무수프탈산을 취급하는 근로자들의 알레르기 질환 유병 실태

임현술,김수근,김기식 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Phthalic anhydride(PA) is widely used in the production of alkyd and unsaturated polyester resins. It has been reported that some workers exposed to PA have developed dermatitis, rhinitis and asthma. The authors intended to investigate the prevalence of PA induced allergic diseases and to develop preventive measures of occupational diseases. Forty-five male workers from PA production and handling were selected as an exposure group. Forty-four male workers not handling PA at tie same factory were chosen as a reference group. A symptom questionnaire, doctor's examination, eosinophil count, serum-total IgE and PA-specific IgE were done on the subjects. There were no significant differences in age, educational level. tenure or smoking habits between groups. Most clinical symptoms were significantly more frequent among the exposure group than the reference group: sneezing(62.2%), rhinorrhea(57.8%), nasal stuffiness(53.3%), coughing(44.4%) and nasal itching(35.6%) were the major symptoms among the exposure group(p<0.01, p<0.05). There were no significant differences in eosinophil count and serum-total IgE between groups but the mean level in PA-specific IgE, in the exposure group, was statistically significantly higher than the reference group(p<0.01). Abnormal rates of eosinophil count, serum-total IgE and PA-specific IgE were not significantly different from each other. The prevalence rate was 68.9%(31 cases) for allergic rhinitis in the exposure group, statistically significantly higher than the reference group(p<0.01). The prevalence rate was 6.7%(3 cases) for bronchial asthma and contact dermatitis in the exposure group, not more statistically significant than the reference group. In the exposure group, the prevalence rate for age, educational level, tenure, smoking habits and use of protective devices are not statistically significant. In PA specific IgE, sensitivity is 10.8%, specificity is 100.0%, positive predictability is 100.0% and negative predictability is 61.2% when criteria point is 3.5 KU/ιor above. As a result, it was recognized that the exposure group had a high prevalence of PA induced allergic rhinitis. Also, in diagnosis of PA induced allergic diseases, medical histories and specific symptoms were the most important where as eosinophil count, serum-total IgE are the only indirect informations. PA-specific IgE has been needed to evaluate the meanings more.

다공성 미립 담체에서의 동물세포 성장 및 부착 속도와 바이러스 백신의 생산

임현수 麗水水産大學校 産業技術硏究所 1996 産業基術硏究所 論文集 Vol.5 No.-

본 실험실에서 개발한 젤라틴 다공성 담체(K-beads)와 상업용 다공성 담체인Cultispher-G를 이용하여 Chinese Hamster Overy(CHO)세포와 African Green Monkey Kidney(Vero)세포에 대한 세포의 담체 부착 속도와 성장성을 살펴보았다. 양 세포주의 담체에 대한 초기 부착 속도는 시간에 따라 일차 함수 관계를 보였으며, 부착율은 접종 세포량의 90%에 달했다. Vero세포의 K-beads에서의 성장은 140시간 배양후 최종농도가 5.6×??cells/ml이었으나, Cultispher-G에서는 세포의 초기 성장이 늦고 최종 세포 농도도 3.5×??cells/ml로 나타났다. Vero세포의 성장이 최고농도에 도달직전에 Vesicular Stomatitis Virus(VSV)를 0.1MOI(Multiplicity of Infection)로 접종하여 이틀 뒤 그 생성농도를 살펴본 결과 K-beads에서 5.7×??pfu/ml로 Cultispher-G 보다 높게 나타났다. 결과적으로 K-beads가 세포의 고농도 배양 및 백신의 고농도 생산에 적합한 담체임을 확인하였다.

皮膚組織內의 反射光 特性에 關한 硏究

임현수,이준규 충남대학교 의과대학 지역사회의학연구소 1994 충남의대잡지 Vol.21 No.1

This paper proposes a method of noninvasive reflectance light to measure the blood fractional volume(Vb) and oxygen saturation(SO_2) of biological tissue. We chose the red light of 660nm and infrared light of 880nm. In Vivo reflectance data were obtained the physiological changes from different laters within a biological tissue was measured by specially designed reflectometer to apply photon path diffusion model. The collected data represent the changes of blood fractional volume and oxygen saturation at each reflected light wavelengths. This study uses the experimental methods to assess the physiological changes due to heat. The result presented in this paper demonstrate to measure consistent changes in tissue optical properties during heat.

