40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

기종성 신우신염의 임상양상 및 사망위험인자

조수연,이호재,조용현,이승주 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Emphysematous pyelonephritis (EPN) is an acute gas forming necrotizing infection of the renal parenchyma with high mortality. Although its incidence is relatively low, it mostly occurs in patients wiith diabetes mellitus. The aim of the study is to identify the risk factors related to mortality and assess the outcome of managements according to the radiologic classification. Materials and Methods : The clinical records of 23 patients diagnosed with EPN were reviewed retrospectively. The cases were grouped into two types on the basis of computed tomography scan. Type 1 EPN was defined as renal necrosis and gas formation with total absence of fluid content. Type 2 EPN was defined as the presence of renal or perirenal fluid in association with bubbly or loculated gas pattern. The patients' symptoms, performed investigations, and treatments were analyzed. Results : All patients had diabetes mellitus. Escherichia coli (78.6%) was the most common pathoqen in urine and blood cultures. The factors showing statistically significant differences between survivors and non-survivors were age (P=0.013), the presence of obstructive uropathy (P= 0.008), and type 1 group (P=0.030). Multivariate logistic regression showed that factor significantly related to death was age (odds ratio=1.20, 95% confidence interval 1.01-1.38, P=0.037). Conservative treatment including antibiotics and percutaneous drainage was successful in type 2 group, Overall mortality was 26.1%; all expired patients were from type 1 group. The mortality of conservative treatment and nephrectomy in type 1 group was 83.3% and 20.0%, respectively. Conclusion : These results suggest that old age is a significant risk factor for mortality in patients with EPN. Nephrectomy should be considered as the main treatment option in patients with type 1 EPN.

다중 제어루프에 의한 자기부상용 DC-DC 전원장치에 관한 연구

조주현,조정민,전기영,이상집,이승환,오봉환,이훈구,한경희 明知大學校 産業技術硏究所 2004 産業技術硏究所論文集 Vol.23 No.-

The author present a modified multi-loop algorithm including feedforward for controlling a 55kW step down chopper in the power supply of Maglev. The control law for the duty cycle consists of three terms. The first is the feedforward term which compensates for variations in the input voltage. The second term consists of the difference between the slowly moving inductor current and output current. The third term consists of proportional and integral terms involving the perturbation in the output voltage. This perturvation is derived by subtracting the desired output voltage from the actual output voltage. The proportional and integral action stabilizes the system and minimizes output voltage error. In order to verify the validity of the proposed multi-loop controller, simulation study was tried using Matlab simulink.

환경친화적 수용성 대전방지제의 합성 및 그 응용에 관한 연구

조승현,하진욱 순천향대학교 부설 산업기술연구소 2001 순천향 산업기술연구소논문집 Vol.7 No.2

Water soluble anti-static coating composition(AS-2001), multi-functional(anti-static and slip-stop)and anti-static functional paint coating agents were formulated. Firstly, the multi-functional coating agents were formulated with AS-2001 and slip stop(SㆍS) with water-born polyurethane. The additive of multi-functional coating agent varied from 5 to 12 wt%, depending on the amount of polyurethane used. The optimum amount of coating agent was 10 wt%, The ratio of coating composition AS-2001: SㆍS was 8:2. The surface resistance and friction factor of coated layer were 10^(9)Ω/㎠ and 0.88 in optimum condition, respectively. Secondly, the anti-static functional paint was formulated with AS-2001 and water soluble paint. The additive amounts of AS-2001 are varied from 5 to 20 wt% depending on the amount of water soluble paint. Results showed that the surface resistance of coated gypsum board decreased up to 10^(6)Ω/㎠ as the amount of coating agent increased. However, water soluble paint was aggregated in 20wt% addition of AS-2001, causing coating problems. Anti-static and anti-stain effects were excellent even though 5 wt% of AS-2001 was added in the board.

Simplified Effective Compressive Strengths of Columns with Intervening Floor Slabs

Seung?Ho Choi,Jin?Ha Hwang,Sun?Jin Han,Hae?Chang Cho,Jae Hyun Kim,Kang Su Kim 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.5

The current design codes discuss the effective compressive strengths of columns, which reflect a decrease in load transfer performance that can occur when columns and slabs have different concrete compressive strengths. The effective compressive strength of a column increases as it is confined by the slab, and the design codes mandate three different effective compressive strengths for interior columns (confinement on four sides), exterior columns (confinement on three sides), and corner columns (confinement on two sides). For both corner and exterior columns, the confinement effect of the slab is significantly smaller than that for the interior column, and there is a more marked decrease in load transfer performance. However, there is still a lack of theoretical studies investigating the effective compressive strengths of the corner and exterior columns. Therefore, based on the analysis model established in previous research, this study has proposed an equation for calculating the effective compressive strengths of the corner, exterior and isolated columns without any confinement effects of the slab. In addition, axial loading tests of isolated columns were conducted and the proposed equation was verified.

