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NAM, KOONG YONG,KIM, YUNG JIN,PARK, KYUNG SOOK,KIM, HYUN SUP,AHN, KWANG SOOK,HONG, SEUNG HO,LEE, CHUNG CHOO 충남대학교 기초과학연구소 1991 연구논문집 Vol.11 No.-
As a part of the investigation for clarifying the genetic composition of Korean population, phenotypes and allele frequencies of complement Factor I and complement Factor H in the blood were analysed by polyacrylamide gel isoelectric focusing followed by immunoblotting. Blood samples were obtained from healthy individuals living in Seoul, Kangreung an Cheju, Korea. Three phenotypes of complement Factor I (FI A, FI AB and FI B) appeared in Korean population. The allele frequencies of FI*A and FI*B were 0.9011 and 0.0989, respectively. Phenotypes of complement Factor H were classified into three common types(FH A, FH AB and FH B) and five rare types (FH A1, FH A1A, FH A1B, FH BM and FH QO). Allele frequencies of FH*A, FH*B, FH*A1, FH*M and FH*QO were 0.4739, 0.5056, 0.0155, 0.0024 and 0.0016, respectively. The FI*B frequency of Mongoloids was lower than that of Caucasoid population. The FH*B frequency appeared relatively higher than FH*A frequency in most populations studied. Rare alleles, FH*M and FH*QO, appeared in Korean and Japanese populations.
남궁선 ( Sun Nam Koong ),김지영 ( Jee Young Kim ),계지원 ( Ji Won Gye ),정지민 ( Ji Min Chung ),홍승필 ( Seung Phil Hong ),김명화 ( Myung Hwa Kim ),박병철 ( Byung Cheol Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10
Hypotrichosis simplex is a descriptive term of hair loss without other ectodermal or systemic abnormalities. Hypotrichosis simplex with non-familial and generalized types has been seldom reported. A 30-year-old man visited our clinic complaining of scalp hair loss since birth. There was no hair on the arms, axillae and legs. He had relatively scanty eyebrows and pubic hairs. None of his family members had known health problems or any hereditary disease. Hair shaft examination based on electron microscopy did not reveal any structural abnormalities. Microscopic examination of a scalp biopsy specimen showed a reduced number of hair follicles with vellus hairs replacing terminal hairs. Herein we report a rare and interesting case of non-familial generalized hypotrichosis simplex. (Korean J Dermatol 2011;49(10):940∼942)
변형된 삼극 전진 피판술을 이용한 피부 결손부 복원의 임상적 의의
남궁선 ( Sun Nam Koong ),김지석 ( Ji Seok Ki ),김지영 ( Jee Young Ki ),계지원 ( Ji Won Gye ),홍승필 ( Seung Phil Hong ),김명화 ( Yung Hwa Ki ),박병철 ( Byung Cheol Park ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.12
Background: Triple advancement flap has been recently introduced to close the skin defect after Mohs microscopic surgery. Objective: The aim of this study is to evaluate the clinical advantage of the modified triple advancement flap compared with rhomboid excision and closure. Methods: The modified triple advancement flap was performed on nine patients with skin cancer. We observed the clinical course after surgery and compared the scar length and the amount of removed normal skin in triple advancement flap with those in rhomboid excision and primary closure, by using an image-analyzing program. Results: The overall cosmetic and functional result was good. Partial flap necrosis was detected in one of nine patients, and hypertrophic scar developed in one of nine patients. The average scar length from the modified triple advancement flap was 102.1 mm, whereas it was 95.0 and 111.0 mm in 1:3 and 1:3.5 rhomboid excision with closure. The amount of removed skin was 716.3 mm2 in modified triple advancement flap, whereas it was 794.0 mm2 (1:3) and 1116.9 mm2 (1:3.5) in rhomboid excision with closure. Conclusion: The triple advancement flap might be used to close a defect in the area of trifurcation or bifurcation of skin tension lines, to spare the normal surrounding tissue as much as possible. (Korean J Dermatol 2014;52(12): 839∼844)
남궁선 ( Sun Nam Koong ),김지석 ( Ji Seok Kim ),김지영 ( Jee Young Kim ),계지원 ( Ji Won Gye ),정지민 ( Ji Min Chung ),최혜인 ( Hye In Choi ),홍승필 ( Seung Phil Hong ),박병철 ( Byung Cheol Park ),김명화 ( Myung Hwa Kim ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.5
Inflammatory linear verrucous epidermal nevi (ILVEN) were first described in the literature, in 1971, by Altman and Mehregan. Most cases were reported as solitary lesions. In contrast, systematized ILVEN, involving wide areas of the integument, has only rarely been reported. A variety of treatment modalities has been reported, ranging from topical medications, such as potent corticosteroids or tretinoin 0.1% to variable procedures, including CO2 and pulsed dye laser, cryotherapy, and surgical excision. However, multifocal skin lesion is more difficult to treat. An 8-year old boy was presented with an extensive thick scaly plaques and patches, affecting the trunk and the four extremities sparing face. It developed when he was 3 years old, and he complained pruritus. On physical examination, linear, or whirl-like scaly plaques were seen, along with Blaschko lines. Pathologic finding was in accordance to ILVEN. We treated him with topical calcipotriol, tacrolimus and systemic acitretin. After 8 months, the lesion and symptoms improved. (Korean J Dermatol 2012;50(5):464∼467)
Invited Review : Therapeutic Application of Nitric Oxide in Human Diseases
( Young Myeong Kim ),( Nam Koong Seung ) 한국응용약물학회 2010 Biomolecules & Therapeutics(구 응용약물학회지) Vol.18 No.4
Nitric oxide (NO), synthesized from L-arginine by three isoforms of NO synthase (NOS), is a gaseous signaling molecule with an astonishingly wide range of biological and pathophysiological activities, including vasorelaxation, angiogenesis, anti-inflammation, and anti-apoptosis in mammalian cells. Recent studies have shown that NO donors and inhaled NO convert to biologically active NO under biological conditions and act as a signaling molecule in pathophysiological conditions. This review will discuss the roles of NO and its potential therapeutic implication in various human diseases, such as tumor, vascular regeneration, hypertension, wound healing, and ischemia-reperfusion injury.
( Ji Min Chung ),( Sun Nam Koong ),( Ji Hyun Sim ),( Joong Sun Lee ),( Seung Phil Hong ),( Myung Hwa Kim ),( Byung Cheol Park ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Compared to cutaneous benign fibrous histiocytoma (BFH), deep-seated BFH is very rare and poorly recognized. Both cutaneous and deep-seated BFH are usually asymptomatic. We herein report a 25 year-old woman who presented with a painful mass in her foot that was poorly controlled by analgesics and associated with walking difficulty. After preoperative ultrasonographic evaluation, the mass was completely excised and histologic exam showed spindle cells loosely arranged in storiform architecture, with CD34-, desmin-, S-100-, focal CD68+, vimentin+, smooth muscle actin+, and factor XIIIa+. The patient was diagnosed with deep-seated BFH based on the histologic, radiologic and intraoperative findings. (Ann Dermatol 23(S2) S239~S242, 2011)