Battery Charging System for PHEV and EV using Single Phase AC/DC PWM Buck Converter

Lee, Jung-Hyo,Jung, Doo-Yong,Park, Sang-Hoon,Lee, Taek-Kie,Kim, Young-Ryul,Won, Chung-Yuen The Korean Institute of Electrical Engineers 2012 Journal of Electrical Engineering & Technology Vol.7 No.5

In this paper, a battery charging system for Plug-in Hybrid Electric Vehicle (PHEV) and Electric Vehicle (EV), and operation algorithm of charging system are introduced. Also, the proposed charging system uses commercial electricity in order to charge the battery of parked PHEV and 48V battery charging system with power factor controllable single phase converter for PHEV is investigated in this paper. This research verifies the power factor control of input and the converter output controlled by the charge control algorithm through simulation and experiment.

Regulation of the Expression of FGF Receptors and Extracellular Matrix Associated Genes in ATDC5 Chondroprogenitor Cells

Sung Jin Lee,Jong Pyl Kim,Yong Min Kim,Kyung Jin Park,Hye Ryun Kim,Seung Ryul Kim,Hak Kyo Lee,Joong Kook Choi 한국유전학회 2007 Genes & Genomics Vol.29 No.2

Molecular Cloning of the Antiapoptotic Gene, p35, from Bombyx mori Nuclear Polyhedrosis Virus K1

Lee, Kwang Sik,Park, Hye Jin,Kim, Seong Ryul,Lee, Sang Mong,Sohn, Hung Dae,Jin, Byung Rae Korean Society of Sericultural Science 2001 International Journal of Industrial Entomology Vol.3 No.1

We have cloned and characterized an antiapoptotic gene, p35, which blocks apoptosis, from Bombyx mori nuclear polyhedrosis virus (BmNPV) K1 strain. The 897 bp p35 has an open reading frame of 299 amino acids. The BmNPV-K1 p35 showed a high identity to Autographa californica nuclear polyhedrosis virus and BmNPV T3 strain. The BmNPV-K1 p35 was different from the amino acid sequences of BmNPV T3 at 6 positions. The p35 gene of BmNPV-K1 was 99.2% identical at the nucleotide level and 98% identical at the amino acid level to BmNPV T3. The location of p35 gene in the BmNPV-K1 genome was confirmed by Southern blot analysis and its expression patterns at the transcriptional level in the infected cells were con- firmed by Northern hybridization analysis.

Validation of QF-PCR for Rapid Prenatal Diagnosis of Common Chromosomal Aneuploidies in Korea

Sung-Hee Han,Jae-Song Ryu,Jeong-Wook An,Ok-Kyoung Park,Hye-Ryoung Yoon,Young-Ho Yang,Kyoung-Ryul Lee 대한의학유전학회 2010 대한의학유전학회지 Vol.7 No.1

