[PF-0035] Identification of Genes Regulating Stone Cell Development in Pear through Transcriptome Analysis

Yunju Hwang(Yunju Hwang ),Sewon Oh(Sewon Oh ),Yumi Kim(Yumi Kim ),Do Yeong Kim(Do Yeong Kim ),Daeil Kim(Daeil Kim ) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Clinical characteristics of acquired ungual fibrokeratoma

Hwang, Sewon,Kim, Miri,Cho, Baik Kee,Park, Hyun Jeong INDIAN ASSOCIATION OF DERMATOLOGIST, VENEROLOGISTS 2017 Indian journal of dermatology, venereology and lep Vol.83 No.3

Oral lichen planus treated with alitretinoin (Alitoc®): A case report

( Sewon Hwang ),( Jihong Lim ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. Oral lesions, compared with cutaneous lesions, rarely undergo spontaneous remission. Clinical classification of oral LP consists of 3 types of lesions: reticular, atrophic or erythematous and erosive LP. Alitretinoin is an endogenous vitamin A derivative, 9-cis-retinoic acid. It is a pan-agonist of both known nuclear retinoid receptor families: retinoic acid receptors (RAR) and retinoid X receptors (RXR). Alitretinoin, compared to acitretin or isotretinoin, is expected to be more effective in retinoid-responsive dermatoses such as LP due to its dual receptor activity. We present a case of 48-year-old man who had painful erythematous crusted erosions on the lip for 6 months. Histopathologically, the lesion showed hyperkeratosis in the epidermis and lichenoid perivascular lymphohistiocytic infiltration in the dermis. He was diagnosed with oral LP. He was treated with oral steroid and cyclosporin combined with topical tacrolimus for 6 months but the lesion remained without much improvement. Oral steroid and cyclosporine were discontinued and oral alitretinoin (Alitoc®) was started in a dose of 30mg daily. Within 3 weeks of taking oral alitretinoin (Alitoc®), the erythematous scales had disappeared without noticeable adverse effect. To our knowledge, this is the first case report of oral LP treated with alitretinoin in the Korean literature.

Subungual osteochondroma

Hwang, Sewon,Kim, Miri,Park, Hyun Jeong INDIAN ASSOCIATION OF DERMATOLOGIST, VENEROLOGISTS 2017 Indian journal of dermatology, venereology and lep Vol.83 No.5

Lobular capillary hemangioma after automicroneedle therapy system in an oriental medicine clinic

( Sewon Hwang ),( Jihong Lim ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Lobular capillary hemangioma(LCH) is a common benign vascular tumor presenting as a rapidly growing angiomatous papule. Trauma and underlying microscopic arteriovenous malformations have been implicated in LCH. Automicroneedle therapy system(AMTS), usually used to treat acne scars and wrinkles, improves transdermal delivery making multiple mechanical holes into the skin. In these days, AMTS is currently being used for cosmetic purposes mainly in oriental medicine clinics. We present a case of 41-year-old woman who had two erythematous papules on the preexisting infantile hemangioma site of the neck for several months. She had history of AMTS procedure on the lesion in an oriental medicine clinic several months ago. Histological examination demonstrated granulation tissue, mainly composed of proliferative capillaries, in the papillary dermis. The patient is scheduled for the pulsed dye laser treatment of the remaining infantile hemangioma. With the rising trends of herbal procedures conducted without accurate knowledgements regarding cutaneous lesions, dermatologists need to understand the current status of oriental medicine clinics and caution the public against indiscreet procedures.

