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( Sang Hoon Kwon ),( Jung Soo Eun ),( Young Mo Kang ),( Eon Jeong Nam ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Dermatomyositis (DM) is an idiopathic infiammatory myopathy with characteristic cutaneous manifestations such as heliotrope rash on eyelids and Gottron`s papule. The myopathy in DM shows proximal and often symmetric muscle involvement in the extremities (hip, thigh and shoulder girdle) but rarely affects paraspinal muscles. Here, we report the case of a 43-year old man diagnosed as DM presenting predominant involvement of psoas and paraspinal muscles. Case: A 43-year-old man presented with diffi culty of supine to sitting position and lower back pain for 3 months. On physical exams, he presented scaling, erythematous, itchy cutaneous rashes on dorsum of hands, scalp, and face, especially eyelids. He did not sit on his own in supine position and showed only a low grade muscle weakness (grade 4/5) on lower proximal extremities. Laboratory fi ndings confi rmed the muscle enzyme elevation: CPK 595 U/L (N<170), aldolase 17.8 U/L (N<7.6), serum myoglobin 442 ng/mL (N: 14-106), and LDH 1039 U/L (N: 240-480). Other laboratory fi ndings were ESR 39 mm/hr (N<10), and CRP 1.63 mg/dL (N<0.5). ANA and antibodies were negative. EMG showed polyphasic motor unit potential and increased insertional activity on psoas, paraspinal and gluteus medius muscles. Positron emission tomography demonstrated increased 18FDG uptake in psoas and paraspinal muscles but no 18FDG uptake in proximal muscles of upper and lower extremities. MRI showed hyperintense signals on T2-weighted and gadolinium-enhanced T1-weighted images on psoas and paraspinal muscles. Paraspinal muscle biopsy revealed diffuse infi ammatory endomysial and perivascular infi ltrates, which were compatible with infi ammatory myopathy. Hewas diagnosed as DM with predominant involvement of paraspinal and psoas muscle involvement. He was treated with high dose of steroid and immunosuppressants and showed decreased muscle enzymes and improved muscular weakness.
Numerical Predictions of the Load-Displacement Curves of Rock-Socketed Concrete Piles
Kwon, Oh-Sung,Kim, Jeong-Hwan,Jeon, Kyung-Soo,Kim, Myoung-Mo Korean Geotechnical Society 1999 지반 : 한국지반공학회지 Vol.15 No.3
암반 근입말뚝의 설계기준은 일반적으로 침하량 기준을 사용하므로 설계단계에서 암반근입말뚝의 하중-변위$(\sigma-\sigma)$ 거동을 잘 이해해야 하나 그 거동의 복잡성으로 인해 하중-변위 거동을 파악하기가 어렵다. 이를 위해 먼저 현장타설 콘크리트 말뚝에 대해 현장재하시험을 실시하여 그 결과로부터 암반 근입말뚝의 하중-변위 거동을 고찰하였고, 상용 프로그램인 ELAC을 이용하여 하중-변위 곡선의 형상에 큰 영향을 주는 입력변수를 변화시켜 가며 말뚝의 하중-변위 관계를 모사하였다. 최종적으로 수치해석 입력데이터와 현장 지반조사결과의 관계를 일반화함으로써 지반공학자가 설계단계에서 적절한 현장데이터를 이용하여 하중-변위 거동을 예측할 수 있도록 하였다. The settlement limit concept is generally adopted as design criteria of rock-socketed pile foundations, therefore, the load-displacement$(\sigma-\sigma)$ behavior of the rock-socketed piles should be well understood at the design stage, which, however, is hard to achieve due to its complexity. To help this out, field pile load tests are executed on cast-in-situ concrete piles, first, to figure out the $\sigma$-$\delta$ behavior of rock-socketed piles. Next, the $\sigma-\sigma$ relations of the piles are simulated numerically using commercial package program(ELAC) varying a couple of input data which are sensitive in shaping the $\sigma$-$\delta$ curves. Finally, the relation between the best input data for the numerical simulations and the geotechnical field data are cultivated to generalize the numerical simulation procedures, which enables geotechnical engineers to predict the $\sigma$-$\delta$ behavior at the design stage, if appropriate geotechnical field data are provided.