목적 : QF-PCR법은 흔한 염색체 이수성에 대한 빠른 산전 진단을 가능하게 하는데, 낮은 가격, 빠른 속도, 그리고 자동화가 가능하여 한꺼번에 많은 검체에 대해 적용할 수 있다는 장점들이 있다. 하지만 아직까지 국내에서 QF-PCR법은 산전 염색체 이수성 선별검사로 주로 사용되는 방법이 아니다. 본 연구에서는 한국인에서 빠른 산전 진단을 목적으로 시행하는 짧은 염기서열 반복(short tandem repeats, STR) 표지자를 이용한 QF-PCR법의 수행능을 검증하고자 한다. 대상 및 방법 : 2007년에서 2009년까지 산전 염색체 이수성 선별을 목적으로 의뢰된 847개의 양수 검체에 대해 QF-PCR법을 시행하였는데 13번, 18번, 21번, X, Y염색체에 위치한 총 20개의 STR 표지자로 구성된 Elucigene kit (Gen-Probe, Abingdon, UK)를 사용하였다. 총 847개의 양수 검체에 대한QF-PCR 결과는 염색체 검사 결과와 비교하였고, STR 표지자의 정보력을 평가하기 위해서 각 표지자에 대해 이형접합체 지수(heterozygosity index)를 구하였다. 결과 : 총 847개 양수 검체에 대한 QF-PCR 검사 결과 19개(2.2%, 19/847)에서 13, 18, 21번 염색체와 X, Y염색체의 수적 이상이 관찰되었는데 염색체 검사에서도 동일한 결과를 보여100% 양성 예측율을 나타냈다. 하지만 염색체 검사 결과 7개(0.8%, 7/847) 검체에서 5개의 균형전좌와 2개의 불균형 염색체 이상이 관찰되었으나 QF-PCR에서는 진단되지 않았다. STR 표지자의 평균 이형접합체 지수(he-terozygosity index)는 0.76으로 서양인에서 보고된 0.8에 비해 다소 낮았다. 본 연구에서 D13S634표지자의 미세수준의 중복(submicroscopic duplication)이 1.4% (12/847)에서 관찰되었는데 이는 한국인에서 특징적인 소견으로 생각된다. 결론 : 본 기관에서는 산전 염색체 이수성 선별을 위한 QF-PCR법을 검증하였으며 효율적이고 신뢰할 수 있는 방법임이 입증되었다. 하지만 QF-PCR결과를 해석하기 위한 지침을 만들기 위해서 검사실마다 독립적으로 각각의 STR표지자에 대한 검증이 필요하며, 또한 QF-PCR법을 통상적인 염색체 검사 업무흐름에 통합하는 것이 필요하다고 사료된다. Purpose: Quantitative fluorescent polymerase chain reaction (QF-PCR) allows for the rapid prenatal diagnosis of common aneuploidies. The main advantages of this assay are its low cost, speed, and automation, allowing for large-scale application. However, despite these advantages, it is not a routine method for prenatal aneuploidy screening in Korea. Our objective in the present study was to validate the performance of QF-PCR using short tandem repeat (STR) markers in a Korean population as a means for rapid prenatal diagnosis. Material and Methods: A QF-PCR assay using an Elucigene kit (Gen-Probe, Abingdon, UK), containing 20 STR markers located on chromosomes 13, 18, 21, X and Y, was performed on 847 amniotic fluid (AF) samples for prenatal aneuploidy screening referred for prenatal aneuploidy screening from 2007 to 2009. The results were then compared to those obtained using conventional cytogenetic analysis. To evaluate the informativity of STR markers, the heterozygosity index of each marker was determined in all the samples. Results: Three autosomes (13, 18, and 21) and X and Y chromosome aneuploidies were detected in 19 cases (2.2%, 19/847) after QF-PCR analysis of the 847 AF samples. Their results are identical to those of conventional cytogenetic analysis, with 100% positive predictive value. However, after cytogenetic analysis, 7 cases (0.8%, 7/847) were found to have 5 balanced and 2 unbalanced chromosomal abnormalities that were not detected by QF-PCR. The STR markers had a slightly low heterozygosity index (average: 0.76) compared to those reported in Caucasians (average: 0.80). Submicroscopic duplication of D13S634 marker, which might be a unique finding in Koreans, was detected in 1.4% (12/847) of the samples in the present study. Conclusion: A QF-PCR assay for prenatal aneuploidy screening was validated in our institution and proved to be efficient and reliable. However, we suggest that each laboratory must perform an independent validation test for each STR marker in order to develop interpretation guidelines of the results and must integrate QF-PCR into the routine cytogenetic laboratory workflow.

Retinoic Acid and BMP4 Cooperate to Induce the Expression of a Subset of Extracellular Matrix Genes during Preosteoblast Differentiation

Sung Jin Lee,Eung Rok Kim,Yong Min Kim,Kyung Jin Park,Hye Ryun Kim,Wun Jae Kim,Sang Jeon Lee,Kwang Youl Lee,Seung Ryul Kim,Hak Kyo Lee,Joong Kook Choi 한국유전학회 2006 Genes & Genomics Vol.28 No.2

Nationwide Long-Term Growth and Developmental Outcomes of Infants for Congenital Anomalies in the Digestive System and Abdominal Wall Defects With Surgery in Korea

Lee Soon Min,Lee Jin A,Chung Sung-Hoon,Lee Jang Hoon,Shim Jae Won,Lim Jae Woo,Kim Chang-Ryul,Chang Yun Sil 대한의학회 2023 Journal of Korean medical science Vol.38 No.49

