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Exercise-induced beige adipogenesis of iWAT in Cidea reporter mice
( Jin Kyung Kim ),( Hye Sun Go ),( Sol Pin Kim ),( Il Yong Kim ),( Yun Hee Lee ),( Seung Hyun Oh ),( Ho Lee ),( Je Kyung Seong ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.4
Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways to treat obesity. Exercise induces ‘beige adipogenesis’ in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2ALuc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis and was detected through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist induce beige adipogenesis in Cidea-dual reporter mouse, which will be widely used for detecting beige adipogenesis in vivo. [BMB Reports 2022; 55(4): 187-191]
Application of Cidea reporter mice, brown adipogenesis in iWAT
Jin Kyung Kim,Hye Sun Go,Sol Pin Kim,Il Yong Kim,Yun Hee Lee,Seung Hyun Oh,Ho Lee,Je Kyung Seong 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Obesity is one of the most serious diseases in modern society as energy intake and energy expenditure make imbalance. As treating the obesity becomes global issue, a number of treatments have been proposed and exercise is getting attention as a one way. It is well known that exercise has numerous benefits that affect whole body metabolism. Especially it can induce ‘browning’ of white adipocyte in adipose tissue. Cidea (Cell Death Inducing DFFA Like Effector A) is one of the disease associated genes including metabolic disorder and adipogenesis. It has been widely used for brown adipogenesis marker. We developed Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) for applying in vivo tracing and measuring brown adipogenesis. Cidea-dual reporter mouse performed voluntary wheel running for 8 weeks. CL was injected intraperitoneally (1 mg/kg of body weight/day) for 3 days to Cidea-reporter mouse for inducing brown adipogenesis. Brown adipogenesis in Cidea-dual reporter mouse was measured not only by optical imaging system but also by histology. As a result of exercise, browning occurred depots in white adipose tissue become luminescent. We confirmed that exercise and CL can induce brown adipogenesis with in vivo reporter system. Cidea-dual reporter mouse will be widely used for detecting brown adipogenesis.