The levels of enrofloxacin and metabolic ciprofloxacin residues in muscle and kidney were higher 2.9∼3.2 folds, 3.6∼3.8 folds more than the residues levels in blood, respectively. These results support we can predict the residues in muscle and kidney from the residues in blood. In comparison of detecting methods for antibiotic residues, microbial method using E. coli for quinolone detection and immuno-chromatography method using Smart kit could detect positive reaction at similar or lower concentration than violative concentration of enrofloxacin and metabolic ciprofloxacin in chicken tissues. These results support what two screening methods are useful for screening of quinolone detection in chickens.

Survey on Resident Education for Surgical Dermatology in South Korea

Jo Seong Jin,Lee Hyun Mo,Rho Nark-Kyoung,Kim Min Sung,Ryu Hwa Jung,Kim Hoon-Soo,Park Byung Cheol,Roh Mi Ryung,Seo Suk Bae,Kim Hyojin,Seo Young-Joon,Li Kapsok,Huh Chang Hun,Song Ki Hoon,Seo Kyle K.,Seo 대한피부과학회 2024 Annals of Dermatology Vol.36 No.3

Background: With the increasing demand for surgical procedures in dermatology, resident education in surgical dermatology has become important for delivering high-quality treatment. However, it remains unclear if a sufficient number of residency programs with quality standards exist, as there has been little research on this subject in South Korea. Objective: To identif y the status of surgical dermatology education among residents and assess dermatologists’ perceptions of the subject. Methods: A 35-question sur vey was developed and distributed to all resident training hospitals and local clinics listed by the Korean Society of Dermatologic Surger y. Only third- and fourth- year residents were included and board-certified specialists from training hospitals and local clinics responded to the sur veys. Results: Sur vey participants included 88 residents and 120 specialists of whom one-quarter of the residents attended regular monthly educational sessions. Most residents (93%) participated in cosmetic procedures, and many performed laser therapy. However, the opportunity for toxin or filler injection was rare, with only 12% of the residents having experience with filler injec- tions. In response, 49% of residents and 32% of specialists said that more cosmetic training was required, whereas 28% of residents and 50% of specialists said that more training for both cosmetic and conventional surgeries was necessar y. Conclusion: The sur vey demonstrated a need for more training programs in surgical dermatol- ogy during residency and a perception gap between residents and specialists. Therefore, devel- oping educational residency programs that focus on basic dermatologic surger y principles and their applications in cosmetic procedures is essential.

일측 폐이식 성견에서 혈역학과 체액조절 호르몬의 상관관계

서강석,박창권,송대규,배재훈,박원균 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1

폐이식에 의한 체액이나 혈압의 변동 및 신경의 절단은 혈압 및 체액의 조절에 관여하는 호르몬의 분비에 영향을 미치리라 생각되어 좌일측 폐이식 시 이식폐에 분포하는 신경이 절단된 상태에서 폐이식 후 수용견의 혈역학적 변동이 ANP 및 ADH의 분비와 어떠한 상관관계가 있는지를 관찰하였다. 한국산 성견 12마리를 대상으로 좌일측 폐이식을 시행하였다. 공여폐의 보존은 low potassium dextrane glucose용액을 이용하여 10℃에서 20시간동안 보존한 다음 수용견에 이식하였다. 수용견의 좌측 폐를 적출하기 전과 후, 그리고 이식 후 재관류 30분, 2시간 후에 각각 혈역학 및 동맥혈 가스분압을 측정하였고, 동맥혈에서 ANP 및 ADH의 농도를 측정하였다. 동맥혈의 P_(O_2) 및 P_(CO_2)는 유의한 변동은 없었다. 대퇴동맥압을 재관류 후 30분에는 유의하게 감소하였고, 재관류 2시간 후에는 다소 회복세를 보이는 경향이었으며, 맥압은 비교적 유지되었다. 폐동맥압은 좌측폐 절제 시 이완기 폐동맥압은 변동이 없는 반면에 수축기 폐동맥압은 증가하였고, 재관류 시 폐동맥압은 어느 정도 회복되는 양상이었다. 심박출량은 좌측 폐절제 후에는 감소하였으며 재관류후에도 낮게 유지되는 양상이었다. 반면에 심박수는 유의한 변화없이 유지되었다. 전신혈관저항 및 폐혈관저항은 좌측 폐절제 후나 재관류 30분에 증가하였으며, 재관류 2시간 후 폐혈관저항은 회복되는 양상이나 전신혈관저항은 회복되지 못하였다. 혈중 ANP는 일측 폐절제 후 증가하였고, 재관류 후에는 점차 회복되는 양상을 보였고, ADH는 일측 폐절제 후, 30분에 증가한 후 회복되는 양상을 보였다. 동맥혈 ANP의 변동은 동맥혈 P_(O_2)및 P_(CO_2)와 상관관계를 보였고, ADH는 전신 동맥압의 변동과 상관관계가 있었다. 이상의 결과로 좌일측 폐이식 시에도 ANP 및 ADH는 혈역학적 변화와 연관하여 동맥압 및 체액의 조절에 생리적으로 관여하는 것으로 사료되며, ANP의 분비는 동맥혈의 저산소증 그리고 ADH의 분비는 동맥의 압수용기를 통한 신경성 조절의 영향을 받을 수 있는 것으로 생각된다. The purpose of this investigation was to study changes of plasma atrial natriuretic peptide (ANP) and antidiuretic hormone (ADH) in Korean mongrel dogs after a left single lung transplantation and to evaluate the correlation between hemodynamic factors and secretory responses of ANP and ADH. Arterial P_(O_2 and P_(CO_2) did not change significantly. Femoral arterial pressure decreased after 30 min of reperfusion and recovered slightly at 120 min, whereas pulse pressure did not change. After pneumonectomy, systolic pulmonary arterial pressure increased, whereas diastolic pulmonary pressure remained unchanged. Althought cardiac output fell following pneumonectomy and reperfusion, heart rate was unchanged. The secretion of plasma ANP initially increased follwoing pneumonectomy, but subsequently recoverd. In each subject, ANP values showed stronger correlation with arterial P_(O_2) than other hemodynamic parameters. The secretion of plasma ADH also initially increased (p<0.05) after 30 min of reperfusion and thereafter recoverd, showing the strongest correlation with mean femoral arterial pressure. The present results suggest that the secretion of ANP and ADH seem to be well regulated in accordance with hemodynamic changes after a single lung transplantation. Hypoxia and systemic arterial pressure are the prominent factors in the secretion of ANP and ADH, respectively.

