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칠복음(七福飮)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)
최공한,박승택,류도곤,최민호,엄상섭,허진영,강성도,고정수,서의석,성은경,조남수,이춘우,황일택,선성규,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Um, Sang-Sub,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Sou, Eui-Suk,Sung, Yeun-Ky 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2
As the average life span have been lengthened and the rate of senile population have been raised, chronic degenerative diseases incident to aging has been increased rapidly and become a social problem. With this social background, recently, the facts that oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease have been turned out, and accordingly lots of studies on the mechanism of the toxic effects of OR on nerves, the diseases caused by OR and the approaches to curing the diseases have been made. The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Chilbokyeum(CBY) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay 2. GO, a oxygen radical, increased lipid peroxidation and the amount of LDH. 3. CBY have efficacy of decreasing lipid peroxidation. 4. CBY have efficacy of decreasing the amount of LOH. From the above results, It is concluded that Chilbokyeum has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And Chilbokyeum is thought to have certain pharmacological effects on controlling over aging and treating Dementia. Further clinical study of this pharmacological effects of Chilbokyeum should be complemented.
석창포(石菖蒲) 전탕액(煎湯液)이 Glucose Oxidase에 의해 손상(損傷)된 대뇌피질(大腦皮質) 신경세포(神經細胞)에 미치는 영향(影響)
최공한,박승택,류도곤,최민호,허진영,강성도,고정수,양상철,성은경,조남수,이춘우,서의석,류영수,Choi, Kong-Han,Park, Seung-Taeck,Ryu, Do-Gon,Choi, Min-Ho,Hea, Jin-Young,Kang, Sung-Do,Go, Jeong-Soo,Yang, Sang-cheal,Sung, Yeun-Kyung,Cho, Nam-Su,L 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2
The purpose of this study is to examine the toxic effects caused by Glucose Oxidase(GO) and the effects of herbal extracts such as Acori Rhizoma(AR) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. GO, a oxygen radical, decreased the survival rate of the cultured cells on NR assay and MTT assay. 2. GO, a oxygen radical, decreased the amount of neurofilaments and total protein. 3. AR have efficacy of increasing the amount of neurofilament. 4. AR have efficacy of increasing the amount of total protein. From the above results, It is concluded that AR has marked efficacy as a treatment for the damages caused in the GO-mediated oxidative process. And AR is thought to have certain pharmacological effects on controlling over aging. Further clinical study of this pharmacological effects of AR should be complemented.
진해제 지놀타(Zipeprol 2HCl) 남용으로 유발된 기질성 정신장애 1례
김홍곤,박민철,노승호,김은숙 圓光大學校 醫科大學 神經精神科學敎室 1993 圓光精神醫學 Vol.9 No.2
We experienced a case of organic mental disorder following Zinolta(Zipeprol 2HCI) abuse for about a year. he showed neuropsychiatric symptoms such as vivid auditory and visual hallucinations, idea of reference, aggressive behaviors, and drowsy mental states. During the hospitalization, he was treated with benzodiazepines without any other specific treatment. He was improved and discharged with clear sensorium without any psychotic symptoms. Zipeprol Hydrochloride is a centrally acting cough suppressant. There have been reports of abuse and overdosage producing neurological symptoms. Although lacking in the comprehensive study explaining the pttersn of abuse, pharmacological effects and incidence of psychotic symptoms, this case suggests the need for evaluation of the potentially dangerous orgainc psychotic symptoms among the populations who are exposed.
Regulatory Effect of Matcha Green Tea on Fine Dust-Exposed Cytotoxicity in Respiratory System
Jong Min Kim,Jong Hyun Moon,Min Ji Kim,Hyo Lim Lee,Hye Rin Jeong,Min Ji Go,Tae Yoon Kim,Seung Gyum Joo,Jong Cheol Kim,Ho Jin Heo 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
This study was performed to evaluate the protective effect of matcha green tea on particulate matter (PM)2.5-indued nasal and pulmonary cytotoxicity. The matcha green tea increased the cell viability and inhibited the ROS production in PM2.5-induced cytotoxicity in nasal RPMI2650 and pulmonary A549 cells. The matcha green tea regulated the expression of apoptosis, such as p-Akt, BCl-2, caspase-3, caspase-1 and HO-1, and inflammation, such as TLR4, TLR4 and Nrf2, in PM2.5-indued RPMI2650 cells. In addition, the matcha green tea showed regulatory effect of the apoptosis and inflammatory effect by increasing the BCl-2 and suppressing the caspase-3, TLR4, TNF-α and COX-2 in A549 cells. In addition, the matcha green tea suppressed antioxidant deficits by regulating the reduced GSH contents, SOD activities and MDA levels, and ameliorated the mitochondrial dysfunction by regulating the mitochondrial ROS production, mitochondrial membrane potential and ATP contents in pulmonary tissue. Ultimately, consumption of matcha green tea down-regulated the inflammatory proteins such as TNF-α, p-JNK, p-IκB-α, p-NF-κB and COX-2 in lung tissue.