Four cases of median nail dystrophy treated with intralesional steroid injection

( Sewon Hwang ),( Hwa Young Jung ),( Jin Hee Kang ),( Miri Kim ),( Hyun Jeong Park ),( Baik Kee Cho ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Median nail dystrophy(MND) is an uncommon and idiopathic dystrophic change, typically showing a central nail groove, beginning at or distal to the proximal nail fold, from which small lateral fissures may emerge. The onset of this nail dystrophy has occasionally been associated with either prior local trauma or initiation of some medical treatment. Various agents have been tried to treat the disease, but it is often resistant to many topical treatments. We performed a clinical study of four patients who were diagnosed with MND, between 2008 and 2014 at the Dermatology Department of Yeouido St. Mary’s Hospital. In three cases, thumbnails were affected and in one case, one 3rd fingernail was affected. All patients were male, with a mean age of 54.3 years (range, 33-63 years). One patient had repeated habitual nail biting. The involved nails showed typical clinical features of MND,including longitudinal groove or split involving one or both thumbnails. All the patients were treated by intralesional triamcinolone injection once a month. After treatment, the patients showed good responses. Here, we report four cases of MCND which were almost cleared by intralesional triamcinolone injection. We suggest intralesional triamcinolone injection as a safe and effective option for the treatment of MND.

Acrodermatitis continua of Hallopeau: A case series

( Sewon Hwang ),( Ji Won Yun ),( Jihong Lim ),( Yuri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis clinically characterized by the presence of periungual and subungual sterile pustules with paronychia, onychodystrophy and osteolysis of the distal phalanx of the fingers, toes and atrophic skin. In this case series, 16 cases of ACH are included. 13 out of 16 patients were female and the range of age was from 9 to 61. All patients had subungual pustulosis with nail changes such as onycholysis(69%), trachyonychia(69%) or yellowish chromonychia(44%). Two patients had additional psoriatic lesions on the other body parts. Histopathological results of the subungual biopsy of 9 patients showed acanthosis, inflammatory cell infiltrates and pustular formation. Treatment included dapsone(69%), NSAIDs (63%), methotrexate(31%) and acitretin(13%). 62.5% of the patients required long-term treatment duration over 5 months. Among these patients, 60% showed poor treatment response of <25%. ACH is often difficult to treat and tends to show recalcitrant prognosis because of its failure or only partial response to various therapies. Therefore, further studies regarding effective treatment regimen for ACH are needed due to lack of established therapy.

Furuncular cutaneous myiasis by Dermatobia hominis

( Sewon Hwang ),( Yu Seok Jung ),( Miri Kim ),( Hyun Jeong Park ),( Baik Kee Cho ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Myiasis in humans can produce furucular, creeping, or traumatic lesions. The most common cause of furuncular myiasis in the Americas is caused by D. hominis, a human botfly. A 58-year-old man presented with a 1-month history of solitary, 0.5cm-sized nodule with central pore around 1.5x0.5cm-sized erythematous patch on the Lt. popliteal fossa. A skin biopsy was performed and larva were exposed and extracted by forceps. The larva was 0.6cm-sized and bottle-neck shaped with backward projection spines. Dermatobia hominis is a member of the Oestridae famly. In appearance, it is approximately 1.5cm in length, yellow-brownish in color, and has a plumose arista. Cutaneous swellings of the larva are found most commonly on the head. Lesions are usually single and will be an inflamed swelling measuring 2-3cm in diameter. Treatment consists of many local remedies for removing the larva such as application of glue, pork fat, mineral oils, and petroleum jelly to suffocate the maggot. Herein, we present a rare case of furuncular cutaneous myiasis by dermatobia hominis in a 58-year-old male.

P292 : Acquired ungual fibrokeratoma: A single-center experience with 20 cases

( Sewon Hwang ),( Miri Kim ),( Hyun Jeoung Park ),( Baik Kee Cho ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Acquired ungula fibrokeratoma is first coined in 1977 by Cahn. It is a benign tumor of fibrous tissue and usually presents as asymptomatic, solitary, smooth, dome-shaped or fingerlike, flesh-colored papules. It emerges from the proximal nail fold or sometimes from the nail bed and nail matrix Objective: This study describes the clinical features with accompanied nail changes, response to treatment, and follow up in 20 patients with acquired ungula fibrokeratoma Methods: Twenty patients with acquired ungula fibrokeratoma who attended our hospital between 2003 and 2014 were retrospectively reviewed. Cases with tuberous sclerosis were not included Results: The mean age was 41.2 years (range, 15 to 79) and male-to-female ration was 11:12. The mean duration of disease was 40.4 months and highest number of cases occurred in patients in their 40s. The mean follow-up period was 8.6 months. All of the patients had single lesion and treated by surgical excision. Most common morphologic type is Dome-shaped, followed by Branching, flat, rod-shaped. And distribution is periungual, intraungual, subungual inorder. Conclusion: In this study, we presented the clinical characteristics with nail abnormalities and classified by location and morphological features of AUFK. These results could make help dermatologist distinguish AUFK from the other skin lesions on the ungual area