아마릴 정(글리메피리드 2㎎)에 대한 글리메드 정의 생물학적 동등성

조혜영,박은자,강현아,백승희,이석,김세미,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tables, Amaryl^(?)(Handok/Aventis Pharm. Co., Ltd.) and Glimed (Kuhn Ⅱ Pharm. Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The glimepiride release from the two glimepiride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solution, water and blend of PSB 80 into each dissolution medium). Twenty six healthy male subjects, 22.65±2.19 years in age and 66.55±8.85 kg in body weight, were divided into two groups and randomized 2×2 cross-over study was employed. After one tablet containing 2 ㎎ as glimepiride was orally administered, blood was taken at predetermined time intervals and the concentrations of glimepiride in serum were determined using HPLC method with UV detctor. The dissolution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC_(t), C_(max) and untransformed T_(max). The results showed that the differences between two formulations based on the Amaryl were -3.70, -8.28 and 0.61% for AUC_(t), C_(max) and T_(max), respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25)(e.g., log(0.84)∼log(1.04) and log(0.82)∼log(1.03) for AUC_(t) and C_(max), respectively). Thus, the criteria of the KFDA guideline for the bioequivalence were satisfied, indicating Glimed tablet and Amaryl tablet were bioequivalent.

4종 전자근관장측정기의 정확성과 일관성에 관한 in vitro 연구

조재현,금기연,이승종 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.5

이번 연구는 서로 다른 4개의 전자근관장측정기의 정확성을 측정하고 각각 0.5지점과 Apex지점에서의 일관성을 비교하고자 하였다. 40개의 발치된 상하악 소구치를 대상으로 치수강 개방 후 alginate model에 고정시키고 근관장을 측정하였다. 사용된 전자근관장측정기는 Root ZX (Morita, Tokyo, Japan), SmarPex (META, Seoul, Korea), Elements Diagnostic Unit (SybronEndo, CA, USA), E-Magic Finder Deluxe (S-Denti, Seoul, Korea)이다. 먼저 모든 치아에서 4개의 전자근관장측정기를 사용하여 0.5지점과 Apex지점에서 근관장을 측정하여 한 치아당 8개의 측정값을 얻었다. 다음으로 치아를 각 전자근관장측정기당 10개씩 4개의 그룹으로 나누어, 각각 제조사의 지시대로 Root ZX, Elements Diagnostic Unit 및 E-Magic Finder Deluxe는 "0.5"지점에서, SmarPex는 ''Apex" 지점에서 file을 치아에 cement로 고정시켰다. 이후 치근단부 4 mm를 삭제하여 100배율의 Image ProPlus로 관찰하여 file 끝에서 주근단공의 외연까지의 실제거리를 측정한 후, 4개의 전자근관장측정기의 0.5지점 및 Apex지점에서 file 끝과 주근단공 사이의 거리를 계산하여 비교하였다. 그 결과 Root ZX와 E-Magic Finder는 실험군 100%, SmarPex는 90%, Elements Diagnostic Unit는 70%에서 주근단공과의 거리가 임상적 허용범위인 土0.5 mm 이내에 있었다. 또한 각 전자근관장측정기마다 0.5지점과 Apex지점에서의 근관장의 표준편차와 사분위 범위를 구하여 두 지점간의 일관성을 비교한 결과, Root ZX, E-Magic Finder는 0.5지점과 Apex지점에서 비슷한 일관성을 보였으며 SmarPex와 Elements Diagnostic unit는 Apex지점에서 0.5지점보다 더 높은 일관성을 보였다. 전자근관장측정기는 근관 내의 조건에 관계없이 근첨협착부에서 항상 일정한 거리를 재현해 낼 수 있는 일관성이 중요하므로, 이렇게 0.5지점 또는 Apex지점에서의 일관성이 증명된다면 실제 임상에서 사용할 때 전자근관장에서 일정한 거리를 가감하여 사용할 수 있다. The purpose of this study was to evaluate the accuracy and the consistency of four different electronic apex locators in an in vitro model. Fourty extracted premolars were used for the study. Four electronic apex locators (EAL) were Root ZX, SmarPex, Elements Diagnostic Unit (EDU), and E-Magic Finder Deluxe (EMF). After access preparation, the teeth were embedded in an alginate model and the length measurements were carried out at "0.5" and "Apex" mark using four EALs. The file was cemented at the location of the manufacturers' instruction (Root ZX, EDU, EMF: 0.5 mark, SmarPex: Apex mark). The apical 4mm of the apex was exposed and the distance from the file tip to the major foramen was measured by Image ProPlus (× 100). The distance from the file tip to the major foramen was calculated at 0.5 and Apex mark and the consistency of 0.5 and Apex mark was compared by SD and Quartile of Box plots. In this study, Root ZX and EMF located the apical constriction accurately within ± 0.5 mm in 100%, whereas SmarPex and EDU located in 90% and in 70% respectively. For Root ZX and EMF, there was no significant difference between the consistency of 0.5 and Apex mark. However, for the EDU and SmarPex, Apex mark was more consistent than 0.5 mark. From the evaluation of the consistency in this study, for Root ZX and EMF, both 0.5 and Apex mark can be used as a standard mark. And for EDU and SmarPex, the Apex mark can be recommended to be used as a standard mark.

