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Park, See-Hyoung,Cho, Jae Youl,Oh, Sae Woong,Kang, Mingyeong,Lee, Seung Eun,Yoo, Ju Ah,Jung, Kwangseon,Lee, Jienny,Lee, Sang Yeol,Lee, Jongsung Elsevier 2018 Chemico-biological interactions Vol.282 No.-
<P><B>Abstract</B></P> <P>The stemness of stem cells is negatively affected by ultraviolet A (UVA) irradiation. This study was performed to examine the effects of arctigenin on UVA-irradiation-induced damage to the stemness of human mesenchymal stem cells (hMSCs) derived from adipose tissue. The mechanisms of action of arctigenin were also investigated.</P> <P>A BrdU-incorporation assay demonstrated that arctigenin attenuated the UVA-induced reduction of the cellular proliferative potential. Arctigenin also increased the UVA-induced reduction in stemness of hMSCs by upregulating stemness-related genes such as <I>SOX2</I>, <I>OCT4</I>, and <I>NANOG</I>. In addition, the UVA-induced reduction in the mRNA expression level of hypoxia-inducible factor (HIF)<I>-</I>1α was significantly recovered by arctigenin. The antagonizing effect of arctigenin on UVA irradiation was mediated by reduced PGE<SUB>2</SUB> production through the inhibition of MAPKs (p42/44 MAPK, p38 MAPK, and JNK) and NF-κB. Overall, these findings suggest that arctigenin can ameliorate the reduced stemness of hMSCs induced by UVA irradiation. The effects of arctigenin are mediated by PGE<SUB>2</SUB>-cAMP signaling-dependent upregulation of <I>HIF-1α</I>. Therefore, arctigenin could be used as an antagonist to attenuate the effects of UVA irradiation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Arctigenin attenuated the UVA-induced reduction of the proliferative potential. </LI> <LI> Arctigenin increased the UVA-induced reduction of the stemness of the hMSCs. </LI> <LI> Arctigenin recovered UVA-induced reduction of the expression level of HIF-1α gene. </LI> <LI> Arctigenin induces an PGE2-cAMP signaling-dependent upregulation of HIF-1α. </LI> <LI> Arctigenin could be used as an antagonist to attenuate the UVA effects. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Park, See-Hyoung,Kang, Mi-Ae,Shim, Hyeong-Soo,Cho, Hyeong-Jin,Won, Jong-Hwa,Lee, Keun-Hyeung Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.9
We investigated in vitro T-cell inhibitory activity and bioavailability of small chemical inhibitors for Lck SH2 domain, which had a different scaffold such as an amide bond, reduced amide bond, N-methyl amide bond, thioamide bond, and urethane bond. Each of these compounds, with its particular scaffold, showed a different logP value, stability against serum enzyme, stability in buffer solution, and in vitro T-cell inhibitory activity. Overall results indicated that the SH2 inhibitor containing urethane bond can be a new lead compound because of its superior bioavailability, potent in vitro T-cell inhibitory activity, and facile synthesis.
Park, See-Hyoung,Lee, Jongsung,Shon, Jong Cheol,Phuc, Nguyen Minh,Jee, Jun Goo,Liu, Kwang-Hyeon Elsevier 2018 Phytomedicine Vol.42 No.-
<P>Conclusion: Overall, this was the first report of the inhibitory effects of BCA on CYP2J2 in HLMs. The present data suggest that BCA is a potential candidate for further evaluation for its CYP2J2 targeting anti-cancer activities.</P>
See-Hyoung Park,Mi-Ae Kang,Hyeong-Soo Shim,조형진,Jonghwa Won,이건형 대한화학회 2006 Bulletin of the Korean Chemical Society Vol.27 No.9
We investigated in vitro T-cell inhibitory activity and bioavailability of small chemical inhibitors for Lck SH2 domain, which had a different scaffold such as an amide bond, reduced amide bond, N-methyl amide bond, thioamide bond, and urethane bond. Each of these compounds, with its particular scaffold, showed a different logP value, stability against serum enzyme, stability in buffer solution, and in vitro T-cell inhibitory activity. Overall results indicated that the SH2 inhibitor containing urethane bond can be a new lead compound because of its superior bioavailability, potent in vitro T-cell inhibitory activity, and facile synthesis.
Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway
Park, See-Hyoung,Lee, Jongsung,Kang, Mi-Ae,Jang, Kyu Yun,Kim, Jung Ryul D.A. Spandidos 2018 Oncology letters Vol.15 No.6
<P>The outcome of chemotherapy for osteosarcoma have improved during the past decade and more patients have access to combination chemotherapy, but there has been no significant clinical progress in the patient survival rate. Recently, forkhead-box O3 (FOXO3) was identified as a pivotal transcription factor responsible for the transcriptional regulation of genes associated with suppression of cancer. The purpose of the present study was to screen small chemicals activating FOXO3 and elucidate their underlying mechanism. Using a drug discovery platform based on the phosphorylation status of FOXO3 in osteosarcoma cells, mitoxantrone (MTZ), a type of DNA-damaging agent, was selected as a possible FOXO3 activator from the food and drug administration-approved drug library. MTZ treatments significantly inhibited the phosphorylation level of Akt-pS473 and caused nuclear localization of FOXO3 in osteosarcoma cells. MTZ treatment inhibited proliferation in osteosarcoma cells <I>in vitro</I>, whereas silencing FOXO3 potently attenuates MTZ-mediated apoptosis in osteosarcoma cells. Taken together, the results indicated that MTZ induces apoptosis in osteosarcoma cells through an Akt/FOXO3-dependent mechanism.</P>
( Sol Lee Park ),( Jang Yeon Cho ),( Su Hyun Kim ),( Hong-ju Lee ),( Sang Hyun Kim ),( Min Ju Suh ),( Sion Ham ),( Shashi Kant Bhatia ),( Ranjit Gurav ),( See-hyoung Park ),( Kyungmoon Park ),( Yun-go 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.1
Ever since bioplastics were globally introduced to a wide range of industries, the disposal of used products made with bioplastics has become an issue inseparable from their application. Unlike petroleum-based plastics, bioplastics can be completely decomposed into water and carbon dioxide by microorganisms in a relatively short time, which is an advantage. However, there is little information on the specific degraders and accelerating factors for biodegradation. To elucidate a new strain for biodegrading poly-3-hydroxybutyrate (PHB), we screened out one PHB-degrading bacterium, Microbulbifer sp. SOL03, which is the first reported strain from the Microbulbifer genus to show PHB degradation activity, although Microbulbifer species are known to be complex carbohydrate degraders found in high-salt environments. In this study, we evaluated its biodegradability using solid- and liquid-based methods in addition to examining the changes in physical properties throughout the biodegradation process. Furthermore, we established the optimal conditions for biodegradation with respect to temperature, salt concentration, and additional carbon and nitrogen sources; accordingly, a temperature of 37℃ with the addition of 3% NaCl without additional carbon sources, was determined to be optimal. In summary, we found that Microbulbifer sp. SOL03 showed a PHB degradation yield of almost 97% after 10 days. To the best of our knowledge, this is the first study to investigate the potent bioplastic degradation activity of Microbulbifer sp., and we believe that it can contribute to the development of bioplastics from application to disposal.
A Study on Performance Evaluation of Magnetic Dental Attachments
Seen-Young Kang,Ji-Min Yu,Hyoung-Sik Kim,Ki-Sook Park,Seung-Youl Lee 한국자기학회 2019 Journal of Magnetics Vol.24 No.4
This study measures retentive force as function of the diameter, the cross-head speed, and the number of detachments of dental magnetic attachments in a clinical environment, and analyzes the validity of the international standard method for testing them. In this study, tests 1, 2, and 3 were used to measure the retentive force as a function of the contact area of the magnetic attachment, and tests 2 and 4 as a function of the cross-head speed. Test 2 and 5 compared function of the retentive force as a function of repeated detachments Results showed that the retentive force increases as the sample surface increases, and decreases as the cross head speed increases. Additionally, after 1500 detachment cycles, the retentive force increased. Finally, the international standard test method was validated, because an objective method for testing magnetic attachments in clinical environment could not be found.
Aspergillus sp. F184가 생산하는 Xanthine Oxidase 저해제에 관한 연구
박시형,윤상웅,박정민,옥승호,유주현,배동훈 한국산업미생물학회 2000 한국미생물·생명공학회지 Vol.28 No.2
통풍과 oxygen free radical의 독성에 관여하는 xanthine oxidase에 대한 새로운 저해물질의 탐색 및 개발을 목적으로 본 연구에서 선택분리한 Aspergillus sp. F184가 생산하는 저해물질을 분리·정제하고 구조를 결정하였으며 효소저해활성을 조사하였다. 본 균주를 배양 후 배양액을 여과하여 균체와 배양액을 분리하고 균체를 acetone으로 추출하고 감압농축하고 남은 수용액층을 배양액과 합쳐 HP-20 adsorption column chromatography, ethyl acetate추출, silica gel column chromatography, 결정화 등을 실시하여 xanthine oxidase에 대한 저해물질을 분리, 정제하였다. 본 저해물질의 구조를 NMR 및 MS 스펙트럼을 측정하여 분석한 결과 5,6-epoxy-2-hydroxy-3-methyl-2-cyclohexene-1,4-dione으로서 terreic acid로 동정되었다. Terreic acid의 xanthine oxidase에 대한 저해활성을 조사한 결과 IC_50가 1.1×10 exp (-7) M로서 기존의 저해제인 allopurinol과 유사하였다. 이에 terreic acid에 의한 xanthine oxidase 저해활성은 보고된 바가 없기에 새로운 통풍치료제로서의 가능성이 있음을 보고한다. Aspergillus sp. F184 was isolated from soil for the development of new xanthine oxidase inhibitor. This xanthine oxidase inhibitor was sequentially purified by filtration, HP-20 adsorption column chromatography, ethyl acetate extraction, silica gel column chromatography and crystallization, and was named as YUX 104. YUX 104 was identified to be 5,6-epoxy-2-hydroxy-3-methyl-2-cyclohexene-1,4-dione(terreic acid) by NMR and mass spectroscopic sudies.