Background: Infants with congenital anomalies of the digestive system and abdominal wall defects requiring surgery are at risk of growth and developmental delays. The aim of this study was to analyze long-term growth and developmental outcomes for infants with congenital anomalies of the digestive system and abdominal wall defects who underwent surgery in Korea. Methods: We extracted data from the Korean National Health Insurance Service database for the years 2013–2019. Major congenital anomalies were defined according to the International Classification of Diseases-10 and surgery insurance claim codes. The χ2 test and the CochranArmitage trend test were performed for data analysis. Results: A total of 4,574 infants with major congenital anomalies in the digestive system and abodminal wall defects, who had undergone surgey, were reviewed. Anorectal obstruction/ stenosis was the most prevalent anomaly (4.9 per 10,000 live births). The prevalence of congenital anomalies of the digestive system was 15.5 per 10,000 live births, and that of abdominal wall defects was 1.5 per 10,000 live births. Seven percent of infants with congenital anomalies in the digestive system died, of which those with diaphragmatic hernia had the highest mortality rate (18.8%). Among 12,336 examinations at 6, 12, 24, 36, 48, 60, and 72 months of age, 16.7% showed a weight below the 10th percentile, 15.8% had a height below the 10th percentile, and 13.2% had a head circumference below the 10th percentile. Abnormal developmental screening results were observed in 23.0% of infants. Infants with esophageal atresia with/without tracheoesophageal fistula most often had poor growth and development. Delayed development and cerebral palsy were observed in 490 (10.7%) and 130 (2.8%) infants respectively. Comparing the results of infants born in 2013 between their 24- and 72-month health examinations, the proportions of infants with poor height and head circumference growth increased by 6.5% and 5.3%, respectively, whereas those with poor weight growth and abnormal developmental results did not markedly change between the two examinations. Conclusion: Infants with congenital anomalies of the digestive system and abdominal wall defects exhibit poor growth and developmental outcomes until 72 months of age. Close monitoring and careful consideration of their growth and development after discharge are required.

Evaluation of Hydrothermally Converted Hydroxyapatite as a Bone Graft Substitute in Vivo

( Sang Ryul Bae ),( Jin Woo Park ),( Jae Mok Lee ),( Jo Young Suh ) 대한치주과학회 2006 대한치주과학회 학술대회자료집 Vol.2006 No.2

Endurance Capacity of the Biceps Brachii Muscle Using the High-to-Low Ratio between Two Signal Spectral Moments of Surface EMG Signals during Isotonic Contractions

Lee, Sang-Sik,Jang, Jee-Hun,Cho, Chang-Ok,Kim, Dong-Jun,Moon, Gun-Pil,Kim, Buom,Choi, Ahn-Ryul,Lee, Ki-Young The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.8 No.1

Many researchers had examined the validity of using the high-to-low ratio between two fixed frequency band amplitudes (H/L-FFB) from the surface electromyography of a face and body as the first spectral index to assess muscle fatigue. Despite these studies, the disadvantage of this index is the lack of a criterion for choosing the optimal border frequency. We tested the potential of using the high-to-low ratio between two signal spectral moments (H/L-SSM), without fixed border frequencies, to evaluate muscle fatigue and predict endurance time ($T_{end}$), which was determined when the subject was exhausted and could no longer follow the fixed contraction cycle. Ten healthy participants performed five sets of voluntary isotonic contractions until they could only produce 10% and 20% of their maximum voluntary contraction (MVC). The $T_{end}$ values for all participants were $138{\pm}35s$ at 10% MVC and $69{\pm}20s$ at 20% MVC. Changes in conventional spectral indices, such as the mean power frequency (MPF), Dimitrov spectral index (DSI), H/L-FFB, and H/L-SSM, were extracted from surface EMG signals and were monitored using the initial slope computed every 10% of $T_{end}$ as a statistical indicator and compared as a predictor of $T_{end}$. Significant correlations were found between $T_{end}$ and the initial H/L-SSM slope as computed over 30% of $T_{end}$. In conclusion, initial H/L-SSM slope can be used to describe changes in the spectral content of surface EMG signals and can be employed as a good predictor of $T_{end}$ compared to that of conventional spectral indices.

