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(Hi Joon Park),(Hyang Sook Lee),(Ying Qiu Xia),(Yun Wang),(Fei Luo),(Ji Sheng Han),(Hye Jung Lee) 경희대학교 한의학연구소 2000 JOURNAL OF ORIENTAL MEDICINE Vol.5 No.1
The aim of the present study was to assess the effect of electroacupuncture(EA) on arthritic pain and trk A mRNA level in spinal cord of the rats with chronic inflammatory pain. The chronic monoarthritic pain model was produced by intra-articular injectio
Electroacupuncture at acupoint GB30 decreases the expression of trk A mRNA in monoarthritic rat
Park, Hi-Joon,Lee, Hyang-Sook,Xia, Ying-Qiu,Wang, Yun,Luo, Fei,Han, Ji-Sheng,Lee, Hye-Jung INSTITUTE OF ORIENTAL MEDICINE KYUNG-HEE UNIVERSIT 2000 JOURNAL OF ORIENTAL MEDICINE Vol.5 No.1
The aim of the present study was to assess the effect of electroacupunctue(EA) on arthritic pain and trk A mRNA level in spinal cord of the rats with chronic inflammatory pain. The chronic monoarthritic pain model was produced by intra-articular injection of complete freunds adjuvant (CFA) at right ankle joint. 2 Hz EA treatment was administered at acupoint GB30 once a week. The ankle bend scores and the differences of ankle perimeter were measured to evaluated the pain and severity of arthritis, and the abundance of mRNA coding for trk A was measured by RT-PCR at lumbar dorsal spinal cords and dorsal root ganglias. In behavioral test, both the ircumferential differences and ankle bend scores decreased significantly after EA treatment compared with those in control group at the late chronic periods. trk A mRNa levels increased in both ipsilateral and contralateral lumbar spinal cords after CFA injection, while they returned to normal after EA treatment. In conclusion, our study showed that 2 Hz EA treatment at GB30 alleviated the arthritic pain, and suppressed the expression of trk A receptor mRNA induced by CFA injection, which might implicate mechanisms of the therapeutic effect of EA.
( An Gao Xu ),( Bo Jiang ),( Zhi Jin Yu ),( Xin Ying Wang ),( Xu Hui Zhong ),( Ji Hong Liu ),( Li Shou Xiong ),( Qiu Yun Luo ),( Ai Hua Gan ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Colorectal cancer is the third leading incidence of malignant tumour in the world and the incidence of colorectal cancer has steadily been increasing in Asia in recently years. The aim of our study is to determine the basic demographic features of patients with colorectal cancer and the anatomic distribution and characteristics of the tumour in Guangdong population. Methods: A review of patients from 1990 to 2004 at five hospitals was conducted, including Peal Triangle Area in Guangdong (Nanfang Hospital and Huizhou Central People`s Hospital), North area of Guangdong (Shaoguan North-Guangdong People`s Hospital), West area of Guangdong (Affiliated Hospital Guangdong Medical Institute) and East area of Guangdong (Meizhou People`s Hospital). Results: Analysis was carried out on 6,501 patents, only 6,488 cases provided age. The age ranged from 5 years old to 91 years old and the mean age of 6,488 cases is 59. 5.2% (340/6,488) of the patients was young CRC patients. The peak incidence was between the ages 61 and 70 years old (29.5%). The mean age increases from 55 years old (1990-1992) to 61 years old (2002-2004) and the proportion of young CRC patients descends from 7.1% to 3.5%. The make to female ratio is 1.5:1 and the ratio increased with age increasing. Of 6,501 lesions, 3,423 (52.7%) were located in rectum and 3,078 (47.3%) in colon, the ratio of rectum cancer to colon cancer is 1.1:1. The proportion of rectum cancer decreased significantly from 74.5% (1990-1992) to 64.9% (2002-2004) and that of the right sides colon cancer increased from 25.5% to 35.1%. In four different areas, the mean age of CRC increasing and East area of Guangdong ranked the fist. There was no significant difference in the ratio of male to female. Conclusions: The demography of colorectal cancer in Guangdong is different from before and further study should be pursued to find the reason.