비유피-4 정(염산프로피베린 20㎎)에 대한 건일염산프로피베린 정의 생물학적동등성

조혜영,박은자,강현아,백승희,김세미,박찬호,오인준,문재동,이용복 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

The purpose of the present study was to evaluate the bioequivalence of two propiverine hydrochloride tablets. BUP-4 (Jeil Pharm. Co., Ltd.) and Kuhnil Propiverine Hydrochloride (Kuhnil Pharm. Co., Ltd.), according to the guidelines of the Korea Food and Drug Administration (KFDA). The propiverine release from the two propiverine hydrochloride formulations in vitro was tested using KP Ⅷ Apparatus Ⅱ method with a variety of dissolution media (pH 1.2, 4.0, 6.8 buffer solutions, water and blend of polysorbate 80 into pH 6.8). Twenty six healthy male subjects, 23.73 ± 2.79 years in age and 67.04 ± 7.93 kg in body weight, were divided into two groups and a randomized 2 x 2 cross-over study was employed. After one tablet containing 20 mg as propiverine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of propiverine in serum were determined using HPLC method with UV detector. The dis-solution profiles of two formulations were similar at all dissolution media. Besides, the pharmacokinetic parameters such as AUC" C _(max) and T _(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC, C_(max), and untransformed T_(max). The results showed that the differences between two formulations based on the BUP-4 were 0.17%, 7.98% and 4.55% for AUC,, C_(max), and respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically trans-formed data were within the acceptance range of log(0.8) to log(1.25) (e.g., log(0.88)-log(l .12) and log(0.90)-log(l.15) for AUC, and _(max), respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating Kuhnil Propiverine Hydrochloride tablet was bioequivalent to BUP-4 tablet.

신발산업의 공급망 비즈니스 프로세스 분석

현승용,최형림,조민제 東亞大學校 經營問題硏究所 2002 經營論叢 Vol.23 No.-

국내 신발산업(Foodwear Industry)은 주로 외국의 대형 바이어에 의존적인 형태로 생산하는 주문자 상표 부착 생산방식이 대부분을 차지하며, 신발 제조에서 인건비가 차지하는 비중이 절대적이어서 대형 바이어들이 중국, 베트남, 인도네시아 등의 저임금 국가로 신발 생산기지를 옮겨가고 있다. 이로 인해 국내 신발산업은 많은 어려움을 겪고 있는 것이 사실이다. 또한 국내의 신발제조기업들도 상당수 해외에 생산공장을 운영하고 있으며, 국내 생산공장은 그 규모가 굉장히 축소되어 있거나 혹은 연구개발 및 부품 조달기지로서의 역할을 수행하고 있다. 이러한 신발산업의 환경에 변화에 대해 산업 차원에서 대응할 필요성이 있다. 앞으로 국내 신발산업이 성장하기 위해서는 전체 공급망의 협업체제를 갖추는 것이 필요하다. 이를 위해서는 신발산업의 공급망 네트워크 구조를 분석하여 비효율적인 부분을 개선해야 하며, 기업간의 비즈니스 프로세스를 새롭게 정립하여 혁신해야 한다. 이에 본 연구에서는 신발산업의 공급망 네트워크 구조를 분석하여 개선 모델을 제시하였으며, 공급망에서 대부분을 차지하는 신발 완제품 제조기업과 부품 제조기업간의 비즈니스 프로세스를 분석하여 개선된 비즈니스 프로세스를 제시하였다.

新興家內工業의 地域形成과 存立形態 : 全南 海南郡 黃山面 옥연의 옥돌工藝業을 中心으로 Hwangsan-myeon, Haenam-gun, Chonnam Province

曺勝鉉 全南大學校 人文科學硏究所 1985 용봉인문논총 Vol.15 No.-

The purpose of this thesis is to investigate how agalmatolite-product domestic industry has grown in Ockyeon village. Through this case study, it is hoped that we can shed some light on the origin and formation process of Korean traditional handicraft industry. The primary data for the present study were collected by utilizing interview schedule. In addition, informal interviews were held to all producers. The study results can be summarized as the followings : 1) The agalmatolite-product industry in this area was originated from a village which is located 10km away from Ockyeon village, in 1930s. But one of the producers migrated to Ockyeon village in 1959. After this happened, the village had become a new center of the industry. The major reason for this relocation- diffusion was that it was much easier to acquire the material, i.e., agalmatolite, in Ockyeon village than in the original village. It is noted that the industry is material-oriented one in its nature. 2) The development of the industry can be marked by two phases : the first phase covers 1959 ~ 1969 time period, and the second phase falls into 1970 ~ 1985 time period. The first phase refers to the period when the products were made through handicraft. The second phase characterized by the use of machines in its production. During this phase, the products became more diverse, and production level increased. 3) The industry is not specialized in terms of production and merchandizing. With respect to specialization, it is also noted that about half of the producers have additional jobs.