펄스옥시메트리 구현을 위한 FIR 디지털 필터 설계

임현수 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

Blood oxygen saturation(SpO_(2)) is an important clinical indicator of patient health. However. pulse oximeter is a complex system that can suffer from the problem of excessive noise. Noise reduction is important to get a precise pulse oximetry reading. We attempted to reduce the noise in the raw signal and to develope an appropriate calibration curve for the pulse oximeter. We used an FIR 35 order Digital Low Pass Filter(LPF) with a signal preprocessor on a measured raw signal to effectively reduce the signal noise. Both applied preprocessor and non-applied preprocessor signals were investigated. By passing the two signals into the 35 order Low pass filter the applied non-preprocessor signal is distorted by peaking noise while the preprocessor signal retains its original characteristics. Therefore. the latter signal is suitable for an appropriate calibration R-curl-e for calculation of pulse oximetry. Application of the preprocessor to the raw signal and passing the signal into a 35 order LPF is appropiate. In this way a calibration curve for 2 pulse oximeter system can be developed. The formulas for SpO_(2) were derived from the calibration curve. These results are useful to obtain an accurate SpO_(2) value for a pulse oximeter system.

Sr·페라이트의 자기특성에 관한 연구

임재근,서강수,문현욱,신용진 明知大學校 産業技術硏究所 1992 産業技術硏究所論文集 Vol.11 No.-

This thesis is the study on the magnetic properties of strontium (Sr) ferrite. Specimens of SrO·nFe₂O₃,basic composition, with n=5.9 which is nonstoichiomatric composition region were prepared by sintering at 1275°C for 1hr, whthin air surroundings. In order to increase coercivity, additives of 0.4wt%SiO₂ and 0.7wt%CaCO₃ were added into basic composition, and 0.5wt%∼2.0wt%Cr₂O₃ was added as second additives. In case of second additives 1.5wt%Cr₂O₃, it was obtained uniformed grain size and magnetic properties was increased. The sintering temperature was 1150°C, 1180°C, 1210°C, 1240°C and 1270°C respectivily and cooling was performed in furnance. From the research and experiments on the magnetic properties of strontium (Sr) ferrite based on the complex additive technique, it was obtained good magnetic properties of (BH)mas=0.72MGOe, at the sintering temperature of 1210°C, in the case of (basic composition)+(basic additive)+(1.5wt%Cr₂O₃)

PDT(Photodynamic Therapy) 레이저 시스템의 방사모드 제어 장치 개발

임현수 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

A new control device for Photodynamic Therapy(PDT) laser system is proposed in this paper. The accuracy measurement of light dose in cancer therapy using the laser is very important role, so the laser output require that high speed and statistical output control. The developed control device is possible to accurate and statistical control output using constant current control. The final beam power is 300mW max. at the 600nm wavelength. The laser power supply was designed to protect the resonator from the over-current and in rush-current etc. The experimental result show that laser beam power increase linearly from 10mW to 300mW for input current. The radiation type are CW, LONG PULSE, SHORT PULSE, SUPER PULSE, BURST PULSE. We can adjust the exposure time from several milli-second to several minute, and according to this experiment, we can make the variable type of power, radiation, exposure time that requested by the PDT system.

PDT(Photodynamic Theraphy) 레이저 시스템 개발

임현수 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

A new diode laser system for therapy of cancer is proposed in this paper. In order to accuracy and statistical output control we used the constant current control method and designed the power source to protect the resonator from the over-current, rush-current and electrical fault. The most important things are the radiation type for cancer therapy in laser system, we developed the radiation type of cw, long pulse, and burst pulse. The experimental result show that laser beam power increase linearly from 10mW to 300mW for input current increasing and the exposure time.