REACTION KINETICS OF SILICON ETCHING IN HF - K2Cr2O7 - H2O SOLUTION

Seo, Young Hun,Nahm, Kee Suk,Hahn, Yoon Bong,Kim, Chong Bae 한국화학공학회 1994 Korean Journal of Chemical Engineering Vol.11 No.2

The reaction kinetics of silicon etching in HF-K₂Cr₂O-H₂O solution was studied experimentally. The etch rates were measured with varying HF and K₂Cr₂O_7 concentrations, agitation speed, reaction temperature and time. The etch rates of n- and p-Si (100) were both similar. The etched surfaces consisted mainly of silicon and showed a relatively smooth and planar morphology. At sufficiently high HF concentration, the etch rate was increased with increasing K₂Cr₂O_7 concentration due to the increase of hole formation on the silicon surface. However, at low HF concentration, the etch rate maintains low value and increases very slowly because of insufficient hole concentration for etching reaction. The apparent activation energy was about 7.8 ㎉/g-mole, and the rate equation for the silicon etching reaction in HF-K₂Cr₂O_7-H₂O solution was obtained as -r_(si) = 600 exp(-3900/T) C_(K₂Cr₂O_7)^(0.5) C_(HF)³ at HF concentrations greater than 8 M.

Inhibition of MMP-2 and MMP-9 Activities by Limonium tetragonum Extract

Bae, Min-Joo,Karadeniz, Fatih,Lee, Seul-Gi,Seo, Youngwan,Kong, Chang-Suk The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.1

Matrix metalloproteinases (MMPs) are crucial extracellular matrices degrading enzymes that take important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. Natural products are on the rise for their potential to provide remarkable health benefits. In this context, halophytes have been of interest in the nutraceutical field with reported instances of isolation of bioactive compounds. In this study, Limonium tetragonum, an edible halophyte, was studied for its ability to inhibit MMP-2 and -9 using HT1080 fibrosarcoma cells. Results showed that L. tetragonum extract was able to inhibit the enzymatic activity and mRNA expression of MMP-2 and -9 according to gelatin zymography and RT-PCR assays, respectively, but it was not able to significantly change the MMP pathway related factors such as tissue inhibitors of metalloproteinases. Also, Mitogen-activated protein kinases pathway-related protein levels and their phosphorylation were assayed. While the phosphorylated p38 levels were decreased, extracellular signal-regulated kinase and c-Jun N-terminal kinase were not affected by L. tetragonum treatment. In conclusion, it was suggested that L. tetragonum contains substances acting as MMP inhibitors on enzymatic activity rather than intracellular pathway intervention, which could be useful for further utilization of L. tetragonum as a source for anti-MMP agents.

Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of PPAR Expression

Seo, Jong Bae,Lee, Yoon Suk,Kim, Woo Sik,Kim, Jae Bum 이화여자대학교 세포신호전달연구센터 2004 고사리 세포신호전달 심포지움 Vol. No.6

Liver X receptors(LXRs) are nuclear hormone receptors that regulate cholesterol and fatty acid metabolism in liver and macrophages. Although LXR activation enhances lipogenesis, it is not well understood whether LXRs are involved in adipocyte differentiation. We demonstrated that LXR activation stimulated execution of adipogenesis, as determined by lipid droplet accumulation and adipocyte-specific gene expression in vivo and in vitro. In adipocytes, LXR activation with T0901317 primarily enhanced the expression of lipogenic genes such as ADD1/SREBP1c and FAS, and substantially increased the expression of adipocyte-specific genes, PPAR and aP2. Administration of the LXR agonist, T0901317, to lean mice promoted expression of most lipogenic and adipogenic genes in fat and liver tissues. It is of interest to note that PPAR is a novel target gene of LXR since PPAR promoter contains the conserved binding site of LXR and was transactivated by expression of LXR. Moreover, activated LXR exhibited increase of DNA binding activity to its target gene promoters such as ADD1/SREBP1c and PPAR, which appeared to be closely associated with hyperacetylation of histone H3 in the promoter regions of those genes. Furthermore, suppression of LXR by small interfering RNA(siRNA) attenuated adipocyte differentiation. Taken together, these results suggest that LXR would play a role in the execution of adipocyte differentiation by regulation of lipogenesis and adipocyte-specific gene expression.

대구지역 응급의료시설로 내원한 외상환자에 대한 연구

서강석,박정배 경북대학교 병원 2001 경북대학교병원의학연구소논문집 Vol.5 No.1

Backgrovnd: To evaluate trauma patients who visited the emergency facilities in the Taegu area and provide basic data for construction of the emergency medical service (EMS) system. Methods: Using a pre-made register that consisted of time of arrival,site of accident, method of presentation to the emergency facility, mechanism of injury, hospital outcome, and vital signs, authors evaluated prospectively trauma patients who visited to 4 emergency medical center(EMC)and 3 emergency room(ER) from April 1 to April 7,1998.The severity of trauma patients was calculated using a Triage score.Chi-square test was applied for statistical analysis. Results: 1. In comparing site of the accident, the distribution in EMC was road(50.4%) and do,icile(26.2%), and ER was domicile(46.2%) and road(37.7%). 2. In the method of presentation to emergency facility, ambulances(58.0%) ranked top in EMC and non-emergency vehicles(59.3%) ranked top in ER. 3. According to the mechanism of injury, traffic accidents ranked top in both EMC and ER. 4. In the hospital outcome, the discharge(64.1%) and admission(32.5%)and ER was discharge(77.4%) and admission(17.7%). 5. In triage score, the mean value of EMC was 8.53±1.47 and ER 8.90±0.59. Conclusion: This study demonstates the need for collecting basic data of trauma patients for constructing the EMS system.Further comorehensive research efforts should be made on the study of trauma patients in the emergency department.

당뇨병성 케톤산증에 대한 임상적 고찰

서강석,이정헌,박정배,김종근,윤영국 대한응급의학회 1998 대한응급의학회지 Vol.9 No.1

Background: Diabetic ketoacidosis(DKA) is serious acute metabolic complication and the most important cause of high morbidity and mortality of diabetes. The object of this study is to examine the clinical characteristics of patients with DKA who had a prior history of diabetes or not. Method: Authers reviewed retrospectively the medical records of 49 cases adimitted to Kyungpook National University Hospital from January 1991 to June 1997 with a diagnosis of DKA and classified cases as type I, type II and newly diagnosed diabetics according to prior history of diabetes. Results: 1. Of 49 cases of DKA, 24(49%) were classified as type I, 17(35%) as type II from data available in the medical records, and 8(16%) had DKA as the initial manifestation of the diasease. 2. The male to female ratio was 0.5:1 in type I, 1.1:1 in type II and 1.7:1 in newly diagnosed diabetics, and the mean age was 24.4 in type I, 57.9 in type II and 23.9 years old in newly diagnosed diabetics. 3. The mean duration between initial diagnosis of diabetes and the occurrence of DKA was 2.6 in type I and 6.9 years in type II diabetes. The occurrence of DKA within 2 years of initial diagnosis of diabetes was 54% in type I and 18% in type II diabetes, but the occurrence of DKA after 5 years of initial diagnosis of diabetes was 17% in type I and 47% in type II diabetes. 4. The precipitating factors of DKA were identified in 88% in type I, 76% in type II and 38% in newly diagnosed diabetics, and the most common precipitating factor was omission of treatment in both type I and type II(type I: 56%, type II: 35%). 5. The altered mental status was correlated with incresed osmolality(p<0.05), but not with other laboratory values such as pH, bicabonate, glucose, anion gap and dehydration status(p<0.05). Conclusion: It is necessary to conduct early aggressive evaluation for early diagnosis and proper treatment of DKA, because DKA occurs in patients with prior history of type II diabetes and without prior diabetic history as well as patients with prior history of type I diabetes.