Mo, Sung-Ji,Son, Eun-Wha,Rhee, Dong-Kwon,Pyo, Suhkneung The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.3
Plant nutrients are believed to provide protection against various diseases including inflammation. Since interactions of the cell adhesion molecules are known to play important roles in mediating inflammation, inhibiting adhesion protein upregulation is a possible therapeutic target. In this study, the interacellular adhesion molecule-1 (ICAM-1) was induced in human umbilical endothelial cells (HUVECs) after stimulation with $TNF-{\alpha}$. In addition, alginate, ascorbic acid and allicin were demonstrated to inhibit the $TNF-{\alpha}$ induced expression of ICAM-1 on the HUVECs in a dose-dependent manner. These compounds also inhibited the production of NO and $H_2O_2$ induced by $TNF-{\alpha}$, which suggests that the inhibition of ICAM-1 expression by the three compounds may be due to the modulated production of the reactive oxygen/nitrogen components. Overall, these results indicate that these dietary components have a therapeutic potential in the treatment of various inflammatory disorders associated with an increase in endothelial leukocyte adhesion molecules.
Effects of lugworm protease on the dyeing properties of protein fibers
Sang-Mo Kang,고준석,Sun-Young Noh,Soo-Jin Kim,Yoon-Jung Kwon 한국공업화학회 2009 Journal of Industrial and Engineering Chemistry Vol.15 No.4
A lugworm protease, Perinereis aibuhitensis, was used to improve the dyeing properties of protein fibers such as wool and silk. The optimal condition for the activity of the lugworm protease was about 40℃ at pH 7. The wool and silk were treated with the protease extracted from a lugworm and the K/S values of the dyed wool and silk were measured using a spectrophotometer in order to compare the dye uptake. The protease treatment enhanced the dyeing properties of protein fibers without severe changes in their mechanical properties. The surface appearances of protease-treated fibers were observed via microscopy.
Mo, SangJoon,Lee, Sung-Kwon,Jin, Ying-Yu,Oh, Chung-Hun,Suh, Joo-Won Springer-Verlag 2013 Applied microbiology and biotechnology Vol.97 No.7
<P>FK506 production by a mutant strain (Streptomyces sp. RM7011) induced by N-methyl-N'-nitro-N-nitrosoguanidine and ultraviolet mutagenesis was improved by 11.63-fold (94.24?mg/l) compared to that of the wild-type strain. Among three different metabolic pathways involved in the biosynthesis of methylmalonyl-CoA, only expression of propionyl-CoA carboxylase (PCC) pathway led to a 1.75-fold and 2.5-fold increase in FK506 production and the methylmalonyl-CoA pool, respectively, compared to those of the RM7011 strain. Lipase activity of the high FK506 producer mutant increased in direct proportion to the increase in FK506 yield, from low detection level up to 43.1?U/ml (12.6-fold). The level of specific FK506 production and lipase activity was improved by enhancing the supply of lipase inducers. This improvement was approximately 1.88-fold (71.5?mg/g) with the supplementation of 5?mM Tween 80, which is the probable effective stimulator in lipase production, to the R2YE medium. When 5?mM vinyl propionate was added as a precursor for PCC pathway to R2YE medium, the specific production of FK506 increased approximately 1.9-fold (71.61?mg/g) compared to that under the non-supplemented condition. Moreover, in the presence of 5?mM Tween 80, the specific FK506 production was approximately 2.2-fold (157.44?mg/g) higher than that when only vinyl propionate was added to the R2YE medium. In particular, PCC expression in Streptomyces sp. RM7011 (RM7011/pSJ1003) together with vinyl propionate feeding resulted in an increase in the FK506 titer to as much as 1.6-fold (251.9?mg/g) compared with that in RM7011/pSE34 in R2YE medium with 5?mM Tween 80 supplementation, indicating that the vinyl propionate is more catabolized to propionate by stimulated lipase activity on Tween 80, that propionyl-CoA yielded from propionate generates methylmalonyl-CoA, and that the PCC pathway plays a key role in increasing the methylmalonyl-CoA pool for FK506 biosynthesis in RM7011 strain. Overall, these results show that a combined approach involving classical random mutation and metabolic engineering can be applied to supply the limiting factor for FK506 biosynthesis, and vinyl propionate could be successfully used as a precursor of important methylmalonyl-CoA building blocks.</P>