Go Sung-Ho,Rho Seung Bae,Yang Dong-Wha,Kim Boh-Ram,Lee Chang Hoon,Lee Seung-Hoon 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.6
The human papillomavirus (HPV)-18 E7 (E7) oncoprotein is a major transforming protein that is thought to be involved in the development of cervical cancer. It is well-known that E7 stimulates tumour development by inactivating pRb. However, this alone cannot explain the various characteristics acquired by HPV infection. Therefore, we examined other molecules that could help explain the acquired cancer properties during E7-induced cancer development. Using the yeast two-hybrid (Y2H) method, we found that the Elk-1 factor, which is crucial for cell proliferation, invasion, cell survival, anti-apoptotic activity, and cancer development, binds to the E7. By determining which part of E7 binds to which domain of Elk-1 using the Y2H method, it was found that CR2 and CR3 of the E7 and parts 1–206, including the ETS-DNA domain of Elk-1, interact with each other. As a result of their interaction, the transcriptional activity of Elk-1 was increased, thereby increasing the expression of target genes EGR-1, c-fos, and E2F. Additionally, the colony forming assay revealed that overexpression of Elk-1 and E7 promotes C33A cell proliferation. We expect that the discovery of a novel E7 function as an Elk-1 activator could help explain whether the E7 has novel oncogenic activities in addition to p53 inactivation. We also expect that it will offer new methods for developing improved strategies for cervical cancer treatment.
Cerebral Fat Embolism That Was Initially Negative on Diffusion-Weighted Magnetic Resonance Imaging
( Seung Je Go ),( Yun Su Mun ),( Seung Ho Bang ),( Yong Han Cha ),( Young Hoon Sul ),( Jin Bong Ye ),( Jae Guk Kim ) 대한외상학회 2021 大韓外傷學會誌 Vol.34 No.2
Fat embolism syndrome is a rare, but serious condition that occurs in patients with fractures of the long bones or who undergo orthopedic surgery. The main clinical features of fat embolism syndrome are an altered mental status, hypoxia, and petechial rash. Cerebral fat embolism is the most severe manifestation of fat embolism syndrome because it can lead to an altered mental status. The diagnosis of cerebral fat embolism is clinical, but brain magnetic resonance image (MRI) is helpful. There is usually an interval until symptoms, such as an altered mental status, develop after trauma. We report a case of cerebral fat embolism in which the patient’s mental status deteriorated several hours after trauma and the initial findings were negative on diffusion-weighted MRI.
Yeun, Go Heum,Lee, Seung Hwan,Lim, Yong Bae,Lee, Hye Sook,Won, Moo-Ho,Lee, Bong Ho,Park, Jeong Ho Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.4
In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between ${\alpha}$-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2-aminoethoxy)ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy)ethanol (linker 1) was switched to the cationic 2-(piperazin-1-yl)ethanol linker (linker 2). The $IC_{50}$ values of the linker-2 hybrid molecules for BuChE inhibition were lower than those of linker-1 hybrid molecules (except 9-2) and they also had the same great selectivity for BuChE over AChE (> 800 fold) as linker-1 hybrid molecules. ALA-acetyl caffeic acid (10-2, ALA-AcCA) was shown as an effective inhibitor of BuChE ($IC_{50}=0.44{\pm}0.24{\mu}M$). A kinetic study using 7-2 showed that it is the same mixed type inhibition as 7-1. Its inhibition constant (Ki) to BuChE is $4.3{\pm}0.09{\mu}M$.
김고은 ( Go-eun Kim ),장성호 ( Seong-ho Jang ),정영빈 ( Young-been Jeong ),양승빈 ( Seung-bin Yang ),류하오 ( Hao Liu ),박성민 ( Seong-min Park ),이승훈 ( Seung-hun Lee ),이재용 ( Jae-yong Lee ) 한국폐기물자원순환학회(구 한국폐기물학회) 2017 한국폐기물자원순환학회 추계학술발표논문집 Vol.2017 No.-
우리나라 경제의 성장을 이끈 기계산업은 2015년 현재 생산액 100조원, 사업체수 9,526개사, 종사자수 31만 5천명, 부가가치 39조원으로써 제조업 중 생산액 5위, 사업체수 2위, 종사자수 3위, 부가가치 4위에 위치하고 있다. 이러한 기계산업에 있어 공작기계를 이용해 금속을 원하는 모양으로 만드는 금속가공은 반드시 필요한 공정으로 금속가공 시 가공 장비의 수명 연장 및 가공물의 품질 향상을 위해 칩이 형성되는 영역에 적용되어 윤활 및 냉각작용을 하는 절삭유(Soluble Cutting Fluids, SCF)가 이용되고 있다. 절삭유는 수용성 및 비수용성으로 나뉘는데 비수용성 절삭유의 경우 윤활성은 우수하나 경제성 및 발연, 발화등의 문제점이 있으며, 수용성 절삭유는 윤활성은 비교적 떨어지나 냉각성과 경제성이 우수하다는 장점이 있다. 또한 절삭유는 기능 향상을 위해 PAH, 방부제, 파라핀계 염소, 아질산염 등 20~30개의 첨가제가 사용된다. 이는 중추신경계 장애, 이비인후 자극, 피부염 발생 등을 일으킬 위험성이 크다고 알려져 있으며, 고농도의 유기성분 및 질소화합물로 인해 수계에 유출시 부영양화, 녹조현상 등과 같은 문제를 일으킬 수 있다. 따라서 본 연구에서는 전기화학적 처리를 통해 반응시간에 따른 폐수용성 절삭유의 COD 및 T-N의 제거율 변화를 분석하였다. 전기화학적 처리의 중요 인자인 전극은 비교적 가격이 저렴하고 용출량이 낮은 것으로 알려져 있는 SUS316전극을 이용하였으며 자세한 실험 조건을 Table 1에, 연구에 사용한 장치의 모식도를 Fig. 1에 나타내었다.