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( Jae Ho Choi ),( Sun Woo Jin ),( Hyung Gyun Kim ),( Chul Yung Choi ),( Hyun Sun Lee ),( Shi Yong Ryun ),( Young Chul Chung ),( Young Jung Hwang ),( Yeon Ji Um ),( Tae Cheon Jeong ),( Hye Gwang Jeong 영남대학교 약품개발연구소 2015 영남대학교 약품개발연구소 연구업적집 Vol.25 No.-
We investigated the inhibitory effects of platycodon grandiflorum root-derived saponins (Cfangkil saponins;CKS) on ovalbumin-induced airway inflammation in mice. CKS suppressed leukocytes number,IgE,Th1/Th2 cytokines, and MPC-1 chemokine secretion in bronchoalveolar lavage fluid. Also,ovalbumin-increased MUC5AC,MMP-2/9,and TLMP-1/-2 mRNA expression,NF-kB activation,leukocyes recruitment,and mucus secretion were inhibited by CKS treatment. Moreover,the active component of CKS,platyconic acid A (PA),suppressed PMA-induced MUC5AC mRNA expression(from2.1±0.2to1.1±0.1)by inhibiting NF-kB activation(from 2.3±0.2 to 1.2±0.1)via Akt(from3.7±0.3 to 2.1±0.2)(P<0.01) in A549 cells. Therefore,we demonstrate that CKS or PA suppressed the development of respiratory inflammation, hyperresponsiveness,and remodeling by reducing allergic responses,and they may be potential herbal drugs for allergen-induced respiratory disease prevention.