http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국에서 분리된 병원성 Salmonella 균주의 장독소 유전자(stn) 분포와 발현조절 기작
유상렬 서울대학교 농업개발연구소 2000 농업생명과학연구 Vol.4 No.-
Role of enterotoxin from Salmonella in pathogenesis is not known. Enterotoxin gene from Salmonella typhimurium (stn) encodes a 29 kDa toxin that has no homology to any other known enterotoxins. Expression of stn is enhanced upon contact with epithelial cell but not all strains having the stn gene express Stn. Based on PCR analysis, we found that all 36 clinical strains of Salmonella isolated in Korea tested carried the stn gene. To understand the regulation of the stn transcription, the expression of stn was studied in vitro. The expression of stn was inhibited by cAMPㆍCRP complex by about 50%.
Mlc 조절단백질이 대장균의 pts 유전자 발현에 미치는 영향
유상렬 서울대학교 농업개발연구소 1999 농업생명과학연구 Vol.3 No.-
Products of the pts operon of Escherichia coli have multiple physiological roles and the operon is controlled by two promoters, P0 and P1. Expression of the pts P0 promoter that is increased during growth in the presence of glucose is also activated by CRP-cAMP. The effects of the Mlc on the pts P0 expression were studied. In vivo transcription assay using wild type and Mlc strains grown in the presence and absence of glucose indicate that Mlc negatively regulates expression of P0, and Mlc-dependent repression is relieved by glucose in the growth medium. In vitro transcription assay using purified Mlc showed that Mlc repressed transcription from the P0 specifically.
Analysis of Salmonella pathogenicity island (SPI) 2 gene expression
Ryu, Sang-Ryeol 서울대학교 농업개발연구소 2001 농업생명과학연구 Vol.5 No.-
Salmonella pathogenicity island 2 (SPI2) encodes a putative type Ⅲ secretion system necessary for replication inside macrophages systemic infection in animals. The genes for the secretion system such as ssaH are transcribed preferentially after Salmonella enters host cells. The transcriptional organization of 3 genes of SPI2 was investigated, which encode components of one of two type Ⅲ secretion apparatus of Salmonella typhimurium. ssaH, I, J constitute one operon of 1.5 kb and the promoter of this operon lies upstream of ssaH. The transcriptional regulation of ssaH (operon) was studied by primer extension analysis. It was found that stationary growth phase-specific transcription of ssaH is most efficient in the presence of OmpR (pleiotropic regulator of Salmonella virulence genes), InvF, SsrB (local regulator of SPI1 and 2), IHF, and Fis (nucleoid associated proteins). Furthermore, we constructed two kinds of reporter plasmid to know whether the ssaH expression is specific to Salmonella. In this study, it was found that SsrB was prerequisite of ssaH expression because a ssaH was not expressed in E. coli which is absent of SPI.