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      • SCIESCOPUSKCI등재

        Loss Analysis and Air-Cooled Design for a Cascaded Electrical Source Transmitter

        Xue, Kai-Chang,Wang, Shuang,Lin, Jun,Li, Gang,Zhou, Feng-Dao The Korean Institute of Power Electronics 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

        Air-cooling method is adopted on the basis of the requirements for the thermal stability and convenient field use of an electrical source transmitter. The power losses of the transmitter are determined after calculating the losses of the alternating current (AC)-direct current (DC) power supply, the constant-current circuit, and the output circuit. According to the analysis of the characteristics of a heat sink with striped fins and a fan, the engineering calculation expression of the Nusselt number and the design process for air-cooled dissipation are proposed. Experimental results verify that the error between calculated and measured values of the transmitter losses is 12.2%, which meets the error design requirements of less than 25%. Steady-state average temperature rise of the heat sink of the AC-DC power supply is $22^{\circ}C$, which meets the design requirements of a temperature rise between $20^{\circ}C$ and $40^{\circ}C$. The transmitter has favorable thermal stability with 40 kW output power.

      • KCI등재

        Loss Analysis and Air-Cooled Design for a Cascaded Electrical Source Transmitter

        Kai-chang Xue,Shuang Wang,Jun Lin,Gang Li,Feng-dao Zhou 전력전자학회 2015 JOURNAL OF POWER ELECTRONICS Vol.15 No.2

        Air-cooling method is adopted on the basis of the requirements for the thermal stability and convenient field use of an electrical source transmitter. The power losses of the transmitter are determined after calculating the losses of the alternating current (AC)?direct current (DC) power supply, the constant-current circuit, and the output circuit. According to the analysis of the characteristics of a heat sink with striped fins and a fan, the engineering calculation expression of the Nusselt number and the design process for air-cooled dissipation are proposed. Experimental results verify that the error between calculated and measured values of the transmitter losses is 12.2%, which meets the error design requirements of less than 25%. Steady-state average temperature rise of the heat sink of the AC?DC power supply is 22 °C, which meets the design requirements of a temperature rise between 20 °C and 40 °C. The transmitter has favorable thermal stability with 40 kW output power.

      • SCIESCOPUSKCI등재

        Microbiological Purification of L-Arabitol from Xylitol Mother Liquor

        ( Ming Guo Jiang ),( Ben Wang ),( Li Fang Yang ),( Shuang Jun Lin ),( Hai Rong Cheng ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.1

        As a rare sugar alcohol, L-arabitol can be used in food and can prevent extra fat deposits in the intestinal tract. Commercially, L-arabitol is prepared from pure L-arabinose by hydrogenation, which needs a high temperature and high pressure, leading to a high production cost for Larabitol. Therefore, this study describes a novel L-arabitol production method based on biological purification from the xylitol mother liquor, a cheap and readily available raw material that contains a high concentration of Larabitol. First, a novel Bacillus megaterium strain was screened that can utilize xylitol, sorbitol, and mannitol, yet not L-arabitol. The isolated strain was inoculated into a medium containing the xylitol mother liquor under formulated culture conditions, where a high L-arabitol yield (95%) and high purity (80%) were obtained when the medium was supplemented with 50 g/l of xylitol mother liquor. Upon further purification of the fermentation broth by ion exchange and decolorization, L-arabitol was crystallized with a purity of 98.5%.

      • KCI등재

        Screening and Anti-virulent Study of N-Acyl Homoserine Lactones DNA Aptamers against Pseudomonas aeruginosa Quorum Sensing

        Zu-Guo Zhao,Yun Mei Yu,Bi Yu Xu,Shuang-Shuang Yan,Jun-Fa Xu,Fang Liu,Guo-Ming Li,Yuan Lin Ding,Shu Qing Wu 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.2

        In Pseudomonas aeruginosa, a quorum sensing (QS) system regulates the expression of many virulence factors. N-acyl homoserine lactone (HSL) is the signal molecule of QS system. In order to find a novel HSL binder to interfere with QS signaling and to attenuate P. aeruginosa virulence, an amino lactam surrogate (ALS) of HSL was used as a target to screen HSL aptamers with the technique of systematic evolution of ligands by exponential enrichment (SELEX). Eight HSL aptamers with high affinities for 3O-C12-HSL (20 nM ≤ Kd < 35 nM) or C4-HSL (25 nM < Kd < 50 nM) were finally obtained. In vitro QS-inhibiting study of P. aeruginosa showed that HSL aptamers could inhibit virulence in a dose-dependent manner. ALSap-8 which bound C4-HSL primarily acted on the rhl system and inhibited the secretion of pyocyanin. ALSap-5 which bound 3O-C12-HSL not only showed strong inhibitory activity on biofilm formation as well as secretions of LasA protease and LasB elastase, but also reduced pyocyanin secretion. Since the las system is capable of activating the rhl system mildly, we speculated that ALSap-5 can simultaneously interfere with the las and rhl systems. High-affinity aptamers against HSL in this study are novel QS and virulence-inhibitors, and may have potential as drug candidates for the treatment of P. aeruginosa infection.

      • KCI등재

        Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China

        Han-Lu Gao,Xuan Wang,Hong-Ru Sun,Jun-De Zhou,Shang-Qun Lin,Yu-Hang Xing,Lin Zhu,Hai-Bo Zhou,Ya-Shuang Zhao,Qiang Chi,Yu-Peng Liu 거트앤리버 소화기연관학회협의회 2018 Gut and Liver Vol.12 No.2

        Background/Aims: Methylation status plays a causal role in carcinogenesis in targeted tissues. However, the relationship between the DNA methylation status of multiple genes in blood leukocytes and colorectal cancer (CRC) susceptibility as well as interactions between dietary factors and CRC risks are unclear. Methods: We performed a case-control study with 466 CRC patients and 507 cancer-free controls to investigate the association among the methylation status of individual genes, multiple CpG site methylation (MCSM), multiple CpG site heterogeneous methylation and CRC susceptibility. Peripheral blood DNA methylation levels were detected by performing methylation-sensitive high-resolution melting. Results: Total heterogeneous methylation of CA10 and WT1 conferred a significantly higher risk of CRC (adjusted odds ratio [ORadjusted], 5.445; 95% confidence interval [CI], 3.075 to 9.643; ORadjusted, 1.831; 95% CI, 1.100 to 3.047; respectively). Subjects with high-level MCSM (MCSM-H) status demonstrated a higher risk of CRC (ORadjusted, 4.318; 95% CI, 1.529 to 12.197). Additionally, interactions between the high-level intake of fruit and CRH, WT1, and MCSM on CRC were statistically significant. Conclusions: The gene methylation status of blood leukocytes may be associated with CRC risk. MCSM-H of blood leukocytes was associated with CRC, especially in younger people. Some dietary factors may affect hypermethylation status and influence susceptibility to CRC.

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