선천적으로 구부러진 양측 네번째 발톱

황세원 ( Sewon Hwang ),김미리 ( Mi Ri Kim ),조백기 ( Baik Kee Cho ),박현정 ( Hyun Jeong Park ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.4

선천적으로 구부러진 네번째 발톱은 드문 손발톱 변형으로, 1991년 Iwasawa 등에 의해 처음 보고 되었으며, 끝마디 뼈의 장축에 평행하게 발바닥쪽으로 구부러진 네번째 발톱판을 특징으로 한다. 환자는 7세 남아로 태어날 때부터 있었던 양측 네번째 발톱 변형을 주소로 내원하였다. 과거력과 가족력에서 특이 사항은 없으며, 신발을 신을 때통증을 호소하였다. 이학적 검사에서 양측 네번째 발톱이 발바닥 쪽으로 굽어져 있었으며 네번째 발의 움직임의 제한은 없었다. 다른 발톱이나 손톱의 변형은 관찰되지 않았다(Fig. 1). 방사선학적 검사에서 양쪽 발의 뼈의 변형이나 연부조직의 결함은 없었다. 이에 저자들은 양측 네번째 발톱 변형을 선천적으로 구부러진 네번째 발톱으로 진단을 하였으며 영구적인 변형이나 합병증을 예방하기 위해 주기적인 경과 관찰을 하기로 하였다. 선천적으로 구부러진 발톱은 다른 손발톱 질환은 동반하지 않으며, 이는 발생과정 상 외배엽의 결함으로 생기는 다른 발가락 변형과 다르게 중배엽의 결함에서 기인하기 때문으로 생각된다1. 그러나 네 번째 발가락에 국한되어 변형이 일어나는 이유에 대해서는 아직 밝혀진 바 없다. 선천적으로 구부러진 네번째 발톱은 대부분 끝마디 뼈의 선천성 저형성(hypoplasia)이나 소실에 이차적으로 발생하는 손발톱 변형이나1,2, 본 증례와 유사하게 골 혹은 연부조직의 결함 없이 발생한 경우도 보고된 바 있다3. 선천적으로 구부러진 네번째 발톱과 감별해야 할 질환에는 역손발톱익상편(pterygium inversum unguis), 매발톱 조갑(claw-like fingers and toes), 앵무새부리 손발톱(parrot beak nail) 등이 있다. 역손발톱 익상편은 대부분의 경우 양 손의 손톱을 침범하나 발톱을 침범하는 경우는 매우 드물며, 끝마디 뼈의 변화와는 관련되어 있지 않은 것으로 알려져 있다. 매발톱 조갑은 손발톱 끝에 연부조직이 결여되어 선천적으로 구부러진 네번째 발톱과는 차이가 있고, 앵무새부리 손발톱은 번연부가 대칭적으로 과굴곡 된다는 점에서 감별 가능하다. 골 혹은 연부조직의 결함이 있는 경우에 확실한 치료법을 찾는 것은 어렵다. 따라서 손발톱박리증, 손발톱거침증 등 추가적인 손발톱 변형을 방지하기 위해서는 환자에게 편한 신발을 권하고 외상에 주의해야 함을 교육해야 하고 변형이 지속되면 수술을 고려해 볼 수 있다. 본 증례에서도 구부러진 부위를 짧게 깎아 연부조직을 누르지 않도록 하였으며 구부러지기 전에 잘라 주도록 권유 하였다. 선천적으로 구부러진 네번째 발톱은 매우 드물어, 저자들이 조사한 바에의하면 외국에서 30∼40예가 보고된 바가 있었지만, 국내에서는 1예만 보고되었다4. 특히, 본 증례와 같이 양측에 동시에 발생한 예는 아직 국내에 보고되지 않아 의미 있는 증례로 생각되어 보고한다.