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( Pil Hoon Park ),( Youn Chul Kim ),( Ren Bo An ),( Jin Hur ),( Dong Hwan Sohn ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
In the present study, we investigated an anti-inflammatory effect of ethyl gallate (EG) isolated from Galla Rhois as evaluated by inhibition of nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression, and a potential role of heme oxygenase-1 (HO-1) in the inhibition of NO production elicited by EG. Treatment of RAW264.7 macrophages with EG significantly inhibited the production of NO and iNOS expression stimulated by lipopolysaccharide (LPS). We also demonstrated that EG treatment increased HO-1 mRNA and protein expression, as assessed by quantitative RT-PCR and Western blot analysis. EG treatment also increased the levels of nuclear factor-erythroid 2-related factor 2, which is critical for transcriptional induction of HO-1. In addition, treatment with SnPP (tin protoporphyrin IX), a selective HO-1 inhibitor, counteracted the inhibitoryeffect of EG on nitrite production, suggesting that HO-1 is, at least in part, implicated in the inhibition of NO production induced by EG treatment. Taken together, these results indicate that EG isolated from Galla Rhois suppresses NO production in LPS-stimulated RAW 264.7 macrophages via HO-1induction.
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Up-regulated claudin 7 expression in intestinal-type gastric carcinoma.
Park, Jeong Youp,Park, Kyung Hwa,Oh, Tae Yun,Hong, Sung Pil,Jeon, Tae Joo,Kim, Chang Hoon,Park, Seung Woo,Chung, Jae Bock,Song, Si Young,Bang, Seungmin National Hellenic Research Foundation 2007 Oncology reports Vol.18 No.2
<P>The disruption of tight junction protein expression in cancer might account for invasiveness, loss of cohesion, and lack of differentiation. Our cDNA array data indicated that claudin 7 was up-regulated in gastric carcinoma. We investigated the expression patterns and clinical implications of claudin 7 in gastric cancer. By immunohistochemical staining and Western blot, claudin 7 was significantly more often expressed in intestinal metaplasia, adenoma and cancer than in normal gastric epithelium. Twenty-seven (47.4%) of 57 normal gastric epithelium samples did not express claudin 7, but 50 (86.2%) of 58 intestinal metaplasia, 11 (91.7%) of 12 adenoma tissues, and 129 (82.7%) of 156 cancer samples did. Claudin 7 was more often unexpressed in diffuse type gastric cancer than in intestinal type. Only 13 (11.2%) of 116 intestinal type samples did not express claudin 7, but 14 (41.2%) of 34 diffuse type samples showed no expression. Compared to normal gastric epithelium, intestinal type gastric cancer significantly more often expressed claudin 7, but diffuse type did not. The expression pattern of claudin 7 did not change as cancer progressed. In this study we show that claudin 7 expression changed with the gastric carcinogenic process and that this is implicated in cancer characteristics.</P>
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Park, Kyung-Pil,Kim, Hyang-Sook,Kim, Eun-Sook,Park, Young-Eun,Lee, Chang-Hoon,Kim, Dae-Seong 대한신경과학회 2011 Journal of Clinical Neurology Vol.7 No.1
<P><B>Background and Purpose</B></P><P>Progressive external ophthalmoplegia (PEO) with Mendelian inheritance is a heterogeneous group of diseases associated with multiple deletions of mitochondrial DNA (mtDNA), which results from the disturbed replication and maintenance of mtDNA secondary to the mutations of nuclear genes including <I>POLG</I>, <I>SLC25A4</I>, <I>C10ORF2</I>, <I>POLG2</I>, <I>OPA1</I>, and <I>RRM2B</I>. The aim of this study was to identify the genetic defects underlying the pathology and clinical features in two Korean kindreds with autosomal dominant PEO.