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Park, Sarah S.,Hong, Minyoung,Ha, Yejin,Sim, Jeongeun,Jhon, Gil-Ja,Lee, Youngmi,Suh, Minah The Royal Society of Chemistry 2015 The Analyst Vol.140 No.10
<P>This study reports real-time, <I>in vivo</I> functional measurement of nitric oxide (NO) and carbon monoxide (CO), two gaseous mediators in controlling cerebral blood flow. A dual electrochemical NO/CO microsensor enables us to probe the complex relationship between NO and CO in regulating cerebrovascular tone. Utilizing this dual sensor, we monitor <I>in vivo</I> change of NO and CO simultaneously during direct epidural electrical stimulation of a living rat brain cortex. Both NO and CO respond quickly to meet physiological needs. The neural system instantaneously increases the released amounts of NO and CO to compensate the abrupt, yet transient hypoxia that results from epidural electrical stimulation. Intrinsic-signal optical imaging confirms that direct electrical stimulation elicits robust, dynamic changes in cerebral blood flow, which must accompany NO and CO signaling. The addition of <SMALL>L</SMALL>-arginine (a substrate for NO synthase, NOS) results in increased NO generation and decreased CO production compared to control stimulation. On the other hand, application of the NOS inhibitor, <SMALL>L</SMALL>-N<SUP>G</SUP>-nitroarginine methyl ester (<SMALL>L</SMALL>-NAME), results in decreased NO release but increased CO production of greater magnitude. This observation suggests that the interaction between NO and CO release is likely not linear and yet, they are tightly linked vasodilators.</P> <P>Graphic Abstract</P><P>This study reports real-time, <I>in vivo</I> functional measurement of nitric oxide (NO) and carbon monoxide (CO), two gaseous mediators in controlling vascular function. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5an00122f'> </P>
Photo-induced hybrid nanopatterning of titanium dioxide <i>via</i> direct imprint lithography
Park, Hyeong-Ho,Choi, Dae-Geun,Zhang, Xin,Jeon, Sohee,Park, Seong-Je,Lee, Soon-Won,Kim, Sarah,Kim, Ki-don,Choi, Jun-Hyuk,Lee, Jihye,Yun, Dae Keun,Lee, Ki Joong,Park, Hyung-Ho,Hill, Ross Henry,Jeong, J Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.10
<P>A novel ultraviolet (UV)-assisted imprinting procedure that employs photosensitive titanium(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) is presented for the fabrication of well-ordered titanium dioxide (TiO<SUB>2</SUB>) nanostructures at room temperature. The main novelty of this technique is the use of the photosensitive titanium organic compound, rather than a commonly used UV-curable resin, for direct UV-assisted nanoimprint lithography. Fourier transform infrared and X-ray photoelectron spectroscopy studies suggest that exposure to UV light resulted in the gradual removal of organic groups from films prepared from titanium(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) photochemically and successively converted the films to TiO<SUB>2</SUB> at room temperature. This approach allows direct fabrication of TiO<SUB>2</SUB> nanopatterns with lines down to 35 nm in width, hole arrays of 265 nm in diameter, and three-dimensional TiO<SUB>2</SUB> hybrid micro/nano-patterns without observable defects for use in applications where ordered surface nanostructures are required, such as photovoltaics, photonics, and optical waveguides.</P> <P>Graphic Abstract</P><P>A novel UV-assisted imprinting procedure that employs photosensitive Ti(<SMALL>IV</SMALL>) di-n-butoxide bis(2-ethylhexanoate) is presented for the fabrication of well-ordered TiO<SUB>2</SUB> and 3-D TiO<SUB>2</SUB> hybrid micro/nano-patterns at room temperature. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b921343k'> </P>
Park, Sarah S.,Hendon, Christopher H.,Fielding, Alistair J.,Walsh, Aron,O’Keeffe, Michael,Dincă,, Mircea American Chemical Society 2017 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.139 No.10
<P>The structure-directing role of the inorganic secondary building unit (SBU) is key for determining the topology of metal organic frameworks (MOFs). Here we show that organic building units relying on strong Ir interactions that are energetically competitive with the formation of common inorganic SBUs can also play a role in defining the topology. We demonstrate the importance of the organic SBU in the formation of Mg2H6(H3O)(TTFTB)(3) (MIT-25), a mesoporous MOF with the new ssp topology. A delocalized electronic hole is critical in the stabilization of the TTF triad organic SBUs and exemplifies a design principle for future MOF synthesis.</P>
Park, Sarah S.,Hontz, Eric R.,Sun, Lei,Hendon, Christopher H.,Walsh, Aron,Van Voorhis, Troy,Dincă,, Mircea American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.5
