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麻黃의 사람 비점막 섬유아세포 monocyte chemotactic protein 중 MCP - 1 , MCP - 2 , 및 MCP - 3 분비에 대한 효과
김현미,이향숙,김정선,조정제,유영천,안현종,최훈,임강현 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1
Recent reports have proposed that Ephedrae Herba may modulate the immune response on allergy or asthma. Human nasal mucosal fibroblasts are a rich source cytokines, inflammatory mediators, and chemokines. Chemokines are important for the recruitment of leukocytes to sites of infection, which is essential in host defense. Objectives : The objective of this study was to investigate the effect of Ephedrae Herba on the release of the chemokines such as monocyte chemotactic protein(MCP)-1, MCP-2, and MCP-3 in human nasal mucosal fibroblasts after stimulation with cytokines like tumor necrosis factor -α(TNF-α), interferon-γ(IFN-γ), and interleukin -1β(IL-1β).
FCP 14 : Screening of psoriatic arthritis in Korean psoriasis patients using PASE questionnaire
( Hyang Suk You ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Marg Aret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Seung Geun Lee ),( In Sook Lee ),( Byung Soo Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Psoriatic arthritis (PsA) is a chronic seronegative oligoarthritis causing irreversible joint damage. Early recognition of PsA in patients with psoriasis is important to prevent physical disability and deformity. However, diagnosing PsA pose a distinct challenge for most dermatologists in the context of a busy clinic. Objectives: The aim of this study was to validate Psoriatic Arthritis Screening Evaluation (PACE) questionnaire in detecting PsA in Korean patients with psoriasis. Methods: A total 148 patients with a diagnosis of psoriasis, but not previously diagnosed with PsA were administered with PACE questionnaire prospectively. All patients underwent radiologic and laboratory examinations. In addition, they were clinically evaluated by a rheumatologist. Results: Eighteen patients (12.1%) were diagnosed with PsA meeting the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. The sum of PACE score in patients with PsA showed signifcant difference compared with those without PsA. Receiver operator curves showed an area under the curve of 0.82 (95% CI 0.72, 0.92) for the total score. A cut-off value ≥36 showed sensitivity of 77.8%, and specificity of 82.3% for the diagnosis of PsA. Conclusion: The PACE questionnaire is simple and convenient screening tool for detecting PsA in Korean dermatologic clinic. Dermatologists should consider PASE questionnaire for psoriasis patients attending clinics, as it proved robust for the early identification of PsA.
( Hyang Suk You ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Seung Geun Lee ),( In Sook Lee ),( Byung Soo 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: Psoriatic arthritis (PsA) is chronic seronegative inflammatory arthritis that causes irreversible joint damage. Early recognition of PsA in patients with psoriasis is important for preventing physical disability and deformity. However, diagnosing PsA in a busy dermatology outpatient clinic can be difficult. Objective: This study aimed to validate the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire for the detection of PsA in Korean patients with psoriasis. Methods: The PASE questionnaire was prospectively given to 148 patients diagnosed with psoriasis but without a previous diagnosis of PsA. All patients underwent radiologic and laboratory examinations, and a subsequent clinical evaluation by a rheumatologist. Results: Eighteen psoriasis patients (12.2%) were diagnosed with PsA according to the Classification Criteria for Psoriatic Arthritis. The PASE questionnaire scores of differed significantly between PsA and non-PsA patients. Receiver operator characteristic analysis showed an area under the curve of 0.82 (95% confidence interval: 0.72, 0.92) for PASE score. A PASE score cut-off of 37 points had a sensitivity of 77.8% and specificity of 82.3% for the diagnosis of PsA. Conclusion: The PASE questionnaire is a simple and convenient screening tool for detecting PsA in Korean dermatology clinics. A PASE questionnaire score of 37 points appears to be an appropriate cut-off for screening Korean psoriasis patients. (Ann Dermatol 27(3) 265∼268, 2015)
혐기성 배양 조건에서의 Quinolone 제제의 항균역가 변동
현향숙,김정민,이제철,이상화,이유철,설성용,조동택 慶北大學校 醫科大學 1994 慶北醫大誌 Vol.35 No.1
목적 : 혐기성 배양 조건에서의 quinolone 제제의 항균력의 변화를 알아보기 위하여 nalidixic acid(NA), ciprofloxacin(Ci), norfloxacin(Nf) 및 pefloxacin(Pf) 등 새로 개발된 비교적 낮은 MIC를 가지는 quinolone 제제를 대상으로 산소 요구도에 따른 항균력을 비교 조사하여 그 성적을 보고한다. 재료 및 방법 : 설사환자의 대변에서 분리한 대장균으로 quinolone 제제에 대한 MIC와 MBC를 조사하고 또한 약제를 함유한 배지에서 호기상태와 혐기상태를 유지하면서 20시간 배양한 후 생균수를 측정하여 살균효과를 비교하였다. 결과 : MIC와 MBC는 Ci가 각각 0.03㎍/㎖, 16㎍/㎖으로 가장 낮았고 NA가 32㎍/㎖, 512㎍/㎖로 가장 높았다. 호기성 배양과 혐기성 배양에서의 균생존율을 비교해 보면 4종의 약제 모두 호기상태의 생존율이 혐기상태보다 낮지만 큰 차이의 변화는 없었다. 결론 : 이상의 결과로 quinolone 제제가 살균작용을 나타내기 위해서는 산소가 필수적이지만 균접종량이 10^7CFU/㎖ 이하의 혐기성 환경에서는 quinolone 제제의 살균작용이 호기성 환경과 큰 차이를 나타내지 않았다. To evaluate the influence of oxygen effect on antimicrobial activity of quinolone derivatives, minimal inhibitory concentration(MIC), most-bactericidal concentration (MBC), and survival rate of E. coli treated with various concentrations of ciprofloxacin(Ci), norfloxacin(Nf), pefloxacin(Pf), and nalidixic acid(NA) under aerobic and anaerobic conditions were determined. The Ci was the most potent agent tested because MIC and MBC of Ci were 0.03 ㎍/㎖ and 16 ㎍/㎖. Compared to the static culture, the shaken cuture was more bactericidal to the quinolone derivatives except NA. The difference of survival rate between static and shaken culture was less than 0.001%. It was found that survival rate of E. coli at an initial inoculum size of 6 × 10 exp (6) CFU/㎖ was no great difference between aerobic and anaerobic conditions. This result suggests that aeration has no effect on the bactericidal activity of quinolone derivatives against E. coli at an initial inoculum size of 10^7CFU/㎖, although the quinolone derivatives specifically need oxygen them to be able actively to kill bacteria.