</P><P><B>Methods</B></P><P>Two pathologically proven PEO patients with a clear autosomal dominant pattern of inheritance were selected. To exclude a large-scale rearrangement, a long-range polymerase chain reaction (PCR) was performed using DNA extracted from biopsied muscle tissue taken from each patient. All coding regions and exon-intron boundaries of <I>POLG</I>, <I>SLC25A4</I>, <I>C10ORF2</I>, and <I>POLG2</I> were amplified by PCR and directly sequenced.</P><P><B>Results</B></P><P>One patient showed multiple deletions of mtDNA on long-range PCR analysis, and two known heterozygous missense mutations in <I>SLC25A4</I> (p.Asp104Gly) and <I>C10ORF2</I> (p.Glu479Lys) were identified in each patient. The p.Asp104Gly mutation in <I>SLC25A4</I> was identified in the patient with an early onset, slowly progressive, pure PEO phenotype, while the p.Glu479Lys mutation in <I>C10ORF2</I> was identified in the other patient, with a late-onset disease and PEO plus phenotype.</P><P><B>Conclusions</B></P><P>Two mutations affecting nuclear genes were identified in Korean patients with autosomal dominant PEO. Further studies are necessary to identify the clear pathogenetic mechanisms and establish genotype-phenotype correlations in autosomal dominant PEO.</P>
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Analysis of factors affecting crestal bone loss around the implants
Park, Ji-Hoon,Kim, Young-Kyun,Yun, Pil-Young,Yi, Yang-Jin,Yeo, In-Sung,Lee, Hyo-Jung,Park, Jin-Young Korean Academy of Dental Science 2009 Journal of korean dental science Vol.2 No.2
Purpose : To determine whether peri-implant crestal bone loss could be affected by systemic disease, primary ISQ value, implantation method (submerged vs. non-submerged), surface treatment, and bone density Materials and methods : Patients who underwent fixture installation from June 24, 2005 to October 23, 2008 at Seoul National University Bundang Hospital were evaluated. A total of 157 patients (male: 52, female: 85) had 346 fixtures installed. Among them, 49 patients had periapical radiographs taken 1 year after prostheses were first set. A total of 97 fixtures were implanted. In particular, 30 fixtures were installed in patients with systemic diseases such as diabetes mellitus, cardiovascular disease, hypertension, and liver disease. The immediate stability of implants was measured with $Osstell^{tm}$. Implant surface treatment was classified into two groups (RBM, Cellnest (Anodized)), and bone density, into four groups (D1~D4). The bone resorption on the mesial and distal areas of fixtures was measured with periapical radiographs using the paralleling technique, and the mean value was calculated. The length determination program in IMPAX (AGFA, Belgium) was used. Results : At least 332 out of 346 (96%) installed GS II implants were successfully osseointegrated 1 year after prostheses were first set. The mean value of the bone resorption of the installed GS II implants was 0.44mm. The minimum value was 0mm, and the maximum value, 2.85mm. There was a statistically significant difference between the implantation methods (submerged, non-submerged) with regard to the amount of alveolar bone loss 1 year after prostheses were first set (p<0.05). Non-submerged implants showed less crestal bone loss. Note, however, that other variables had no correlation with crestal bone loss (p>0.05). Conclusion : There was a statistically significant difference between the 1-stage method and 2-stage method with regard to the amount of alveolar bone loss 1 year after prostheses were first set. Systemic disease, primary ISQ value, surface treatment, and bone density were not associated with alveolar bone loss. Other variables were assumed to have a correlation with alveolar bone loss.