한국판 섬망 평가 척도-98(K-DRS-98)의 표준화 연구

임경옥,김수영,이양현,이선우,김정란 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.6

Objective : This study was conducted to develop and to validate the Korean version of Delirium Rating Scale-Revised-98(K-DRS-98), which is a scale for diagnosing delirium and evaluating its severity. Method : After developing the K-DRS-98, 102 patients were rated by it among 4 diagnostic groups, such as delirium (N=25), dementia (N=27), schizophrenia (N=25) and others (N=25). To test for reliability, K-DRS-98 was independently administered by two psychiatrist. To test for validity, Korean version of Mini-Mental State Examination (MMSE-K) and Clinical Global Impression (CGI) were administered simultaneously. Statistical analysis was done with SPSS window version 12 package and statistical significance was p<0.05. Result : Intemal consistencies (Cronbach α) of two raters were 0.867 and 0.858, respectively. Inter-rater reliability (κ) was 0.893 for severity items of K-DRS-98 and κ value of diagnosis items was 0.969. In Delirium group, Pearson correlation Coefficients (r) of K-DRS-98 were -0.682 for MMSE-K and 0.667 for CGI. In comparison Delirium group with Others, ANOVA post hoc multiple comparison LSD was statistically significant (p<0.001). The cutoff score to diagnosis of delirium can be recommended 16 for seventy items and 21.5 for total score, respectively. Conclusion : The K-DRS-98 was showed good reliability and validity for the assessment of delirium. The K-DRS-98 is an easy and useful tool for diagnosing delirium and assessing its severity.

초임계이산화탄소에 의한 유기염소계 잔류농약의 포집효율

임상빈,좌미경,김수현 濟州大學校 産業技術硏究所 1996 산업기술연구소논문집 Vol.7 No.1

Collection efficiencies of organochlorine pesticides by supercritical fluid extraction(SFE) was investigated to develop a simple, fast and inexpensive extraction method. Standard organochlorine pesticides mixture(SOPM, no water) showed no evidence of metering valve plugging in contrast to the plugging associated with SFE of fish tissues(wet sample). Maximum percent recovery of SOPM was obtained at bar by collecting the extract within 3 min through the metering valve without heating into a capped screw-top tube half filled with solid CO_(2) Recovery of SOPM itself shwes 98.3% while recovery of that spiker in fish tissue 85.6%.

효소적 방법으로 제조된 키토산 올리고당의 첨가에 따른 김치의 숙성 및 저장 기간 연장에 관한 연구

임현수,김진만,유은정,최명락 여수대학교 1998 論文集 Vol.13 No.2

효소로 처리된 키토산 올리고당의 첨가에 의한 김치의 숙성 기간 연장 효과를 알아보기 위하여 배추김치에는 0.2-0.4%, 2일째에 0.4%를 첨가하여 20℃에서 10일간 관찰한 결과 0.2% 첨가시 대조군에 비해 2일, 0.4% 첨가시는 4일, 2일째에 0.4%를 첨가한 경우는 8일 이후로 연장 효과가 2-4배 있었으며, 0.4% 이상에서는 미생물 생육자체가 억제되므로 풍미 및 유기산의 생성을 고려할 때 2일째 첨가된 0.4%가 젖산균의 수는 어느정도 유지하면서 stationary phage를 연장시킴으로서 더 좋은 결과를 나타냈다. 갓 김치의 경우 0.1%-0.5% 첨가시 대조군에 비해 1.2-1.4배의 연장 효과가 있어서 배추 김치에 비해서는 낮은 효과를 나타냈다. 따라서, 효소로 처리된 키토산 올리고당의 첨가에 의해 배추 김치는 2-4배의 연장 효과, 갓김치는 1.2-1.4배의 연장 효과를 나타내어 미생물 증식 억제에 의한 김치의 숙성 및 저장 기간 연장 효과를 기대할 수 있었다. To prolong the fermenting and preservation period of Kimchi, chitosanoligosaccharide was prepared by chitosanase. Various concentrations of chitosanoligosaccharide were added into Chinese cabbage Kimchi and Gat Kimchi. Chinese cabbage Kimchi was formulated with various chitosanoligosaccharide concentrations(0.2-0.4%) and fermented at 20℃. And Gat Kimchi was prepared with various chitosanoligosaccharide(0.1-0.5%) concentrations during 26 days at 4℃. In this results, the fermentation period was increased 2-2.5 and 1.2-1.4 folds more than control(0% of chitosanoligosaccharide) for Chinese cabbage Kimchi and Gat Kimchi, respectively. Conclusively, adding of chitosanoligosaccharide into Kimchi significantly prolonged the fermentation and preservation period.