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SENSITIVITY ANALYSIS OF MIDAS TESTS USING THE SPACE CODE
Shin Eom(엄신),Seung-Jong Oh(오승종),Aya Diab 한국전산유체공학회 2018 한국전산유체공학회지 Vol.23 No.1
The nodalization sensitivity analysis for the ECC(Emergency Core Cooling) bypass phenomena was performed using the SPACE(Safety and Performance Analysis CodE) thermal hydraulic analysis computer code. The results of MIDAS(Multi-dimensional Investigation in Downcomer Annulus Simulation) test were used. The MIDAS test was conducted by the KAERI(Korea Atomic Energy Research Institute) for the performance evaluation of the ECC bypass phenomenon in the DVI(Direct Vessel Injection) system. The main aim of this study is to examine the sensitivity of the SPACE code results to the number of thermal hydraulic channels used to model the annulus region in the MIDAS experiment. The sensitivity study involves three nodalization cases (4, 6, and 12 channels) and the result show that the effect of nodalization on the bypass fraction for the MIDAS high steam flow rate tests is minimal. For computational efficiency, a 4 channels representation is recommended for the SPACE code nodalization. For the low steam flow rate tests, the SPACE code over-predicts the bypass fraction irrespective of the nodalization scheme. The over-prediction at low steam flow may be attributed to the difficulty to accurately represent the three dimensional flow pattern in the vicinity of the broken cold leg using a one-dimensional code.
Keyword-based mobile semantic search using mobile ontology
Shin, Sangjin,Ko, Jihoon,Eom, Sungkwang,Song, Minjae,Shin, Dong-Hoon,Lee, Kyong-Ho SAGE Publications 2015 JOURNAL OF INFORMATION SCIENCE Vol.41 No.2
<P>A large volume of mobile data is being generated and shared among mobile devices such as smartphones. Most of the mobile platforms provide a user with a keyword-based full text search (FTS) in order to search for mobile data. However, FTS only returns the data corresponding to the keywords given by users as results without considering a user’s query intention. To overcome this limitation, we propose a semantically enhanced keyword-based search method. Although there are various semantic search techniques, it is hard to apply existing methods to mobile devices just as they are. This is caused by the characteristics of mobile devices such as isolated database structures and limited computing resources. To enable semantic search on mobile devices, we also propose a lightweight mobile ontology. Experimental results from the prototype implementation of the proposed method show that the proposed method provides a better user experience than the conventional FTS and returns accurate search results in an acceptable response time.</P>
Mitochondrial DNA copy number and hnRNP A2/B1 protein: biomarkers for direct exposure of benzene.
Eom, Ha-Young,Kim, Hye-Ran,Kim, Hwan-Young,Han, Dong-Kyun,Baek, Hee-Jo,Lee, Jae-Hyuk,Moon, Jai Dong,Shin, Jong-Hee,Suh, Soon-Pal,Ryang, Dong-Wook,Kook, Hoon,Shin, Myung-Geun Pergamon 2011 Environmental toxicology and chemistry Vol.30 No.12
<P>The present study was performed to identify biomarkers for exposure of benzene in blood cells and hematopoietic tissues. Peripheral mononuclear cells, hematopoietic stem cells, and leukemia cell lines were cultured in RPMI 1640 media with the addition of 0, 1, and 10 mM of benzene. Hydrogen peroxide was measured using an enzyme immunoassay. Mitochondrial mass, membrane potential, and mitochondrial DNA (mtDNA) copy number were measured using MitoTracker Green/Red probes, and real-time polymerase chain reaction. In addition, two-dimensional gel electrophoresis and mass spectrometry matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) technology were performed to identify protein markers. The mitochondrial contents and membrane potentials were dramatically increased after three weeks of direct benzene exposure. The hydrogen peroxide level increased significantly after two weeks of treatment with benzene (4.4 1.9 ?M/mg protein) compared to the non-benzene treatment group (1.2 1.0; p = 0.001). The mtDNA copy number gradually increased after exposure to benzene. Numerous protein markers showed significant aberrant expression after exposure to benzene. Among them, the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 was markedly decreased after exposure to benzene. Thus, increased mitochondrial mass, mtDNA copy number, and the hnRNP A2/B1 protein were biomarkers for benzene-related toxicity and hematotoxicity.</P>
Eom Ji-Eun,Kim Gun-Dong,Kim Young In,Lim Kyung min,Song Ju Hye,Kim Yiseul,Song Hyeon-Ji,Shin Dong-Uk,Lim Eun Yeong,Kim Ha-Jung,Kim Sung Hoon,Lee Deuk Sik,Lee So-Young,Shin Hee Soon 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.5
Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chainenhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.
Shin, Song Yub,Kang, Shin-Won,Lee, Dong Gun,Eom, Soo Hyun,Song, Woo Keun,Kim, Jae Il 부산대학교 유전공학연구소 2000 분자생물학 연구보 Vol.16 No.-
CRAMP-18 (GEKLKKIGQKIKNFFQKL) is the anti-bacterial sequence derived from CRMAP, a member of cathelicidin-derived antimicrobial peptides. To develop the novel antibiotic peptides useful as therapeutic drugs requires strong antibiotic activity against bacterial and fungal cells without hemolytic effect. To this goal, the analogues were designed to increase only net positively charge by Lys-substitution of positions 2, 9, 13, or 16 at the hydrophilic helix face of CRAMP-18 without any change at the hydrophobic helix face. In particular, Lys-substitution (K^2-CRAMP-18) of position 2 in CRAMP-18 induced the enhanced antibiotic activity without any increase in hemolysis. Thus, this peptide may provide a useful template for the design novel antibiotic peptides for the treatment of infectious diseases. Additional CD spectra studies suggested that the α-helical structure of the peptides plays an important role in killing bacterial and fungal cells, but the increase of α-helical content is less connected with the enhanced antibiotic activity.
BIM 교육을 위한 u-Learning System 구축방안
엄신조(Eom Shin-Jo) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(구조계)
Recently, construction industry has adopted BIM very rapidly. However, adoption of BIM or 3D drawing means a lot of time and labors are needed to develop the 3D model, also all participants in the project have to familiar with 3D tools. Internationally, adequate BIM training is recognized as the most challenging area, but in domestic BIM education is rely on BIM tool vendor’s instruction education or related seminar. This research suggest the case study of the development of the 1st private BIM u-learning system in Korea, analyzing the structure of overall system and services at present, current issues, and development plan.