<P>Isostructural metal–organic frameworks (MOFs) M<SUB>2</SUB>(TTFTB) (M = Mn, Co, Zn, and Cd; H<SUB>4</SUB>TTFTB = tetrathiafulvalene tetrabenzoate) exhibit a striking correlation between their single-crystal conductivities and the shortest S···S interaction defined by neighboring TTF cores, which inversely correlates with the ionic radius of the metal ions. The larger cations cause a pinching of the S···S contact, which is responsible for better orbital overlap between p<SUB><I>z</I></SUB> orbitals on neighboring S and C atoms. Density functional theory calculations show that these orbitals are critically involved in the valence band of these materials, such that modulation of the S···S distance has an important effect on band dispersion and, implicitly, on the conductivity. The Cd analogue, with the largest cation and shortest S···S contact, shows the largest electrical conductivity, σ = 2.86 (±0.53) × 10<SUP>–4</SUP> S/cm, which is also among the highest in microporous MOFs. These results describe the first demonstration of tunable intrinsic electrical conductivity in this class of materials and serve as a blueprint for controlling charge transport in MOFs with π-stacked motifs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2015/jacsat.2015.137.issue-5/ja512437u/production/images/medium/ja-2014-12437u_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja512437u'>ACS Electronic Supporting Info</A></P>
Park, Kyoung Hwan,Kim, Sarah,Yang, Seung-Man,Park, Hyun Gyu American Scientific Publishers 2009 Journal of Nanoscience and Nanotechnology Vol.9 No.2
<P>In this study, we used localized surface plasmon resonances (LSPR) to observe a phenomenon of binding of DNA on Au and Au/Ag nanostructure arrays. Au and Au/Ag nanostructures of various geometric sizes and metal compositions were fabricated by colloidal lithography technique. The immobilization of capture DNA and subsequent hybridization with target DNA on the nanostructures caused the shift of maximum peak in LSPR spectra of the nanostructures. Using the peak shift, the immobilization of capture DNA was clearly verified in a nondestructive manner and hybridization with complementary target DNA was reliably differentiated from the non-specific binding with noncomplementary DNA. This work firmly implies that the LSPR spectra of the nanostructrues can be efficiently utilized to achieve a novel strategy for the detection of DNA on the nanostructures.</P>
Mental Health of People with Retinitis Pigmentosa :
Kim, Sarah,Shin, Dong Wook,An, Ah Reum,Lee, Choong Hyung,Park, Jong Hyock,Park, Jong Heon,Oh, Moo Kyung,Hwang, Soo Hee,Kim, Yoon,Cho, Belong,Lee, Hyun Ki Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2013 Optometry and vision science Vol.90 No.5
<P>The purpose of this study was to evaluate and compare the mental health of patients with retinitis pigmentosa (RP) with that of the general population of Korea.</P>
( Sejun Park ),( Ji Eun Lee ),( Myung Ah Lee ),( Sarah Park ),( Sang Young Roh ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Neuroendocrine tumor can be developed in any area of whole body, also differentiated from prostate cancer. On Jul, 2013, the Prostate Cancer Foundation proposed the classi fication of prostate cancer and neuroendocrine cancer. The neuroendocrine cancer can be differentiated from prostate cancer, but large cell neuroendocrine cell is known to be extremely rare. We report a case of large neuroendocrine carcinoma mimicking progressive lung & liver metastasis of advanced prostate cancer. A 68-year-old man presented with a 3 weeks history of anal bleeding in Sep, 2008. The colonoscopy showed submucosal rectal mass and CT showed multiple intra-abdominal lymph node enlargement. The pathologic findings of rectal mass was consistent with prostate cancer with 54.5 ng/mL of serum PSA level. After treatment of hormonal therapy followed by resection of prostate and radiation, the level of PSA decreased to 0.135 ng/ mL. On Oct, 2013, multiple metastatic lesions in lung, liver, and multiple lymph nodes developed. The biopsy of inguinal lymph nodes showed poorly differentiated carcinoma of prostate, so the hormonal treatment was restarted, resulting in progressive disease in liver and lung metastasis. After 6 cycles of docetaxel and prednisolone chemotherapy, most of metastatic lymph node showed partial response, but lung & liver metastasis lesions revealed still progressive disease with 0.006 ng/ml of serum PSA level. He underwent biopsy for metastatic lung & liver mass. The immunohistochemistry stain were negative for CDX-2 and PSA, but positive for chromogranin and synaptophysin, showing large cell neuroendocrine carcinoma. After treatment with etoposide and cisplatin, partial response was achieved in lung & liver metastasis, as well as other metastatic lymph node. Herein, we suggest that neuroendocrine differentiation should be considered in case of progressive disease prostate cancer especially with normal PSA level.
Sahng Wook Park,Sarah Yoon,Jong-Seok Moon,Byeong-Woo Park,Kyung-Sup Kim 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.5
Overexpression of HER2 in breast cancer cells is considered to induce the expression of acetyl-CoA carboxylase α (ACACA) and fatty acid synthase (FASN) through activation of mammalian target of rapamycin (mTOR) signaling pathway. Resveratrol, a red wine polyphenol, has been shown to induce apoptosis in several cancers by interfering in several signaling pathways. Present study elucidated the mechanism by which resveratrol downregulates ACACA and FASN in breast cancer cells. Resveratrol activated AMP-activated protein kinase (AMPK) and downregulated mTOR in BT-474 cells. These effects of resveratrol were mimicked by AICAR, an AMPK activator, and exogenously expressed constitutively active AMPK, while they were abolished by a dominant-negative mutant of AMPK. The downregulation of mTOR was not accompanied with changes in Akt, the upstream regulator of mTOR. These findings indicate that the downregulation of ACACA and FASN by resveratrol is mediated by the downregulation of mTOR signaling pathway via activation of AMPK.