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Adiponectin as an Anti-fibrotic and Anti-inflammatory Adipokine in the Liver
( Pil Hoon Park ),( Carlos Sanz Garcia ),( Laura E Nagy ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-
Hepatic fibrosis is a dynamic process resulting from excessive deposition of extracellular matrix in the liver; uncontrolled progression of fibrosis can eventually lead to liver cirrhosis and/or hepatocellular carcinoma. The fibrogenic process is complex and modulated by a number of both hepatic and extra-hepatic biological factors. Growing evidence indicates that adipokines, a group of cytokines produced by adipose tissue, impart dynamic fibrosis. In particular, two key adipokines, adiponectin and leptin, directly regulate many biological responses closely associated with development and progression of hepatic fibrosis. Leptin acts as a pro-fibrogenic cytokine, while adiponectin possesses anti-fibrogenic and anti-inflamma-tory properties. Adiponectin, acting via its cognate recep-tors, adiponectin receptors 1 and 2, potently suppresses fibrosis and inflammation in liver via multiple mechanism. This review summarize recent findings concerning the role of adiponectin in fibrogenic process in liver and addresses the underlying molecular mechanisms in modu-lation of fibrosis.
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Sang-Hoon Kim,Jang Hyun Kim,YongHee Lee,Hyunseok Yang,Joo-Youn Park,Kyoung-Su Park,Young-Pil Park IEEE 2009 IEEE transactions on magnetics Vol.45 No.5
<P>Tilt error can affect a serious effect to holographic data storage system using angle(polytopic) multiplexing. Because the tolerance about tilt error is very tight it is important to measure the tilt error and compensate it. In this paper, tilt error measurement system with additional red laser and reflection geometry is suggested and servo control experiments are conducted. A servo controller to compensate tilt error is designed using disturbance observer. Amount of tilt is decreased smaller than 0.01 degree and signal-to-noise ratio is increased with the tilt servo controller when 0.216 degree of tilt disturbance is applied.</P>
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Magnetic resonance imaging evaluation of Yukatan minipig brains for neurotherapy applications
Seung Pil Yun,Dong Hyun Kim,Jung Min Ryu,Jae Hong Park,Su Shin Park,Ji Hoon Jeon,Bit Na Seo,Hyun-Jeong Kim,Jun-Gyu Park,Kyoung-Oh Cho,Ho Jae Han 한국실험동물학회 2011 Laboratory Animal Research Vol.27 No.4
Magnetic resonance imaging (MRI) of six Yukatan minipig brains was performed. The animals were placed in stereotaxic conditions currently used in experiments. To allow for correctpositioning of the animal in the MRI instrument, landmarks were previously traced on the snout of the pig. To avoid movements, animal were anesthetized. The animals were placed in a prone position in a Siemens Magnetom Avanto 1.6 System with a head coil. Axial T2-weighted and sagittal T1-weighted MRI images were obtained from each pig. Afterwards, the brains of the pigs were fixed and cut into axial sections. Histologic and MR images were compared. The usefulness of this technique is discussed.
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Ki-Hoon Kim,No-Cheol Park,Young-Pil Park,Kyoung-Su Park IEEE 2011 IEEE transactions on magnetics Vol.47 No.3
<P>In this paper, we propose a thermally assisted magnetic recording (TAMR) system with an optical fiber and specially designed prism attachment. The TAMR system utilizes an optical fiber and prism to facilitate the delivery of light to the slider and media. However, problems such as increasing suspension stiffness were encountered. Using an optical fiber increases the TAMR suspension stiffness and affects the pitch torque of the system. The pitch torque affects the flying height (FH), which can lead to slider-disk contact. Therefore, we investigated the stiffness of the TAMR suspension and the relationship between FH and the pitch static attitude (PSA). The various factors affecting the FH loss and the environmental conditions were also investigated. Finally, to compensate the large pitch stiffness and prevent slider-disk contact, the air bearing surface (ABS) of the TAMR system was optimized for robust slider performance, and the tolerance of the TAMR system was analyzed for the PSA considering various parameters such as temperature, relative humidity, operating conditions and manufacturing errors. The final PSA tolerances of the conventional and TAMR suspension were calculated. These values were 1.58° and 0.37°, respectively. The sensitivity of the optimal PSA design was decreased by about 21.5%. The PSA tolerance using the optimal design was 0.47°. This indicates that the tolerance of the optimal model is larger than that of original model, which was about 21.3%.</P>
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