Major Congenital Anomalies in Korean Livebirths in 2013–2014: Based on the National Health Insurance Database

Lee Jin A,Lee Soon Min,Chung Sung-Hoon,Lee Jang Hoon,Shim Jae Won,Lim Jae Woo,Kim Chang-Ryul,Chang Yun Sil 대한의학회 2023 Journal of Korean medical science Vol.38 No.39

Background: In Korea, there have been no reports comparing the prevalence of major congenital anomalies with other countries and no reports on surgical treatment and longterm mortality. We investigated the prevalence of 67 major congenital anomalies in Korea and compared the prevalence with that of the European network of population-based registries for the epidemiological surveillance of congenital anomalies (EUROCAT). We also investigated the mortality and age at death, the proportion of preterm births, and the surgical rate for the 67 major congenital anomalies. Methods: Korean National Health Insurance claim data were obtained for neonates born in 2013–2014 and admitted within one-year-old. Sixty-seven major congenital anomalies were defined by medical diagnoses classified by International Classification of Diseases-10 codes according to the EUROCAT definition version 2014. Mortality and surgery were defined if any death or surgery claim code was confirmed until 2020. Poisson distribution was used to calculate the 95% confidence interval of the congenital anomaly prevalence. Results: The total prevalence of the 67 major anomalies was 433.5/10,000 livebirths. When compared with the prevalence of each major anomaly in EUROCAT, the prevalence of spina bifida, atrial septal defect (ASD), congenital megacolon, hip dislocation and/or dysplasia and skeletal dysplasia were more than five times higher in Korea. In contrast, the prevalence of aortic atresia/interrupted aortic arch and gastroschisis was less than one-fifth in Korea. The proportion of preterm births was 15.7%; however, more than 40% of infants with anencephaly, annular pancreas and gastroschisis were preterm infants. Additionally, 29.2% of the major anomalies were admitted to the neonatal intensive care units at birth, and 25.6% received surgical operation. The mortality rate was 1.7%, and 78.2% of the deaths occurred within the first year of life. However, in neonates with tricuspid valve atresia and stenosis, duodenal atresia or stenosis, and diaphragmatic hernia, more than half died within their first month of life. ASD and ventricular septal defect were the most common anomalies, and trisomy 18 and hypoplastic left heart syndrome were the most fatal anomalies. All infants with aortic atresia/interrupted aortic arch and conjoined twins received surgery. Conclusion: The proportion of surgeries, preterm births and mortality was high in infants with major congenital anomalies. The establishment of a national registry of congenital anomalies and systematic support by national medical policies are needed for infants with major congenital anomalies in Korea.

Endurance Capacity of the Biceps Brachii Muscle Using the High-to-Low Ratio between Two Signal Spectral Moments of Surface EMG Signals during Isotonic Contractions

Sang-Sik Lee,Jee-Hun Jang,Chang-Ok Cho,Dong-Jun Kim,Gun-Pil Moon,Buom Kim,Ahn-Ryul Choi,Ki-Young Lee 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.4

Many researchers had examined the validity of using the high-to-low ratio between two fixed frequency band amplitudes (H/L-FFB) from the surface electromyography of a face and body as the first spectral index to assess muscle fatigue. Despite these studies, the disadvantage of this index is the lack of a criterion for choosing the optimal border frequency. We tested the potential of using the high-to-low ratio between two signal spectral moments (H/L-SSM), without fixed border frequencies, to evaluate muscle fatigue and predict endurance time (Tend), which was determined when the subject was exhausted and could no longer follow the fixed contraction cycle. Ten healthy participants performed five sets of voluntary isotonic contractions until they could only produce 10% and 20% of their maximum voluntary contraction (MVC). The Tend values for all participants were 138 ± 35 s at 10% MVC and 69 ± 20 s at 20% MVC. Changes in conventional spectral indices, such as the mean power frequency (MPF), Dimitrov spectral index (DSI), H/L-FFB, and H/L-SSM, were extracted from surface EMG signals and were monitored using the initial slope computed every 10% of Tend as a statistical indicator and compared as a predictor of Tend. Significant correlations were found between Tend and the initial H/L-SSM slope as computed over 30% of Tend. In conclusion, initial H/L-SSM slope can be used to describe changes in the spectral content of surface EMG signals and can be employed as a good predictor of Tend compared to that of conventional spectral indices.