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Ng, C.T.,Oh, S.,Lee, Y. Elsevier BV 2016 Statistical methodology Vol.32 No.-
<P>Recently, the selection consistency of penalized least square estimators has received a great deal of attention. For the penalized likelihood estimation with certain non-convex penalties, search space can be constructed within which there exists a unique local minimizer that exhibits selection consistency in high-dimensional generalized linear models under certain conditions. In particular, we prove that the SCAD penalty of Fan and Li (2001) and a new modified version of the unbounded penalty of Lee and Oh (2014) can be employed to achieve such a property. These results hold even for the non-sparse cases where the number of relevant covariates increases with the sample size. Simulation studies are provided to compare the performance of SCAD penalty and the newly proposed penalty. (C) 2016 Elsevier B.V. All rights reserved.</P>
Solubilization and formulation of chrysosplenol C in solid dispersion with hydrophilic carriers
Ng, C.L.,Lee, S.E.,Lee, J.K.,Kim, T.H.,Jang, W.S.,Choi, J.S.,Kim, Y.H.,Kim, J.K.,Park, J.S. Elsevier/North Holland 2016 International journal of pharmaceutics Vol.512 No.1
We investigated how to overcome problems associated with the solubility, dissolution, and oral bioavailability of the poorly water-soluble drug compound, chrysosplenol C (CRSP), as well as the effects of single and binary hydrophilic polymers (PVP K-25 and/or PEG 6000) on the solubility and dissolution parameters of CRSP. Then an optimized formulation was further developed with a surfactant. To select a surfactant suitable for a CRSP-loaded solid dispersion (SD), the solubility of CRSP in distilled water containing 1% surfactant was compared with the solubilities in other surfactants. Sodium lauryl sulfate (SLS) showed the highest drug solubility. Overall, a formulation containing CRSP, binary hydrophilic polymers (PVP and PEG 6000), and SLS at a ratio of 2.0/0.2/1.1/0.7 showed the optimum in vitro release profile. This optimized formulation had better safety properties than pure CRSP in cell viability examinations. SD formulations were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray powder diffraction (XRD), and Fourier-transform infrared (FT-IR) spectroscopy. Our optimized SD formulation is expected to improve the bioavailability of CRPS because it improves the solubility and dissolution rate of CRSP.
C.K. Ng,S. Ramesh,C.Y. Tan,C.Y. Ching,N. Lwin,A. Muchtar 한양대학교 세라믹연구소 2016 Journal of Ceramic Processing Research Vol.17 No.5
In the present work, the effect of manganese oxide (MnO2) additions (0, 0.5, 1 and 5 wt%) on the properties of ceria-dopedscandia stabilized zirconia (10Sc1CeSZ) was investigated over the temperature range of 1400 oC to 1550 oC. The results showedthat the addition up to 1 wt% had negligible effect on the mechanical properties of the ceramic. The samples containing upto 1 wt% MnO2 attained above 97.5% relative density, Vickers hardness of 13-14 GPa and fracture toughness of about3 MPam1/2. In addition, it was revealed that the 0.5 wt% MnO2 addition was beneficial in suppressing the cubic zirconia graingrowth i.e. the highest average grain size was measured at 4.9 µm when sintered at 1550 oC as compared to 9.9 µm measuredfor the undoped zirconia when sintered at the same temperature. On the other hand, the addition of 5 wt% MnO2 was foundto be detrimental to the densification and properties of the zirconia, particularly when sintered at higher temperatures. Thiswas attributed to the accelerated grain growth of the doped samples, i.e. the grain size increased by 2 fold, to 18.6 µm whensintered at 1550 oC.
Single-Port Thoracic Surgery: A New Direction
Calvin S. H. Ng,F.R.C.S. 대한흉부외과학회 2014 Journal of Chest Surgery (J Chest Surg) Vol.47 No.4
Single-port video-assisted thoracic surgery (VATS) has slowly established itself as an alternate surgical approach for the treatment of an increasingly wide range of thoracic conditions. The potential benefits of fewer surgical incisions, better cosmesis, and less postoperative pain and paraesthesia have led to the technique’s popularity worldwide. The limited single small incision through which the surgeon has to operate poses challenges that are slowly being addressed by improvements in instrument design. Of note, instruments and video-camera systems that are narrower and angulated have made single-port VATS major lung resection easier to perform and learn. In the future, we may see the development of subcostal or embryonic natural orifice translumenal endoscopic surgery access, evolution in anaesthesia strategies, and cross-discipline imaging-assisted lesion localization for single-port VATS procedures.