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RISS 인기검색어
- 검색키워드
- 저자 : ( Soie Kwon ) (검색결과 2 건)
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( Soie Kwon ),( Jin Seong Hyeon ),( Youngae Jung ),( Lilin Li ),( Jung Nam An ),( Yong Chul Kim ),( Seung Hee Yang ),( Tammy Kim ),( Dong Ki Kim ),( Chun Soo Lim ),( Geum-sook Hwang ),( Jung Pyo Lee ) 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.4
Background: As a leading cause of chronic kidney disease, clinical demand for noninvasive biomarkers of diabetic kidney disease (DKD) beyond proteinuria is increasing. Metabolomics is a popular method to identify mechanisms and biomarkers. We investigated urinary targeted metabolomics in DKD patients. Methods: We conducted a targeted metabolomics study of 26 urinary metabolites in consecutive patients with DKD stage 1 to 5 (n = 208) and healthy controls (n = 26). The relationships between estimated glomerular filtration rate (eGFR) or urine protein-creatinine ratio (UPCR) and metabolites were evaluated. Multivariate Cox analysis was used to estimate relationships between urinary metabo lites and the target outcome, end-stage renal disease (ESRD). C statistics and time-dependent receiver operating characteristics (ROC) were used to assess diagnostic validity. Results: During a median 4.5 years of follow-up, 103 patients (44.0%) progressed to ESRD and 65 (27.8%) died. The median fold changes of nine metabolites belonged to monosaccharide and tricarboxylic acid (TCA) cycle metabolites tended to increase with DKD stage. Myo-inositol, choline, and citrates were correlated with eGFR and choline, while mannose and myo-inositol were correlated with UPCR. Elevated urinary monosaccharide and TCA cycle metabolites showed associations with increased morality and ESRD progres sion. The predictive power of ESRD progression was high, in the order of choline, myo-inositol, and citrate. Although urinary metabo lites alone were less predictive than serum creatinine or UPCR, myo-inositol had additive effect with serum creatinine and UPCR. In time-dependent ROC, myo-inositol was more predictive than UPCR of 1-year ESRD progression prediction. Conclusion: Myo-inositol can be used as an additive biomarker of ESRD progression in DKD.
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( Jeonghwan Lee ),( Yong Chul Kim ),( Soie Kwon ),( Lilin Li ),( Sohee Oh ),( Do Hyoung Kim ),( Jung Nam An ),( Jang-hee Cho ),( Dong Ki Kim ),( Yong-lim Kim ),( Yun Kyu Oh ),( Chun Soo Lim ),( Yon Su 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: The effect of each health-related quality of life (HRQOL) component on hemodialysis prognosis has not been well studied. We aimed to investigate the clinical factors associated with HRQOL and the effect of HRQOL after dialysis initiation on long-term survival in an Asian population. Methods: A total of 568 hemodialysis patients were included from a nationwide prospective cohort study. HRQOL was evaluated using the Kidney Disease Quality of Life (KDQOL) Short FormTM 1.3 at 3 months after dialysis initiation. The effect of each KDQOL item score on mortality was analyzed. Multivariable Cox analysis was performed after adjusting for age, sex, modified Charlson comorbidity index, and causes of primary kidney disease. Results: Old age, diabetes mellitus, high comorbidities, and low serum albumin levels were associated with poor physical health status. Decreased urine output was associated with both poor physical and mental health status. The scores of 3 indices in the kidney disease domain (effect of kidney disease, social support, and dialysis staff encouragement) showed significant associations with mortality, as did the 3 indices (physical function, physical role limitation, and body pain) in the physical health domain. Neither the 4 indices in the mental health domain nor the mental composite score showed a significant association with mortality. However, a high physical composite score was associated with decreased overall patient mortality (P = 0.003). The effect of physical composite score on survival was prominent among young or middle-aged groups. Conclusion: Poor physical health status 3 months after hemodialysis start correlates significantly with overall mortality.
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