Yeom, Jung Sook,Choi, Myung Bum,Seo, Ji-Hyun,Park, Ji Sook,Lim, Jae-Young,Park, Chan-Hoo,Woo, Hyang-Ok,Youn, Hee-Shang,Ko, Gyung-Hyuck,Baik, Seung-Chul,Lee, Woo-Kon,Cho, Myung-Je,Rhee, Kwang-Ho SAGE Publications 2013 Cephalalgia Vol.33 No.5
<P><B>Background</B></P><P>Although many patients with functional dyspepsia experience headache concurrently with dyspeptic symptoms, studies suggesting mechanisms underlying this phenomenon are limited. Herein, we explore the relationship between gastrointestinal inflammatory cells and presence of headache associated with dyspeptic symptoms in children with <I>Helicobacter pylori</I>-negative functional dyspepsia.</P><P><B>Methods</B></P><P>Fifty-six patients with <I>H. pylori</I>-negative functional dyspepsia underwent upper endoscopy with biopsy to investigate recurrent epigastric pain or discomfort. Patients were divided into two groups according to self-reported presence of headache associated with dyspeptic symptoms. Inflammatory cells including mast cells, and enteroendocrine cells in the gastroduodenal mucosa were evaluated. Associations between headache presence and cellular changes in the gastroduodenal mucosa were examined.</P><P><B>Results</B></P><P>Headache was not associated with the grade of lymphocytes, neutrophil infiltration, or enteroendocrine cell density in the gastroduedenal mucosa. However, headache was significantly associated with high mast cell density in the body (27.81 ± 8.71 vs. 20.30 ± 8.16, <I>p</I> < 0.01) and duodenum (23.16 ± 10.40 vs. 14.84 ± 5.88, <I>p</I> < 0.01).</P><P><B>Conclusions</B></P><P>Presence of headache associated with dyspeptic symptoms is strongly related to mucosal mast cell density in pediatric patients with <I>H. pylori</I>-negative functional dyspepsia. Thus, our results may help clinicians understand and treat headache during dyspeptic symptoms in such pediatric patients.</P>
지주막하강 및 뇌막에 미만성으로 전이된 수아세포종 1 예
임인숙,고일향,지제근 인제대학교 1984 仁濟醫學 Vol.5 No.4
Medulloblastoma, a highly malignant tumor of the cerebellum, accounts for 20 percent of the intracranial neoplasms in the pediatric age group with a 2:1 male preponderance and a peak frequency between 3 and 8 years of age. The tumor is believed to be derived from the medulloblast, an embryonal, bipotential cell, capable of maturation along either glial or neuronal cell lines. While medulloblastomas are known to occasionally spread along the CSF pathways, metastasis of this tumor outside of the CNS is considered rarely. Progressive head enlargement and hydrocephalus were the commonest modes of prerentation. The present report is on a case of medulloblastoma with diffuse subarachnoid and meningeal spread presenting with hydrocephalus. At autopsy, a well circumscribed, gray-white, soft, tumor mass, measuring 5.5×4.5cm in size, presents in the cerebellar vermis and 4th ventricle. Microscopically the tumor is highly cellular and is composed of small dark cells without any organoid patterns. The invidual tumor cells show round to ovoid, hyperchromatic nuclei and indistinct scanty cytoplasms. Occasionally pseudorosette and microcyst formation are noted and memerous mitotic figures are observed. The tumor is extending to the subarachnoid space and central canal of the spinal cord.
Case Report : Sorafenib-Induced Interstitial Pneumonitis in a Patient with Hepatocellular Carcinoma
( Hyung Joon Myung ),( Sook Hyang Jeong ),( Jin Wook Kim ),( Hee Sup Kim ),( Je Hyuck Jang ),( Ho Il Yoon ),( Jae Sung Kim ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.4
Sorafenib is an oral multikinase inhibitor that has shown a survival benefit in patients with advanced hepatocellular carcinoma, and is considered to be generally safe. We treated a patient with interstitial lung disease that was associated with sorafenib therapy for the treatment of advanced hepatocellular carcinoma. A 74-year-old man with hepatitis-C-virus-related hepatocellular carcinoma was treated with sorafenib. After 8 days of sorafenib administration, he received radiation therapy for an intrahepatic tumor located in segment eight. On the 24th day of sorafenib treatment, the patient developed acute interstitial pneumonitis that rapidly improved after the discontinuation of sorafenib and treatment with high-dose steroids. This case alerts physicians to the possibility of sorafenib-induced interstitial lung disease. (Gut Liver 2010;4:543-546)